Variceal bleeding in primary biliary cirrhosis patients: a subgroup with improved prognosis and a model to predict survival after first bleeding.

Abstract:

BACKGROUND:Varices are a late complication in primary biliary cirrhosis (PBC). However, patients without clinical jaundice do bleed from varices; whether their prognosis differs is unknown. AIM:Evaluate PBC patients, particularly those with bilirubin 34 micromol/l (P=0.001, log rank test). Hazard ratios (95% confidence intervals) for independent predictors of mortality after bleeding were: age 1.02 (1-1.05), log10 bilirubin 4.64 (2.56-8.41), ascites 2.13 (1.29-3.51) and hepatic encephalopathy 2.72 (1.56-4.74). CONCLUSION:Variceal bleeding complicates histologically advanced PBC. A distinct subgroup with near normal bilirubin and lower alkaline phosphatase first presents with variceal bleeding in 50% of cases and has a better prognosis than jaundiced PBC variceal bleeders.

authors

Vlachogiannakos J,Carpenter J,Goulis J,Triantos C,Patch D,Burroughs AK

doi

10.1097/MEG.0b013e328320005f

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

701-7

issue

6

eissn

0954-691X

issn

1473-5687

journal_volume

21

pub_type

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