Follow-up of treated coeliac patients: sugar absorption test and intestinal biopsies compared.

Abstract:

OBJECTIVE:To determine whether the sugar absorption test (SAT) during follow-up of patients with coeliac disease on a gluten-free diet (GFD) correlates with improvement of the villous architecture of the small intestine. METHODS:The SAT was performed in coeliacs at diagnosis and during follow-up with GFD. For the SAT, a solution of lactulose (L) and mannitol (M) was given to the fasting patient and the L-M ratio calculated in a 5-hour urine sample by gas chromatography: ratios > 0.089 are considered abnormal. The solution was made hyperosmolar by adding sucrose (1560 mmol/l). RESULTS:The L-M ratio was 2-3 times higher at diagnosis than either at 8 months to 2 years gluten free, or beyond 2 years gluten free, consecutively. The L-M ratio (mean, range) was significantly higher in cases of biopsies with (sub)total villous atrophy (VA) (0.388, 0.062-0.804, n = 28), partial VA (0.240, 0.062-0.841, n = 18) and villous irregularity (0.143, 0.017-0.322, n = 29) than in case of normalized histology after GFD (0.085, 0.021-0.230, n = 19). The rate of normalization of functional integrity was slower in adults than in children, demonstrated by a combination of histology and SAT. CONCLUSION:The SAT correlates well with the degree of VA. It is important for daily clinical practice that the simple and non-invasive SAT can be used as an indicator of intestinal damage, thus influencing need for and timing of intestinal biopsies.

authors

Uil JJ,van Elburg RM,van Overbeek FM,Meyer JW,Mulder CJ,Heymans HS

doi

10.1097/00042737-199603000-00006

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

219-23

issue

3

eissn

0954-691X

issn

1473-5687

journal_volume

8

pub_type

杂志文章
  • Short article: The effect of implementation of a treatment algorithm for infliximab on remission rates and drug costs in inflammatory bowel disease patients.

    abstract:INTRODUCTION:The effective, but expensive, drug infliximab is used in patients with inflammatory bowel disease (IBD). Monitoring infliximab trough levels and anti-infliximab antibody (ATI) formation can lead to a more cost-effective use of infliximab therapy. The aim of our study was to investigate the effect of implem...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章

    doi:10.1097/MEG.0000000000000763

    authors: Taks M,Pijls PA,Derijks LJ,Ten Broeke R,Grouls RJ,Curvers J,Gilissen LP

    更新日期:2017-02-01 00:00:00

  • Spontaneous bacterial peritonitis caused by quinolone-resistant Escherichia coli: could steroid therapy play a role?

    abstract::Prophylaxis with norfloxacin has been shown to be effective in preventing spontaneous bacterial peritonitis (SBP) in liver cirrhosis. This therapy is associated with the appearance of quinolone-resistant Escherichia coli. However, only four cases of SBP caused by quinolone-resistant E. coli have been reported so far. ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200201000-00014

    authors: Cereto F,Genescà J,Smithson A,González A,Moreno G,del Valle Ortiz O,Esteban R,Guardia J

    更新日期:2002-01-01 00:00:00

  • Impact of nitazoxanide on sustained virologic response in Egyptian patients with chronic hepatitis C genotype 4: a double-blind placebo-controlled trial.

    abstract:BACKGROUND:Nitazoxanide, approved for the treatment of Cryptosporidium parvum and Giardia lamblia, was found to inhibit hepatitis C virus replication. AIM:The aim of this study was to assess the impact of nitazoxanide as an add-on therapy to pegylated interferon α-2a and ribavirin on sustained virologic response (SVR)...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MEG.0000000000000492

    authors: Kohla MA,El-Said H,El-Fert A,Ehsan N,Ezzat S,Taha H

    更新日期:2016-01-01 00:00:00

  • The prevalence of occult hepatitis B virus infection in type 2 diabetes mellitus patients.

