Helicobacter pylori infection is unlikely to be transmitted between partners: evidence from genotypic study in partners of infected patients.

Abstract:

INTRODUCTION:We postulated that the oro-oral route of transmission between spouses could be an important route of transmission of Helicobacter pylori. AIMS:To estimate the prevalence of different genotypes of H. pylori as distinguished by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in our local population, and to compare the genotypes of H. pylori isolated from patients and their spouses. METHODS:Gastric biopsies were obtained from 183 dyspeptic patients during endoscopy. PCR for H. pylori was carried out using the uceC gene for amplification, and PCR products were digested further for RFLP analysis using the enzyme MboI. Spouses of H. pylori-positive index cases were screened for the infection using serological testing; if found to be positive serologically, endoscopy and gastric biopsies were performed for genotypic study of the micro-organism. For couples with indistinguishable H. pylori strain on RFLP with restriction endonuclease MboI, the process of RFLP was repeated with digestion of the PCR products using restriction endonuclease HhaI. RESULTS:We established our PCR technique to be 89.5% sensitive and 95.5% specific. Eighty-nine subjects were found to be H. pylori positive by PCR, and eight different genotypic strains were found according to our RFLP analysis. Two genotypes accounted for 80.8% of the cases. Sixteen of 31 spouses tested serologically for H. pylori were positive. All 13 spouses who agreed to undergo endoscopy were PCR positive for H. pylori. Five couples shared indistinguishable H. pylori genotypes, but this strain was also the commonest genotype in our local population, as based on RFLP with restriction endonuclease MboI. Further RFLP on the PCR products on these five couples using restriction endonucleases HhaI showed that the H. pylori isolated from these five couples were of different strains. CONCLUSION:The oro-oral route of transmission between spouses is unlikely to be an important mode for H. pylori infection.

authors

Luman W,Zhao Y,Ng HS,Ling KL

doi

10.1097/00042737-200205000-00009

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

521-8

issue

5

eissn

0954-691X

issn

1473-5687

journal_volume

14

pub_type

杂志文章
  • Prognostic significance of inflammation-based score in patients with hepatocellular carcinoma after liver transplantation.

    abstract:BACKGROUND:Recent studies have revealed that combining of the platelet to lymphocyte ratio (PLR) and the neutrophil to lymphocyte ratio (NLR) [(combination of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio (CNP)] links with dismal prognosis in diverse cancers. Here, we elucidated the prognostic significance ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000002037

    authors: Kong W,Qu E,Sheng N,Zhang J,Li X,Zheng J,Gao Y

    更新日期:2021-01-06 00:00:00

  • Impact of complementary and alternative medicine on the quality of life in inflammatory bowel disease: results from a French national survey.

    abstract:BACKGROUND:Complementary and alternative medicines (CAM) are widely used by patients with inflammatory bowel disease (IBD). Few data have been published on the impact of CAM on the quality of life (QOL). AIMS:The aim of the study was to describe CAM use in French patients with IBD, identify characteristics associated ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000040

    authors: Abitbol V,Lahmek P,Buisson A,Olympie A,Poupardin C,Chaussade S,Lesgourgues B,Nahon S

    更新日期:2014-03-01 00:00:00

  • Making the diagnosis of coeliac disease: is there a role for push enteroscopy?

    abstract::Coeliac disease is one of the most common genetically based diseases. The wide clinical spectrum of the disease and the availability of highly specific antibody testing have led to an increased number of patients undergoing gastroscopy with distal duodenal biopsies. Histological confirmation of the characteristic smal...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 评论,杂志文章

    doi:10.1097/00042737-200411000-00007

    authors: Frenz MB,Mee AS

    更新日期:2004-11-01 00:00:00

  • Postinfective bile acid malabsorption: is this a long-term condition?

    abstract:BACKGROUND:Postinfective bile acid malabsorption comprises a group of patients with a history of an episode of acute gastroenteritis triggering chronic diarrhoea. We identified these patients retrospectively from our medical records and assessed their long-term clinical course. MATERIALS AND METHODS:We examined the re...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283457ba6

    authors: Menon S,Jones BJ

    更新日期:2011-04-01 00:00:00

  • Clinical usefulness of K-ras gene mutation detection and cytology in pancreatic juice in the diagnosis and screening of pancreatic cancer.

    abstract:BACKGROUND:The significance of K-ras codon 12 mutation in pancreatic juice is still unclear. Although considerable controversy surrounds this question, the diagnostic utility of K-ras in patients with clinical suspicion of pancreatic cancer (PC) and in PC-risk patients remains unknown. OBJECTIVE:To study prospectively...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200110000-00006

    authors: Boadas J,Mora J,Urgell E,Puig P,Roca M,Cussó X,Capellà G,Lluís F,Farré A

