Abnormal brain processing in hepatic encephalopathy: evidence of cerebral reorganization?

Abstract:

BACKGROUND AND AIM:Hepatic encephalopathy (HE) is a severe and frequent complication of liver cirrhosis characterized by abnormal cerebral function. Little is known about the underlying neural mechanisms in HE and human data are sparse. Electrophysiological methods such as evoked brain potentials after somatic stimuli can be combined with inverse modeling of the underlying brain activity. Thereby, information on neuronal dynamics and brain activity can be studied in vivo. The aim of this study was to investigate the sensory brain processing in patients with HE. PATIENTS AND METHODS:Twelve patients with minimal or overt HE and 26 healthy volunteers were included in the study. Cerebral sensory processing was investigated as (i) an auditory reaction time task; (ii) visual and somatosensory evoked brain potentials, and (iii) reconstruction of the underlying brain activity. RESULTS:Somatosensory evoked potentials were reproducible (all P>0.05), whereas flash evoked potentials were not reproducible (all P<0.05). Compared with healthy volunteers, the patient group had a prolonged reaction time index (P=0.03) along with increasing prolongation of latencies of median nerve evoked potentials (P<0.03). Reconstruction of the underlying brain sources showed a lateral shift in source localization of the P45 (P<0.001) and N60 components (P=0.02). A correlation between the psychometric hepatic encephalopathy score and the dipole shift corresponding to the N60 (P=0.003) component was seen. CONCLUSION:HE patients have evidence of prolonged intracerebral nerve conduction, along with lateralization of brain activity following median nerve stimulation. This possibly represents cortical reorganization and may be important in our understanding of this condition.

authors

Blauenfeldt RA,Olesen SS,Hansen JB,Graversen C,Drewes AM

doi

10.1097/MEG.0b013e32833d4717

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

1323-30

issue

11

eissn

0954-691X

issn

1473-5687

journal_volume

22

pub_type

杂志文章
  • Halothane-induced acute liver failure: continuing occurrence and use of liver transplantation.

    abstract:BACKGROUND/AIMS:This study was aimed at determining if the frequency and pattern of acute liver failure (ALF) following halothane anaesthesia had decreased during the last 11 years in comparison with a previous series of 48 patients referred between 1965 and 1984 and whether clinical outcome had been altered by the int...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:

    authors: Lo SK,Wendon J,Mieli-Vergani G,Williams R

    更新日期:1998-08-01 00:00:00

  • Serological prevalence of hepatitis B virus and hepatitis C virus infection in the elderly population: Polish nationwide survey--PolSenior.

    abstract:BACKGROUND:The hepatitis B virus (HBV) and hepatitis C virus (HCV) infections may seriously affect survival rate. The median length of life in developed countries is increasing and the elderly may be considered as an epidemiologically distinct group due to higher whole-life risk of blood-borne viral infections. AIM:To...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MEG.0b013e328357632a

    authors: Hartleb M,Gutkowski K,Zejda JE,Chudek J,Więcek A

    更新日期:2012-11-01 00:00:00

  • Aspartate aminotransferase to platelet ratio index for fibrosis evaluation in chronic viral hepatitis.

    abstract:OBJECTIVE:We assessed the value of the recently developed aspartate aminotransferase to platelet ratio index (APRI) for predicting significant fibrosis or cirrhosis in patients with chronic hepatitis C or HBeAg-negative chronic hepatitis B. METHODS:In total, 489 patients (chronic hepatitis C, 284 patients; HBeAg-negat...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200604000-00012

    authors: Chrysanthos NV,Papatheodoridis GV,Savvas S,Kafiri G,Petraki K,Manesis EK,Archimandritis AJ

    更新日期:2006-04-01 00:00:00

  • Nicorandil-associated ulcerations.

