Abstract:
BACKGROUND:Hyperuricemia is a significant risk factor for nonalcoholic fatty liver disease (NAFLD). It may also have an impact on the histologic severity of NAFLD. However, data on this association are limited. We conducted this meta-analysis to investigate the relationship of serum uric acid with liver histologic severity as determined by NAFLD activity score (NAS) in patients with NAFLD. PATIENTS AND METHODS:MEDLINE and EMBASE databases were searched through August 2016 for studies that investigated the association between hyperuricemia and NAS among patients with biopsy-proven NAFLD. Pooled odds ratio and 95% confidence interval were calculated using a random-effects model (generic inverse variance method). The between-study heterogeneity of effect size was quantified using the Q statistic and I. RESULTS:Five observational studies with 777 NAFLD patients were identified. Patients with NAFLD who had hyperuricemia had a high NAS (defined as score of ≥5) significantly more often than did those without hyperuricemia with a pooled odds ratio of 2.17 (95% confidence interval: 1.51-3.12). The statistical heterogeneity was low, with I of 16% (Pheterogeneity=0.31). CONCLUSION:In patients with NAFLD, hyperuricemia is associated with a higher degree of histological liver damage. Further studies are required to establish the role of uric acid-lowering therapy among these patients.
journal_name
Eur J Gastroenterol Hepatoljournal_title
European journal of gastroenterology & hepatologyauthors
Jaruvongvanich V,Ahuja W,Wirunsawanya K,Wijarnpreecha K,Ungprasert Pdoi
10.1097/MEG.0000000000000931subject
Has Abstractpub_date
2017-09-01 00:00:00pages
1031-1035issue
9eissn
0954-691Xissn
1473-5687journal_volume
29pub_type
杂志文章,meta分析,评审abstract::Coeliac disease is generally well controlled with gluten-free diet but a small proportion of patients require corticosteroids or immunomodulatory agents. Response to anti-tumour necrosis factor (anti-TNF) agents raises interesting questions about both the pathogenesis of coeliac disease and the mechanism of action of ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,评审
doi:10.1097/00042737-200506000-00002
更新日期:2005-06-01 00:00:00
abstract::Endoscopic sclerotherapy or ligation and/or drugs are the standard treatments for the prevention of variceal rebleeding. Failure of this treatment indicates the need for rescue transjugular intrahepatic portosystemic shunt (TIPS) implantation. The current practice to use endoscopic treatment as first-line and TIPS as ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,评审
doi:10.1097/00042737-200104000-00007
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:To establish the pattern of practice of sigmoidoscopy and rectal biopsy in the UK, and to estimate the rate of occurrence of important complications. DESIGN:Postal questionnaire enquiring about practice in the previous 2 years. SUBJECTS:Consultant members of the British Society of Gastroenterology. MAIN OU...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199602000-00011
更新日期:1996-02-01 00:00:00
abstract:OBJECTIVES:Serine Protease Inhibitor Kazal type 1 (SPINK1) protects against premature intracellular activation of trypsinogen and development of acute pancreatitis. Our aim was to determine the prevalence of SPINK1 mutations (a) in unselected patients with first-time acute pancreatitis and (b) in the Danish background ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,meta分析
doi:10.1097/MEG.0b013e32834ee5e2
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Spontaneous hepatic rupture is a rare clinical event associated with various pathologies of the liver. Most series to date reported the incidence and characteristics of a single etiology. METHODS:Data were collected for all patients admitted with spontaneous hepatic rupture from 1995 to 2007. RESULTS:Ten p...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e3283293d27
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVES:Clostridium difficile infection (CDI) is an acute gastrointestinal infection caused by anaerobic, toxin-producing bacteria. During the course of CDI, there is a general inflammatory state. In order to gain a deeper understanding of the role of fatty acids (FAs) in the pathogenesis of acute infection we analy...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001600
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:To determine the efficacy of a three times daily (t.i.d.) versus a twice daily (b.i.d.) regimen of combination amoxycillin and metronidazole and famotidine in the eradication of Helicobacter pylori and the influence of metronidazole resistance on the outcome of treatment. PATIENTS:Patients selected had uneq...
