Prevalence and risk factors of HCV infection in Poland.

Abstract:

BACKGROUND:According to small studies carried out in preselected populations, the estimated prevalence of anti-hepatitis C virus (HCV) antibodies in Poland ranges from 0.6 to 2.1%. AIMS:The aim of this study was to evaluate the prevalence of anti-HCV and HCV RNA among patients and healthcare workers. METHODS:Anti-HCV antibodies were measured (Elecsys, Roche) in serum samples from 26,057 adults, consecutive patients or healthcare workers, from hospitals and out patient clinics not involved in the management of liver diseases. The majority of them (18,233) consented to fill out an anonymous questionnaire related to possible risk factors for HCV infection. Anti-HCV-positive samples were assessed for HCV RNA (Cobas Amplicor, Roche). A multivariate logistic regression model and the χ² test or the Fisher's exact test were applied. RESULTS:Anti-HCV antibodies were detected in 1.9% of individuals, and 31% of them demonstrated HCV RNA, which varied from 26% in hospitals to 66% in specialistic out-patient clinics. Prevalence of anti-HCV was significantly lower in healthcare workers (1.42%) than in patients (1.92%). Significant independent risk factors for anti-HCV positivity were as follows: male sex, more than three hospitalizations in a lifetime, blood transfusions before 1992, and intravenous drug use. The only significant risk factor for HCV RNA was intravenous drug use. An analysis carried out for multispecialistic hospitals demonstrated significantly lower prevalence of HCV RNA positivity in healthcare workers. CONCLUSION:Prevalence of anti-HCV in the Polish population studied was up to 1.9%, but active infection could be diagnosed in only 31% of them. Intravenous drug use, blood transfusions before 1992, multiple hospitalizations, and male sex increase the risk of HCV infection.

authors

Flisiak R,Halota W,Horban A,Juszczyk J,Pawlowska M,Simon K

doi

10.1097/MEG.0b013e32834d173c

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

1213-7

issue

12

eissn

0954-691X

issn

1473-5687

journal_volume

23

pub_type

杂志文章,多中心研究
  • Early transjugular intrahepatic portosystemic shunt in cirrhotic patients with acute variceal bleeding: a systematic review and meta-analysis of controlled trials.

    abstract:INTRODUCTION:There is conflicting evidence on the benefit of early transjugular intrahepatic portosystemic shunt (TIPSS) on the survival of patients with acute variceal bleeding (AVB). AIM:To assess the effect of early TIPSS on patient prognosis. MATERIALS AND METHODS:We carried out a meta-analysis of trials evaluati...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MEG.0000000000000403

    authors: Deltenre P,Trépo E,Rudler M,Monescillo A,Fraga M,Denys A,Doerig C,Fournier N,Moreno C,Moradpour D,Bureau C,Thabut D

    更新日期:2015-09-01 00:00:00

  • Prevalence of pathological duodenogastric reflux and the relationship between duodenogastric and duodenogastrooesophageal reflux in chronic gastrooesophageal reflux disease.

    abstract:UNLABELLED:The role of duodenogastric reflux in gastrooesophageal reflux disease is still controversial. AIMS:(i) To determine the prevalence of pathological duodenogastric reflux (DGR) in gastrooesophageal reflux disease patients and (ii) to define the relationship between DGR and duodenogastrooesophageal reflux. ME...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32830aba6d

    authors: Brillantino A,Monaco L,Schettino M,Torelli F,Izzo G,Cosenza A,Marano L,Di Martino N

    更新日期:2008-12-01 00:00:00

  • Risk factors and clinical characteristics of early-onset colorectal cancer vs. late-onset colorectal cancer: a case-case study.

    abstract:BACKGROUND AND OBJECTIVES:Early-onset colorectal cancer (eoCRC), defined as colorectal cancer (CRC) before the age of 50 is increasing in incidence. We evaluated exogenous and endogenous risk factors, and clinical features of eoCRC, compared to late-onset CRC (loCRC). METHODS:In this retrospective case-case study, pat...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000002000

    authors: Di Leo M,Zuppardo RA,Puzzono M,Ditonno I,Mannucci A,Antoci G,Russo Raucci A,Patricelli MG,Elmore U,Tamburini AM,Albarello L,Azzolini F,Bonura GF,Esposito D,Fanti L,Notaristefano C,Viale E,Perea J,Testoni PA,Rosati R

