Abstract：
BACKGROUND:Patients with inflammatory bowel disease (IBD) have a higher risk of developing thromboembolic events (TE) compared with the healthy population. AIM:This study aimed to describe a cohort of IBD patients with a history of TE focusing on recurrence of TE, disease activity and IBD medication at the time of TE and surgery before TE. MATERIALS AND METHODS:In a retrospective monocentric cohort study, we included IBD patients in whom an arterial and/or venous TE occurred. RESULTS:Eighty-four IBD patients with a history of TE (63% Crohn's disease, 44% men) and a mean age of 45±15 years were included; 25/84 patients (30%) were identified to have recurrent TE. Seventy out of 84 (83%) developed a venous TE, with a deep vein thrombosis as the major manifestation (28/70, 40%), followed by a pulmonary embolism (16/70, 23%). At the time of TE, 60/84 (71%) patients were diagnosed with active disease. In all, 23% patients were on 5-aminosalicylic acids, 36% on steroids, 18% on azathioprine, 5% on methotrexate, 12% on biologicals and 23% were not receiving specific IBD treatment. Moreover, within a 6-month period preceding the TE, 28/84 (33%) patients underwent surgery, of whom 17% received thromboprophylaxis at hospital discharge. CONCLUSION:We confirm the association between disease activity and the occurrence of TE. A substantial number of patients had additional risk factors such as recurrence of TE. In all, 36% received steroids at the time of TE and 33% underwent recent surgery, of whom only a minority received thromboprophylaxis at hospital discharge. Further efforts are required to increase thromboprophylaxis in at-risk patients.
journal_name
Eur J Gastroenterol Hepatoljournal_title
European journal of gastroenterology & hepatologyauthors
Bollen L,Vande Casteele N,Ballet V,van Assche G,Ferrante M,Vermeire S,Gils Adoi
10.1097/MEG.0000000000000495subject
Has Abstractpub_date
2016-01-01 00:00:00pages
1-7issue
1eissn
0954-691Xissn
1473-5687journal_volume
28pub_type
杂志文章abstract：BACKGROUND:Data from studies in patients with nonalcoholic steatohepatitis (NASH) suggest an increased hepatic fatty acid oxidation. We have previously shown higher fasting plasma bile acid concentrations in patients with NASH. In-vivo and in-vitro studies suggest that bile acids by binding to peroxisome proliferator-a...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e328345c8c7
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND AND AIMS:It has been reported that the incidence of liver cancer and intrahepatic bile duct tumours might be increasing in some developed countries. The purpose of this study was to examine time trends of incidence and mortality rates of liver cirrhosis and liver cancer for the period 1980-1997 in Catalonia,...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-200409000-00009
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND:Two novel antiendotoxin peptides, P6 and C1, may reduce the inflammatory response. This study aimed to determine the effect of endotoxin on hepatic cytokine response and to assess P6 and C1-related attenuation of the proinflammatory response to endotoxemia, in experimental biliary obstruction. MATERIALS AND...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e32834dfb8c
更新日期：2012-03-01 00:00:00
abstract：AIM:A combination of omeprazole plus amoxycillin (Amo) and clarithromycin (CIa) for 7 days has been studied extensively. However, the role of other proton pump inhibitors, such as pantoprazole (Pan), in this therapy is not well known. On the other hand, ranitidine bismuth citrate (RBC) also seems to be effective when c...
