Abstract:
OBJECTIVE:To determine the efficacy of lansoprazole 30 mg given in the morning compared with high-dose ranitidine 300 mg twice daily in the treatment of patients with oesophageal strictures. DESIGN:A multicentre, outpatient, double-blind, parallel group, prospectively randomized clinical trial. PATIENTS:One hundred and fifty-eight patients (lansoprazole 30 mg n = 78, ranitidine 600 mg n = 80) were enrolled from 19 centres in the UK over 23 months. INTERVENTIONS:Patients with an oesophageal stricture were randomized to receive either lansoprazole 30 mg once daily or high-dose ranitidine 300 mg twice daily for 12 months. Dilatation was performed at entry and repeat endoscopies were scheduled at 6 and 12 months and additionally at other times if there was symptomatic relapse. Redilatation was performed as required and according to a predefined scale. The patient's assessment of dysphagia over the previous 7 days was recorded by the investigator at 1, 3, 6, 9 and 12 months. Safety was assessed by laboratory tests, physical examination and all adverse events. MAIN OUTCOME MEASURES:Efficacy was assessed primarily by the time to redilatation, the proportion of patients requiring at least one redilatation, and the number of redilatations over 12 months. The relief of dysphagia and reduction in stricture grade were secondary efficacy measures. RESULTS:The time to redilatation was longer and the probability of no redilatation were higher in the lansoprazole group than in the ranitidine group; for all patients randomized (intention to treat principle), this difference was of borderline significance (life table, P = 0.053). The proportions of patients requiring at least one redilatation during the 12-month treatment period were 30.8% (24/78) with lansoprazole and 43.8% (35/80) with ranitidine (all patients randomized, chi 2 test, P = 0.092). Compared to ranitidine, patients receiving lansoprazole reported significantly lower dysphagia grades at 6 months (stratified Wilcoxon test, P = 0.0086) but not at 12 months (stratified Wilcoxon test, P = 0.074). A greater proportion of patients in the ranitidine group-33.8% (27/80)-withdrew prematurely compared to the lansoprazole group (26.9%, 21/78). The most frequent reasons for premature withdrawal were adverse events and protocol violations. There were no clinically significant differences in incidence or severity of adverse events between the two groups. The mean increase in gastrin levels after 12 months' treatment was significantly greater for patients in the lansoprazole group (124.2 pg/ml, P = 0.0056) than those in the ranitidine group (31.9 pg/ml). No significant changes in gastric mucosal histology were detected for patients in either group. CONCLUSION:It is concluded that lansoprazole 30 mg once daily is superior to ranitidine 300 mg twice daily in relieving dysphagia, and at least as effective in reducing the need for a repeat dilatation.
journal_name
Eur J Gastroenterol Hepatoljournal_title
European journal of gastroenterology & hepatologyauthors
Swarbrick ET,Gough AL,Foster CS,Christian J,Garrett AD,Langworthy CHsubject
Has Abstractpub_date
1996-05-01 00:00:00pages
431-8issue
5eissn
0954-691Xissn
1473-5687journal_volume
8pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract:OBJECTIVE:Isotope ratio mass spectrometry (IRMS) is the accepted method for accurately measuring the 13CO2:12CO2 ratio in the non-invasive and non-radioactive [13C]urea breath test (13C-UBT) for Helicobactor pylori. The IRMS instrument, an expensive and highly specialized analyser, is rarely available. The objective of...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199807000-00008
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVE:Ulcerative colitis and Crohn's disease are the two clinical forms of inflammatory bowel disease (IBD). Diverse studies have shown the association of single nucleotide polymorphism (SNP) in molecules of the immune system and the occurrence of IBD. Here, several SNPs of the immune system with controversial resu...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001540
更新日期:2020-01-01 00:00:00
abstract::Carcinoids are rare compared to other tumours of the gastrointestinal tract, but present a significant portion of tumours of the small intestine. The case of a 50-year-old man who suffered perforation of a small-bowel carcinoid after failed diagnostic trials is reported here. Since intestinal perforation is rarely the...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200012070-00015
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:To examine the influence of dietary factors in Italian patients with ulcerative colitis and Crohn's disease. DESIGN:We studied dietary habits immediately prior to the onset of disease in 104 patients enrolled in a prospective, epidemiological study of the incidence of inflammatory bowel disease in Italy. ME...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract:INTRODUCTION:Serrated polyposis (SP) is an infrequent colorectal cancer (CRC) predisposition syndrome. An unidentified genetic defect is believed to play a role in this condition. The risk of SP and/or CRC for first-degree relatives (FDRs) is not yet well known. The aim of our study was to determine the incidence of bo...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e3283598506
