When is a herb a drug?

Abstract:

:With the growing popularity and use of herbal remedies in the industrial countries there has been an increasing recognition and reporting of adverse reactions. Drug development represents discovery and characterization of naturally occurring plant metabolites or their synthetic analogues. Therefore, a herbal remedy should be considered a drug for all clinical purposes. The liver, being central to the metabolism of virtually all xenobiotics, is inevitably exposed to reactive metabolites and liver injury is a potential complication of nearly every medication, including herbal remedies. Recognition of herb induced hepatotoxicity depends on clinical awareness of the problem, a suspicion that a herbal preparation is involved, and detailed enquiry regarding the use of all supplements and remedies. Herbal medicines should be regulated more systematically and monitoring for adverse reaction should improve.

authors

Aithal GP

doi

10.1097/00042737-200504000-00001

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

391-3

issue

4

eissn

0954-691X

issn

1473-5687

pii

00042737-200504000-00001

journal_volume

17

pub_type

杂志文章
  • Glucocorticoids can increase the survival rate of patients with severe viral hepatitis B: a meta-analysis.

    abstract:OBJECTIVES:Severe viral hepatitis B is a disease associated with significant morbidity and mortality. Clinical controlled trials show that the efficacy of treatment of severe viral hepatitis B with glucocorticoids remains debatable. Therefore, we carried out this meta-analysis to evaluate the safety, efficacy, and side...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MEG.0b013e32835f4cbd

    authors: He B,Zhang Y,Lü MH,Cao YL,Fan YH,Deng JQ,Yang SM

    更新日期:2013-08-01 00:00:00

  • Defining a proper setting for endoscopy in coeliac disease.

    abstract:OBJECTIVE:As it has been demonstrated that a careful duodenal inspection during upper gastrointestinal endoscopy may be useful in predicting coeliac disease, we tried to define the usefulness of endoscopy in detecting unsuspected coeliac patients. DESIGN AND METHODS:We considered all the first diagnoses of coeliac dis...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200306000-00015

    authors: Vjero K,Martucci S,Alvisi C,Broglia F,Viera FT,Perego M,Corazza GR

    更新日期:2003-06-01 00:00:00

  • Tuberculous peritonitis--reports of 26 cases, detailing diagnostic and therapeutic problems.

    abstract:OBJECTIVE:To evaluate the clinical presentation, biochemical (ascites and serum) and laparoscopic findings, and to assess the efficacy of triple antituberculous therapy without rifampicin for 6 months in patients with tuberculous peritonitis. METHODS:Twenty-six tuberculous peritonitis patients (11 male, 15 female) wit...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200105000-00019

    authors: Demir K,Okten A,Kaymakoglu S,Dincer D,Besisik F,Cevikbas U,Ozdil S,Bostas G,Mungan Z,Cakaloglu Y

    更新日期:2001-05-01 00:00:00

  • Gallstone disease in an elderly population: the Silea study.

    abstract:BACKGROUND:Little is known on gallbladder emptying and gallstone composition in the elderly. AIMS AND SUBJECTS: Cross-sectional survey on the prevalence of gallstone disease and associated factors, gallstone characteristics and gallbladder emptying in a population aged > or = 60 years. METHODS:Gallstone number and siz...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199905000-00004

    authors: Lirussi F,Nassuato G,Passera D,Toso S,Zalunardo B,Monica F,Virgilio C,Frasson F,Okolicsanyi L

    更新日期:1999-05-01 00:00:00

  • In-vivo effect of nicotine on cytokine production by human non-adherent mononuclear cells.

    abstract:OBJECTIVE:Ulcerative colitis (UC) is predominantly a disease of non-smokers and treatment with transdermal nicotine improves symptoms in UC patients, whereas smoking seems to have a deleterious effect in patients with Crohn's disease (CD). In CD the cytokine profile is of a dominant TH1 (T helper 1) pattern whereas in ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199610000-00016

    authors: Madretsma S,Wolters LM,van Dijk JP,Tak CJ,Feyerabend C,Wilson JH,Zijlstra FJ

    更新日期:1996-10-01 00:00:00

  • Proton pump inhibitors reduce phlebotomy burden in patients with HFE-related hemochromatosis: a systematic review and meta-analysis.

