Hepatitis C virus treatment rates and outcomes in HIV/hepatitis C virus co-infected individuals at an urban HIV clinic.


OBJECTIVES:The factors associated with hepatitis C virus (HCV) treatment uptake and responses were assessed among HCV/HIV co-infected individuals referred for HCV therapy at an urban HIV clinic. METHODS:Retrospective review of HIV/HCV patients enrolled in the HCV treatment program at the John Ruedy Immunodeficiency Clinic in Vancouver. The factors associated with treatment uptake were assessed using multivariate analysis. RESULTS:A total of 134 HCV/HIV co-infected individuals were recalled for assessment for HCV therapy. Overall 64 (48%) initiated treatment, and of those treated 49 (76.6%) attained end treatment response, whereas 35 (57.8%) achieved sustained virological response (SVR). When evaluated by genotype, 53% (17/32) of those with genotype 1, and 65% (20/31) of those with genotype 2 or 3 infections attained SVR. In treated individuals, alanine aminotransferase dropped significantly after treatment (P<0.001). During treatment, CD4 counts dropped significantly (P<0.001) in all patients. The counts recovered to baseline in patients who achieved SVR, but remained lower in patients who failed the therapy (P=0.015). On multivariate analysis, history of injection drug use (odds ratio: 3.48; 95% confidence interval: 1.37-8.79; P=0.009) and low hemoglobin levels (odds ratio: 4.23; 95% confidence interval: 1.36-13.10; P=0.013) were associated with those who did not enter the treatment. CONCLUSION:Only half of treatment-eligible co-infected patients referred for the therapy initiated treatment. Of those referred for the therapy, history of injection drug use was associated with lower rates of treatment uptake. Treated HIV/HCV co-infected individuals benefitted from both decreased alanine aminotransferase (independent of SVR), and rates of SVR similar to those described in HCV monoinfected patients.


Murray MC,Barrios R,Zhang W,Hull M,Montessori V,Hogg RS,Montaner JS




Has Abstract


2011-01-01 00:00:00














  • Individualized surveillance of chronic hepatitis B patients according to hepatocellular carcinoma risk based on PAGE-B scores.

    abstract:BACKGROUND AND AIMS:Current guidelines for chronic hepatitis B (CHB) patients are to undergo surveillance for hepatocellular carcinoma (HCC) with 6-month ultrasonography. We aimed to compare detection rates of very-early-stage HCC in two groups: group A, undergoing 6-month ultrasonography versus group B, undergoing 6-m...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Kim JH,Kang SH,Lee M,Choi HS,Jun BG,Kim TS,Choi DH,Suk KT,Kim MY,Kim YD,Cheon GJ,Baik SK,Kim DJ

    更新日期:2020-08-14 00:00:00

  • Hepatic venous outflow obstruction after hydatid cyst surgery: evaluation with contrast enhanced magnetic resonance angiography.

    abstract:INTRODUCTION:The aim of this study is to present the contrast enhanced magnetic resonance angiography findings of hepatic venous outflow obstruction in patients in whom surgery had been performed for hepatic hydatidosis. No patient history of parasitic hepatic venous invasion or earlier hepatic venous outflow obstructi...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Haliloglu N,Erden A

    更新日期:2009-07-01 00:00:00

  • The association between functional dyspepsia and depression: a meta-analysis of observational studies.

    abstract::Concomitant functional dyspepsia (FD) and psychosocial stressors have been reported; however, the association between FD and depression remains controversial and no quantitative meta-analysis exists. Published articles were identified through a comprehensive review of PubMed, Embase, and Web of Science from inception ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析,评审


    authors: Lin S,Gao T,Sun C,Jia M,Liu C,Ma A

    更新日期:2019-08-01 00:00:00

  • Endoscopic sedation and monitoring practices in Portugal: a nationwide web-based survey.

    abstract:BACKGROUND:National surveys have been used to obtain information on sedation and monitoring practices in endoscopy in several countries. AIMS:To provide data from Portugal and query the Portuguese endoscopists on nonanesthesiologist administration of propofol. MATERIALS AND METHODS:A 31-item web survey was sent to al...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Ferreira AO,Torres J,Dinis-Ribeiro M,Cravo M

    更新日期:2015-03-01 00:00:00

  • Treatment of refractory post-transjugular portosystemic stent-shunt encephalopathy: a novel case of stent luminal reduction.

    abstract::Encephalopathy is a significant complication of transjugular intrahepatic portosystemic stent-shunt (TIPSS). The majority respond to medical treatment but a proportion prove recalcitrant to conservative measures and eventually require some modulation of shunt blood flow in order to ameliorate their symptoms. This is p...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Clarke G,Patel R,Tsao S,Blanshard K

