Liver steatosis in patients with chronic hepatitis B infection: host and viral risk factors.

Abstract:

BACKGROUND:Liver steatosis (LS) and chronic infection with hepatitis B virus (HBV) are two common causes of chronic liver disease in Iran. LS is also a common histopathological feature of chronic hepatitis B (CHB). Association of chronic HBV infection and LS has not been extensively studied. AIM:We investigated the prevalence of histological evidence of LS in a group of patients with chronic HBV infection undergoing liver biopsy and compared clinical data, laboratory features, and severity of hepatic fibrosis between patients both with and without steatosis. METHODS:A total of 132 patients with CHB, undergoing liver biopsy for diagnostic purposes over a 2-year period were enrolled in this study. Clinical, biochemical, and histological factors that might have any kind of association with the presence of steatosis were evaluated. RESULTS:Of the 132 patients with a liver biopsy, steatosis was present in 56 (42.4%) of the patients, of whom 36 (64%) had grade 1, 14 (25%) grade 2, and six (10.7%) grade 3. Our data showed that LS is not associated with age, sex, HBeAg, viral load, amount of fibrosis, serum cholesterol level, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase. Although body mass index, serum triglyceride, fasting blood glucose, and gamma-glutamyl transpeptidase showed significant correlation with LS in univariate analysis, in multivariate analysis only the serum triglyceride level was significantly correlated with LS. CONCLUSION:Steatosis is a relatively common finding in CHB and metabolic host factors rather than viral factors responsible for the presence of steatosis in these patients.

authors

Minakari M,Molaei M,Shalmani HM,Mohammad Alizadeh AH,Jazi AH,Naderi N,Shavakhi A,Mashayekhi R,Zali MR

doi

10.1097/MEG.0b013e328326792e

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

512-6

issue

5

eissn

0954-691X

issn

1473-5687

journal_volume

21

pub_type

杂志文章
  • Decision making and outcome of pregnancies in female patients with inflammatory bowel disease: findings from a community-based practice.

    abstract:INTRODUCTION:The aim of this study was to evaluate information provided on pregnancy, personal decision making, disease course, and outcome of pregnancy from a patient's perspective in a population of patients with inflammatory bowel disease (IBD) attending two general hospitals. PATIENTS AND METHODS:A questionnaire w...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MEG.0000000000001117

    authors: Hoekstra J,van Roon AHC,Bekkering FC,van Tilburg AJP,West RL

    更新日期:2018-07-01 00:00:00

  • Laparoscopic surgery for treatment of splenic disorders: an update.

    abstract::Laparoscopic splenectomy is a feasible and safe technique in the hands of skilled laparoscopic surgeons. The special characteristics of the spleen, a fragile solid organ with a rich vascularization, pose a number of technical questions (patient position, organ mobilization and retrieval) which have been successfully r...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-199708000-00003

    authors: Trías M,Targarona EM,Benarroch G,Fernández-Cruz L

    更新日期:1997-08-01 00:00:00

  • Feasibility study of colorectal cancer screening by immunochemical faecal occult blood testing: results in a northern Italian community.

    abstract:AIM:Screening by means of faecal occult blood testing (FOBT) has proved to be effective in reducing colorectal cancer incidence and mortality. We performed a pilot screening for colorectal cancer by latex immunological FOBT in two municipalities of the region Valle d'Aosta, Italy, focusing on problems and obtaining ind...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200401000-00006

    authors: Crotta S,Castiglione G,Grazzini G,Valle F,Mosconi S,Rosset R

    更新日期:2004-01-01 00:00:00

  • Assessment of p21, p53 expression, and Ki-67 proliferative activities in the gastric mucosa of children with Helicobacter pylori gastritis.

    abstract:BACKGROUND:Helicobacter pylori that is generally acquired in childhood and infects the gastric mucosa is considered to be responsible for many pathobiological changes that are linked to the pathogenesis of gastric cancer. Although the majority of studies on the subject have been carried out in adults, there are a limit...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000246

    authors: Saf C,Gulcan EM,Ozkan F,Cobanoglu Saf SP,Vitrinel A

    更新日期:2015-02-01 00:00:00

  • Characterization of serum irisin in patients with severe acute pancreatitis.