    abstract:BACKGROUND AND AIMS:Proton pump inhibitors (PPIs) may reduce iron absorption and serum ferritin levels in patients with homeostatic iron regulator (HFE)-related hemochromatosis, reducing the need for frequent phlebotomies. Our study aimed to perform for the first time a meta-analysis of existing observational and rando...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001857

    authors: Dirweesh A,Anugwom CM,Li Y,Vaughn BP,Lake J

    更新日期:2020-08-04 00:00:00

  • Ethnic variation in colorectal cancer risk following a positive faecal occult blood test in an English bowel cancer screening programme centre.

    abstract:BACKGROUND AND AIMS:The literature on colorectal cancer (CRC) screening and ethnic diversity is dominated by studies from the USA. There are no such published data from the UK bowel cancer screening programme (BCSP) population. The Wolverhampton Bowel Cancer Screening Centre serves a population of 900,000 in the Black ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000443

    authors: Padmanabhan H,Widlak M,Nevill A,McKaig B,Brookes M,Veitch A

    更新日期:2015-11-01 00:00:00

  • Ascitic calprotectin for the diagnosis of spontaneous bacterial peritonitis: a systematic review and meta-analysis.

    abstract::Calprotectin is a promising diagnostic biomarker for spontaneous bacterial peritonitis (SBP) among cirrhotic patients, but published studies report a wide variation of its diagnostic accuracy. We systematically searched six databases for eligible studies (i.e., all original studies that reported ascitic calprotectin a...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001709

    authors: Dibas M,Rajab AM,Zaghloul MS,Atiah MJ,Aljundi S,Amir A,Saquib N

    更新日期:2020-09-01 00:00:00

  • Resolution of a complex mediastinal pseudocyst in a patient with alcohol-related chronic pancreatitis following abstinence from alcohol.

    abstract::We describe a 55-year-old patient with alcoholic chronic pancreatitis, a large mediastinal pseudocyst and a hemorrhagic pleural effusion. A single thoracocentesis and withdrawal of alcohol without other conservative or invasive measures resulted in a complete resolution of the pleural effusion and the mediastinal pseu...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200601000-00020

    authors: Groeneveld JH,Tjong A Lieng JG,de Meijer PH

    更新日期:2006-01-01 00:00:00

  • Paroxysmal nocturnal hemoglobinuria and Budd-Chiari syndrome: therapeutic challenge with bone marrow transplantation, transjugular intrahepatic portosystemic shunt, and vena cava stent.

    abstract::Stenosis of inferior vena cava can be a cause of or a consequence of Budd-Chiari syndrome (BCS). However, its occurrence after transjugular intrahepatic portosystemic shunt (TIPS) insertion has only been twice reported. We report the case of a 23-year-old man who presented BCS of the three suprahepatic veins. The caus...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200504000-00011

    authors: Vergniol J,Laharie D,Drouillard J,Etienne G,Pigneux A,Plessier A,Couzigou P,de Lédinghen V

    更新日期:2005-04-01 00:00:00

  • An interval report on prospective investigation of adjustable silicone gastric banding devices for the treatment of severe obesity.

    abstract::A review and updated report of an ongoing prospective investigation of two different adjustable silicone gastric banding devices is presented. One cohort of this study includes 40 subjects who have had a band placed by laparotomy. A second cohort includes 22 subjects who have had a newly designed adjustable silicone g...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199902000-00010

    authors: Doherty C,Maher JW,Heitshusen DS

    更新日期:1999-02-01 00:00:00

  • Serological prevalence of hepatitis B virus and hepatitis C virus infection in the elderly population: Polish nationwide survey--PolSenior.

    abstract:BACKGROUND:The hepatitis B virus (HBV) and hepatitis C virus (HCV) infections may seriously affect survival rate. The median length of life in developed countries is increasing and the elderly may be considered as an epidemiologically distinct group due to higher whole-life risk of blood-borne viral infections. AIM:To...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MEG.0b013e328357632a

    authors: Hartleb M,Gutkowski K,Zejda JE,Chudek J,Więcek A

    更新日期:2012-11-01 00:00:00

  • Leukotriene receptor antagonism in experimental acute pancreatitis in rats.

    abstract:OBJECTIVES:Acute pancreatitis is a multifactorial disease caused by activation of several inflammatory mediators. Leukotrienes, beside other mediators, may be involved in acute pancreatitis. The aim of this study was to investigate the effects of 'zafirlukast', a leukotriene receptor antagonist, in acute pancreatitis a...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200404000-00003

    authors: Oruc N,Yukselen V,Ozutemiz AO,Yuce G,Celik HA,Musoglu A,Batur Y

    更新日期:2004-04-01 00:00:00

  • Improving diagnostic yield in obscure gastrointestinal bleeding--how virtual chromoendoscopy may be the answer.

