Abstract:
OBJECTIVES:Clostridium difficile infection (CDI) is an acute gastrointestinal infection caused by anaerobic, toxin-producing bacteria. During the course of CDI, there is a general inflammatory state. In order to gain a deeper understanding of the role of fatty acids (FAs) in the pathogenesis of acute infection we analyzed their plasma content in both patients with CDI and controls. METHODS:The study groups included 40 patients with CDI and 40 healthy volunteers. Plasma FA content was analyzed by gas chromatography, resolvin D1 (RvD1) level using ELISA assay, and we assessed the white blood cell (WBC) count, neutrophil count and C-reactive protein (CRP) level. RESULTS:Patients with CDI were characterized by significantly higher values of WBC, neutrophils, platelets and CRP compared with the control group. The saturated FA index was statistically higher and total n-3 FA was significantly decreased in the plasma of CDI patients as compared with the control group. RvD1 content was significantly higher in the control group as compared with patients with CDI. CONCLUSION:In patients with good outcomes, we probably observed the effective resolution of inflammation, as reflected in n-3 FA metabolism and their significant decrease in plasma. This may indicate the therapeutic role of n-3 FA in CDI infection.
journal_name
Eur J Gastroenterol Hepatoljournal_title
European journal of gastroenterology & hepatologyauthors
Dróżdż M,Gdula-Argasińska J,Biesiada G,Jurczyszyn A,Perucki W,Wołkow P,Borys A,Sroczyńska K,Zając A,Librowski T,Garlicki A,Czepiel Jdoi
10.1097/MEG.0000000000001600subject
Has Abstractpub_date
2020-03-01 00:00:00pages
318-324issue
3eissn
0954-691Xissn
1473-5687journal_volume
32pub_type
杂志文章abstract::Intestinal lymphangiectasia is a rare condition, which is characterized by the dilation of small bowel lymphatics and presents with signs and symptoms of protein-losing enteropathy. Some patients have complained of occlusive symptoms attributable to the mechanical obstruction caused by the considerable mucosal edema a...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e3282f5dda4
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND AND AIMS:The natural history of functional dyspepsia is not well known. We prospectively assess the quality of life and severity of symptoms in a group of Spanish patients with functional dyspepsia. PATIENTS AND METHODS:One hundred and twelve consecutive patients with functional dyspepsia, according to Rome...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200311000-00005
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:We assessed the impact of direct-acting antiviral (DAA) therapy on liver fibrosis regression measured by transient elastography (TE) in patients with chronic hepatitis C virus (HCV) infection. PATIENTS AND METHODS:A prospective cohort study was carried out in HCV monoinfected patients with advanced liver fib...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000964
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Although the number of ulcerative colitis patients has increased rapidly in Japan, few reports have been published regarding their clinical aspects. We investigated the clinical characteristics and chronological change of ulcerative colitis in Japanese patients. METHODS:Patients diagnosed with ulcerative co...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,多中心研究
doi:10.1097/MEG.0b013e3280110fb9
更新日期:2007-03-01 00:00:00
abstract::Over the last decade, major advancements have been made in our understanding of both the beneficial and detrimental role that microorganisms play in our innate functioning. Research into the intestinal microbiota has moved from the laboratory into our medical clinics and is being put forth as an effective therapy for ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001938
更新日期:2020-11-10 00:00:00
abstract::Radiation enteritis can be challenging to diagnose and treat. We report the case of a 44-year-old woman who was diagnosed with a squamous cell carcinoma of the cervix in 1978 and treated with hysterectomy and post-operative radiotherapy. Over the next 20 years she required multiple intestinal operations resulting in s...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200606000-00017
更新日期:2006-06-01 00:00:00
abstract::Inflammatory bowel disease (IBD) is a chronic inflammatory process, the aetiology of which is complex and probably multi-factorial. Nutrition has been proposed to be an important aetiological factor for IBD. The present review critically examines the relationship between components of the diet (such as sugar, fat, fib...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,评审
doi:10.1097/00042737-200306000-00005
更新日期:2003-06-01 00:00:00
abstract:INTRODUCTION:The effective, but expensive, drug infliximab is used in patients with inflammatory bowel disease (IBD). Monitoring infliximab trough levels and anti-infliximab antibody (ATI) formation can lead to a more cost-effective use of infliximab therapy. The aim of our study was to investigate the effect of implem...
