Abstract：
AIM:Intrahepatic cholestasis of pregnancy (ICP) is associated with safe maternal outcomes but perinatal outcomes have been variable. We assessed clinical factors and impact of bile acid levels on maternal and neonatal outcomes in ICP. METHODS:Patients with ICP (defined as pruritus with serum bile acids ≥ 10 mmol/l) were included prospectively with an assessment of risk factors, modes of delivery as well as maternal and neonatal outcomes. Mild and severe ICP were diagnosed when serum bile acid was always <40 mmol/l and ≥40 mmol/l, respectively. Patients with gestational pruritus served as controls. RESULTS:Out of 643 patients, 375 patients (mean age 29 ± 7.6 years, 45.8% primigravida) met inclusion criteria. Pregnancy-induced hypertension [PIH: 10.5%; odds ratio (OR): 4.8; 95% confidence interval (CI): 2.4-8.5; P = 0.0014], gestational diabetes (GDM: 12.5%; OR: 2.6; 95% CI: 2.3-4.1; P = 0.045) and spontaneous preterm labor (15.1%; OR: 2.5; 95% CI: 1.2-3.5; P = 0.040) were higher in patients with ICP. Ursodeoxycholic acid (UDCA) (median dose 900 mg; 600-1800 mg) ameliorated symptoms of cholestasis, bile acid levels and liver aminotransferases in 79% cases. When compared with patients with mild ICP, patients with severe ICP presented at a lower gestational period (26 vs. 32 weeks, P = 0.036), required frequent induction (12.5%; OR: 3.2; 95% CI: 2.1-5.6; P = 0.045) and had increased fetal distress (15%; OR: 1.9; 95% CI: 1.3-4.9; P = 0.048).Overall eight stillbirths were recorded. CONCLUSION:Severe ICP is associated with a higher incidence of GDM and PIH, risk of pre-term labor, elective induction and stillbirths. UDCA remains a first-line agent in treating ICP.
journal_name
Eur J Gastroenterol Hepatoljournal_title
European journal of gastroenterology & hepatologyauthors
Roy A,Premkumar M,Mishra S,Mehtani R,Suri V,Aggarwal N,Singh S,Dhiman RKdoi
10.1097/MEG.0000000000001954subject
Has Abstractpub_date
2020-10-29 00:00:00eissn
0954-691Xissn
1473-5687pub_type
杂志文章abstract：:Physicians should try to reach an optimal cure rate with initial anti-Helicobacter therapy. Helicobacter pylori infection in patients with peptic ulcer disease (PUD) is more likely to be cured then in patients with 'functional' dyspepsia (FD). Differences in cure rates of 5-15% are usually reported, which is considere...
journal_title：European journal of gastroenterology & hepatology
pub_type： 评论,杂志文章
doi：10.1097/00042737-200111000-00002
更新日期：2001-11-01 00:00:00
abstract：:Acute liver failure arises from an imbalance between liver cell death and regeneration. The severity of the insult determines whether liver cells die by apoptosis or necrosis, and this in turn affects the magnitude of the inflammatory reaction. Liver cell death occurs through complex cellular interactions and is media...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,评审
doi：10.1097/00042737-199909000-00002
更新日期：1999-09-01 00:00:00
abstract：BACKGROUND AND AIM:Pancreatitis and hyperamylasaemia are common complications of ERCP and this study was designed to explain which operative and patient factors predispose to them. PATIENTS AND METHODS:A 1 year prospective study of consecutive patients in a single operator centre with detailed attention to technical f...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-199805000-00012
更新日期：1998-05-01 00:00:00
abstract：:Syndecan expression, or the lack thereof by tumor cells, has been associated with poor prognosis in several types of cancer, including colorectal cancer. Syndecan is a heparan sulfate proteoglycan involved in tumor adhesion, invasion, and metastasis. In addition, the expression of the enzyme heparanase by cancer cells...
journal_title：European journal of gastroenterology & hepatology
pub_type： 评论,杂志文章,评审
doi：10.1097/MEG.0b013e3282fc2660
更新日期：2008-08-01 00:00:00
abstract：:This editorial briefly reviews the significance of lymphoid nodular hyperplasia in the intestinal tract of children with autistic spectrum disorder. The distinction between physiological and pathological lymphoid hyperplasia of the intestinal tract is of importance in the context of a possible causative link with auti...
