当前位置： SCI文献检索 > EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY期刊下所有文献 > Long-term course after initial iron removal of iron excess in patients with dysmetabolic iron overload syndrome.

Long-term course after initial iron removal of iron excess in patients with dysmetabolic iron overload syndrome.

Abstract：

BACKGROUND:Initial venesection therapy in dysmetabolic iron overload syndrome (DIOS) was shown to improve insulin resistance. However, no data are available on the long-term outcome of iron store, thus questioning the relevance of maintenance therapy. AIM:The aim of the study was to describe the long-term evolution of iron overload after successful iron removal in patients with DIOS. PATIENTS AND METHODS:Patients diagnosed with DIOS from 1998 to 2003 and having completed venesection therapy were proposed an outpatient visit in 2009. Inclusion criteria were as follows: confirmation of the DIOS diagnosis, absence of iron-related treatment or bloodletting since the end of the initial venesection treatment, at least 2 years of follow-up since last phlebotomy. Clinical and biological data were recorded at diagnosis and at inclusion. RESULTS:A total of 58 patients were included. The mean liver iron content at diagnosis was 80±43 µmol/g and the mean amount of iron removed was 2.2±1.2 g. The mean follow-up time was 71±23 months since end of treatment. At inclusion, 64% of patients had recurrence of iron overload. Serum ferritin at diagnosis was the only parameter associated with recurrence of iron overload. CONCLUSION:In patients with DIOS, the course of iron loading after initial iron removal supports periodical follow-up to detect those patients with recurrence of iron overload who could benefit from maintenance therapy.

journal_name

Eur J Gastroenterol Hepatol

journal_title

European journal of gastroenterology & hepatology

authors

Bardou-Jacquet E,Lainé F,Morcet J,Perrin M,Guyader D,Deugnier Y

doi

10.1097/MEG.0000000000000058

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

418-21

issue

4

eissn

0954-691X

issn

1473-5687

journal_volume

26

pub_type

杂志文章

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