    abstract:AIM:The prevalence of occult hepatitis B virus (HBV) infection is relatively frequent among patients with immune suppression. The impairment of the immune system is well demonstrated in diabetics. We aimed to investigate the prevalence of occult HBV infection among hepatitis B core antibody (HbcAb)+/- hepatitis B surfa...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3282f55e1e

    authors: Demir M,Serin E,Göktürk S,Ozturk NA,Kulaksizoglu S,Ylmaz U

    更新日期:2008-07-01 00:00:00

  • Monoethyl glycine xylidide (MEGX) test evaluation in primary biliary cirrhosis: comparison with Mayo score.

    abstract:OBJECTIVE:To evaluate the clinical and prognostic value of the monoethyl glycine xylidide (MEGX) test in patients with primary biliary cirrhosis (PBC) in comparison with the Mayo score (Mayo). DESIGN:A prospective study. METHODS:MEGX determinations at enrolment were compared to the Mayo score as well as to convention...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Gindro T,Arrigoni A,Martinasso G,Rosina F,Perardi S,Cappello N,Benedetti P,Actis GC,Verme G,Rizzetto M

    更新日期:1997-12-01 00:00:00

  • Smoking and gastro-oesophageal reflux disease.

    abstract::The role of smoking in the pathogenesis of gastrooesophageal reflux disease has been controversial since the early 1970s when Stanciu reported the two to be 92% epidemiologically associated (a study subsequently challenged by inconsistencies in the observational data). Mechanistically, reflux disease is caused by exce...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200012080-00002

    authors: Pandolfino JE,Kahrilas PJ

    更新日期:2000-08-01 00:00:00

  • Decision making for transjugular intrahepatic portosystemic stent shunt in refractory ascites and variceal bleeding: MELD, or not MELD, that is the question.

    abstract:PURPOSE:The model of end-stage liver disease (MELD) score has been shown to predict 3-month prognosis following transjugular intrahepatic portosystemic stent shunt (TIPS) in liver cirrhosis; however, that score was derived from a mixed cohort, including patients with refractory ascites and variceal bleeding. This study...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000002009

    authors: Pitton MB,Zimmermann T,Mildenberger P,Weinmann A,Kloeckner R,Düber C,Mittler J,Hoppe-Lotichius M,Otto G

    更新日期:2020-11-20 00:00:00

  • Comparison of telbivudine efficacy in treatment-naive patients with hepatitis B virus-related compensated and decompensated cirrhosis in 96 weeks.

    abstract:OBJECTIVE:Data are limited for comparison of the long-term efficacy of telbivudine (LdT) between hepatitis B virus (HBV)-related compensated and decompensated cirrhosis. The aim of this study was to compare the efficacy of LdT in treatment-naive patients with HBV-related compensated and decompensated cirrhosis in 96 we...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000062

    authors: Yang X,Li J,Zhou L,Liu J,Wang J,Lu W

    更新日期:2014-04-01 00:00:00

  • Pathophysiology of duodenal ulcer disease.

    abstract::Before the discovery of Helicobacter pylori infection some 12 years ago, three major disturbances in gastric physiology had been identified in patients with duodenal ulcer disease. These abnormalities were: impaired acid inhibition of gastrin release from the antral mucosa, increased basal and stimulated acid secretio...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:

    authors: McColl KE

    更新日期:1997-04-01 00:00:00

  • Suboptimal endogenous erythropoietin response in chronic hepatitis C patients during ribavirin and PEG interferon treatment.

    abstract:BACKGROUND:During the treatment of hepatitis C, anaemia may necessitate pegylated-interferon and ribavirin dose reductions with reduced sustained viral response rates. Although erythropoietic growth factors are frequently used to improve anaemia, it is controversial whether endogenous erythropoietic response is insuffi...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/MEG.0b013e32833e784d

    authors: Van Vlerken LG,Van Soest H,Janssen MP,Boland GJ,Drenth JP,Burger DM,Siersema PD,Van Erpecum KJ

    更新日期:2010-11-01 00:00:00

  • Reprocessing practice in digestive endoscopy units of district hospitals: results of a Portuguese National Survey.

