Abstract:
OBJECTIVES:The diagnostic and prognostic value of critical flicker frequency (CFF) analysis for assessment of severity and dynamics of hepatic encephalopathy (HE) was studied before and after implantation of a transjugular intrahepatic portosystemic shunt (TIPS). BASIC METHODS:Sixty-three cirrhotic patients were retrospectively analyzed for the consequences of TIPS implantation. Thirty-one cirrhotic patients without TIPS implantation served as age-matched, sex-matched, Child-Pugh-matched controls. CFF and computer psychometric tests as objective test parameters of HE-severity were evaluated for analysis of visual discrimination ability, general arousal and cognitive function. Kaplan-Meier method and Cox proportional hazards regression model were used for analysis of prognostic significances. MAIN RESULTS:In the control group, HE-severity was stable during the observation period (442+/-428 days) with minimal changes in CFF (-0.1+/-1.9 Hz). In the intervention group, TIPS implantation had no effect on HE-severity in 44% of the patients and CFF shifted by only 0.01+/-1.5 Hz. Thirty-five and 21% of the patients experienced an aggravation or improvement of HE after TIPS implantation, respectively. In HE improvers CFF increased by 3.3+/-2.3 Hz and decreased by 3.5+/-1.5 Hz in those experiencing an aggravation of HE-severity. Univariate analysis showed that overall survival in the study population inversely correlated with HE-severity and serum alkaline phosphatase activity and positively correlated with serum sodium, albumin and CFF. Serum albumin, alkaline phosphatase levels and CFF were independent predictors of survival in a multivariate Cox regression analysis. CONCLUSION:The data show that pre-TIPS HE does not predict post-TIPS encephalopathy. Otherwise, CFF can reliably pick up the evolution of HE-severity after TIPS implantation. Low pre-TIPS CFF is indicative for a poor prognosis and may help to identify transplant candidates without delay.
journal_name
Eur J Gastroenterol Hepatoljournal_title
European journal of gastroenterology & hepatologyauthors
Kircheis G,Bode JG,Hilger N,Kramer T,Schnitzler A,Häussinger Ddoi
10.1097/MEG.0b013e328310e0c3subject
Has Abstractpub_date
2009-12-01 00:00:00pages
1383-94issue
12eissn
0954-691Xissn
1473-5687journal_volume
21pub_type
杂志文章abstract:AIMS:The purpose of this study was to investigate the expression level of KAI-1 in gastric carcinomas and compare with the clinicopathological characteristics. METHODS:KAI-1 expressions were detected with immunohistochemical methods in 257 patients with gastric carcinomas. RESULTS:KAI-1 was highly expressed in normal...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e328323aac9
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:Hepatopancreaticobiliary cancers can be difficult to diagnose. Nuclear magnetic resonance (NMR) spectroscopy provides non-invasive information on phospholipid metabolism, and previous studies of liver tissue have highlighted changes in phospholipids in malignancy. We hypothesised that in-vitro NMR spectroscop...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200507000-00007
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Recently, the postoperative Model for End stage Liver Disease score (POPMELD) was suggested as a definition of postoperative graft dysfunction and a predictor of outcome after liver transplantation (LT). AIM:The aim of the present study was to validate this concept in the context of extended criteria donor ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000851
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:Spontaneous bacterial peritonitis (SBP) is one of the potentially life-threatening complications in ascitic cirrhotic patients with a mortality rate ranging between 30 and 50%. The improved survival might be explained by a more rapid diagnosis and treatment. The aim of our study was to assess the utility of t...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200406000-00011
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:To study the effect of supplemental calcium carbonate on faecal water, calcium, bile acid and lipid concentration and output in intestinal bypass subjects with diarrhoea. DESIGN:Prospective, single-arm treatment trial of oral calcium carbonate, 2400 or 3600 mg Ca2+ per day, given for 12 weeks. METHODS:Faeca...
