Molecular and immunohistochemical profile of a basaloid (cloacogenic) carcinoma of the sigmoid colon: possible predictive value for clinical outcomes.


:A 61-year-old woman was hospitalized with a 5-week history of abdominal discomfort, change in bowel habits, and weight loss. Colonoscopy showed a protruded tumor of the sigmoid colon first diagnosed as undifferentiated carcinoma. Surgical resection of the sigmoid colon was performed. Histological examination of the surgical specimen showed a proliferation of basaloid cells arranged in tumor clusters with central comedonecrosis and peripheral palisading of the nuclei. The tumor invaded the subserosa and presented liver metastasis without lymph node metastases. The tumor cells were marked by keratin AE1/AE3, keratin 5/6, epithelial membrane antigen, bcl-2, vascular endothelial growth factor, CD105, neuron-specific enolase, MLH-1, MSH-2, and p53, and were negative for keratin 7/20, chromogranin, synaptophysin, carcinoembryonic antigen, p63, c-KIT, and maspin. A high p53 nuclear index was also detected. On the basis of these characteristics and molecular examinations, the final diagnosis was microsatellite stable/human papilloma virus-negative/K-ras mutated/BRAF wild-type basaloid carcinoma (BC). Only seven BCs of the colon were reported in the literature, this being the eighth one and the first case that reports new molecular findings about microsatellite instability, K-ras/BRAF mutations, angiogenesis, and maspin expression in BC, with direct involvement in targeted therapy.


Gurzu S,Szentirmay Z,Bara T,Bara T Jr,Iurcsuk O,Jung I




Has Abstract


2014-05-01 00:00:00












  • Adjuvant chemotherapy for stage II colon cancer: influence of care structures' characteristics on a controversial clinical practice.

    abstract:BACKGROUND:Adjuvant chemotherapy for stage II colon cancer is a controversial practice and is not recommended by the French Consensus Conference outside of therapeutic trial. OBJECTIVE:To assess, within a well-defined population, the influence of hospital characteristics in this practice. PATIENTS AND METHODS:In the ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究


    authors: Alter E,Phelip JM,Guilhot JN,Matysiak M,Vermorel M,Roblin X

    更新日期:2007-11-01 00:00:00

  • Calcium carbonate treatment of diarrhoea in intestinal bypass patients.

    abstract:OBJECTIVE:To study the effect of supplemental calcium carbonate on faecal water, calcium, bile acid and lipid concentration and output in intestinal bypass subjects with diarrhoea. DESIGN:Prospective, single-arm treatment trial of oral calcium carbonate, 2400 or 3600 mg Ca2+ per day, given for 12 weeks. METHODS:Faeca...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章


    authors: Steinbach G,Lupton J,Reddy BS,Lee JJ,Kral JG,Holt PR

    更新日期:1996-06-01 00:00:00

  • Audit of a Barrett's epithelium surveillance database.

    abstract:BACKGROUND:Barrett's epithelium is a premalignant condition in which endoscopic surveillance is recommended but remains contentious. AIM:To audit our Barrett's epithelium surveillance database and to calculate the incidence and natural history of dysplasia and cancer in this cohort. METHODS:A retrospective analysis o...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Basu KK,Pick B,de Caestecker JS

    更新日期:2004-02-01 00:00:00

  • Follow-up of treated coeliac patients: sugar absorption test and intestinal biopsies compared.

    abstract:OBJECTIVE:To determine whether the sugar absorption test (SAT) during follow-up of patients with coeliac disease on a gluten-free diet (GFD) correlates with improvement of the villous architecture of the small intestine. METHODS:The SAT was performed in coeliacs at diagnosis and during follow-up with GFD. For the SAT,...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Uil JJ,van Elburg RM,van Overbeek FM,Meyer JW,Mulder CJ,Heymans HS

    更新日期:1996-03-01 00:00:00

  • High red blood cell distribution width is closely associated with nonalcoholic fatty liver disease.