    abstract:BACKGROUND:Irisin, as a novel and versatile hormone secreted by skeletal myocytes and fat tissues, is reported to be involved in inflammation-related diseases; one of the main characteristics of severe acute pancreatitis (SAP) is inflammatory responses. This study aims to describe the characteristics of irisin in SAP. ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001454

    authors: Chen S,Wang L,Gao X,Chen M,Zeng Z,Zhao L

    更新日期:2019-08-01 00:00:00

  • Safety of variceal band ligation in patients with cirrhosis and portal vein thrombosis treated with anticoagulant therapy: A retrospective study.

    abstract:BACKGROUND AND AIMS:Anticoagulant therapy has been recommended in patients with cirrhosis and portal vein thrombosis especially in candidates for liver transplantation. These patients are also likely to need variceal band ligation. This study aimed to assess the incidence of upper gastrointestinal bleeding after electi...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001522

    authors: Ponthus S,Spahr L,Casini A,Berney T,Frossard JL,Majno P,Elkrief L

    更新日期:2020-03-01 00:00:00

  • The Glasgow Dyspepsia Severity Score--a tool for the global measurement of dyspepsia.

    abstract:OBJECTIVE:There is currently no reliable tool for providing a global measurement of the severity of dyspepsia in patients with a variety of upper gastrointestinal disorders. We have designed a questionnaire which records frequency of symptoms, effect on routine activities, time off work, frequency of medical consultati...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199610000-00006

    authors: el-Omar EM,Banerjee S,Wirz A,McColl KE

    更新日期:1996-10-01 00:00:00

  • Stenting of malignant upper oesophageal obstruction: experience in a regional hospital in Singapore.

    abstract::Oesophageal stenting for palliation of malignant obstruction with self-expanding metallic stents is undoubtedly well established. Numerous studies have proven it to be safe and easy to perform with good clinical outcomes. However, stenting of the upper oesophagus is still regarded with apprehension, with many endoscop...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283496543

    authors: Yim HB

    更新日期:2011-10-01 00:00:00

  • Hereditary hyperferritinaemia-cataract syndrome: a challenging diagnosis for the hepatogastroenterologist.

    abstract::Hereditary hyperferritinaemia-cataract syndrome (HHCS) is a relatively rare disorder with an autosomal dominant trait. It can be caused by various mutations within the iron responsive element (IRE) of the L-ferritin gene. These mutations result in an increased translation of L-ferritin mRNA and consequently the accumu...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200511000-00016

    authors: Ferrante M,Geubel AP,Fevery J,Marogy G,Horsmans Y,Nevens F

    更新日期:2005-11-01 00:00:00

  • IL28B favorable genotype and ultrarapid viral response as the earliest treatment predictors of a sustained viral response in a Georgian cohort infected with the hepatitis C genotype 1.

    abstract:OBJECTIVES:The early identification of factors contributing to the successful treatment of hepatitis C infection is important for researchers and clinicians. Studies carried out on the role of an ultrarapid viral response (URVR) for the prediction of a sustained viral response (SVR) have shown its high positive predict...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328353fd11

    authors: Karchava M,Sharvadze L,Chkhartishvili N,Nelson K,Gochitashivli N,Gatserelia L,Dvali N,Dolmazashvili E,Dzigua L,Badridze N,Zhamutashvili M,Tsertsvadze T

    更新日期:2012-07-01 00:00:00

  • Haemodynamic changes after high-volume plasmapheresis in patients with chronic and acute liver failure.

    abstract:OBJECTIVE:To evaluate the haemodynamic changes during treatment with high-volume plasmapheresis in patients with chronic liver failure compared to patients with acute liver failure. METHODS:Haemodynamic measurements were performed with a Swan-Ganz catheter and thermodilution technique. High-volume plasmapheresis (mean...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199701000-00014

    authors: Clemmesen JO,Larsen FS,Ejlersen E,Schiødt FV,Ott P,Hansen BA

    更新日期:1997-01-01 00:00:00

  • Guidelines for the management of dyspepsia.