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:Sacral nerve stimulation (SNS) may provide long-term symptom relief to patients suffering from chronic constipation. Patients are currently selected for SNS using a 2-week peripheral nerve evaluation (PNE) comprising stimulation by temporary leads. However, only 40% of test responders receive long-term benef...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,随机对照试验
doi:10.1097/MEG.0000000000001379
更新日期:2019-06-01 00:00:00
abstract:AIM:Hepatitis A is among the diseases that can be prevented with vaccination in our time. Acute hepatitis A progresses more severely in individuals with a liver disease. Therefore, patients with a chronic liver disease (because of hepatitis B or hepatitis C) are advised vaccination with the hepatitis A vaccine. This st...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000547
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:Previous studies have found a differential expression of microRNAs (miRNAs) in the blood of patients with Crohn's disease (CD) compared with healthy controls. The aim of this study was to identify circulating miRNAs expressed in CD and assess their performance as biomarkers in patients with clinically suspect...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000430
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Inflammatory bowel diseases (IBDs) are characterized by a breakdown of colon epithelial barrier function. Antimicrobial peptides like cathelicidins are molecules of the innate immune system located at epithelial surfaces. Cathelicidins influence microbial growth and inflammation and may play a role in IBD. I...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200606000-00007
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:To investigate the colonic endocrine cells in patients with colon carcinoma in order to establish a possible abnormality. PATIENTS:Twelve patients with colon adenocarcinoma (eight women and four men; mean age 69 years; range 52-88 years) were studied. As controls, macroscopically and histologically normal ti...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199806000-00015
更新日期:1998-06-01 00:00:00
abstract:INTRODUCTION:The aim of this study is to present the contrast enhanced magnetic resonance angiography findings of hepatic venous outflow obstruction in patients in whom surgery had been performed for hepatic hydatidosis. No patient history of parasitic hepatic venous invasion or earlier hepatic venous outflow obstructi...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e328305b9f3
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:According to small studies carried out in preselected populations, the estimated prevalence of anti-hepatitis C virus (HCV) antibodies in Poland ranges from 0.6 to 2.1%. AIMS:The aim of this study was to evaluate the prevalence of anti-HCV and HCV RNA among patients and healthcare workers. METHODS:Anti-HCV...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,多中心研究
doi:10.1097/MEG.0b013e32834d173c
更新日期:2011-11-01 00:00:00
abstract::We describe a 55-year-old patient with alcoholic chronic pancreatitis, a large mediastinal pseudocyst and a hemorrhagic pleural effusion. A single thoracocentesis and withdrawal of alcohol without other conservative or invasive measures resulted in a complete resolution of the pleural effusion and the mediastinal pseu...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200601000-00020
更新日期:2006-01-01 00:00:00
abstract::Prophylactic antibiotics have been recommended in patients with a previous history of spontaneous bacterial peritonitis (SBP). Recently, there has been interest in the use of rifaximin for the prevention of SBP and hepatorenal syndrome (HRS). We conducted a meta-analysis to evaluate this association of rifaximin. We s...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MEG.0000000000000940
更新日期:2017-10-01 00:00:00
abstract:AIM:Anthropometry is a good evaluation tool that establishes the association between body fat distribution and metabolic risk factors precisely. The aim of this study was to test the association of anthropometric measurements with subclinical atherosclerosis and liver fibrosis. METHODS:A total of 78 patients with nona...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001431
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:To examine the impact of ileorectal anastomosis on vitamin B12 absorption, as measured by the Schilling test, in patients with Crohn's disease. PATIENTS:Eighty-two patients with Crohn's disease who had undergone ileorectal anastomosis. METHODS:Of the 82 patients with Crohn's disease and ileorectal anastomos...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:Recently, the serotonin antagonist ondansetron has been reported to have a positive effect on cholestasis-associated pruritus. OBJECTIVES:To study the effect of orally administered ondansetron on pruritus in chronic liver disease in a randomized, placebo-controlled, double-blind, cross-over study. METHODS:...