    abstract::This leading article refers to the paper by Abdelrazeq AS, Owen C, Smith L, McAdam JG, Pearson HJ, Leveson SH. Nicorandil-associated para-stomal ulceration: case series Eur J Gastroenterol Hepatol 2006; 18:1293-1295. We apologise to all concerned for the dissociation between the two papers, which was due to an adminis...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 评论,杂志文章,评审

    doi:10.1097/MEG.0b013e328010b184

    authors: Egred M

    更新日期:2007-05-01 00:00:00

  • Surveillance of Barrett's oesophagus: physicians' practices and review of current guidelines.

    abstract:BACKGROUND:Endoscopic biopsy surveillance of Barrett's oesophagus is generally recommended. However, optimal patient selection and frequency of follow-up are subject to ongoing discussion. OBJECTIVE:To investigate current surveillance practices for Barrett's oesophagus in the Netherlands and to explore their concordan...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:

    authors: van Sandick JW,Bartelsman JF,van Lanschot JJ,Tytgat GN,Obertop H

    更新日期:2000-01-01 00:00:00

  • Consumption of gluten-free products: should the threshold value for trace amounts of gluten be at 20, 100 or 200 p.p.m.?

    abstract:OBJECTIVE:The threshold of gluten contamination in gluten-free products of both dietary and normal consumption is under debate. The objective of this study was to gather information on consumption of gluten-free products intended for dietary use of people under a gluten-free diet. This information is essential to ascer...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/01.meg.0000236884.21343.e4

    authors: Gibert A,Espadaler M,Angel Canela M,Sánchez A,Vaqué C,Rafecas M

    更新日期:2006-11-01 00:00:00

  • Prevalence, incidence, and autoimmune comorbidities of celiac disease: a nation-wide, population-based study in Denmark from 1977 to 2016.

    abstract:AIM:The aim of this study was to describe and identify potential trends with respect to prevalence, incidence, age, sex, and autoimmune comorbidity of celiac disease (CD). PATIENTS AND METHODS:A Danish nationwide cohort study of CD using data from The National Patient Register. Patients with a primary or secondary dia...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000992

    authors: Grode L,Bech BH,Jensen TM,Humaidan P,Agerholm IE,Plana-Ripoll O,Ramlau-Hansen CH

    更新日期:2018-01-01 00:00:00

  • Gastrointestinal allergy in adults.

    abstract::The prevalence of food allergy reaches 3% in the adult population. Chronic gastrointestinal allergy is a rare entity: 4.2% of food allergies in adults, and represents 3.2% of all intestinal disorders. Non-specific symptoms are the rule but eosinophilic gastrointestinal disorders are the subject of much interest. Endos...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200512000-00005

    authors: Moneret-Vautrin AD

    更新日期:2005-12-01 00:00:00

  • Clinical significance of a scoring formula of liver injury for the preoperative evaluation of patients with liver cirrhosis.

    abstract:OBJECTIVE:The aim of this study was to establish a clinical scoring formula of liver injury (SFLI) using the matter element analysis method, in order to provide the necessary information for the preoperative assessment and treatment of liver cirrhosis in clinical practice. MATERIALS AND METHODS:We collected preoperati...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283632189

    authors: Liu W,Zheng J,Xing R

    更新日期:2014-01-01 00:00:00

  • Protective effect of carnosol on CCl(4)-induced acute liver damage in rats.

    abstract:BACKGROUND:We recently reported that (Lamiaceae) may alleviate CCl(4)-induced acute hepatotoxicity in rats, possibly blocking the formation of free radicals generated during CCl(4) metabolism. Carnosol, one of the main constituents of Rosmarinus, has been shown to have antioxidant and scavenging activities. Therefore, ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200209000-00011

    authors: Sotelo-Félix JI,Martinez-Fong D,Muriel De la Torre P

    更新日期:2002-09-01 00:00:00

  • Retrieval and re-evaluation of previously diagnosed chronic hepatitis C infections lost to medical follow-up in the Netherlands.