    更新日期:2020-11-17 00:00:00

  • Prevalence of hepatitis B and C and factors for infection and nonimmune in inflammatory bowel disease patients in China.

    abstract:OBJECTIVE:The aims of this study were to investigate the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in inflammatory bowel disease (IBD) patients and the risk factors related to the infection and nonimmune status. METHODS:A retrospective study was carried out at two clinical centers. Th...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MEG.0000000000000838

    authors: Chen D,Luo S,Ben Q,Lu L,Wan X,Wu J

    更新日期:2017-05-01 00:00:00

  • Gallstone disease in an elderly population: the Silea study.

    abstract:BACKGROUND:Little is known on gallbladder emptying and gallstone composition in the elderly. AIMS AND SUBJECTS: Cross-sectional survey on the prevalence of gallstone disease and associated factors, gallstone characteristics and gallbladder emptying in a population aged > or = 60 years. METHODS:Gallstone number and siz...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199905000-00004

    authors: Lirussi F,Nassuato G,Passera D,Toso S,Zalunardo B,Monica F,Virgilio C,Frasson F,Okolicsanyi L

    更新日期:1999-05-01 00:00:00

  • Conclusiveness of the Cochrane Reviews in Pediatric-Gastroenterology: a systematic analysis.

    abstract:AIM:To assess the conclusiveness of the Cochrane Reviews (CRs) in the field of Pediatric-Gastroenterology. We tested the hypotheses that (a) the majority of CRs are inconclusive, (b) the majority of CRs recognize the need for further studies, (c) the ability to reach a conclusion is dependent on both the number of stud...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32835a1083

    authors: Cohen S,Lubetzky R,Mimouni FB,Marom R,Mandel D

    更新日期:2013-02-01 00:00:00

  • Coeliac crisis presenting with cytomegalovirus hepatitis.

    abstract::We present the case of a 23-year-old woman who presented with cytomegalovirus infection complicated by pancytopaenia, haemolysis and disseminated intravascular coagulopathy on a background diagnosis of coeliac crisis as the first presentation of coeliac disease. This is the first reported case of coeliac crisis presen...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/01.meg.0000224471.28626.a6

    authors: Kelly E,Cullen G,Aftab AR,Courtney G

    更新日期:2006-07-01 00:00:00

  • Hepatitis C virus treatment rates and outcomes in HIV/hepatitis C virus co-infected individuals at an urban HIV clinic.

    abstract:OBJECTIVES:The factors associated with hepatitis C virus (HCV) treatment uptake and responses were assessed among HCV/HIV co-infected individuals referred for HCV therapy at an urban HIV clinic. METHODS:Retrospective review of HIV/HCV patients enrolled in the HCV treatment program at the John Ruedy Immunodeficiency Cl...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328341ef54

    authors: Murray MC,Barrios R,Zhang W,Hull M,Montessori V,Hogg RS,Montaner JS

    更新日期:2011-01-01 00:00:00

  • Clinical significance of a scoring formula of liver injury for the preoperative evaluation of patients with liver cirrhosis.

    abstract:OBJECTIVE:The aim of this study was to establish a clinical scoring formula of liver injury (SFLI) using the matter element analysis method, in order to provide the necessary information for the preoperative assessment and treatment of liver cirrhosis in clinical practice. MATERIALS AND METHODS:We collected preoperati...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283632189

    authors: Liu W,Zheng J,Xing R

    更新日期:2014-01-01 00:00:00

  • Clinical impact of serum α-fetoprotein and its relation on changes in liver fibrosis in hepatitis C virus patients receiving direct-acting antivirals.