journal_title:European journal of gastroenterology & hepatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00042737-199711000-00012
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:This study aimed to investigate the association between nonalcoholic fatty pancreas disease and the severity of acute pancreatitis (AP). PATIENTS AND METHODS:Among the 1662 AP patients admitted between August 2010 and August 2017, 82 eligible patients with moderately severe acute pancreatitis (SAP) and SAP ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001477
更新日期:2019-08-01 00:00:00
abstract::Abdominal pain is a common symptom in individuals with cystic fibrosis (CF). As prognosis has improved, CF has changed from a pediatric disease to the current situation wherein most people with CF are adults. With improved survival, the spectrum of pathologies causing abdominal pain in CF has shifted. Despite this, th...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,评审
doi:10.1097/MEG.0000000000000011
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Patients with achalasia require repeated invasive therapies and may experience multiple complications. The objectives of this study were to determine the incidence of such complications, causes of death, and life expectancy in 253 patients. METHODS:Patients consisted of two groups: group A comprised 177 pat...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e3282fbf5e5
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:We assessed the impact of direct-acting antiviral (DAA) therapy on liver fibrosis regression measured by transient elastography (TE) in patients with chronic hepatitis C virus (HCV) infection. PATIENTS AND METHODS:A prospective cohort study was carried out in HCV monoinfected patients with advanced liver fib...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000964
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:Pregnant women often suffer from gastroesophageal reflux disease (GERD). GERD symptoms are known to influence the quality of life; however, there is a lack of data in pregnant women. The aim of this study was to establish the impact of GERD symptoms on health-related quality of life (HRQOL) during pregnancy. ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000905
更新日期:2017-08-01 00:00:00
abstract::We report a case of a distinctive familial internal anal sphincter myopathy with unique histological and radiological features. A 67-year-old woman presented with a 20-year history of proctalgia fugax and outlet obstruction; other family members were similarly affected. Computed tomograpy and magnetic resonance imagin...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199702000-00023
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVE:A wide range in values of liver stiffness measurement (LSM) is observed among cirrhotic patients. These variations reflect the extent of fibrosis and might influence the risk of hepatocellular carcinoma (HCC) occurrence. METHODS:We compared LSM in 66 Child-Pugh A patients with HCC and alcoholic (n=23) or HCV...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e32830eb8d7
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:Recent studies have suggested that endotoxin-induced cytokines play an important role in nonalcoholic fatty liver disease (NAFLD). Rifaximin is a nonabsorbable antibiotic that might act on Gram-negative bacteria, thereby inhibiting endotoxin proinflammatory cytokine production in patients with NAFLD. Our aim ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000348
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Postoperative clinical and endoscopic recurrence is common in Crohn's disease. AIM:We aimed to assess postoperative recurrence and management in a cross-sectional patient cohort in one specialist unit, before the introduction of a uniform postoperative preventive strategy. METHODS:Review of patients who ha...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e328326a01e
更新日期:2009-05-01 00:00:00
abstract:AIM:To review the evidence that Helicobacter pylori promotes gastric carcinogenesis, with particular reference to gastric epithelial proliferation. MATERIALS AND METHODS:Gastric epithelial kinetics were reviewed and a series of studies of gastric mucosal proliferation in H. pylori-associated gastritis were performed i...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,评审
doi:
更新日期:1995-08-01 00:00:00
abstract:OBJECTIVE:Endoscopic resection is a standard treatment for gastric superficial lesions. A positive or a nonevaluable margin is considered a noncurative criterion. We aimed to systematically review recurrence, residual disease, lymph node metastasis (LNM) and cancer-related death following Rx/R1 resection of gastric les...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MEG.0000000000000440
