Nitric oxide--a mediator of inflammation or mucosal defence.

Abstract:

:Nitric oxide (NO) can exert both protective and proinflammatory actions in the gastrointestinal tract. NO, formed physiologically by constitutive NO synthases, regulates vascular tone, protects the microvasculature from injury, and modulates adhesion of inflammatory cells. In contrast, expression of an inducible isoform of NO synthase, capable of producing excessive NO levels, is implicated in tissue injury. Such proinflammatory effects of NO, observed in epithelial and endothelial cells, may depend on degree of expression, as well as local environment, and involve further cytotoxic moities such as peroxynitrite. Therapeutic potential of selective inhibitors of NO formation is thus anticipated.

authors

Whittle BJ

doi

10.1097/00042737-199711000-00002

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

1026-32

issue

11

eissn

0954-691X

issn

1473-5687

journal_volume

9

pub_type

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