Effect of nicotine on large bowel mucus thickness, eicosanoids and faecal proteinase in ferrets.

Abstract:

BACKGROUND:Following observations on the effect of subcutaneous nicotine on rectal mucosal eicosanoids and mucus in the rabbit we have repeated the work in ferrets which may be a more suitable animal model. AIMS AND METHODS:The effect of nicotine on mucosal eicosanoids, the adherent mucus layer, and faecal proteinases in the large bowel of ferrets was examined in forty animals randomly allocated to five groups, a control and four treatment groups. They were given subcutaneous saline or nicotine via an Alzet pump in doses of 0.3, 0.6, 1.2 and 2.0 mg/kg/day for 10 days and then sacrificed; measurements were made of serum nicotine and cotinine levels, rectal mucosal eicosanoids, adherent rectal and colonic mucus thickness, and faecal proteinases. RESULTS:No significant differences were observed for any measurements, except for serum nicotine and cotinine levels, which were raised consistent with the dose given. CONCLUSION:Nicotine had no effect on measurements, which may possibly be important in the relationship between smoking and ulcerative colitis.

authors

Thomas GA,Pullan RD,Zijlstra FJ,Rankin BJ,Russell MA,Feyerabend C,Allen A,Rhodes J

doi

10.1097/00042737-199702000-00013

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

179-82

issue

2

eissn

0954-691X

issn

1473-5687

journal_volume

9

pub_type

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