    更新日期:2001-10-01 00:00:00

  • Prognostic factors in hepatocellular carcinoma patients undergoing transarterial chemoembolization and radioembolization: a retrospective study.

    abstract:OBJECTIVE:Most patients with hepatocellular carcinoma are diagnosed at intermediate or advanced stages (BCLC B or C) and undergo palliative local treatments such as transarterial chemoembolization or selective internal radiation therapy, also called radioembolization. In terms of liver function and tumor extent, stages...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001625

    authors: Jeliazkova P,Umgelter A,Braren R,Kaissis G,Mustafa M,Einwächter H

    更新日期:2020-08-01 00:00:00

  • Difficulty in walking 10 years after gastric surgery.

    abstract::A 65-year-old gentleman presented with a history of abdominal distension and difficulty in walking 10 years after a Polya partial gastrectomy. Clinical history and neurological examination suggested an axonal sensory neuropathy. A computed tomographic scan of the abdomen showed a large afferent jejunal loop, and a hyd...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328349d030

    authors: Lewis HI,Sen A,Cockerell CO,Greaves RR

    更新日期:2011-10-01 00:00:00

  • Five minute endoscopic urea breath test with 25 mg of (13)C-urea in the management of Helicobacter pylori infection.

    abstract:OBJECTIVE:The endoscopic (13)C-urea breath test ((13)C-EUBT), which combines the urea breath test (UBT) with endoscopy, provides high accuracy for the detection of Helicobacter pylori. This study was conducted to determine whether the (13)C-EUBT using low doses of urea and short sampling times could preserve accuracy i...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00042737-200210000-00010

    authors: Isomoto H,Inoue K,Shikuwa S,Furusu H,Nishiyama T,Omagari K,Mizuta Y,Murase K,Murata I,Enjoji A,Kanematsu T,Kohno S

    更新日期:2002-10-01 00:00:00

  • Enteral nutrition.

    abstract::This review summarizes research studies published in recent years that are useful for clinicians considering the enteral route as a means of nutritional support for their patients. In this period, there has been a move away from emphasis on what nutrients are given to a more considered appraisal of how nutrients are p...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:

    authors: Payne-James JJ

    更新日期:1995-06-01 00:00:00

  • Epidemiology of cancer from the oral cavity and oropharynx.

    abstract::The classification of sites in tumors of the oral cavity, oropharynx, pharynx, and hypopharynx varies in the literature. More than 90% of these tumors of the mucosal lining are classified as squamous cell carcinoma developed from premalignant lesions such as leukoplakia and erythroleukoplakia. These carcinomas are ass...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/MEG.0b013e3283484795

    authors: Lambert R,Sauvaget C,de Camargo Cancela M,Sankaranarayanan R

    更新日期:2011-08-01 00:00:00

  • Hepatitis C in a Mobile Low-Threshold Methadone Program.

    abstract:INTRODUCTION:Data on the epidemiology of hepatitis C among individuals who use drugs in low-threshold settings are lacking, although crucial to assess the burden of disease and aid in the design of treatment strategies. OBJECTIVE:The aim of this study was to characterize the epidemiology and disease related to hepatit...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000843

    authors: Silva MJ,Pereira C,Loureiro R,Balsa C,Lopes P,Água-Doce I,Belo E,Martins HC,Coutinho R,Pádua E

    更新日期:2017-06-01 00:00:00

  • Factors affecting abdominal pain during colonoscopy.

    abstract:OBJECTIVE:The actual degree of pain or discomfort experienced during colonoscopy varies between patients. This prospective study was conducted to determine what variables, apart from the endoscopist's skill, are associated with a patient's discomfort during this procedure. DESIGN/METHODS:From December 2003 to Septembe...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/01.meg.0000219097.32811.24

    authors: Park DI,Kim HJ,Park JH,Cho YK,Sohn CI,Jeon WK,Kim BI,Ryu SH,Sung IK

    更新日期:2007-08-01 00:00:00

  • Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis in chronic hepatitis C.

    abstract:OBJECTIVE:Blood tests are usually designed to identify significant fibrosis. We evaluated their diagnostic accuracy, and how to increase it, for the clinically important targets of severe fibrosis and cirrhosis. METHODS:The accuracy for severe fibrosis or cirrhosis of four blood tests was evaluated based on Metavir st...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究,评审

    doi:10.1097/MEG.0b013e32830cebd7

    authors: Boursier J,Bacq Y,Halfon P,Leroy V,de Ledinghen V,de Muret A,Bourlière M,Sturm N,Foucher J,Oberti F,Rousselet MC,Calès P

    更新日期:2009-01-01 00:00:00

  • One-week low-dose triple therapy for the eradication of Helicobacter pylori infection.