    abstract:OBJECTIVES:Many individuals previously diagnosed with chronic hepatitis C virus (HCV) infection are likely to be lost to medical follow-up and, therefore, remain untreated despite new highly effective drug treatment, direct acting antivirals. We aim to identify and retrieve these chronic HCV-infected individuals to re-...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001593

    authors: Heil J,Soufidi K,Stals F,Frantzen H,Robroek-Schaecken A,Bakker CM,van Nunen AB,Dukers-Muijrers NHTM,Hoebe CJPA

    更新日期:2020-07-01 00:00:00

  • Effects of low-power argon plasma coagulation thermoablation of Barrett's epithelium on oesophageal motility.

    abstract:INTRODUCTION:Oesophageal dysmotility contributes to the pathogenesis of Barrett's epithelium (BE) allowing prolonged mucosal contact with injurious refluxate. Argon plasma coagulation (APC) is effective for BE ablation, but it is unknown whether the procedure affects oesophageal motility. AIM:To assess the effect of l...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/01.meg.0000216928.91618.9a

    authors: Basu KK,Talwar V,de Caestecker JS

    更新日期:2006-07-01 00:00:00

  • Chronic hepatitis C infection and sicca syndrome: a clear association with HLA DQB1*02.

    abstract:BACKGROUND:Hepatitis C virus infection is a major cause of nonA, nonB hepatitis worldwide. A high prevalence of immunological abnormalities has been shown to occur in patients with chronic hepatitis C virus infection. AIM:The aim of this study was to assess the development of sicca syndrome in a cohort of patients inf...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328010687d

    authors: Smyth CM,McKiernan SM,Hagan R,Pilkington R,O'Regan M,Lawlor E,Kelleher D

    更新日期:2007-06-01 00:00:00

  • Clinical characteristics and prognosis of hepatocellular carcinoma with different sets of serum AFP and PIVKA-II levels.

    abstract:OBJECTIVE:α-Fetoprotein (AFP) and prothrombin induced by the absence of vitamin K or antagonist-II (PIVKA-II) are useful tumor markers for hepatocellular carcinoma (HCC). However, little is known about the clinical characteristics and prognosis of HCC with different levels of AFP and PIVKA-II. METHODS:Consecutive 1447...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283535c34

    authors: Kang SH,Kim DY,Jeon SM,Ahn SH,Park JY,Kim SU,Kim JK,Lee KS,Chon CY,Han KH

    更新日期:2012-07-01 00:00:00

  • Amyloidosis of the gastrointestinal tract and the liver: clinical context, diagnosis and management.

    abstract::Amyloidosis is a group of disorders that can manifest in virtually any organ system in the body and is thought to be secondary to misfolding of extracellular proteins with subsequent deposition in tissues. The precursor protein that is produced in excess defines the specific amyloid type. This requires histopathologic...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/MEG.0000000000000695

    authors: Syed U,Ching Companioni RA,Alkhawam H,Walfish A

    更新日期:2016-10-01 00:00:00

  • Hepatitis E infection in patients with severe alcoholic hepatitis: is there a place for systematic screening?

    abstract:BACKGROUND:One study has suggested that markers of acute hepatitis E virus (HEV) infection are present in 3.6% of patients with severe alcoholic hepatitis (AH). However, validation of these preliminary results is lacking, as well as the impact of HEV infection on the 6-month survival. AIMS:The aims of this study were ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000459

    authors: Rudler M,Thibault V,Mouri S,Akhavan S,Mallet M,Charlotte F,Poynard T,Thabut D

    更新日期:2015-12-01 00:00:00

  • Combination amoxycillin and metronidazole with famotidine in the eradication of Helicobacter pylori--a randomized, double-blind comparison of a three times daily and twice daily regimen.