    abstract:BACKGROUND:The red blood cell distribution width (RDW) has been reported to be a risk marker of morbidity and mortality for cardiovascular diseases in various study populations. Nonalcoholic fatty liver disease (NAFLD) is also a risk factor for cardiovascular diseases. However, the relationship between RDW and NAFLD is...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Yang W,Huang H,Wang Y,Yu X,Yang Z

    更新日期:2014-02-01 00:00:00

  • Hepcidin and inflammatory bowel disease: dual role in host defence and iron homoeostasis.

    abstract:OBJECTIVE:Hepcidin is an endogenous antimicrobial peptide with a key role in iron homoeostasis. Hepcidin is similar to defensin, the deficiency of which is associated with Crohn's disease. To date there has been no validated method to reliably assay serum hepcidin. We studied iron indices in inflammatory bowel disease ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Arnold J,Sangwaiya A,Bhatkal B,Geoghegan F,Busbridge M

    更新日期:2009-04-01 00:00:00

  • Haematochezia in Crohn's disease caused by late-onset haemobilia following percutaneous liver biopsy.

    abstract::The case of a patient with Crohn's disease and who presented 4 days after a percutaneous liver biopsy with haematochezia suggestive of an exacerbation of his inflammatory bowel disease is described. Subsequent abdominal ultrasonography revealed free fluid in the peritoneal cavity and around the gallbladder. Haemobilia...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Hodgson RS,Taylor-Robinson SD,Jackson JE

    更新日期:2004-02-01 00:00:00

  • Vitamin B12 absorption after ileorectal anastomosis for Crohn's disease: effect of ileal resection and time span after surgery.

    abstract:OBJECTIVE:To examine the impact of ileorectal anastomosis on vitamin B12 absorption, as measured by the Schilling test, in patients with Crohn's disease. PATIENTS:Eighty-two patients with Crohn's disease who had undergone ileorectal anastomosis. METHODS:Of the 82 patients with Crohn's disease and ileorectal anastomos...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Behrend C,Jeppesen PB,Mortensen PB

    更新日期:1995-05-01 00:00:00

  • Can oral 5-aminosalicylic acid be administered once daily in the treatment of mild-to-moderate ulcerative colitis? A meta-analysis of randomized-controlled trials.

    abstract:OBJECTIVES:Several trials have demonstrated that oral delayed-release mesalamine might be administered once daily. We aimed to conduct a meta-analysis to investigate this. METHODS:A comprehensive and multiple-source literature search was carried out. Only randomized-controlled trials (RCTs) were investigated by compar...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析


    authors: Zhu Y,Tang RK,Zhao P,Zhu SS,Li YG,Li JB

    更新日期:2012-05-01 00:00:00

  • Gastric emptying time in patients with primary hypothyroidism.

    abstract:BACKGROUND AND OBJECTIVES:Symptoms due to slowing of gastrointestinal motility constitute an important problem in most patients with primary hypothyroidism. The purpose of this study was to calculate gastric emptying time in patients with primary hypothyroidism using a radioisotopic method. PATIENTS AND METHODS:Fiftee...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Kahraman H,Kaya N,Demirçali A,Bernay I,Tanyeri F

    更新日期:1997-09-01 00:00:00

  • Total ascitic fluid leukocyte count for reliable exclusion of spontaneous bacterial peritonitis in patients with ascites.

    abstract:BACKGROUND AND AIMS:The diagnosis of spontaneous bacterial peritonitis (SBP) in patients with ascites is established by definition with a polymorphonuclear (PMN) cell count in the ascitic fluid greater than 0.250 g/l determined via cytological (microscopic) examination. In this study, we correlated the automatically as...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Link BC,Ziske CG,Schepke M,Schmidt-Wolf IG,Sauerbruch T

    更新日期:2006-02-01 00:00:00

  • Association of gastric disease with polymorphisms in the inflammatory-related genes IL-1B, IL-1RN, IL-10, TNF and TLR4.

    abstract:OBJECTIVES:This study aimed to investigate if single nucleotide polymorphisms (SNPs) in a series of inflammatory genes were associated with the development of the most common pathologies thought to precede gastric cancer development namely; Helicobacter pylori (H. pylori)-associated gastritis and intestinal metaplasia....