    更新日期:2004-11-01 00:00:00

  • Cholescintigraphy in patients with acute cholecystitis before and after percutaneous gallbladder drainage.

    abstract:OBJECTIVE:To investigate gallbladder function by use of cholescintigraphy in patients with acute cholecystitis before and after percutaneous gallbladder drainage. DESIGN:A cholescintigraphy was performed in 40 patients with acute cholecystitis before and after the performance of percutaneous gallbladder drainage. Duri...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Borly L,Stage JG,Grønvall S,Højgaard L

    更新日期:1995-11-01 00:00:00

  • Hepatitis C virus infection in Spanish volunteer blood donors: HCV RNA analysis and liver disease.

    abstract:OBJECTIVE:To evaluate in a large group of volunteer blood donors the prevalence of antibodies to hepatitis C virus (anti-HCV) and the relation of transaminase (ALT) levels and viraemia to liver damage. DESIGN:A prospective study. SETTING:Transfusion Centre of the Autonomous Community of Madrid and the Liver Unit of t...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Muñoz-Gómez R,García-Monzón C,García-Buey L,Lo Iacono O,Borque MJ,Garía-Sánchez A,Pajares JM,Moreno-Otero R

    更新日期:1996-03-01 00:00:00

  • Faecal microbiota transplantation: establishment of a clinical application framework.

    abstract:BACKGROUND:Faecal microbiota transplantation (FMT) is currently being established as a second-line treatment for recurrent Clostridium difficile infection. FMT is further being considered for other infectious and inflammatory conditions. Safe and reproducible methods for donor screening, laboratory processing and clini...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Jørgensen SMD,Hansen MM,Erikstrup C,Dahlerup JF,Hvas CL

    更新日期:2017-11-01 00:00:00

  • Liver transplantation for intractable pruritus is contraindicated before an adequate trial of opiate antagonist therapy.

    abstract::A woman with stage III (pre-cirrhotic) primary biliary cirrhosis was referred for liver transplantation because of intractable pruritus. Oral administration of 50 mg naltrexone precipitated a severe opioid withdrawal-like reaction. Subsequently, when oral naltrexone therapy was reintroduced following a cautious infusi...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Neuberger J,Jones EA

    更新日期:2001-11-01 00:00:00

  • Protective effect of carnosol on CCl(4)-induced acute liver damage in rats.

    abstract:BACKGROUND:We recently reported that (Lamiaceae) may alleviate CCl(4)-induced acute hepatotoxicity in rats, possibly blocking the formation of free radicals generated during CCl(4) metabolism. Carnosol, one of the main constituents of Rosmarinus, has been shown to have antioxidant and scavenging activities. Therefore, ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Sotelo-Félix JI,Martinez-Fong D,Muriel De la Torre P

    更新日期:2002-09-01 00:00:00

  • Risk of liver fibrosis progression in patients with suboptimal diagnosis of hepatitis C virus infection.

    abstract:OBJECTIVE:Many hepatitis C virus (HCV)-infected patients have a suboptimal diagnosis. Particularly, the characteristics and risk of fibrosis progression of HCV antibody-positive patients without RNA testing are unknown. METHODS:Patients with a positive HCV antibody performed during 2005-2007 were classified based on R...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Morales-Arraez D,Nieto Bujalance Y,Diaz-Flores F,de Vera A,Jiménez A,Garcia Dopico JA,Quintero E,Hernández-Guerra M

    更新日期:2020-04-01 00:00:00

  • Thalidomide in advanced hepatocellular carcinoma as antiangiogenic treatment approach: a phase I/II trial.

    abstract:BACKGROUND:The high vascularity of hepatocellular carcinoma (HCC) seems to be a potential therapeutic target. We evaluated the efficacy, toxicity, and histologic response to thalidomide in advanced HCC in a single center phase I/II pilot trial. METHODS:Between September 2000 and August 2004 patients with HCC uneligibl...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Pinter M,Wichlas M,Schmid K,Plank C,Müller C,Wrba F,Peck-Radosavljevic M

    更新日期:2008-10-01 00:00:00

  • Perceptions of gastroenterologists and nurses regarding irritable bowel syndrome and inflammatory bowel disease.

    abstract:OBJECTIVE:Irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) have similar symptoms, and both adversely affect patients' quality of life. The objective of this study was to compare the perceptions of physicians and nurses regarding IBS and IBD. METHODS:The Illness Perception Questionnaire Revised, adap...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Dickman R,Segev M,Levi S,Reicher-Atir R,Steinmetz A,Horev N,Niv Y

    更新日期:2011-09-01 00:00:00

  • Serum anti-Lewis X antibody is associated with VacA seropositivity but not atrophic gastritis in patients with Helicobacter pylori infection.