    abstract::Dyspepsia is a common problem necessitating strategies for investigation and management because of the scarcity of available resources for investigation, i.e. endoscopy, and the need to focus on those at risk of serious disease. It is agreed that those in the older age group, with the presence of alarm symptoms or non...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 评论,杂志文章

    doi:10.1097/00042737-199903000-00001

    authors: Mullins PD,Colin-Jones DG

    更新日期:1999-03-01 00:00:00

  • Prospective evaluation of a clinical score for 60-day mortality after transjugular intrahepatic portosystemic stent-shunt: Bonn TIPSS early mortality analysis.

    abstract:OBJECTIVE:Transjugular intrahepatic portosystemic stent-shunt (TIPSS) is increasingly used to treat complications of portal hypertension, but proven tools for risk assessment of early mortality are lacking. DESIGN:The prospective evaluation of a new 60-day mortality score. PATIENTS AND METHODS:In a tertiary medical c...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200207000-00003

    authors: Brensing KA,Raab P,Textor J,Görich J,Schiedermaier P,Strunk H,Paar D,Schepke M,Sudhop T,Spengler U,Schild H,Sauerbruch T

    更新日期:2002-07-01 00:00:00

  • Effects of recognizing depression with a standardized questionnaire (CES-D) versus patient reporting of depression after a single-standardized question on the outcomes of treatment for hepatitis C with pegylated interferon-α-2b and ribavirin.

    abstract:BACKGROUND:Depression may worsen during antiviral treatment for hepatitis C virus, resulting in noncompliance treatment. AIM:The aim was to compare the response and compliance rates between the groups of veteran patients using two different methods of identifying depression, either the Centers for Epidemiology Studies...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MEG.0b013e32833eb8c6

    authors: Phillips FH,Prebis M,Grumbeck C,Hale T,Cubillas R,Brown GR

    更新日期:2010-12-01 00:00:00

  • Regression of liver fibrosis over a 24-week period after completing direct-acting antiviral therapy in patients with chronic hepatitis C receiving care within the national hepatitis C elimination program in Georgia: results of hepatology clinic HEPA exper

    abstract:OBJECTIVE:We assessed the impact of direct-acting antiviral (DAA) therapy on liver fibrosis regression measured by transient elastography (TE) in patients with chronic hepatitis C virus (HCV) infection. PATIENTS AND METHODS:A prospective cohort study was carried out in HCV monoinfected patients with advanced liver fib...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000964

    authors: Dolmazashvili E,Abutidze A,Chkhartishvili N,Karchava M,Sharvadze L,Tsertsvadze T

    更新日期:2017-11-01 00:00:00

  • Heterotopic gastric mucosa of the proximal oesophagus (inlet patch): endoscopic prevalence, histological and clinical characteristics in paediatric patients.

    abstract:BACKGROUND:Heterotopic gastric mucosa is found in the proximal oesophagus, just below the upper oesophageal sphincter, and is encountered when the oesophagus is examined carefully during endoscopy. AIMS:In this study on paediatric patients, we aimed to determine the endoscopic prevalence of heterotopic gastric mucosa ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000177

    authors: Rodríguez-Martínez A,Salazar-Quero JC,Tutau-Gómez C,Espín-Jaime B,Rubio-Murillo M,Pizarro-Martín A

    更新日期:2014-10-01 00:00:00

  • Treatment with a potassium-iron-phosphate-citrate complex improves PSE scores and quality of life in patients with minimal hepatic encephalopathy: a multicenter, randomized, placebo-controlled, double-blind clinical trial.

    abstract:OBJECTIVE:Minimal hepatic encephalopathy (MHE) is one of the possible complications of liver cirrhosis. In this study, a potassium-iron-phosphate-citrate complex was analyzed for its efficacy and safety in the treatment of MHE, as this complex is supposed to bind to the major pathogenic factor of MHE: intestinal ammoni...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/MEG.0b013e32835afaa5

    authors: Burkard T,Biedermann A,Herold C,Dietlein M,Rauch M,Diefenbach M

    更新日期:2013-03-01 00:00:00

  • Clinical usefulness of K-ras gene mutation detection and cytology in pancreatic juice in the diagnosis and screening of pancreatic cancer.