    abstract:OBJECTIVE:To evaluate the efficacy and safety of two 1-week low-dose triple therapy regimens for the treatment of Helicobacter pylori infection. PATIENTS AND METHODS:Eighty patients with H. pylori infection and peptic ulcer disease (n = 64) or functional dyspepsia (n = 16), with similar demographic and clinical charac...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Labenz J,Stolte M,Rühl GH,Becker T,Tillenburg B,Sollböhmer M,Börsch G

    更新日期:1995-01-01 00:00:00

  • First complete laparoscopic resection of a gangrenous falciform ligament.

    abstract::Surgical resection is the treatment of choice for patients with gangrene or an abscess of the falciform ligament. We describe the first complete laparoscopic resection of a gangrenous falciform ligament in a 44-year-old female patient with first signs and symptoms of peritonitis. ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32832b15f2

    authors: Czymek R,Bouchard R,Hollmann S,Kagel C,Frank A,Bruch HP,Buerk C

    更新日期:2010-01-01 00:00:00

  • Transcatheter arterial chemoembolization for hepatocellular carcinoma in cirrhosis: influence on portal hypertension.

    abstract:BACKGROUND:Transcatheter arterial chemoembolization (TACE) is a routine treatment for hepatocellular carcinoma in cirrhotic patients. Whether TACE influences the degree of portal hypertension remains uncertain. AIM AND PATIENTS: We retrospectively analyzed the clinical course of 283 TACE to investigate the incidence of...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32834701f5

    authors: Elia C,Venon WD,Stradella D,Martini S,Brunello F,Marzano A,Saracco G,Rizzetto M

    更新日期:2011-07-01 00:00:00

  • Nitric oxide--a mediator of inflammation or mucosal defence.

    abstract::Nitric oxide (NO) can exert both protective and proinflammatory actions in the gastrointestinal tract. NO, formed physiologically by constitutive NO synthases, regulates vascular tone, protects the microvasculature from injury, and modulates adhesion of inflammatory cells. In contrast, expression of an inducible isofo...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-199711000-00002

    authors: Whittle BJ

    更新日期:1997-11-01 00:00:00

  • Influence of biliary anastomosis on recovery from secondary biliary cirrhosis.

    abstract:OBJECTIVE:The influence of choledochoduodenostomy and choledochojejunostomy on the repair of hepatic lesions secondary to biliary obstruction is not well known. The aim of the present study was to compare the effects of choledochoduodenostomy and choledochojejunostomy on the recovery of these lesions in rats with bilia...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283551fed

    authors: dos Santos JS,Kemp R,de Andrade MF,Neder L

    更新日期:2012-09-01 00:00:00

  • Telomeres and telomerases: intimations of immortality.

    abstract::There is a constant balance in cancer cells between division and death. The malignant phenotype is associated with a continuing cell cycle or 'immortalization'. Telomeres, structures that cap the chromosomes, are related to cell longevity and are regulated by a ribonucleoprotein called telomerase. This review describe...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 评论,杂志文章

    doi:10.1097/00042737-200108000-00002

    authors: Crocker J

    更新日期:2001-08-01 00:00:00

  • Hyperuricemia is associated with nonalcoholic fatty liver disease activity score in patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis.

    abstract:BACKGROUND:Hyperuricemia is a significant risk factor for nonalcoholic fatty liver disease (NAFLD). It may also have an impact on the histologic severity of NAFLD. However, data on this association are limited. We conducted this meta-analysis to investigate the relationship of serum uric acid with liver histologic seve...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MEG.0000000000000931

    authors: Jaruvongvanich V,Ahuja W,Wirunsawanya K,Wijarnpreecha K,Ungprasert P

    更新日期:2017-09-01 00:00:00

  • Octreotide in the treatment of intestinal lymphangiectasia.

    abstract::Primary intestinal lymphangiectasia is characterized by dilated small bowel lymphatics and loss of lymph into the bowel lumen resulting in hypoproteinaemia and oedema. Some patients have a more generalized lymphatic abnormality associated with lymphoedema of the limbs and chylous pleural effusions. There is no specifi...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:

    authors: Ballinger AB,Farthing MJ

    更新日期:1998-08-01 00:00:00

  • The effect of hyperbaric oxygen therapy on the adverse effects of octreotide on wound healing.

    abstract:OBJECTIVE:Octreotide, a long-acting somatostatin analogue, has been used in the treatment of various disorders. Octreotide has significant detrimental impacts upon wound healing. We tested the hypothesis that hyperbaric oxygen therapy may overcome octreotide-mediated suppression of wound healing. DESIGN:Prospective, r...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200405000-00007

    authors: Yildiz S,Uluutku H,Gunay A,Yildirim I,Yildirim S,Gurbuz AK

    更新日期:2004-05-01 00:00:00

  • Successful prophylaxis with valaciclovir for relapsing HSV-1 in a girl treated with infliximab for moderate Crohn's disease.

