Short article: Hepatitis delta in patients with resolved hepatitis B virus infection.

Abstract:

BACKGROUND:The hepatitis delta virus (HDV) causes the most aggressive form of chronic viral hepatitis. As HDV replication requires hepatitis B virus (HBV), HDV screening is limited to HBsAg+ carriers. To date, individuals with HDV-antibodies and markers of resolved hepatitis B are considered cured. However, a subset shows elevated liver enzymes and hepatic fibrosis. Could they represent HBsAg-seronegative occult HDV infections? METHODS:We tested for HDV-antibodies 406 individuals with markers of past HBV exposure. RESULTS:Overall, 20 (4.9%) were reactive for HDV-antibodies. All were negative for serum HDV-RNA, including four with elevated liver enzymes. CONCLUSION:These results support the current policy of screening for hepatitis delta only in HBsAg+ individuals.

authors

Aguilera A,Rodríguez-Calviño J,de Mendoza C,Soriano V

doi

10.1097/MEG.0000000000001187

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

1063-1065

issue

9

eissn

0954-691X

issn

1473-5687

journal_volume

30

pub_type

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