    abstract:BACKGROUND:The significance of K-ras codon 12 mutation in pancreatic juice is still unclear. Although considerable controversy surrounds this question, the diagnostic utility of K-ras in patients with clinical suspicion of pancreatic cancer (PC) and in PC-risk patients remains unknown. OBJECTIVE:To study prospectively...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200110000-00006

    authors: Boadas J,Mora J,Urgell E,Puig P,Roca M,Cussó X,Capellà G,Lluís F,Farré A

    更新日期:2001-10-01 00:00:00

  • Deoxycholic acid stimulates migration in colon cancer cells.

    abstract:BACKGROUND:Deoxycholic acid and other secondary bile acids have long been considered tumour promoters in the colon. However, their effect on cell migration, known to play an important role in colon carcinogenesis, has not been studied so far. OBJECTIVE:To investigate the possible effects of deoxycholic acid on colon c...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200108000-00012

    authors: Milovic V,Teller IC,Murphy GM,Caspary WF,Stein J

    更新日期:2001-08-01 00:00:00

  • Hodgkin's disease presenting as cholestatic hepatitis with prominent ductal injury.

    abstract::In advanced stages of Hodgkin's disease, liver involvement is common. However, Hodgkin's disease mimicking cholestatic hepatitis at presentation is rare. We describe a patient with Hodgkin's disease who was initially considered to have acute cholestatic hepatitis. Liver biopsy demonstrated prominent bile duct injury a...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200203000-00019

    authors: Liangpunsakul S,Kwo P,Koukoulis GK

    更新日期:2002-03-01 00:00:00

  • Time trends in incidence and mortality for chronic liver disease and liver cancer in the interval 1980-1997 in Catalonia, Spain.

    abstract:BACKGROUND AND AIMS:It has been reported that the incidence of liver cancer and intrahepatic bile duct tumours might be increasing in some developed countries. The purpose of this study was to examine time trends of incidence and mortality rates of liver cirrhosis and liver cancer for the period 1980-1997 in Catalonia,...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200409000-00009

    authors: Ribes J,Clèries R,Borràs J,Galceran J,Bosch FX

    更新日期:2004-09-01 00:00:00

  • Haematochezia in Crohn's disease caused by late-onset haemobilia following percutaneous liver biopsy.

    abstract::The case of a patient with Crohn's disease and who presented 4 days after a percutaneous liver biopsy with haematochezia suggestive of an exacerbation of his inflammatory bowel disease is described. Subsequent abdominal ultrasonography revealed free fluid in the peritoneal cavity and around the gallbladder. Haemobilia...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200402000-00018

    authors: Hodgson RS,Taylor-Robinson SD,Jackson JE

    更新日期:2004-02-01 00:00:00

  • Colonic wall thickening is related to age and not dose of high strength pancreatin microspheres in children with cystic fibrosis.

    abstract:OBJECTIVE:Colonic fibrosis causing stricture is a recently described complication in cystic fibrosis (CF). Studies have suggested that ultrasound evidence of bowel thickening predicts this complication and that it is prevalent among children receiving large doses of high-strength pancreatin preparations. We performed u...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199902000-00020

    authors: Connett GJ,Lucas JS,Atchley JT,Fairhurst JJ,Rolles CJ

    更新日期:1999-02-01 00:00:00

  • Comparison of 2 days versus 5 days of octreotide infusion along with endoscopic therapy in preventing early rebleed from esophageal varices: a randomized clinical study.