    abstract:OBJECTIVES:To determine the efficacy of a three times daily (t.i.d.) versus a twice daily (b.i.d.) regimen of combination amoxycillin and metronidazole and famotidine in the eradication of Helicobacter pylori and the influence of metronidazole resistance on the outcome of treatment. PATIENTS:Patients selected had uneq...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00042737-199711000-00012

    authors: Goh KL,Parasakthi N,Chuah SY,Toetsch M

    更新日期:1997-11-01 00:00:00

  • Comparison of anthropometric measurements for prediction of the atherosclerosis and liver histology in young adults with nonalcoholic fatty liver disease.

    abstract:AIM:Anthropometry is a good evaluation tool that establishes the association between body fat distribution and metabolic risk factors precisely. The aim of this study was to test the association of anthropometric measurements with subclinical atherosclerosis and liver fibrosis. METHODS:A total of 78 patients with nona...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001431

    authors: Dogan T,Ozturk K,Celikkanat S,Aykan MB,Uygun A

    更新日期:2019-11-01 00:00:00

  • Doppler measurements: a surrogate marker of liver fibrosis?

    abstract:OBJECTIVE:The potential diagnostic value of performing Doppler measurements of liver vasculature to assess early stages of liver fibrosis has not been established. Due to the potential clinical impact, this study focused on the correlation between Doppler measurements and histologically proven liver fibrosis. METHODS:...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200204000-00008

    authors: Bernatik T,Strobel D,Hahn EG,Becker D

    更新日期:2002-04-01 00:00:00

  • Management of bleeding gastric varices: a single session of histoacryl injection may be sufficient.

    abstract:OBJECTIVE:Gastric variceal bleeding is one of the most feared complications of portal hypertension and hence merits investigation for its optimal therapy. We aimed to evaluate the efficacy and long-term outcome(s) of patients treated with a single session of histoacryl sclerotherapy for active gastric variceal bleeding...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000080

    authors: Khawaja A,Sonawalla AA,Somani SF,Abid S

    更新日期:2014-06-01 00:00:00

  • Effect of chronic treatment with nadolol plus isosorbide mononitrate on liver blood flow and liver metabolic activity in cirrhosis.

    abstract:OBJECTIVE:To assess the long-term effect of the addition of long-acting nitrates to beta-blockers on liver blood flow and liver metabolic activity in patients with cirrhosis and portal hypertension. METHODS:Eleven patients with cirrhosis and portal hypertension were investigated by using hepatic vein catheterization a...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199911000-00006

    authors: Merkel C,Sacerdoti D,Bolognesi M,Buonamico P,Sticca A,Amodio P,Angeli P,Micotti L,Gatta A

    更新日期:1999-11-01 00:00:00

  • Prevention of recurrence of oesophageal stricture, a comparison of lansoprazole and high-dose ranitidine.

    abstract:OBJECTIVE:To determine the efficacy of lansoprazole 30 mg given in the morning compared with high-dose ranitidine 300 mg twice daily in the treatment of patients with oesophageal strictures. DESIGN:A multicentre, outpatient, double-blind, parallel group, prospectively randomized clinical trial. PATIENTS:One hundred a...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Swarbrick ET,Gough AL,Foster CS,Christian J,Garrett AD,Langworthy CH

    更新日期:1996-05-01 00:00:00

  • Role of ursodeoxycholic acid on maternal serum bile acids and perinatal outcomes in intrahepatic cholestasis of pregnancy.

    abstract:AIM:Intrahepatic cholestasis of pregnancy (ICP) is associated with safe maternal outcomes but perinatal outcomes have been variable. We assessed clinical factors and impact of bile acid levels on maternal and neonatal outcomes in ICP. METHODS:Patients with ICP (defined as pruritus with serum bile acids ≥ 10 mmol/l) we...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001954

    authors: Roy A,Premkumar M,Mishra S,Mehtani R,Suri V,Aggarwal N,Singh S,Dhiman RK

    更新日期:2020-10-29 00:00:00

  • Endoscopic drainage in patients with malignant extrahepatic biliary obstruction: when and how.