    abstract:BACKGROUND:α-Fetoprotein (AFP) is used widely as a serological marker for hepatocellular carcinoma. However, the AFP value is elevated in chronic hepatitis C virus (HCV) patients without hepatocellular carcinoma. Yet, data on the impact of direct-acting antiviral agents (DAAs) therapy on AFP levels after viral eradicat...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001400

    authors: Fouad R,Elsharkawy A,Abdel Alem S,El Kassas M,Alboraie M,Sweedy A,Afify S,Abdellatif Z,Khairy M,Esmat G

    更新日期:2019-09-01 00:00:00

  • An improved ex vivo method of primary porcine hepatocyte isolation for use in bioartificial liver systems.

    abstract:INTRODUCTION:Primary porcine hepatocytes are commonly, used in bioartificial liver devices and for in vitro studies of hepatocyte function. Although in vivo isolation of porcine hepatocytes can give high yield and viability, such methods are time-consuming and expensive, requiring specialist surgical facilities. AIM:T...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200012080-00012

    authors: Nelson LJ,Newsome PN,Howie AF,Hadoke PW,Dabos KJ,Walker SW,Hayes PC,Plevris JN

    更新日期:2000-08-01 00:00:00

  • Association of smoking with liver fibrosis and mortality in primary biliary cholangitis.

    abstract:BACKGROUND:The outcome of primary biliary cholangitis (PBC) is affected by both genetic and environmental factors. OBJECTIVE:The aim of this study was to study the effect of smoking on liver histology and mortality in a genetically homogeneous population having PBC. PATIENTS AND METHODS:Smoking and drinking habits at...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001234

    authors: Mantaka A,Koulentaki M,Samonakis D,Sifaki-Pistolla D,Voumvouraki A,Tzardi M,Kouroumalis E

    更新日期:2018-12-01 00:00:00

  • Liver failure in adult Still's disease during corticosteroid treatment.

    abstract::Adult Still's disease is a well-characterized rheumatic disorder of unknown origin, which may affect multiple organs and may have a fatal course. However, liver failure has rarely been described in adult Still's disease. We present the case of a 25-year-old woman who was admitted with acute liver failure 2 years after...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200301000-00015

    authors: Ott SJ,Baron A,Berghaus T,Lamerz R,Beuers U

    更新日期:2003-01-01 00:00:00

  • Platelet indices and inflammatory markers as diagnostic predictors for ascitic fluid infection.

    abstract:BACKGROUND AND AIM:Ascitic fluid infection (AFI) is a common complication in patients with cirrhosis and ascites. Mean platelet volume (MPV) and platelet distribution width (PDW) may be considered as simple and inexpensive indicators of inflammation in some diseases. We aimed to investigate whether platelet size altera...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000202

    authors: Abdel-Razik A,Eldars W,Rizk E

    更新日期:2014-12-01 00:00:00

  • Genetic susceptibility to primary biliary cirrhosis.

    abstract::Family studies suggest that genetic factors play a role in determining susceptibility to primary biliary cirrhosis (PBC). A number of polymorphic genes with small and additive effects may thus encode factors predisposing to this 'polygenic' disease. All the published data on genetic predisposition to PBC have been obt...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-199906000-00004

    authors: Agarwal K,Jones DE,Bassendine MF

    更新日期:1999-06-01 00:00:00

  • hMLH1 promoter methylation and JC virus T antigen presence in the tumor tissue of colorectal cancer Israeli patients of different ethnic groups.

    abstract:BACKGROUND:Hypermethylation of tumor suppressor genes' promoter and JC virus infection may be etiologic factors in the development of colorectal cancer (CRC). OBJECTIVES:To look at both JC virus T antigen and hMLH1 promoter methylation in CRC tissue in Israeli ethnic groups with different incidence of CRC. METHODS:Tw...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32832e9d2c

    authors: Niv Y,Vilkin A,Brenner B,Kendel Y,Morgenstern S,Levi Z

    更新日期:2010-08-01 00:00:00

  • Diagnostic and prognostic values of critical flicker frequency determination as new diagnostic tool for objective HE evaluation in patients undergoing TIPS implantation.