    abstract::Biological agents such as inhibitors of tumour necrosis factor alpha (TNF-alpha ) are associated with the development of opportunistic infections. Although there are no international recommendations for the management of opportunistic infections, their prevention is a key safety issue for patients with inflammatory bo...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32831de271

    authors: Checchin D,Buda A,Sgarabotto D,Sturniolo GC,D' Incà R

    更新日期:2009-09-01 00:00:00

  • Long-term rifaximin therapy as a primary prevention of hepatorenal syndrome.

    abstract:BACKGROUND:Hepatorenal syndrome (HRS) is a severe complication of liver cirrhosis, with poor survival. Rifaximin is a gut-selective broad-spectrum antibiotic. AIM:The aim of this study was to evaluate the role of rifaximin as a primary prevention of HRS. PATIENTS AND METHODS:Eighty patients with liver cirrhosis and a...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MEG.0000000000000967

    authors: Ibrahim ES,Alsebaey A,Zaghla H,Moawad Abdelmageed S,Gameel K,Abdelsameea E

    更新日期:2017-11-01 00:00:00

  • Hyperbaric oxygen as a treatment for malabsorption in a radiation-damaged short bowel.

    abstract::Radiation enteritis can be challenging to diagnose and treat. We report the case of a 44-year-old woman who was diagnosed with a squamous cell carcinoma of the cervix in 1978 and treated with hysterectomy and post-operative radiotherapy. Over the next 20 years she required multiple intestinal operations resulting in s...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200606000-00017

    authors: Huddy JE,Patel P,Johnson MW,Hamilton-Farrell MR,Ede RJ,Sanderson JD

    更新日期:2006-06-01 00:00:00

  • One-week therapy with pantoprazole versus ranitidine bismuth citrate plus two antibiotics for Helicobacter pylori eradication.

    abstract:AIM:A combination of omeprazole plus amoxycillin (Amo) and clarithromycin (CIa) for 7 days has been studied extensively. However, the role of other proton pump inhibitors, such as pantoprazole (Pan), in this therapy is not well known. On the other hand, ranitidine bismuth citrate (RBC) also seems to be effective when c...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00042737-200012050-00003

    authors: Gisbert JP,Carpio D,Marcos S,Gisbert JL,García Grávalos R,Pajares JM

    更新日期:2000-05-01 00:00:00

  • Pancreatitis-associated protein has no additional value as a marker of disease activity in a real-life cohort of IBD patients.

    abstract:BACKGROUND AND AIM:Monitoring of mucosal inflammation in inflammatory bowel disease (IBD) is of major importance. New noninvasive markers for intestinal inflammation are needed. Previous studies have reported that pancreatitis-associated protein (PAP) correlates with clinical activity in IBD subgroups. Our aim was to i...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000141

    authors: Bodelier AG,Pierik MJ,van den Heuvel T,Bovee-Oudenhoven IM,de Boer E,Hameeteman W,Masclee AA,Jonkers D

    更新日期:2014-08-01 00:00:00

  • Novel drug therapies in inflammatory bowel disease.

    abstract::This paper reviews the published data on novel drug treatments for inflammatory bowel disease. Steroids that are topically active or rapidly metabolized have a definite therapeutic role and have fewer long-term side-effects than other steroids. Methotrexate can promote remission in approximately 50% of patients, but i...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:

    authors: Debinski HS,Kamm MA

    更新日期:1995-02-01 00:00:00

  • NUDT15 variant is the most common variant associated with thiopurine-induced early leukopenia and alopecia in Korean pediatric patients with Crohn's disease.

    abstract:PURPOSE:Thiopurine-induced leukopenia is a relatively common adverse event related to thiopurine medication in Korean pediatric Crohn's disease. In addition to the mutations of TPMT gene, the NUDT15 c.415C>T variant was recently identified to have a strong association with thiopurine-induced early leukopenia. We conduc...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000564

    authors: Lee YJ,Hwang EH,Park JH,Shin JH,Kang B,Kim SY

    更新日期:2016-04-01 00:00:00

  • Ambulatory seton placement followed by fistulotomy: efficacy and safety for perianal fistula treatment.

    abstract:PURPOSE:To evaluate the efficacy and safety of ambulatory seton placement followed by superficial fistulotomy as treatment of perianal fistula. METHODS:Retrospective observational analysis of patients with cryptogenic perianal fistula aged 18-90 years, followed in a central hospital proctology consultation between 200...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001913

    authors: Gamelas V,Simões G,Santos S,Loureiro R,Seves I,Costa Simões J,David Marques A,Bettencourt MJ

    更新日期:2020-09-09 00:00:00