    abstract::The question of when and how to drain a malignant biliary obstruction (MBO), both intrinsic or extrinsic, remains a controversial point among endoscopists. An important factor that influences the decision to drain an MBO or not is if the patient is a surgical candidate or not and, in the former case, if the patients m...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001752

    authors: Mangiavillano B,Papanikolaou IS,Arvanitakis M,Auriemma F,Bianchetti M,Tarantino I,Traina M,Deviere J,Repici A

    更新日期:2020-10-01 00:00:00

  • Screening for hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is a major worldwide health problem and the most common cause of cancer induced mortality. This review article examines the natural history of HCC and the known risk factors, as well as evaluating the current methods of detection of HCC and their impact on patient survival. ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:

    authors: Haydon GH,Hayes PC

    更新日期:1996-09-01 00:00:00

  • Cost-effectiveness and long-term impact of Helicobacter pylori 'test and treat' service in reducing open access endoscopy referrals.

    abstract:INTRODUCTION:We have shown that the introduction of a carbon urea breath test (13C-UBT) service for Helicobacter pylori screening and eradication is effective in reducing the rate of open access endoscopy referrals in patients aged < 40 years in the short term. This has been substantiated by several randomized controll...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200410000-00005

    authors: Sreedharan A,Clough M,Hemingbrough E,Gatta L,Chalmers DM,Axon AT,Moayyedi P

    更新日期:2004-10-01 00:00:00

  • Unusual manifestation of brucellosis: liver abscess and pancytopenia caused by Brucella melitensis.

    abstract::Brucellosis is a zoonosis with a worldwide distribution, and still endemic in Greece. Although hepatic involvement is common, cholecystitis and hepatic abscesses represent rare complications of the disease. Hematological manifestations of brucellosis include various abnormalities such as anemia and leucopenia, but the...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3282ef9493

    authors: Starakis I,Polyzogopoulou E,Siagris D,Mazokopakis E,Gogos CA

    更新日期:2008-04-01 00:00:00

  • The association between functional dyspepsia and depression: a meta-analysis of observational studies.

    abstract::Concomitant functional dyspepsia (FD) and psychosocial stressors have been reported; however, the association between FD and depression remains controversial and no quantitative meta-analysis exists. Published articles were identified through a comprehensive review of PubMed, Embase, and Web of Science from inception ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MEG.0000000000001451

    authors: Lin S,Gao T,Sun C,Jia M,Liu C,Ma A

    更新日期:2019-08-01 00:00:00

  • Prevalence of intestinal complications in inflammatory bowel disease: a comparison between paediatric-onset and adult-onset patients.

    abstract:INTRODUCTION:Intestinal complications in inflammatory bowel disease indicate active inflammation and typically result in the intensification of therapy. AIM:To analyse whether the rates of intestinal complications were associated with age at disease onset. PATIENTS AND METHODS:Data from 1506 individuals with Crohn's ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000896

    authors: Herzog D,Fournier N,Buehr P,Rueger V,Koller R,Heyland K,Nydegger A,Braegger CP,Swiss IBD Cohort Study Group.

    更新日期:2017-08-01 00:00:00

  • Validity of N-terminal propeptide of the brain natriuretic peptide in predicting left ventricular diastolic dysfunction diagnosed by tissue Doppler imaging in patients with chronic liver disease.

    abstract:BACKGROUND AND AIMS:Left ventricular diastolic dysfunction has been reported in patients with liver cirrhosis. Although conventional Doppler echocardiography has been used to assess diastolic filling dynamics, this technique is limited in diagnosing left ventricular diastolic dysfunction. The aim of the study was to va...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3282fb7cd0

    authors: Raedle-Hurst TM,Welsch C,Forestier N,Kronenberger B,Hess G,Herrmann E,Zeuzem S,Raedle J

    更新日期:2008-09-01 00:00:00