Neuromuscular alterations in the dilated ileum of an adult patient with segmental lymphangiectasia.

Abstract:

:Intestinal lymphangiectasia is a rare condition, which is characterized by the dilation of small bowel lymphatics and presents with signs and symptoms of protein-losing enteropathy. Some patients have complained of occlusive symptoms attributable to the mechanical obstruction caused by the considerable mucosal edema associated with the lymphatic dilation. On the basis of the hypothesis that alterations in the neuromuscular structures controlling clearance function or gut tone may play a role in ileal dilation, we examined the resected ileum of a 48-year-old male patient with segmental lymphangiectasia histologically, immunohistochemically (for S100 protein, PGP 9.5, Bcl-2, neuron-specific enolase, neurofilaments, synaptophysin, and CD117/C-kit), and by means of electron microscopy. Histology showed pseudocystic dilation of the mucosal, submucosal, and muscular lymphatics with fragmentation of the circular and longitudinal muscle layers. Hardly any neural expression of synaptophysin was observed, but the neural structures were otherwise morphologically normal and reacted normally to the other neural markers. This case shows that neuromuscular alterations can be found in the dilated ileum of patients with segmental lymphangiectasia.

authors

Paggi S,Ferrero S,Braidotti P,de Rai P,Conte D,Basilisco G

doi

10.1097/MEG.0b013e3282f5dda4

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

935-8

issue

9

eissn

0954-691X

issn

1473-5687

pii

00042737-200809000-00019

journal_volume

20

pub_type

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