journal_title:European journal of gastroenterology & hepatology
pub_type: 临床试验,杂志文章
doi:10.1097/MEG.0000000000000763
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Mass screening programmes in Europe and in the USA have shown that a 15-18% decrease in mortality rate from colo-rectal cancer can be achieved with biannual testing. In a 10 year screening programme in the Isère region (France), we have noticed that the positivity percentage of Hemoccult II changes significa...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200310000-00008
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVES:Because bacteria represent the sole source of gut hydrogen (H2) and methane (CH4), fasting breath H2 and CH4 gases have been used as markers of colonic fermentation. The presence of carbohydrates in the colonic lumen inhibits gastric and pancreatic secretions, and also influences lower oesophageal sphincter ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200605000-00013
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Increasing HDL cholesterol concentrations by stimulating de-novo apolipoprotein A-I (apoA-I) production in the liver and/or in the small intestine is a potential strategy to reduce coronary heart disease risk. Although there is quite some knowledge concerning regulatory effects in the liver, less is known co...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/meg.0b013e328321b0c8
更新日期:2009-06-01 00:00:00
abstract:INTRODUCTION:Hepatitis C virus (HCV) is a principal cause of severe liver diseases worldwide and a possible source of significant morbidity and fatality in the long term. Information on the genotype is more significant because it has prognostic value in the response to antiviral therapy. OBJECTIVES:This study aimed to...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,meta分析
doi:10.1097/MEG.0b013e328362dc3f
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Inflammatory bowel disease (IBD) is a debilitating immune disorder that impairs function and health-related quality of life (HRQOL). A goal of IBD treatment is mucosal healing, but it is not known whether it achieves normalization of the patients' perception of health. This can be assessed by using a cut-off...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,多中心研究
doi:10.1097/MEG.0b013e32835414b2
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:We assessed the value of the recently developed aspartate aminotransferase to platelet ratio index (APRI) for predicting significant fibrosis or cirrhosis in patients with chronic hepatitis C or HBeAg-negative chronic hepatitis B. METHODS:In total, 489 patients (chronic hepatitis C, 284 patients; HBeAg-negat...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200604000-00012
更新日期:2006-04-01 00:00:00
abstract::The preoperative diagnosis of extraluminal gastrointestinal stromal tumours in the duodenum is difficult to establish due to their rare occurrence and the lack of pathognomonic signs. This report describes the case of a 61-year-old woman who suffered from an immunohistologically confirmed gastrointestinal stromal tumo...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200309000-00017
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Current treatments of chronic hepatitis C virus (HCV) are effective, but expensive and susceptible to induce significant side effects. OBJECTIVES:To evaluate the proportion of HCV patients who are eligible for a treatment. METHODS:In a database comprising 1726 viraemic HCV patients, the files of 299 patien...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200511000-00006
更新日期:2005-11-01 00:00:00
abstract:INTRODUCTION:It is unclear how the transient remission of nonalcoholic fatty liver disease (NAFLD) affects incident type 2 diabetes mellitus (T2DM). Here, we sought to determine the effect of the transient remission of NAFLD on incident T2DM in Japanese men. MATERIALS AND METHODS:We used a population-based health chec...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000736
更新日期:2016-12-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/01.meg.0000435546.87251.f7
更新日期:2014-01-01 00:00:00
abstract::Our aim was to study the possible alterations of redox status (enzymatic and nonenzymatic parameters and metal elements) in erythrocytes of patients with hepatocellular carcinoma (HCC), colorectal liver metastases (CRLM) and benign liver neoplasms. The function of redox homeostasis is closely connected to the energy l...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e3282f495c7