    abstract:BACKGROUND AND AIM:An inadequate disinfection of endoscopes and associated accessories can result in the transmission of infections to patients. The aim of this study was to access reprocessing practice in the endoscopy units of Portuguese district general hospitals. METHODS:An anonymous questionnaire on cleaning and ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328348d5d6

    authors: Soares JB,Gonçalves R,Banhudo A,Pedrosa J

    更新日期:2011-11-01 00:00:00

  • Prevalence of atypical symptoms and their association with typical symptoms of gastroesophageal reflux in Spain.

    abstract:BACKGROUND:The association between typical and atypical symptoms of gastroesophageal reflux (GER) has received little attention in population-based studies. This study therefore sought to examine the prevalence of atypical symptoms, and their association with typical GER symptoms in Spain. METHODS:A telephone survey u...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/01.meg.0000230081.53298.03

    authors: Rey E,Elola-Olaso CM,Rodríguez-Artalejo F,Locke GR 3rd,Díaz-Rubio M

    更新日期:2006-09-01 00:00:00

  • Surgical management of gallbladder disease in the very elderly: are we operating them at the right time?

    abstract:BACKGROUND:As life expectancy rises worldwide and the prevalence of gallstones increases with age, the number of very elderly patients requiring treatment for gallstone diseases is increasing. The aim of this study was to compare the results of cholecystectomy in patients 80 years or older according to different clinic...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32835b7124

    authors: Lupinacci RM,Nadal LR,Rego RE,Dias AR,Marcari RS,Lupinacci RA,Farah JF

    更新日期:2013-03-01 00:00:00

  • An assessment of open access referral for percutaneous endoscopic gastrostomy in a district general hospital.

    abstract:OBJECTIVE:To determine the indications, technical success and outcomes of open access percutaneous endoscopic gastrostomy (PEG) insertion in the district general hospital setting. DESIGN:This study was a retrospective audit of patients receiving PEG by the thread pull method from November 1998 to November 1999, follow...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200211000-00013

    authors: Fox MR,Harris AW

    更新日期:2002-11-01 00:00:00

  • Zooming in on Barrett oesophagus using narrow-band imaging: an international observer agreement study.

    abstract:BACKGROUND:Several classifications of mucosal morphology have been proposed in Barrett oesophagus using narrow-band imaging (NBI). We evaluated a simplified classification in which only the regularity of mucosal and vascular patterns were evaluated. AIM:To assess the inter and intraobserver agreement and the correlati...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MEG.0b013e3283271e87

    authors: Alvarez Herrero L,Curvers WL,Bansal A,Wani S,Kara M,Schenk E,Schoon EJ,Lynch CR,Rastogi A,Pondugula K,Weusten B,Sharma P,Bergman JJ

    更新日期:2009-09-01 00:00:00

  • Risk factors for symptomatic stone recurrence after transpapillary laser lithotripsy for difficult bile duct stones using a laser with a stone recognition system.

    abstract:BACKGROUND:Laser-induced shock-wave lithotripsy (LISL) is successfully used for the treatment of difficult bile duct stones. The aim of this study was to assess the long-term risk for a symptomatic bile duct stone recurrence after LISL and to detect risk factors predicting recurrence. METHODS:Between 1993 and 2001, 80...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200605000-00003

    authors: Jakobs R,Hartmann D,Kudis V,Eickhoff A,Schilling D,Weickert U,Siegler KE,Riemann JF

    更新日期:2006-05-01 00:00:00

  • Diagnosis of spontaneous bacterial peritonitis in cirrhotic patients by use of two reagent strips.

    abstract:OBJECTIVE:Spontaneous bacterial peritonitis (SBP) is one of the potentially life-threatening complications in ascitic cirrhotic patients with a mortality rate ranging between 30 and 50%. The improved survival might be explained by a more rapid diagnosis and treatment. The aim of our study was to assess the utility of t...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200406000-00011

    authors: Thévenot T,Cadranel JF,Nguyen-Khac E,Tilmant L,Tiry C,Welty S,Merzoug N

    更新日期:2004-06-01 00:00:00

  • A patient with portal hypertension and blindness after transjugular intrahepatic portosystemic shunt.

