Effects of low-power argon plasma coagulation thermoablation of Barrett's epithelium on oesophageal motility.

Abstract:

INTRODUCTION:Oesophageal dysmotility contributes to the pathogenesis of Barrett's epithelium (BE) allowing prolonged mucosal contact with injurious refluxate. Argon plasma coagulation (APC) is effective for BE ablation, but it is unknown whether the procedure affects oesophageal motility. AIM:To assess the effect of low power (30 W) APC therapy on oesophageal motility in patients with BE. METHODS:Thirty-three patients with at least 4 cm of BE underwent oesophageal manometry before and after APC ablation. All were on proton pump inhibitors. Oesophageal body peristaltic wave duration and amplitude, and lower oesophageal sphincter (LOS) pressure and length were compared before and after treatment. RESULTS:In a total of 28 men and five women, with a mean age of 63.4 years (range 39-79) and mean BE length 6.5 cm (range 4-19), macroscopic clearance was achieved in 28 patients. A small statistically significant (P<0.05) increase in peristaltic wave amplitude was seen after APC [mean (SD) mmHg before versus after: 30.4 (15.2) versus 36.2 (20.1) at 13.5 cm, 47.6 (27.1) versus 54.5 (26.8) at 8.5 cm, and 51.2 (35.3) versus 58 (34.4) at 3.5 cm above the LOS]. No changes in either peristaltic wave duration or LOS parameters [mean (SD) pressure 10.6 (5.6) versus 10.3 (4.3) mmHg; length 2.8 (1.3) versus 2.8 (1.0) cm] were observed. CONCLUSION:APC ablation of BE at a power setting of 30 W does not impair oesophageal motility.

authors

Basu KK,Talwar V,de Caestecker JS

doi

10.1097/01.meg.0000216928.91618.9a

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

733-7

issue

7

eissn

0954-691X

issn

1473-5687

pii

00042737-200607000-00007

journal_volume

18

pub_type

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