journal_title:European journal of gastroenterology & hepatology
pub_type: 临床试验,杂志文章
doi:10.1097/00042737-199606000-00012
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:Patients with achalasia require repeated invasive therapies and may experience multiple complications. The objectives of this study were to determine the incidence of such complications, causes of death, and life expectancy in 253 patients. METHODS:Patients consisted of two groups: group A comprised 177 pat...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e3282fbf5e5
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:This study was conducted to determine which type and dose of sedative drugs should be given to cirrhotic patients with compensation or decompensation during esophagogastroduodenoscopy (EGD) to prevent hepatic encephalopathy (HE) after sedation. METHODS:We reviewed the medical records of cirrhotic patients c...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001755
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:Complete review of wireless capsule endoscopy (WCE) recordings by a physician is time-consuming and laborious and may be perceived as a limitation to perform WCE. The aim of this study was to evaluate the efficacy of a nurse in interpreting WCE. METHODS:A total of 102 WCE videos were evaluated by a single ga...
journal_title:European journal of gastroenterology & hepatology
pub_type: 临床试验,杂志文章
doi:10.1097/meg.0b013e3283433abf
更新日期:2011-02-01 00:00:00
abstract:INTRODUCTION:We postulated that the oro-oral route of transmission between spouses could be an important route of transmission of Helicobacter pylori. AIMS:To estimate the prevalence of different genotypes of H. pylori as distinguished by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200205000-00009
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:Proton pump inhibitors (PPIs) are usually prescribed to patients undergoing dual antiplatelet therapy to decrease the risk of gastrointestinal bleeding. Recent studies have raised concerns that PPIs could reduce clopidogrel's efficacy by competitive inhibition of cytochrome P450 2C19 isoenzyme. All PPIs are ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,随机对照试验
doi:10.1097/MEG.0b013e3283460110
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:There is currently no reliable tool for providing a global measurement of the severity of dyspepsia in patients with a variety of upper gastrointestinal disorders. We have designed a questionnaire which records frequency of symptoms, effect on routine activities, time off work, frequency of medical consultati...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199610000-00006
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Current guidelines for chronic hepatitis B (CHB) patients are to undergo surveillance for hepatocellular carcinoma (HCC) with 6-month ultrasonography. We aimed to compare detection rates of very-early-stage HCC in two groups: group A, undergoing 6-month ultrasonography versus group B, undergoing 6-m...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001870
更新日期:2020-08-14 00:00:00
abstract:OBJECTIVE:The aim of this study was to explore the underlying pathophysiological mechanism for portal hypertension in primary biliary cirrhosis (PBC) using radiological findings. PATIENTS AND METHODS:The study included 10 patients with PBC (Scheuer stage I, one patient; stage II, two patients; and cirrhosis, seven pat...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000268
更新日期:2015-03-01 00:00:00
abstract::The autosomal dominantly inherited juvenile polyposis syndrome (JPS) leads to the development of multiple hamartomatous polyps in the gastrointestinal tract and is a precancerous condition. In a large family with a newly identified SMAD4 mutation (c.543delC), we describe the clinical manifestations of JPS. Nine affect...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e328354f43e
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:Enterally administered glucose modifies gut sensation, diminishes hunger, and slows gastric emptying by suppressing antral motility and stimulating pyloric pressures. We aimed to clarify the mechanism of small intestinal glucose sensing. METHODS:We studied eight healthy males twice, in random order. An antro...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e3283200073
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVES:To investigate the prevalence of Helicobacter pylori in patients with erosive oesophagitis in comparison with asymptomatic subjects. DESIGN:Hospital based case-control study. METHODS:Two hundred and nineteen consecutive patients with erosive oesophagitis diagnosed over 2 years were studied. Patients with s...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199806000-00005
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVES:Although all international guidelines state that there is no indication to perform a faecal occult blood test (FOBT) in symptomatic patients, we believe the test is frequently used as a diagnostic test. The objective of this study was to investigate whether the current guidelines for FOBT use are being follo...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e328313bbd3
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To examine the impact of ileorectal anastomosis on vitamin B12 absorption, as measured by the Schilling test, in patients with Crohn's disease. PATIENTS:Eighty-two patients with Crohn's disease who had undergone ileorectal anastomosis. METHODS:Of the 82 patients with Crohn's disease and ileorectal anastomos...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
abstract:PURPOSE:Thiopurine-induced leukopenia is a relatively common adverse event related to thiopurine medication in Korean pediatric Crohn's disease. In addition to the mutations of TPMT gene, the NUDT15 c.415C>T variant was recently identified to have a strong association with thiopurine-induced early leukopenia. We conduc...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000564
更新日期:2016-04-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e3282f2468d
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and side-effect profile of two currently advocated treatment regimens for eradicating Helicobacter pylori. DESIGN:A randomized, controlled, open, single-centre study. SETTING:A community hospital in The Netherlands. PARTICIPANTS:Seventy-six consecutive patients with (chronic) ulcer d...