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:Intestinal metaplasia is a well-established risk factor in the development of stomach cancer. However, since the specificity is low it would be of great practical value to find a marker to separate cases of intestinal metaplasia into low and high risk for progression to dysplasia/carcinoma. So far this has no...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/01.meg.0000085462.12407.fc
更新日期:2003-09-01 00:00:00
abstract::We present the case of a 23-year-old woman who presented with cytomegalovirus infection complicated by pancytopaenia, haemolysis and disseminated intravascular coagulopathy on a background diagnosis of coeliac crisis as the first presentation of coeliac disease. This is the first reported case of coeliac crisis presen...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/01.meg.0000224471.28626.a6
更新日期:2006-07-01 00:00:00
abstract::Cystic fibrosis is the most common, potentially lethal genetic defect in the Caucasian population. During recent years it has been increasingly associated with a number of hepatic and biliary abnormalities, of which chronic cholestatic liver disease is by far the most relevant. Plugging of intrahepatic bile ducts with...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,评审
doi:
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVE:To study the effect of supplemental calcium carbonate on faecal water, calcium, bile acid and lipid concentration and output in intestinal bypass subjects with diarrhoea. DESIGN:Prospective, single-arm treatment trial of oral calcium carbonate, 2400 or 3600 mg Ca2+ per day, given for 12 weeks. METHODS:Faeca...
journal_title:European journal of gastroenterology & hepatology
pub_type: 临床试验,杂志文章
doi:10.1097/00042737-199606000-00012
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND/AIMS:The number of cases with coronavirus disease 2019 (COVID-19) has exceeded seven million worldwide. However, the data describing the global prevalence of liver injury associated with COVID-19 is lacking secondary to the novelty of this ongoing pandemic. Therefore, we conducted a meta-analysis to determin...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001817
更新日期:2020-07-03 00:00:00
abstract:OBJECTIVE:Radiolucent pancreatic lithiasis (RPL) has been identified as a different entity from calcified pancreatic lithiasis. The purpose of this study is to evaluate the frequency, characteristics and evolution of RPL. PATIENTS:Between 1983 and 1995, 278 consecutive patients who presented with pancreatic lithiasis ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199707000-00010
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:The significance of K-ras codon 12 mutation in pancreatic juice is still unclear. Although considerable controversy surrounds this question, the diagnostic utility of K-ras in patients with clinical suspicion of pancreatic cancer (PC) and in PC-risk patients remains unknown. OBJECTIVE:To study prospectively...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200110000-00006
更新日期:2001-10-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND AND AIMS:Left ventricular diastolic dysfunction has been reported in patients with liver cirrhosis. Although conventional Doppler echocardiography has been used to assess diastolic filling dynamics, this technique is limited in diagnosing left ventricular diastolic dysfunction. The aim of the study was to va...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e3282fb7cd0
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:Complete review of wireless capsule endoscopy (WCE) recordings by a physician is time-consuming and laborious and may be perceived as a limitation to perform WCE. The aim of this study was to evaluate the efficacy of a nurse in interpreting WCE. METHODS:A total of 102 WCE videos were evaluated by a single ga...
journal_title:European journal of gastroenterology & hepatology
pub_type: 临床试验,杂志文章
doi:10.1097/meg.0b013e3283433abf
更新日期:2011-02-01 00:00:00
abstract:AIM:The prevalence of occult hepatitis B virus (HBV) infection is relatively frequent among patients with immune suppression. The impairment of the immune system is well demonstrated in diabetics. We aimed to investigate the prevalence of occult HBV infection among hepatitis B core antibody (HbcAb)+/- hepatitis B surfa...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e3282f55e1e
更新日期:2008-07-01 00:00:00