Gastric hepatoid adenocarcinoma and familial investigation: does it always produce alpha-fetoprotein?

Abstract:

:We present the case of a 68-year-old Caucasian man with gastric hepatoid adenocarcinoma without increased levels of alpha-fetoprotein (AFP) in the serum. The patient had a strong history of gastric cancer in his family, affecting seven members, including a brother and a sister. The patient underwent subtotal gastrectomy, but 4 months later presented hepatic metastases, and 6 months after the initial diagnosis he succumbed to the disease. Immunohistochemical tests showed that the tumour was positive for AFP, hepatocyte paraffin 1, and neuron-specific enolase, but negative for synaptophysin and chromogranin. Previously reported cases of hepatoid gastric tumours showed that they produce large amounts of AFP and that they have a poor prognosis.

authors

Trompetas V,Varsamidakis N,Frangia K,Polimeropoulos V,Kalokairinos E

doi

10.1097/00042737-200311000-00015

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

1241-4

issue

11

eissn

0954-691X

issn

1473-5687

journal_volume

15

pub_type

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