journal_title：European journal of gastroenterology & hepatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00042737-200012050-00003
更新日期：2000-05-01 00:00:00
abstract：:Intraductal papillary mucinous neoplasms (IPMNs), characterized by intraductal papillary growth and thick mucin secretion, have increasingly been recognized. Despite modern preoperative evaluation, major difficulties still remain in distinguishing malignant invasive types from benign IPMNs. Following a PubMed database...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,评审
doi：10.1097/MEG.0b013e32833b00f9
更新日期：2010-09-01 00:00:00
abstract：:We report the case of a 66-year-old man with chronic hepatitis C and a slowly growing left chest wall mass. Two years after the patient first noticed the mass, it was resected. A diagnosis of hepatocellular carcinoma (HCC) was established. The liver was studied by ultrasound, computed tomography (CT), magnetic resonan...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-200107000-00018
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND AND AIM:An inadequate disinfection of endoscopes and associated accessories can result in the transmission of infections to patients. The aim of this study was to access reprocessing practice in the endoscopy units of Portuguese district general hospitals. METHODS:An anonymous questionnaire on cleaning and ...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e328348d5d6
更新日期：2011-11-01 00:00:00
abstract：OBJECTIVE:To determine whether the sugar absorption test (SAT) during follow-up of patients with coeliac disease on a gluten-free diet (GFD) correlates with improvement of the villous architecture of the small intestine. METHODS:The SAT was performed in coeliacs at diagnosis and during follow-up with GFD. For the SAT,...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-199603000-00006
更新日期：1996-03-01 00:00:00
abstract：BACKGROUND:The hepatitis B virus (HBV) and hepatitis C virus (HCV) infections may seriously affect survival rate. The median length of life in developed countries is increasing and the elderly may be considered as an epidemiologically distinct group due to higher whole-life risk of blood-borne viral infections. AIM:To...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,多中心研究
doi：10.1097/MEG.0b013e328357632a
更新日期：2012-11-01 00:00:00
abstract：:Primary cutaneous B-cell lymphoma is a low-grade malignancy, distinct from other lymphomas in terms of biological activity and response to treatment. We describe a 77-year-old woman with a five-year history of chronic hepatitis C infection who developed a lower-limb lesion over a period of 3 months which was diagnosed...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-199906000-00014
更新日期：1999-06-01 00:00:00
abstract：:Before the discovery of Helicobacter pylori infection some 12 years ago, three major disturbances in gastric physiology had been identified in patients with duodenal ulcer disease. These abnormalities were: impaired acid inhibition of gastrin release from the antral mucosa, increased basal and stimulated acid secretio...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,评审
doi：
更新日期：1997-04-01 00:00:00
abstract：:Coeliac disease is generally well controlled with gluten-free diet but a small proportion of patients require corticosteroids or immunomodulatory agents. Response to anti-tumour necrosis factor (anti-TNF) agents raises interesting questions about both the pathogenesis of coeliac disease and the mechanism of action of ...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,评审
doi：10.1097/00042737-200506000-00002
更新日期：2005-06-01 00:00:00
abstract：:A gluten-free diet is the cornerstone treatment of coeliac disease. Until now, it is not known conclusively whether trace amounts of gluten might be allowed in the diet, as suggested by Codex Alimentarius. Gluten-free foods intended for dietary use can now be analysed reliably for residual gluten by the new R5 enzyme-...
journal_title：European journal of gastroenterology & hepatology
pub_type： 评论,杂志文章
doi：10.1097/01.meg.0000059124.68845.8c
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND:Screening colonoscopy is less effective in preventing proximal colon cancers than distal colon cancers. A repeat examination of the right side of the colon may increase the lesion detection. The study aimed to assess the results of a second examination of the right side of the colon with forward-view or retr...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,meta分析,评审
doi：10.1097/MEG.0000000000001009
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Correa's hypothesis proposes that gastric carcinogenesis is due to atrophic gastritis and hypochlorhydria which permit gastric bacterial colonization, the reduction of dietary nitrates to nitrites and the formation of potentially carcinogenic N-nitroso compounds (NOCs). OBJECTIVE:To test the hypothesis that...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-200012020-00006
更新日期：2000-02-01 00:00:00
abstract：OBJECTIVES:Currently, the (13)C-urea breath test is the reference method for non-invasive diagnosis of Helicobacter pylori infection and therapy control. Therefore, new technologies have been developed to measure the ratio of (13)CO(2)/(12)CO(2) in breath. The laser-assisted ratio analyser (LARA) device is based on opt...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-200107000-00008
更新日期：2001-07-01 00:00:00
abstract：OBJECTIVE:To assess the efficacy and side-effect profile of two currently advocated treatment regimens for eradicating Helicobacter pylori. DESIGN:A randomized, controlled, open, single-centre study. SETTING:A community hospital in The Netherlands. PARTICIPANTS:Seventy-six consecutive patients with (chronic) ulcer d...
