Abstract:
INTRODUCTION:Excessive alcohol consumption has steadily risen to become the third leading cause of preventable death in the USA. One consequence of heavy alcohol use recently under considerable investigation is alcoholic hepatitis. Although many risk factors for developing alcoholic hepatitis have been documented, our aim in this study was to examine the potential association between sarcopenia and severity, mortality, 30 days readmission rate, complication, infections and length of hospital stay in alcoholic hepatitis patients. METHODS:A retrospective analysis was performed at a large, academic hospital in 194 alcoholic hepatitis patients aged 18-60 who had cross-sectional computed tomography imaging and met our clinical definition of alcoholic hepatitis. The fifth percentile of the psoas muscle index was used as a cutoff for sarcopenia. RESULTS:One hundred ninety-four patients met the criteria for alcoholic hepatitis and had cross-sectional imaging. Higher Model for End-Stage Liver disease score was found in the sarcopenia group when compared to the non-sarcopenia group (mean Model for End-Stage Liver disease 21.5 and 24.2, respectively, P = 0.03). Sarcopenia also correlated with significantly longer hospital stay; the average length of stay in the sarcopenia group was 17.2 days while the non-sarcopenia patients had an average of 12.4 days. We found higher risk of developing pneumonia, sepsis and hepatic encephalopathy in sarcopenic patients. CONCLUSION:Alcoholic hepatitis patients with sarcopenia have significantly worse outcomes when compared with the patients without sarcopenia, including a severe form of alcoholic hepatitis, longer hospital stays, higher risk of developing pneumonia, sepsis and hepatic encephalopathy.
journal_name
Eur J Gastroenterol Hepatoljournal_title
European journal of gastroenterology & hepatologyauthors
Al-Azzawi Y,Albo B,Fasullo M,Coukos J,Watts GJ,Tai R,Radcliffe D,Kroll-Desrosiers A,Devuni D,Szabo Gdoi
10.1097/MEG.0000000000001583subject
Has Abstractpub_date
2020-06-01 00:00:00pages
733-738issue
6eissn
0954-691Xissn
1473-5687journal_volume
32pub_type
杂志文章abstract:OBJECTIVE:To investigate the influence of untreated (super)morbid obesity and the effects of massive weight loss and chronic gastric distension on gastro-oesophageal reflux. PATIENTS AND METHODS:Seventeen young morbidly obese patients (32 years old; body weight 166.5 kg; body mass index 55 kg/m2) underwent 24-h ambula...
journal_title:European journal of gastroenterology & hepatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-07-01 00:00:00
abstract::Obstetric trauma is by far the commonest cause of anal incontinence in women. Denervation and reinnervation of the pelvic floor and anal sphincter following vaginal delivery has been previously demonstrated. The advent of anal endosonography, however, has enabled the identification of occult anal sphincter defects fol...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,评审
doi:10.1097/00042737-199705000-00002
更新日期:1997-05-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,随机对照试验
doi:10.1097/MEG.0000000000000300
更新日期:2015-04-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
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doi:10.1097/MEG.0000000000000078
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journal_title:European journal of gastroenterology & hepatology
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doi:10.1097/00042737-200605000-00013
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abstract::Malignant pericardial effusion is an uncommon disorder and is usually caused by far advanced lung cancer, breast cancer, lymphoma and leukaemia. Pericardial effusion in recurrent gastric cancer has been reported in only three patients. We report the case of a 53-year-old male with sudden onset of dyspnoea, pericardial...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199807000-00018
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,meta分析
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,评审
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更新日期:2005-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/MEG.0b013e3282f01e91
更新日期:2007-11-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001731
更新日期:2020-09-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,多中心研究
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更新日期:2012-11-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e3282f2468d
更新日期:2008-04-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000111
更新日期:2014-07-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e32832ca091
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pub_type: 杂志文章
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章
doi:10.1097/00042737-200102000-00016
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200103000-00002
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e32834b8d18
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200511000-00006
更新日期:2005-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/MEG.0b013e32830e2885
更新日期:2009-04-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
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doi:10.1097/MEG.0b013e328326cab6
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pub_type: 杂志文章,评审
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doi:10.1097/00042737-200502000-00013
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pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00