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Murphy G,Thornton J,McManus R,Swan N,Ryan B,Hughes DJ,O'Morain CA,O'Sullivan M

    更新日期:2009-06-01 00:00:00

  • Hyperbaric oxygen as a treatment for malabsorption in a radiation-damaged short bowel.

    abstract::Radiation enteritis can be challenging to diagnose and treat. We report the case of a 44-year-old woman who was diagnosed with a squamous cell carcinoma of the cervix in 1978 and treated with hysterectomy and post-operative radiotherapy. Over the next 20 years she required multiple intestinal operations resulting in s...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Huddy JE,Patel P,Johnson MW,Hamilton-Farrell MR,Ede RJ,Sanderson JD

    更新日期:2006-06-01 00:00:00

  • Ultrasonography in the diagnosis and monitoring of ascites in acute abdominal attacks of hereditary angioneurotic oedema.

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Farkas H,Harmat G,Kaposi PN,Karádi I,Fekete B,Füst G,Fáy K,Vass A,Varga L

    更新日期:2001-10-01 00:00:00

  • Management of chronic hepatitis B.

    abstract::Chronic hepatitis B continues to be a major global health burden. It accounts for a substantial impact on health care resources and finances in many parts of the world including Europe. Natural history and disease spectrum are varied, depending on when and how the infection is acquired. The chronic infective state inc...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审


    authors: Massoumi H,Martin P,Tan HH

    更新日期:2011-08-01 00:00:00

  • High frequency of gastric cancer precursor lesions in patients with gastric xanthelasma: a prospective case-control study.

    abstract:OBJECTIVE:An association of gastric cancer and precursor lesions with gastric xanthelasma has frequently been reported. However, the incidence of both gastric xanthelasma and gastric cancer precursor lesions increases with age. The aim of this study was to evaluate the frequency and characteristics of atrophic gastriti...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Sayar S,Ayranci G,Kürbüz K,Ak Ç,Tarikçi Kiliç E,Kahraman R,Atalay R,Öztürk O,Çalişkan Z,Adali G,Doganay L,Özdil K

    更新日期:2020-09-01 00:00:00

  • Clinical and surgical recurrence of Crohn's disease after ileocolonic resection in a specialist unit.

    abstract:BACKGROUND:Postoperative clinical and endoscopic recurrence is common in Crohn's disease. AIM:We aimed to assess postoperative recurrence and management in a cross-sectional patient cohort in one specialist unit, before the introduction of a uniform postoperative preventive strategy. METHODS:Review of patients who ha...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Ng SC,Lied GA,Arebi N,Phillips RK,Kamm MA

    更新日期:2009-05-01 00:00:00

  • Is nutrition an aetiological factor for inflammatory bowel disease?

    abstract::Inflammatory bowel disease (IBD) is a chronic inflammatory process, the aetiology of which is complex and probably multi-factorial. Nutrition has been proposed to be an important aetiological factor for IBD. The present review critically examines the relationship between components of the diet (such as sugar, fat, fib...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审


    authors: Cashman KD,Shanahan F

    更新日期:2003-06-01 00:00:00

  • Feasibility study of colorectal cancer screening by immunochemical faecal occult blood testing: results in a northern Italian community.

    abstract:AIM:Screening by means of faecal occult blood testing (FOBT) has proved to be effective in reducing colorectal cancer incidence and mortality. We performed a pilot screening for colorectal cancer by latex immunological FOBT in two municipalities of the region Valle d'Aosta, Italy, focusing on problems and obtaining ind...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Crotta S,Castiglione G,Grazzini G,Valle F,Mosconi S,Rosset R

    更新日期:2004-01-01 00:00:00

  • Helicobacter pylori, gastric cancer and gastric epithelial kinetics: a review.