journal_title：European journal of gastroenterology & hepatology
pub_type： 评论,社论
doi：10.1097/00042737-200508000-00007
更新日期：2005-08-01 00:00:00
abstract：OBJECTIVES:Gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) are highly prevalent in the general population, with significant symptom overlap, whereas the interaction between both remains poorly understood. We aim to identify the clinical and psychological factors that contribute toward the over...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000000334
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND AND AIMS:Proton pump inhibitors (PPIs) may reduce iron absorption and serum ferritin levels in patients with homeostatic iron regulator (HFE)-related hemochromatosis, reducing the need for frequent phlebotomies. Our study aimed to perform for the first time a meta-analysis of existing observational and rando...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000001857
更新日期：2020-08-04 00:00:00
abstract：:Amyloidosis is a group of disorders that can manifest in virtually any organ system in the body and is thought to be secondary to misfolding of extracellular proteins with subsequent deposition in tissues. The precursor protein that is produced in excess defines the specific amyloid type. This requires histopathologic...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,评审
doi：10.1097/MEG.0000000000000695
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVE:To elucidate the role of Helicobacter pylori in relapsing disease after partial gastrectomy for peptic ulcer. DESIGN:Retrospective study of gastroscopies between January 1985 and February 1988. SETTING:Department of Surgery, Helsinki University Central Hospital, Finland. PARTICIPANTS:One hundred and fifty-...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：BACKGROUND AND AIM:A significant proportion of patients presenting with obscure gastrointestinal bleeding (OGIB) have negative small bowel capsule endoscopy (SBCE) examinations, and yet remain at risk of rebleeding. We aimed to evaluate whether a second-look review of SBCE images using flexible spectral color enhanceme...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000000358
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to evaluate the serum lipid profile and to assess the prevalence of hepatic steatosis in adult beta-thalassaemic patients with chronic hepatitis C virus (HCV) infection. METHODS:Thirty-five adult HCV infected, multi-transfused, beta-thalassaemia patients (beta-HCV patients), 63 oth...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-200503000-00014
更新日期：2005-03-01 00:00:00
abstract：BACKGROUND/AIMS:Bleeding remains a serious complication after endoscopic submucosal dissection (ESD). Second-look endoscopy for hemostasis helps prevent post-ESD bleeding. We investigated the relationships between patient characteristics, tumor characteristics, and the Forrest classification for exposed vessels on arti...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000000419
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVES:¹⁸F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) is a less invasive diagnostic tool and promising in detecting gastrointestinal lesions of pediatric inflammatory bowel disease (IBD) patients. Co-registration of low-dose computed tomography (CT) could lead to improvements in the assessment of d...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e3283410222
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Helicobacter pylori that is generally acquired in childhood and infects the gastric mucosa is considered to be responsible for many pathobiological changes that are linked to the pathogenesis of gastric cancer. Although the majority of studies on the subject have been carried out in adults, there are a limit...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000000246
更新日期：2015-02-01 00:00:00
abstract：:Acute lower gastrointestinal hemorrhage (LGIH) has traditionally been defined as bleeding that occurs distal to the ligament of Treitz. More recently, however, it has been subdivided into mid-intestinal (small bowel) hemorrhage and bleeding that originates from the colon. Acute LGIH has diverse etiologies, is a freque...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,评审
doi：10.1097/MEG.0b013e3282f198f7
更新日期：2007-12-01 00:00:00
abstract：INTRODUCTION:The present study was conducted to compare the efficacy and side effects of Spironolactone and Eplerenone in management of ascites due to liver cirrhosis. MATERIALS AND METHODS:105 patients of ascites with liver cirrhosis were randomized into three groups of 35 patients each. Group I was given Spironolact...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000001678
更新日期：2020-04-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is a major worldwide health problem and the most common cause of cancer induced mortality. This review article examines the natural history of HCC and the known risk factors, as well as evaluating the current methods of detection of HCC and their impact on patient survival. ...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,评审
doi：
更新日期：1996-09-01 00:00:00
abstract：OBJECTIVE:This study was designed to evaluate the role of technetium-99m (99mTc) hexamethyl propylene amine oxime (HMPAO)-labelled leucocyte imaging as an initial screening test in patients suspected of having inflammatory bowel disease (IBD). PATIENTS AND METHODS:Thirty-one patients in whom a final diagnosis of irrit...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-199612000-00012
