Comparison of the efficacy and safety of 1.5 compared with 3.0 g oral slow-release mesalazine (Pentasa) in the maintenance treatment of ulcerative colitis. Dutch Pentasa Study Group.

Abstract:

OBJECTIVE:To investigate a possible dose-effect relationship with two dosages of oral slow-release mesalazine in patients with quiescent ulcerative colitis. METHOD:One hundred and sixty-nine patients with ulcerative colitis in remission were treated with either 1.5 or 3.0 g/day mesalazine for 1 year or until relapse into active colitis. RESULTS:Fewer of the 3.0 g dose group relapsed than of the 1.5 g dose group (33 compared with 46%). This difference failed to reach statistical significance (P = 0.057). A significant relationship between age and relapse rate was established. No dose-related adverse events were found. Three serious drug-related adverse events were, however, reported. All of the serious adverse reactions resolved after the medication was discontinued. CONCLUSION:There is a trend for high doses of oral mesalazine to be more effective in prevention of relapse of ulcerative colitis. These higher doses are not associated with a higher incidence of adverse reactions.

authors

Fockens P,Mulder CJ,Tytgat GN,Blok P,Ferwerda J,Meuwissen SG,Tuynman HA,Dekker W,Gasthuis K,van Hees PA

doi

10.1097/00042737-199511000-00003

subject

Has Abstract,Author List Incomplete

pub_date

1995-11-01 00:00:00

pages

1025-30

issue

11

eissn

0954-691X

issn

1473-5687

journal_volume

7

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    journal_title:European journal of gastroenterology & hepatology

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    pub_type: 杂志文章,评审

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    更新日期:2005-06-01 00:00:00

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    doi:10.1097/00042737-199806000-00005

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    更新日期:1998-06-01 00:00:00

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

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  • Feasibility study of colorectal cancer screening by immunochemical faecal occult blood testing: results in a northern Italian community.

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200401000-00006

    authors: Crotta S,Castiglione G,Grazzini G,Valle F,Mosconi S,Rosset R

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

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    authors: Marshall RE,Anggiansah A,Owen WA,Manifold DK,Owen WJ

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  • Circulating intercellular adhesion molecule-1 in patients with hepatocellular carcinoma.

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199708000-00013

    authors: Soresi M,Cervello M,Lipani G,Carroccio A,Cartabellotta A,Marasà L,Casto C,Virruso L,Montalto G

    更新日期:1997-08-01 00:00:00

  • Safety of variceal band ligation in patients with cirrhosis and portal vein thrombosis treated with anticoagulant therapy: A retrospective study.

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001522

    authors: Ponthus S,Spahr L,Casini A,Berney T,Frossard JL,Majno P,Elkrief L

    更新日期:2020-03-01 00:00:00

  • Improved diagnosing of small hepatocellular carcinomas by echo-enhanced power Doppler sonography in patients with cirrhosis.

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200308000-00010

    authors: Rickes S,Schulze S,Neye H,Ocran KW,Wermke W

    更新日期:2003-08-01 00:00:00

  • Lack of association between porphyria cutanea tarda and alpha 1-antitrypsin deficiency.

    abstract:OBJECTIVE:To determine whether alpha 1-antitrypsin deficiency is involved in the pathogenesis of chronic liver disease in patients with porphyria cutanea tarda and in their recently described high prevalence of hepatitis C virus infection. DESIGN:Consecutive patients diagnosed as having porphyria cutanea tarda and chr...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199604000-00018

    authors: Fargion S,Sergi C,Bissoli F,Fracanzani AL,Suigo E,Carazzone A,Roberto C,Cappellini MD,Fiorelli G

    更新日期:1996-04-01 00:00:00

  • Nonsteroidal anti-inflammatory drugs and their colonic effects: more interesting than irritating?

    abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) have both beneficial and deleterious effects on the colon. Long-term use is associated with a substantial decrease in colorectal cancer incidence and regression of adenomatous polyps. In contrast, significant adverse effects are also interesting, but rare, and include muco...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 评论,杂志文章

    doi:10.1097/00042737-200211000-00003

    authors: Mulcahy HE,O'Donoghue D

    更新日期:2002-11-01 00:00:00

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    abstract:OBJECTIVES:The diagnostic and prognostic value of critical flicker frequency (CFF) analysis for assessment of severity and dynamics of hepatic encephalopathy (HE) was studied before and after implantation of a transjugular intrahepatic portosystemic shunt (TIPS). BASIC METHODS:Sixty-three cirrhotic patients were retro...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328310e0c3

    authors: Kircheis G,Bode JG,Hilger N,Kramer T,Schnitzler A,Häussinger D

    更新日期:2009-12-01 00:00:00

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    doi:10.1097/MEG.0000000000000085

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    更新日期:2000-07-01 00:00:00

  • Asbestos fibers in the gallbladder of patients affected by benign biliary tract diseases.