journal_title:European journal of gastroenterology & hepatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00042737-199512000-00011
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:The role of heterozygosity for alpha-1 antitrypsin (A1AT) alleles in patients with chronic hepatitis C virus (HCV) is unclear. There is limited evidence to suggest that there is an increased prevalence of heterozygous A1AT carriers in HCV, but it is unclear how this affects treatment success. AIM:To investi...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e3283320113
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:Hepatitis C virus (HCV) is the major cause of cryoglobulinemia. Direct-acting antivirals (DAAs) have markedly changed the therapeutic outcomes in the treatment of patients with HCV. We evaluate the efficacy, safety, immunological, and clinical response of different DAA regimens in HCV-cryoglobulinemia. PATI...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001239
更新日期:2018-10-01 00:00:00
abstract:AIM:To review the evidence that Helicobacter pylori promotes gastric carcinogenesis, with particular reference to gastric epithelial proliferation. MATERIALS AND METHODS:Gastric epithelial kinetics were reviewed and a series of studies of gastric mucosal proliferation in H. pylori-associated gastritis were performed i...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,评审
doi:
更新日期:1995-08-01 00:00:00
abstract:AIM:Many researchers consider portal thrombosis (PT) as a contraindication to transjugular intrahepatic portosystemic shunt (TIPS). The aim of this retrospective study was to compare the feasibility and long-term prognosis of TIPS in cirrhotic patients, with and without, complete PT. PATIENTS AND METHODS:Four hundred ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e328338d995
更新日期:2010-09-01 00:00:00
abstract::We report the case of a young woman with Crohn's disease of the bowel who presented with a purulent tracheobronchitis and life-threatening upper airway obstruction. Fibreoptic bronchoscopy demonstrated severe tracheal and upper bronchial pseudotumours and stenosis. The role of recent discontinuation of corticosteroids...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200112000-00015
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:Ileocaecal resection is the most common operation performed in Crohn's disease. Our study aimed to identify the risk factors for anastomotic recurrence following primary ileocaecal resection. PATIENTS AND METHODS:We retrospectively analysed data from all Crohn's disease surgical patients in a single colorect...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001206
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Small intestinal lesions in coeliac disease (CD) have a variable severity. Early diagnosis of CD is important because treatment allows a normal psycho-physical development, especially in children, and can avoid associated disorders. The aim of this study was to evaluate the predictive value of...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200012010-00010
更新日期:2000-01-01 00:00:00
abstract::Here we report two cases of inverted hyperplastic polyps of the colon. The first patient showed three inverted hyperplastic polyps in the ascending colon, one of which was associated with adenoma. We immunostained this adenoma-associated polyp using anti-beta-catenin antibody and found accumulation of beta-catenin in ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200401000-00016
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:Causes of small-bowel villous atrophy (VA) include coeliac disease (CD), its complications and other rare non-coeliac enteropathies. However, forms of VA of unknown aetiology may also exist. We defined them as idiopathic VA (IVA). To retrospectively classify the largest cohort of IVA patients and compare thei...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001726
更新日期:2020-08-01 00:00:00