    abstract:OBJECTIVES:Lipopolysaccharides of Helicobacter pylori have an antigenic structure that mimics Lewis X occurring in gastric mucosa. The pathogenic role of antigenic mimicry in H. pylori-induced gastritis has been of recent interest. The aim of this study was to examine the relevance of anti-Lewis X antibody in the devel...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Shimoyama T,Fukuda S,Tanaka M,Sugawara N,Kurimoto F,Munakata A

    更新日期:2001-03-01 00:00:00

  • Evaluation of serum procollagen C-proteinase enhancer 1 level as a fibrosis marker in patients with chronic hepatitis B.

    abstract:AIM:Although liver biopsy has long been considered the gold standard for staging fibrosis, because of the disadvantages and risks of biopsy, several noninvasive processes such as serum biomarkers have been introduced for the assessment of liver fibrosis. The aim of this study was to assess the diagnostic value of serum...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Gokce O,Ozenirler S,Atak Yucel A,Oruklu N,Yilmaz Esendagli G,Karahan S

    更新日期:2018-08-01 00:00:00

  • Perforation--a rare complication of a small-bowel carcinoid.

    abstract::Carcinoids are rare compared to other tumours of the gastrointestinal tract, but present a significant portion of tumours of the small intestine. The case of a 50-year-old man who suffered perforation of a small-bowel carcinoid after failed diagnostic trials is reported here. Since intestinal perforation is rarely the...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Duvnjak M,Pavic T,Goranovic T

    更新日期:2000-07-01 00:00:00

  • Labour productivity losses caused by premature death associated with hepatitis C in Spain.

    abstract:BACKGROUND AND AIMS:Hepatitis C virus (HCV) infection places a huge burden on healthcare systems. There is no study assessing the impact of HCV infection on premature deaths in Spain. The aim of this study was to estimate productivity losses because of premature deaths attributable to hepatitis C occurring in Spain dur...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Oliva-Moreno J,Peña-Longobardo LM,Alonso S,Fernández-Bolaños A,Gutiérrez ML,Hidalgo-Vega Á,de la Fuente E,Fernández-Rodríguez CM

    更新日期:2015-06-01 00:00:00

  • Radiolucent pancreatic lithiasis: a precursor stage for calcified pancreatic lithiasis or a new entity?

    abstract:OBJECTIVE:Radiolucent pancreatic lithiasis (RPL) has been identified as a different entity from calcified pancreatic lithiasis. The purpose of this study is to evaluate the frequency, characteristics and evolution of RPL. PATIENTS:Between 1983 and 1995, 278 consecutive patients who presented with pancreatic lithiasis ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Barthet M,Daniel R,Bernard JP,Valantin V,Sahel J

    更新日期:1997-07-01 00:00:00

  • Characterization of serum irisin in patients with severe acute pancreatitis.

    abstract:BACKGROUND:Irisin, as a novel and versatile hormone secreted by skeletal myocytes and fat tissues, is reported to be involved in inflammation-related diseases; one of the main characteristics of severe acute pancreatitis (SAP) is inflammatory responses. This study aims to describe the characteristics of irisin in SAP. ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Chen S,Wang L,Gao X,Chen M,Zeng Z,Zhao L

    更新日期:2019-08-01 00:00:00

  • Late onset primary oxalosis type I: an uncommon presentation of a rare disease.

    abstract::A 46-year-old woman developed rapidly worsening renal insufficiency. Extensive calcification of the kidneys was found. The patient also suffered from ischaemic neuropathy, myopathy and arthritis. In a muscle biopsy multiple calcium oxalate crystals could be demonstrated surrounded by inflammatory infiltrates. Levels o...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Glück T,Krämer BK,Zülke C,Rüschoff J,Rogler G,Schweda F,Anthuber M,Lang B,Schölmerich J

    更新日期:1998-09-01 00:00:00

  • Hepatobiliary manifestations of cystic fibrosis.

    abstract::Cystic fibrosis is the most common, potentially lethal genetic defect in the Caucasian population. During recent years it has been increasingly associated with a number of hepatic and biliary abnormalities, of which chronic cholestatic liver disease is by far the most relevant. Plugging of intrahepatic bile ducts with...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审


    authors: Colombo C,Battezzati PM

    更新日期:1996-08-01 00:00:00

  • Systematic review: endoluminal therapy for gastro-oesophageal reflux disease: evidence from clinical trials.