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Disease phenotype and outcome of late-onset Crohn's disease are still poorly defined. METHODS:In this Italian nationwide multicentre retrospective study, patients diagnosed ≥65 years (late-onset) were compared with young adult-onset with 16-39 years and adult-onset Crohn's disease 40-64 years. Data were col...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001546
更新日期:2019-11-01 00:00:00
abstract::Treatment of Crohn's disease with infliximab is an important drug therapy for patients with refractory and fistulating disease. There are concerns over its use in a proportion of Crohn's patients with concurrent hepatitis C infection, since there are theoretical risks of accelerated hepatic decompensation due to the i...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200102000-00016
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVES:The primary aim of this study was to evaluate the histological adequacy of the liver tissue specimens obtained with a 20-gauge fine-needle biopsy needle and the secondary aim was to test the safety endoscopic ultrasound-guided liver biopsy with a 20-gauge fine-needle biopsy needle with the wet-heparinized su...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001929
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The accuracy of diagnostic tests to assess Helicobacter pylori eradication has rarely been performed. AIM:To compare the tests most commonly used for this purpose, i.e. histology, culture and (13)C urea breath test performed in centralized facilities. METHODS:Prospective study where patients were included ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,多中心研究
doi:10.1097/00042737-200012060-00009
更新日期:2000-06-01 00:00:00
abstract::Biological agents such as inhibitors of tumour necrosis factor alpha (TNF-alpha ) are associated with the development of opportunistic infections. Although there are no international recommendations for the management of opportunistic infections, their prevention is a key safety issue for patients with inflammatory bo...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e32831de271
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:Liver cirrhosis is considered as a premalignant state, as about 80% of hepatocellular carcinoma (HCC) is associated with liver cirrhosis. Although alpha-fetoprotein (AFP) has a high negative predictive value, its sensitivity for detecting HCC is poor. The aim of this study was to evaluate circulating endoglin...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,多中心研究
doi:10.1097/MEG.0b013e3282202bea
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:Ulcerative colitis and Crohn's disease are the two clinical forms of inflammatory bowel disease (IBD). Diverse studies have shown the association of single nucleotide polymorphism (SNP) in molecules of the immune system and the occurrence of IBD. Here, several SNPs of the immune system with controversial resu...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001540
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate the potential usefulness of contrast-enhanced power Doppler ultrasound in the detection and follow-up of local complications (phlegmon and abscess) in Crohn's disease. METHODS:With this aim, 28 patients with suspected abdominal inflammatory mass were examined with po...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200303000-00008
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:There are increasing indications for assessing Helicobacter pylori status by non-invasive means in dyspeptic patients. There is also increasing use of proton pump inhibitor therapy for dyspeptic disease. AIMS:To determine the effect of proton pump inhibitor therapy on the accuracy of the [14C]urea breath te...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199809000-00006
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:The quality of Barrett's surveillance relies on an adequate endoscopic inspection, obtaining a sufficient number of biopsy specimens, good communication of the endoscopic findings to the pathologist, and an accurate description of the histological findings by the pathologist. The aim of this study was to asse...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,多中心研究
doi:10.1097/MEG.0b013e3282f8295d
更新日期:2008-07-01 00:00:00
abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) have both beneficial and deleterious effects on the colon. Long-term use is associated with a substantial decrease in colorectal cancer incidence and regression of adenomatous polyps. In contrast, significant adverse effects are also interesting, but rare, and include muco...
journal_title:European journal of gastroenterology & hepatology
pub_type: 评论,杂志文章
doi:10.1097/00042737-200211000-00003
更新日期:2002-11-01 00:00:00
abstract::Multidrug-resistant infections represent an increasing problem in the management of hospitalized patients worldwide. With respect to Gram-negative infections, carbapenems are an important antimicrobial class for the treatment of infections caused by extended-spectrum beta lactamase producers enterobacteriaceae. Howeve...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e328355d8a2
更新日期:2012-10-01 00:00:00