    abstract:AIM:To review the evidence that Helicobacter pylori promotes gastric carcinogenesis, with particular reference to gastric epithelial proliferation. MATERIALS AND METHODS:Gastric epithelial kinetics were reviewed and a series of studies of gastric mucosal proliferation in H. pylori-associated gastritis were performed i...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审


    authors: Lynch DA,Axon AT

    更新日期:1995-08-01 00:00:00

  • Evaluation of serum procollagen C-proteinase enhancer 1 level as a fibrosis marker in patients with chronic hepatitis B.

    abstract:AIM:Although liver biopsy has long been considered the gold standard for staging fibrosis, because of the disadvantages and risks of biopsy, several noninvasive processes such as serum biomarkers have been introduced for the assessment of liver fibrosis. The aim of this study was to assess the diagnostic value of serum...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Gokce O,Ozenirler S,Atak Yucel A,Oruklu N,Yilmaz Esendagli G,Karahan S

    更新日期:2018-08-01 00:00:00

  • Renal involvement in Crohn's disease: granulomatous inflammation in the form of mass lesion.

    abstract::Extraintestinal manifestations of Crohn's disease (CD) are varied and concentrated mainly to the skin and eye. Urinary tract or renal involvement is extremely rare. Herein we report on a case of renal lesion of a 50-year-old woman with a 15-year history of CD. Abdominal computed tomography scan of the patient identifi...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Semjén D,Fábos Z,Pakodi F,Vincze A,Szabó I,Degrell P,Csete M,Tornóczky T

    更新日期:2011-11-01 00:00:00

  • Clinical identification and long-term surveillance of 22 hereditary non-polyposis colon cancer Italian families.

    abstract:OBJECTIVE:To assess the efficacy of a hereditary non-polyposis colon cancer (HNPCC) identification and surveillance policy. METHODS:Familial clustering of colorectal cancer (CRC) and extracolonic cancers (ECs) was investigated in 1520 consecutive CRC patients and relatives. HNPCC was identified by Amsterdam criteria, ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Arrigoni A,Sprujevnik T,Alvisi V,Rossi A,Ricci G,Pennazio M,Spandre M,Cavallero M,Bertone A,Foco A,Rossini FP

    更新日期:2005-02-01 00:00:00

  • Prevention of recurrence of oesophageal stricture, a comparison of lansoprazole and high-dose ranitidine.

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Swarbrick ET,Gough AL,Foster CS,Christian J,Garrett AD,Langworthy CH

    更新日期:1996-05-01 00:00:00

  • Risk factors for anastomotic recurrence after primary ileocaecal resection in Crohn's disease.

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Aaltonen G,Keränen I,Carpelan-Holmström M,Lepistö A

    更新日期:2018-10-01 00:00:00

  • Levofloxacin based regimens for the eradication of Helicobacter pylori.

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Di Caro S,Zocco MA,Cremonini F,Candelli M,Nista EC,Bartolozzi F,Armuzzi A,Cammarota G,Santarelli L,Gasbarrini A

    更新日期:2002-12-01 00:00:00

  • The effect of surgical fecal stream diversion of the healthy colon on the colonic microbiota.

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: van der Sluis WB,Bouman MB,Mullender MG,Degen MC,Savelkoul PHM,Meijerink WJHJ,de Boer NKH,van Bodegraven AA,Budding AE

    更新日期:2019-04-01 00:00:00

  • Implementation of a guideline versus use of individual prognostic factors to prioritize waiting lists for upper gastrointestinal endoscopy.

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Cardin F,Zorzi M,Terranova O

    更新日期:2007-07-01 00:00:00

  • Comparison of telbivudine efficacy in treatment-naive patients with hepatitis B virus-related compensated and decompensated cirrhosis in 96 weeks.

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Yang X,Li J,Zhou L,Liu J,Wang J,Lu W

    更新日期:2014-04-01 00:00:00

  • Perforation--a rare complication of a small-bowel carcinoid.

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Duvnjak M,Pavic T,Goranovic T

    更新日期:2000-07-01 00:00:00