    abstract::During the last few decades many endoscopic interventions have been developed as an alternative for the treatment of gastro-oesophageal reflux disease (GORD). In many countries, these interventions are thus being performed in the general clinical setting. The aim of this study is to systematically review the evidence ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析,评审


    authors: Fry LC,Mönkemüller K,Malfertheiner P

    更新日期:2007-12-01 00:00:00

  • Effects of recognizing depression with a standardized questionnaire (CES-D) versus patient reporting of depression after a single-standardized question on the outcomes of treatment for hepatitis C with pegylated interferon-α-2b and ribavirin.

    abstract:BACKGROUND:Depression may worsen during antiviral treatment for hepatitis C virus, resulting in noncompliance treatment. AIM:The aim was to compare the response and compliance rates between the groups of veteran patients using two different methods of identifying depression, either the Centers for Epidemiology Studies...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,随机对照试验


    authors: Phillips FH,Prebis M,Grumbeck C,Hale T,Cubillas R,Brown GR

    更新日期:2010-12-01 00:00:00

  • The role of cholecystokinin and the cholinergic system in intravenous amino acid-induced gallbladder emptying.

    abstract:BACKGROUND:Recent studies have demonstrated that separate intravenous infusion of amino acids (IVAA) at high doses induces gallbladder emptying. However, little is known about the mechanisms mediating IVAA-induced gallbladder contraction. OBJECTIVE AND METHODS:To investigate whether the effect of IVAA on gallbladder m...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gielkens HA,de Boer SY,Lam WF,Rovati LC,Lamers CB,Masclee AA

    更新日期:1997-12-01 00:00:00

  • An unusual case of haemobilia.

    abstract::Arterio-biliary fistula is an uncommon cause of haemobilia. We describe a case of right hepatic artery pseudo-aneurysm causing arterio-biliary fistula and presenting as severe melaena and cholangitis. Gastroduodenoscopy failed to establish the exact source of bleeding and hepatic artery angiography and selective embol...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Rai R,Rose J,Manas D

    更新日期:2003-12-01 00:00:00

  • Heparanase-2, syndecan-1, and extracellular matrix remodeling in colorectal carcinoma.

    abstract:AIM:To propose a quantitative method to detect heparanase-2 (HPA2) and syndecan-1 (Syn-1) using immunohistochemistry in colorectal (colon and rectal) carcinomas compared with nonneoplastic tissues and evaluate the possible role of these molecules in tumor development and extracellular remodeling. METHODS:Cytoplasmic s...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Peretti T,Waisberg J,Mader AM,de Matos LL,da Costa RB,Conceição GM,Lopes AC,Nader HB,Pinhal MA

    更新日期:2008-08-01 00:00:00

  • Intraductal papillary mucinous neoplasms of the pancreas: diagnosis and management.

    abstract::Intraductal papillary mucinous neoplasms (IPMNs), characterized by intraductal papillary growth and thick mucin secretion, have increasingly been recognized. Despite modern preoperative evaluation, major difficulties still remain in distinguishing malignant invasive types from benign IPMNs. Following a PubMed database...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审


    authors: Dongbin L,Fei L,Werner Josefin B,Roland A

    更新日期:2010-09-01 00:00:00

  • Mapping the relationships between inflammatory bowel disease and comorbid diagnoses to identify disease associations.

    abstract:BACKGROUND:Massive amounts of patient data are captured daily in electronic medical records (EMR). Utilizing the power of such large data may help identify disease associations and generate hypotheses that can lead to a better understanding of disease associations and mechanisms. We aimed to comprehensively identify an...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Waljee AK,Noureldin M,Berinstein JA,Cohen-Mekelburg SA,Wallace BI,Cushing KC,Hanauer DA,Keeney-Bonthrone TP,Nallamothu B,Higgins PDR

    更新日期:2020-10-01 00:00:00

  • Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants.

    abstract:BACKGROUND:Tropical calcific pancreatitis (TCP) is a relatively common form of chronic pancreatitis in parts of Asia and Africa. The SPINK1 variant p.N34S is strongly associated with TCP, but other genetic factors remain to be defined. Chymotrypsinogen C (CTRC) degrades trypsinogen and loss-of-function variants have be...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Derikx MH,Szmola R,te Morsche RH,Sunderasan S,Chacko A,Drenth JP

    更新日期:2009-08-01 00:00:00

  • Omeprazole-induced cough in a patient with gastroesophageal reflux disease.

    abstract::Persistent cough could be caused by various diseases such as postnasal drip syndrome, asthma and gastroesophageal reflux disease (GERD) or adverse event of drugs such as angiotensin-converting enzyme inhibitors. We report a case of persistent cough associated with high plasma levels of the proton pump inhibitor omepra...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章


    authors: Reiche I,Tröger U,Martens-Lobenhoffer J,Kandulski A,Neumann H,Malfertheiner P,Bode-Böger SM

    更新日期:2010-07-01 00:00:00