    abstract:OBJECTIVES:The diagnostic and prognostic value of critical flicker frequency (CFF) analysis for assessment of severity and dynamics of hepatic encephalopathy (HE) was studied before and after implantation of a transjugular intrahepatic portosystemic shunt (TIPS). BASIC METHODS:Sixty-three cirrhotic patients were retro...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328310e0c3

    authors: Kircheis G,Bode JG,Hilger N,Kramer T,Schnitzler A,Häussinger D

    更新日期:2009-12-01 00:00:00

  • In-vivo effect of nicotine on cytokine production by human non-adherent mononuclear cells.

    abstract:OBJECTIVE:Ulcerative colitis (UC) is predominantly a disease of non-smokers and treatment with transdermal nicotine improves symptoms in UC patients, whereas smoking seems to have a deleterious effect in patients with Crohn's disease (CD). In CD the cytokine profile is of a dominant TH1 (T helper 1) pattern whereas in ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199610000-00016

    authors: Madretsma S,Wolters LM,van Dijk JP,Tak CJ,Feyerabend C,Wilson JH,Zijlstra FJ

    更新日期:1996-10-01 00:00:00

  • Neuromuscular alterations in the dilated ileum of an adult patient with segmental lymphangiectasia.

    abstract::Intestinal lymphangiectasia is a rare condition, which is characterized by the dilation of small bowel lymphatics and presents with signs and symptoms of protein-losing enteropathy. Some patients have complained of occlusive symptoms attributable to the mechanical obstruction caused by the considerable mucosal edema a...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3282f5dda4

    authors: Paggi S,Ferrero S,Braidotti P,de Rai P,Conte D,Basilisco G

    更新日期:2008-09-01 00:00:00

  • The gastrin receptor antagonist netazepide (YF476) in patients with type 1 gastric enterochromaffin-like cell neuroendocrine tumours: review of long-term treatment.

    abstract:OBJECTIVE:Netazepide (YF476) is a recently developed, orally active gastrin receptor antagonist that, in short trials in patients with type 1 gastric enterochromaffin-like cell neuroendocrine tumours, has been shown to induce a significant reduction in the number and size of tumours as well as serum chromogranin A (CgA...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000713

    authors: Sagatun L,Mjønes P,Jianu CS,Boyce M,Waldum HL,Fossmark R

    更新日期:2016-11-01 00:00:00

  • Nitric oxide--a mediator of inflammation or mucosal defence.

    abstract::Nitric oxide (NO) can exert both protective and proinflammatory actions in the gastrointestinal tract. NO, formed physiologically by constitutive NO synthases, regulates vascular tone, protects the microvasculature from injury, and modulates adhesion of inflammatory cells. In contrast, expression of an inducible isofo...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-199711000-00002

    authors: Whittle BJ

    更新日期:1997-11-01 00:00:00

  • Carbon dioxide insufflation during colonoscopy in inflammatory bowel disease patients: a double-blind, randomized, single-center trial.

    abstract:OBJECTIVE:Bowel distension by insufflated air causes abdominal discomfort after colonoscopy. Carbon dioxide (CO2) instead of air insufflation during colonoscopy can reduce postprocedural discomfort in diagnostic and screening cases. Discomfort after colonoscopy and CO2 insufflation have never been studied in inflammato...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MEG.0000000000000791

    authors: Falt P,Šmajstrla V,Fojtík P,Hill M,Urban O

    更新日期:2017-03-01 00:00:00

  • Risk factors for band-induced ulcer bleeding after prophylactic and therapeutic endoscopic variceal band ligation.

    abstract:BACKGROUND AND AIMS:Endoscopic variceal band ligation (EVBL) aims to eradicate high-risk oesophageal varices. There is a small risk of precipitating bleeding from EVBL-induced oesophageal ulceration, which is associated with significant mortality. We explore the risk factors and outcome of EVBL-induced ulcer bleeding. ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000387

    authors: Sinclair M,Vaughan R,Angus PW,Gow PJ,Parker F,Hey P,Efthymiou M

    更新日期:2015-08-01 00:00:00

  • Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis?