更新日期：1996-12-01 00:00:00
abstract：BACKGROUND AND AIMS:The role of thyroid function in the portal hypertension development and prognosis remains unclear. This study aimed to investigate the correlation between serum-free triiodothyronine (fT3) levels and the outcomes of cirrhotic portal hypertension. METHODS:A total of 385 cirrhotic patients with confi...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000001658
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Initial venesection therapy in dysmetabolic iron overload syndrome (DIOS) was shown to improve insulin resistance. However, no data are available on the long-term outcome of iron store, thus questioning the relevance of maintenance therapy. AIM:The aim of the study was to describe the long-term evolution of...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000000058
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVE:Our aim is to establish the risk factors for carrying high-grade dysplasia or carcinoma by analyzing endoscopically treated adenoma cases. METHODS:Patients who underwent endoscopic polypectomy at our hospitals between January 2003 and August 2004 were analyzed. RESULTS:A total of 889 patients (mean age: 63+...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,多中心研究
doi：10.1097/MEG.0b013e3282f1cbef
更新日期：2008-02-01 00:00:00
abstract：:The results of systemic treatments for hepatocellular carcinoma are currently disappointing. In patients with advanced disease, none of the tested treatments (particularly systemic chemotherapy or hormonal treatment, such as tamoxifen) demonstrated an unequivocal benefit in terms of survival, and the trials including ...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,评审
doi：10.1097/00042737-200403000-00005
更新日期：2004-03-01 00:00:00
abstract：OBJECTIVE:There is currently no reliable tool for providing a global measurement of the severity of dyspepsia in patients with a variety of upper gastrointestinal disorders. We have designed a questionnaire which records frequency of symptoms, effect on routine activities, time off work, frequency of medical consultati...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-199610000-00006
更新日期：1996-10-01 00:00:00
abstract：BACKGROUND AND AIM:Hepatic encephalopathy (HE) is a severe and frequent complication of liver cirrhosis characterized by abnormal cerebral function. Little is known about the underlying neural mechanisms in HE and human data are sparse. Electrophysiological methods such as evoked brain potentials after somatic stimuli ...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e32833d4717
更新日期：2010-11-01 00:00:00
abstract：AIM:MicroRNA-93 (miR-93) has been shown to suppress proliferation and colony formation of colon cancer stem cells. The aim of this study was to examine the expression pattern and prognostic value of miR-93 in patients with colon cancer. MATERIALS AND METHODS:A quantitative real-time PCR analysis was carried out to det...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e32835c077a
更新日期：2013-03-01 00:00:00
abstract：:Eosinophilic gastroenteritis is a rare disease of unknown aetiology characterized by eosinophilic infiltration of the gastrointestinal wall and increased peripheral blood eosinophilia. The frequent finding of concomitant extradigestive involvement calls for differential diagnosis to distinguish some multisystemic path...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-199705000-00022
更新日期：1997-05-01 00:00:00
abstract：OBJECTIVES:Nitric oxide (NO) is involved in the control of pancreatic blood flow and secretion, and its role in the maintenance of pancreatic tissue has been suggested. The aim of our study was to evaluate the influence of NO on pancreatic trophic parameters during acute pancreatitis induction and the pancreas recovery...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-199909000-00012
更新日期：1999-09-01 00:00:00
abstract：BACKGROUND:Liver steatosis (LS) and chronic infection with hepatitis B virus (HBV) are two common causes of chronic liver disease in Iran. LS is also a common histopathological feature of chronic hepatitis B (CHB). Association of chronic HBV infection and LS has not been extensively studied. AIM:We investigated the pr...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e328326792e
更新日期：2009-05-01 00:00:00
abstract：:Diabetes mellitus (DM) is a well known complication of interferon therapy for chronic hepatitis C virus (HCV) infection, but resolution of interferon-induced DM was rarely reported. In HIV and HCV co-infected patients, only two cases of incident DM during interferon therapy were reported and both cases required perman...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,评审
doi：10.1097/MEG.0b013e328317f4c8
更新日期：2009-04-01 00:00:00
abstract：:We describe a 55-year-old patient with alcoholic chronic pancreatitis, a large mediastinal pseudocyst and a hemorrhagic pleural effusion. A single thoracocentesis and withdrawal of alcohol without other conservative or invasive measures resulted in a complete resolution of the pleural effusion and the mediastinal pseu...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-200601000-00020
更新日期：2006-01-01 00:00:00