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    pub_type: 杂志文章

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    authors: Grosso F,Randi L,Croce A,Mirabelli D,Libener R,Magnani C,Bellis D,Allegrina M,Bertolotti M,Degiovanni D,Rinaudo C

    更新日期:2015-07-01 00:00:00

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    pub_type: 杂志文章,meta分析,评审

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    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283491438

    authors: Wohl P,Bednařík M,Wohl P,Cervenka M,Spičák J

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    pub_type: 杂志文章

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MEG.0000000000000403

    authors: Deltenre P,Trépo E,Rudler M,Monescillo A,Fraga M,Denys A,Doerig C,Fournier N,Moreno C,Moradpour D,Bureau C,Thabut D

    更新日期:2015-09-01 00:00:00

  • Argon plasma coagulation (APC) in gastroenterology: experimental and clinical experiences.

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00042737-199706000-00006

    authors: Johanns W,Luis W,Janssen J,Kahl S,Greiner L

    更新日期:1997-06-01 00:00:00

  • Aspartate aminotransferase to platelet ratio index for fibrosis evaluation in chronic viral hepatitis.

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200604000-00012

    authors: Chrysanthos NV,Papatheodoridis GV,Savvas S,Kafiri G,Petraki K,Manesis EK,Archimandritis AJ

    更新日期:2006-04-01 00:00:00

  • Dietary habits as risk factors for inflammatory bowel disease.

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:

    authors: Tragnone A,Valpiani D,Miglio F,Elmi G,Bazzocchi G,Pipitone E,Lanfranchi GA

    更新日期:1995-01-01 00:00:00

  • Variceal bleeding in primary biliary cirrhosis patients: a subgroup with improved prognosis and a model to predict survival after first bleeding.

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328320005f

    authors: Vlachogiannakos J,Carpenter J,Goulis J,Triantos C,Patch D,Burroughs AK

    更新日期:2009-06-01 00:00:00

  • Thalidomide in advanced hepatocellular carcinoma as antiangiogenic treatment approach: a phase I/II trial.

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283036740

    authors: Pinter M,Wichlas M,Schmid K,Plank C,Müller C,Wrba F,Peck-Radosavljevic M

    更新日期:2008-10-01 00:00:00

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199602000-00011

    authors: Robinson RJ,Stone M,Mayberry JF

    更新日期:1996-02-01 00:00:00

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    abstract::The question of when and how to drain a malignant biliary obstruction (MBO), both intrinsic or extrinsic, remains a controversial point among endoscopists. An important factor that influences the decision to drain an MBO or not is if the patient is a surgical candidate or not and, in the former case, if the patients m...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001752

    authors: Mangiavillano B,Papanikolaou IS,Arvanitakis M,Auriemma F,Bianchetti M,Tarantino I,Traina M,Deviere J,Repici A

    更新日期:2020-10-01 00:00:00

  • The management of low-risk primary upper gastrointestinal haemorrhage in the community: a 5-year observational study.

    abstract:BACKGROUND:Acute upper gastrointestinal haemorrhage is a common medical emergency, initially managed with inpatient care. Bleeding stops spontaneously in over 80% of cases, indicating that patients with low-risk upper gastrointestinal haemorrhage may be more optimally managed in the community, without the need for admi...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32834febef

    authors: McLaughlin C,Vine L,Chapman L,Deering P,Whittaker S,Beckly J,Fortun P,Murray IA,Hussaini SH,Michell NP,Stableforth B,Thatcher P,Hare NC,Palmer J,Dalton HR

    更新日期:2012-03-01 00:00:00

  • Spontaneous regression of peritoneal carcinomatosis from a rectal cancer.

    abstract::Spontaneous regression of adult solid tumours is rare. Here, we present the case of a 51-year-old man who underwent a curative resection for an adenocarcinoma of the rectum in 1989. He remained well until 12 months after surgery when he developed a large-fixed mass proximal to the anastomosis, which was treated with r...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200512000-00025

    authors: Abdelrazeq AS,Lund JN,Leveson SH

    更新日期:2005-12-01 00:00:00