    abstract:OBJECTIVES:Serine Protease Inhibitor Kazal type 1 (SPINK1) protects against premature intracellular activation of trypsinogen and development of acute pancreatitis. Our aim was to determine the prevalence of SPINK1 mutations (a) in unselected patients with first-time acute pancreatitis and (b) in the Danish background ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析

    doi:10.1097/MEG.0b013e32834ee5e2

    authors: Jøergensen MT,Brusgaard K,Novovic S,Andersen AM,Hansen MB,Gerdes AM,de Muckadell OB

    更新日期:2012-03-01 00:00:00

  • Omeprazole-induced cough in a patient with gastroesophageal reflux disease.

    abstract::Persistent cough could be caused by various diseases such as postnasal drip syndrome, asthma and gastroesophageal reflux disease (GERD) or adverse event of drugs such as angiotensin-converting enzyme inhibitors. We report a case of persistent cough associated with high plasma levels of the proton pump inhibitor omepra...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283320129

    authors: Reiche I,Tröger U,Martens-Lobenhoffer J,Kandulski A,Neumann H,Malfertheiner P,Bode-Böger SM

    更新日期:2010-07-01 00:00:00

  • Extraintestinal pathology associated with Helicobacter infection.

    abstract::Helicobacter pylori appears to be the most important cause of gastritis and gastric and duodenal ulcer. Its eradication, in fact, promotes healing of these diseases and significantly reduces ulcer recurrence. In the last few years, moreover, besides a local tissue damage, an association between H. pylori infection and...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 社论,评审

    doi:10.1097/00042737-199703000-00001

    authors: Gasbarrini A,Franceschi F,Gasbarrini G,Pola P

    更新日期:1997-03-01 00:00:00

  • Treatment of chronic hepatitis C with pegylated interferon and ribavirin in treatment-naive patients in 'true life': a plea in favor of independent postmarketing evaluations.

    abstract:BACKGROUND:Results of treatments for chronic hepatitis C virus are only estimated and disclosed from pivotal trials. AIM:To report the 'true life' results of pegylated interferon and ribavirin in treatment-naive patients. METHODS:A prospective, multicenter observatory in 22 general hospitals. RESULTS:Five-hundred an...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/meg.0b013e32833bb4b0

    authors: Pariente A,Lahmek P,Duprat C,Denis J,Faroux R,Renou C,Nalet B,Morin T,Cadranel JF,Investigator Group belonging to Association Nationale des Gastroentérologues des Hôpitaux Généraux (ANGH).

    更新日期:2010-11-01 00:00:00

  • Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes.

    abstract:OBJECTIVE:There is a controversy about the performance of blood tests for the diagnostic of metabolic liver disease in patients with type-2-diabetes in comparison with patients without type-2-diabetes. These indirect comparisons assumed that the gold-standard is binary, whereas fibrosis stages, steatosis and nonalcohol...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001606

    authors: Poynard T,Peta V,Deckmyn O,Pais R,Ngo Y,Charlotte F,Ngo A,Munteanu M,Imbert-Bismut F,Monneret D,Housset C,Thabut D,Valla D,Boitard C,Castera L,Ratziu V,FLIP consortium, the FibroFrance Group, the EPIC-3 program and the QU

    更新日期:2020-08-01 00:00:00

  • Mechanisms of liver cell damage and repair.

    abstract::Acute liver failure arises from an imbalance between liver cell death and regeneration. The severity of the insult determines whether liver cells die by apoptosis or necrosis, and this in turn affects the magnitude of the inflammatory reaction. Liver cell death occurs through complex cellular interactions and is media...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-199909000-00002

    authors: Thomson RK,Arthur MJ

    更新日期:1999-09-01 00:00:00

  • Hepatitis C and hepatitis C-related advanced liver disease hospitalisation trends before and after the Strategic Plan for Tackling Hepatitis C in the National Health System.

    abstract:INTRODUCTION:This work evaluates the burden and trends of hepatitis C virus (HCV)-associated hospitalisations in Spain before and after the implementation of the Strategic Plan for Tackling Hepatitis C in the National Health System in 2015. METHODS:HCV-related hospitalisation discharges from 2005 to 2017 were obtained...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001841

    authors: Garrido-Estepa M,Latasa P,Flores-Herrera J,García Comas L

    更新日期:2020-07-29 00:00:00