    abstract::We report on a case of recurrent variceal bleeding from gastric varices, which was treated with transjugular intrahepatic portosystemic shunt (TIPS) and Histoacryl injection into the gastric varices. Furthermore, the patient had a small patent foramen ovale without a right-to-left shunt. After the intervention, the pa...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200604000-00022

    authors: Appenrodt B,Schepke M,Kuntz-Hehner S,Schmiedel A,Sauerbruch T

    更新日期:2006-04-01 00:00:00

  • Photodynamic therapy of human Barrett's cancer using 5-aminolaevulinic acid-induced protoporphyrin IX: an in-vivo dosimetry study in athymic nude mice.

    abstract:OBJECTIVE:There has been a dramatic increase in recent years in the incidence of Barrett's oesophagus and the oesophageal adenocarcinoma associated with it. Alongside surgical treatment for early Barrett's carcinomas, endoscopic treatment procedures such as photodynamic therapy (PDT), which have much lower complication...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200206000-00011

    authors: Pech O,Nagy CD,Gossner L,May A,Ell C

    更新日期:2002-06-01 00:00:00

  • Usefulness of endoscopic submucosal dissection for the treatment of rectal carcinoid tumors.

    abstract:BACKGROUND AND AIM:Various techniques of endoscopy have been developed to treat rectal carcinoids. This retrospective study aimed to evaluate the feasibility and efficacy of endoscopic submucosal dissection for the treatment of rectal carcinoids smaller than 10 mm in diameter. PATIENTS AND METHODS:A total of 18 consec...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283526f38

    authors: Hamada Y,Tanaka K,Tano S,Katsurahara M,Kosaka R,Noda T,Aoki M,Toyoda H,Takei Y,Katayama N

    更新日期:2012-07-01 00:00:00

  • High incidence of fermentation in the digestive tract in patients with reflux oesophagitis.

    abstract:OBJECTIVES:Because bacteria represent the sole source of gut hydrogen (H2) and methane (CH4), fasting breath H2 and CH4 gases have been used as markers of colonic fermentation. The presence of carbohydrates in the colonic lumen inhibits gastric and pancreatic secretions, and also influences lower oesophageal sphincter ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200605000-00013

    authors: Urita Y,Sugimoto M,Hike K,Torii N,Kikuchi Y,Kurakata H,Kanda E,Sasajima M,Miki K

    更新日期:2006-05-01 00:00:00

  • Comparison of stool immunoassay with standard methods for detection of Helicobacter pylori infection in patients with upper-gastrointestinal bleeding of peptic origin.

    abstract:OBJECTIVE:To assess the accuracy of the determination of Helicobacter pylori infection by a stool immunoassay in patients with upper-gastrointestinal bleeding (UGB) of peptic origin, in comparison with the routine histological study, serology, rapid urease and 13C-breath tests. METHODS:Sixty-eight patients with endosc...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/01.meg.0000059114.41030.a9

    authors: Griñó P,Pascual S,Such J,Casellas JA,Niveiro M,Andreu M,Sáez J,Aparicio JR,Griñó E,Compañy L,Laveda R,Pérez-Mateo M

    更新日期:2003-05-01 00:00:00

  • Angiodysplasia in a duodenal diverticulum as an unusual cause of upper gastrointestinal bleeding.

    abstract::The majority of duodenal diverticula are asymptomatic but may also induce major haemorrhage on rare occasions. Gastrointestinal bleeding due to angiodysplasia in a duodenal diverticulum is very rare. We present a 70-year-old woman with repeated melaena in whom the diagnosis of angiodysplasia in a diverticulum of the f...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200106000-00017

    authors: Günşar F,Yildiz C,Aydin A,Ozütemiz OA

    更新日期:2001-06-01 00:00:00

  • Combination amoxycillin and metronidazole with famotidine in the eradication of Helicobacter pylori--a randomized, double-blind comparison of a three times daily and twice daily regimen.