journal_title：European journal of gastroenterology & hepatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00042737-199512000-00011
更新日期：1995-12-01 00:00:00
abstract：BACKGROUND AND AIMS:This study was performed to evaluate the treatment efficacy of endoscopic variceal obturation (EVO) in patients with gastric variceal bleeding (GVB) according to the type of varices. PATIENTS AND METHODS:All patients who were treated with EVO for bleeding from gastric varices (GVs) were included. P...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000001271
更新日期：2019-02-01 00:00:00
abstract：:We report the case of a young woman with Crohn's disease of the bowel who presented with a purulent tracheobronchitis and life-threatening upper airway obstruction. Fibreoptic bronchoscopy demonstrated severe tracheal and upper bronchial pseudotumours and stenosis. The role of recent discontinuation of corticosteroids...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-200112000-00015
更新日期：2001-12-01 00:00:00
abstract：:Endoscopic sclerotherapy or ligation and/or drugs are the standard treatments for the prevention of variceal rebleeding. Failure of this treatment indicates the need for rescue transjugular intrahepatic portosystemic shunt (TIPS) implantation. The current practice to use endoscopic treatment as first-line and TIPS as ...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,评审
doi：10.1097/00042737-200104000-00007
更新日期：2001-04-01 00:00:00
abstract：:The question of when and how to drain a malignant biliary obstruction (MBO), both intrinsic or extrinsic, remains a controversial point among endoscopists. An important factor that influences the decision to drain an MBO or not is if the patient is a surgical candidate or not and, in the former case, if the patients m...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000001752
更新日期：2020-10-01 00:00:00
abstract：:Syndecan expression, or the lack thereof by tumor cells, has been associated with poor prognosis in several types of cancer, including colorectal cancer. Syndecan is a heparan sulfate proteoglycan involved in tumor adhesion, invasion, and metastasis. In addition, the expression of the enzyme heparanase by cancer cells...
journal_title：European journal of gastroenterology & hepatology
pub_type： 评论,杂志文章,评审
doi：10.1097/MEG.0b013e3282fc2660
更新日期：2008-08-01 00:00:00
abstract：AIM:Anthropometry is a good evaluation tool that establishes the association between body fat distribution and metabolic risk factors precisely. The aim of this study was to test the association of anthropometric measurements with subclinical atherosclerosis and liver fibrosis. METHODS:A total of 78 patients with nona...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000001431
更新日期：2019-11-01 00:00:00
abstract：INTRODUCTION:Excessive alcohol consumption has steadily risen to become the third leading cause of preventable death in the USA. One consequence of heavy alcohol use recently under considerable investigation is alcoholic hepatitis. Although many risk factors for developing alcoholic hepatitis have been documented, our ...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000001583
更新日期：2020-06-01 00:00:00
abstract：:The majority of duodenal diverticula are asymptomatic but may also induce major haemorrhage on rare occasions. Gastrointestinal bleeding due to angiodysplasia in a duodenal diverticulum is very rare. We present a 70-year-old woman with repeated melaena in whom the diagnosis of angiodysplasia in a diverticulum of the f...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-200106000-00017
更新日期：2001-06-01 00:00:00
abstract：OBJECTIVE:To investigate a possible dose-effect relationship with two dosages of oral slow-release mesalazine in patients with quiescent ulcerative colitis. METHOD:One hundred and sixty-nine patients with ulcerative colitis in remission were treated with either 1.5 or 3.0 g/day mesalazine for 1 year or until relapse i...
journal_title：European journal of gastroenterology & hepatology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1097/00042737-199511000-00003
更新日期：1995-11-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:The data regarding the microbial spectrum in necrotizing pancreatitis and its impact on mortality is limited. Therefore, in this study, we aimed to investigate the agents identified in cultures and their impact on in-hospital and 1-year all-cause mortality. METHODS:Patients with necrotizing pancr...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000001687
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Recent studies have revealed that combining of the platelet to lymphocyte ratio (PLR) and the neutrophil to lymphocyte ratio (NLR) [(combination of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio (CNP)] links with dismal prognosis in diverse cancers. Here, we elucidated the prognostic significance ...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000002037
更新日期：2021-01-06 00:00:00
abstract：BACKGROUND AND AIM:Body composition has emerged as a prognostic factor for end-stage liver disease. We therefore investigated muscle mass, body fat and other clinical-pathological variables as predictors of posttransplant survival. METHODS:A total of 368 patients, who underwent orthotopic liver transplantation (OLT) a...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000001552
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVES:To examine the interdigestive and postprandial antroduodenal motility patterns of patients with functional dyspepsia using prolonged ambulatory antroduodenal manometry and to compare these findings with conventional stationary manometry. METHODS:Prolonged ambulatory and short-term stationary antroduodenal m...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