journal_title:European journal of gastroenterology & hepatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00042737-199810000-00010
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:Bowel distension by insufflated air causes abdominal discomfort after colonoscopy. Carbon dioxide (CO2) instead of air insufflation during colonoscopy can reduce postprocedural discomfort in diagnostic and screening cases. Discomfort after colonoscopy and CO2 insufflation have never been studied in inflammato...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,随机对照试验
doi:10.1097/MEG.0000000000000791
更新日期:2017-03-01 00:00:00
abstract::Idiopathic fibrosing pancreatitis is an uncommon condition in children and adolescents of unknown aetiology. This syndrome has been reported in 36 cases so far. To our knowledge none of these cases was definitively associated with Crohn's disease. In this report we describe a young female patient who developed Crohn's...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200012090-00010
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:Analytical methods for measurements of gluten in the low level range of 20-200 ppm of gluten, as required for gluten-free food, have never been endorsed by the Codex Alimentarius. With the aim of investigating standardized and reliable methods for the detection of gliadin in food with detection limits lower t...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,多中心研究
doi:10.1097/00042737-200510000-00008
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:Although antimony electrodes are by far the most popular for performing oesophageal pH monitoring, there are few data comparing the accuracy of glass and antimony electrodes. Therefore, we tested the accuracy of both electrodes in the prediction of oesophagitis. METHOD:pH monitoring using a glass electrode a...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200412000-00015
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:Recently, the postoperative Model for End stage Liver Disease score (POPMELD) was suggested as a definition of postoperative graft dysfunction and a predictor of outcome after liver transplantation (LT). AIM:The aim of the present study was to validate this concept in the context of extended criteria donor ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000851
更新日期:2017-06-01 00:00:00
abstract::Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease. Frequently, it can slowly progress to cirrhosis and, finally, death. Liver transplantation is the only way to avoid this endpoint. For patients not accepted for liver transplantation, only symptomatic treatment remains. In advanced PBC, one of the...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199908000-00021
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND AND AIMS:It has been reported that the incidence of liver cancer and intrahepatic bile duct tumours might be increasing in some developed countries. The purpose of this study was to examine time trends of incidence and mortality rates of liver cirrhosis and liver cancer for the period 1980-1997 in Catalonia,...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200409000-00009
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:Blood tests are usually designed to identify significant fibrosis. We evaluated their diagnostic accuracy, and how to increase it, for the clinically important targets of severe fibrosis and cirrhosis. METHODS:The accuracy for severe fibrosis or cirrhosis of four blood tests was evaluated based on Metavir st...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,多中心研究,评审
doi:10.1097/MEG.0b013e32830cebd7
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Oesophageal dysmotility contributes to the pathogenesis of Barrett's epithelium (BE) allowing prolonged mucosal contact with injurious refluxate. Argon plasma coagulation (APC) is effective for BE ablation, but it is unknown whether the procedure affects oesophageal motility. AIM:To assess the effect of l...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/01.meg.0000216928.91618.9a
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVES:Symptoms of achalasia are often misinterpreted, resulting in delayed diagnosis. The aims of our study were (1) to estimate the evolution of clinical and radiological features of a large population of achalasic patients between two successive periods; and (2) to determine the influence of symptoms on diagnost...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200102000-00006
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVES:Irritable bowel syndrome (IBS) is a chronic, disabling and functional gastrointestinal disorder. Effective treatments are lacking. Self-care and coping with symptoms are considered important but little is known about what patients with IBS actually do to manage their illness. The aim of this study was to exp...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e328365abd3
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND/AIM:Although there have been numerous reports concerning the virulence factors of isolates for investigating the pathogenesis of Helicobacter pylori infection, few studies have been carried out regarding the association of HLA class II genes of the host with H. pylori related diseases. Two published studies ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199908000-00011
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVES:The distribution of the intestinal vascular lesions and their relation with the fibrinolysis process are poorly known in Crohn's disease (CD). The mediators of the plasminogen activator system, namely urokinase-type plasminogen activator (u-PA), tissue-type plasminogen activator (t-PA) and plasminogen activa...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199910000-00007
更新日期:1999-10-01 00:00:00