    abstract:OBJECTIVES:To determine the efficacy of a three times daily (t.i.d.) versus a twice daily (b.i.d.) regimen of combination amoxycillin and metronidazole and famotidine in the eradication of Helicobacter pylori and the influence of metronidazole resistance on the outcome of treatment. PATIENTS:Patients selected had uneq...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00042737-199711000-00012

    authors: Goh KL,Parasakthi N,Chuah SY,Toetsch M

    更新日期:1997-11-01 00:00:00

  • Infrequent p16/CDKN2 alterations in squamous cell carcinoma of the oesophagus.

    abstract::Loss of heterozygosity (LOH) on chromosome 9 and p16 (MTS1/CDKN2) gene mutations have been reported in various human cancers. The present study aimed to determine the prevalence of LOH in 100 oesophageal squamous cell carcinomas (OSCCs) by typing microsatellite loci and mutations of the p16 gene. The methods used incl...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200201000-00004

    authors: Giroux MA,Audrezet MP,Metges JP,Lozac'h P,Volant A,Nousbaum JB,Labat JP,Gouérou H,Ferec C,Robaszkiewicz M

    更新日期:2002-01-01 00:00:00

  • Screening for hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is a major worldwide health problem and the most common cause of cancer induced mortality. This review article examines the natural history of HCC and the known risk factors, as well as evaluating the current methods of detection of HCC and their impact on patient survival. ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:

    authors: Haydon GH,Hayes PC

    更新日期:1996-09-01 00:00:00

  • Sclerosing peritonitis complicated by sepsis: a potential cause of portal hypertension.

    abstract::A 27-year-old woman with chronic renal failure, who had been treated with chronic ambulatory peritoneal dialysis and had developed sclerosing peritonitis, was admitted to the hospital with intra-abdominal sepsis. In spite of antibiotic therapy, sepsis recurred and was associated with intrahepatic cholestasis. In addit...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199801000-00017

    authors: Jones EA,Bronkhorst CM,de Jonge E,ten Kate FJ

    更新日期:1998-01-01 00:00:00

  • Ectopic hepatocellular carcinoma arising in the left chest wall: a long-term follow-up.

    abstract::We report the case of a 66-year-old man with chronic hepatitis C and a slowly growing left chest wall mass. Two years after the patient first noticed the mass, it was resected. A diagnosis of hepatocellular carcinoma (HCC) was established. The liver was studied by ultrasound, computed tomography (CT), magnetic resonan...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200107000-00018

    authors: Asselah T,Condat B,Cazals-Hatem D,Hassani Z,Bernuau J,Groussard O,Mussot S,Lesèche G,Marcellin P,Erlinger S,Valla D

    更新日期:2001-07-01 00:00:00

  • Infected retroperitoneal pelvic necrosis in severe acute pancreatitis: how can we manage it?

    abstract:OBJECTIVES:Retroperitoneal necrosis in the pelvic cavity is a rare complication of severe acute pancreatitis (SAP), mainly developing in critically ill patients. Because of its particular anatomy, it is difficult to perform drainage or surgery. We hypothesized that computed tomography (CT)-guided drainage is an effecti...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000305

    authors: Shen X,Tong Z,Li W,Li N,Li J

    更新日期:2015-04-01 00:00:00

  • No difference in mortality between terlipressin and somatostatin treatments in cirrhotic patients with esophageal variceal bleeding and renal functional impairment.

    abstract:OBJECTIVE:To study the differences in mortality between terlipressin and somatostatin treatments in cirrhotic patients with esophageal variceal bleeding (EVB) and renal functional impairment (RFI). METHODS:The National Health Insurance Database, part of the Taiwan National Health Insurance Program, was used to enroll ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000703

    authors: Hung TH,Tsai CC,Tseng CW,Tseng KC,Hsieh YH,Tsai CC

    更新日期:2016-11-01 00:00:00