    abstract:BACKGROUND:Variceal bleeding is a medical emergency with 20% mortality at 6 weeks. The role of vasoactive agents in achieving hemostasis and preventing rebleeding has been well documented. The optimal duration of these agents has not been well established. There are no previous studies yielding the exact duration of oc...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MEG.0000000000000300

    authors: Rengasamy S,Ali SM,Sistla SC,Lakshmi CP,Harichandra Kumar KT

    更新日期:2015-04-01 00:00:00

  • Switching from branched-chain amino acid granules to branched-chain amino acid-enriched nutrient improves the branched-chain amino acid-to-tyrosine ratio in patients with cirrhosis with hypoalbuminemia: a prospective study.

    abstract:OBJECTIVE:The present study aimed to elucidate the effect of switching from branched-chain amino acid granules to branched-chain amino acid-enriched nutrient in patients with cirrhosis with hypoalbuminemia. METHODS:Twenty-six patients with cirrhosis with hypoalbuminemia despite treatment with branched-chain amino acid...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001544

    authors: Fukui A,Kawabe N,Hashimoto S,Kamei H,Yoshioka K

    更新日期:2020-04-01 00:00:00

  • The prevalence of occult hepatitis B virus infection in type 2 diabetes mellitus patients.

    abstract:AIM:The prevalence of occult hepatitis B virus (HBV) infection is relatively frequent among patients with immune suppression. The impairment of the immune system is well demonstrated in diabetics. We aimed to investigate the prevalence of occult HBV infection among hepatitis B core antibody (HbcAb)+/- hepatitis B surfa...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3282f55e1e

    authors: Demir M,Serin E,Göktürk S,Ozturk NA,Kulaksizoglu S,Ylmaz U

    更新日期:2008-07-01 00:00:00

  • Management of systolic blood pressure after endoscopic submucosal dissection is crucial for prevention of post-ESD gastric bleeding.

    abstract:OBJECTIVE:Endoscopic submucosal dissection (ESD) is a useful technique for early gastric neoplasms without lymph node metastasis. However, a critical complication is unpredictable post-ESD bleeding. Some risk factors for post-ESD bleeding have been reported previously, although those risk factors have not directly cont...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000072

    authors: Ebi M,Shimura T,Nishiwaki H,Tanaka M,Tsukamoto H,Ozeki K,Sawada T,Mizoshita T,Mori Y,Kubota E,Tanida S,Kataoka H,Joh T

    更新日期:2014-05-01 00:00:00

  • Acute inflammatory intestinal vascular lesions and in situ abnormalities of the plasminogen activation system in Crohn's disease.

    abstract:OBJECTIVES:The distribution of the intestinal vascular lesions and their relation with the fibrinolysis process are poorly known in Crohn's disease (CD). The mediators of the plasminogen activator system, namely urokinase-type plasminogen activator (u-PA), tissue-type plasminogen activator (t-PA) and plasminogen activa...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199910000-00007

    authors: Desreumaux P,Huet G,Zerimech F,Gambiez L,Balduyck M,Baron P,Degand P,Cortot A,Colombel JF,Janin A

    更新日期:1999-10-01 00:00:00

  • Rectal lymphoma in ulcerative colitis treated with azathioprine.

    abstract::Primary malignant lymphoma of the bowel is a rare complication of inflammatory bowel disease. The association of gastrointestinal lymphoma, inflammatory bowel disease and prior immunosuppression remains unclear. We report the first case of azathioprine-treated ulcerative colitis developing rectal lymphoma. ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200108000-00022

    authors: Tan CW,Wilson GE,Howat JM,Shreeve DR

    更新日期:2001-08-01 00:00:00

  • The association of nonalcoholic fatty liver disease with genetic polymorphisms: a multicenter study.

    abstract:INTRODUCTION:Growing evidence suggests that multiple factors, such as insulin resistance, nutritional factors, gut microbiota, and hormones released from the adipose tissue, act together on genetically predisposed individuals. We aimed to investigate whether various single-nucleotide polymorphisms (SNPs) play a role in...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MEG.0000000000000813

    authors: Uygun A,Ozturk K,Demirci H,Oztuna A,Eren F,Kozan S,Yilmaz Y,Kurt O,Turker T,Vatansever S,Alper E,Unsal B

    更新日期:2017-04-01 00:00:00