    abstract:BACKGROUND AND AIM:A significant proportion of patients presenting with obscure gastrointestinal bleeding (OGIB) have negative small bowel capsule endoscopy (SBCE) examinations, and yet remain at risk of rebleeding. We aimed to evaluate whether a second-look review of SBCE images using flexible spectral color enhanceme...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000358

    authors: Dias de Castro F,Magalhães J,Boal Carvalho P,Cúrdia Gonçalves T,Rosa B,Moreira MJ,Cotter J

    更新日期:2015-06-01 00:00:00

  • Results of a second examination of the right side of the colon in screening and surveillance colonoscopy: a systematic review and meta-analysis.

    abstract:BACKGROUND:Screening colonoscopy is less effective in preventing proximal colon cancers than distal colon cancers. A repeat examination of the right side of the colon may increase the lesion detection. The study aimed to assess the results of a second examination of the right side of the colon with forward-view or retr...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MEG.0000000000001009

    authors: Ai X,Qiao W,Han Z,Tan W,Bai Y,Liu S,Zhi F

    更新日期:2018-02-01 00:00:00

  • Novel drug therapies in inflammatory bowel disease.

    abstract::This paper reviews the published data on novel drug treatments for inflammatory bowel disease. Steroids that are topically active or rapidly metabolized have a definite therapeutic role and have fewer long-term side-effects than other steroids. Methotrexate can promote remission in approximately 50% of patients, but i...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:

    authors: Debinski HS,Kamm MA

    更新日期:1995-02-01 00:00:00

  • Deoxycholic acid stimulates migration in colon cancer cells.

    abstract:BACKGROUND:Deoxycholic acid and other secondary bile acids have long been considered tumour promoters in the colon. However, their effect on cell migration, known to play an important role in colon carcinogenesis, has not been studied so far. OBJECTIVE:To investigate the possible effects of deoxycholic acid on colon c...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200108000-00012

    authors: Milovic V,Teller IC,Murphy GM,Caspary WF,Stein J

    更新日期:2001-08-01 00:00:00

  • Octreotide in the treatment of intestinal lymphangiectasia.

    abstract::Primary intestinal lymphangiectasia is characterized by dilated small bowel lymphatics and loss of lymph into the bowel lumen resulting in hypoproteinaemia and oedema. Some patients have a more generalized lymphatic abnormality associated with lymphoedema of the limbs and chylous pleural effusions. There is no specifi...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:

    authors: Ballinger AB,Farthing MJ

    更新日期:1998-08-01 00:00:00

  • Immunosuppressive treatment for refractory ulcerative colitis--where do we stand and where are we going?

    abstract::Effective medical treatment of ulcerative colitis is available. However, 20-40% of patients remain refractory and become steroid dependent, or have chronic activity. Azathioprine and its metabolite 6-mercaptopurine have been found to be effective in this setting, although duration of treatment and doses are not entire...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-199709000-00004

    authors: Schölmerich J

    更新日期:1997-09-01 00:00:00

  • Genetic susceptibility to primary biliary cirrhosis.

    abstract::Family studies suggest that genetic factors play a role in determining susceptibility to primary biliary cirrhosis (PBC). A number of polymorphic genes with small and additive effects may thus encode factors predisposing to this 'polygenic' disease. All the published data on genetic predisposition to PBC have been obt...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-199906000-00004

    authors: Agarwal K,Jones DE,Bassendine MF

    更新日期:1999-06-01 00:00:00

  • Liver transplantation for intractable pruritus is contraindicated before an adequate trial of opiate antagonist therapy.

    abstract::A woman with stage III (pre-cirrhotic) primary biliary cirrhosis was referred for liver transplantation because of intractable pruritus. Oral administration of 50 mg naltrexone precipitated a severe opioid withdrawal-like reaction. Subsequently, when oral naltrexone therapy was reintroduced following a cautious infusi...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200111000-00022

    authors: Neuberger J,Jones EA

    更新日期:2001-11-01 00:00:00

  • Prospective evaluation of a clinical score for 60-day mortality after transjugular intrahepatic portosystemic stent-shunt: Bonn TIPSS early mortality analysis.

    abstract:OBJECTIVE:Transjugular intrahepatic portosystemic stent-shunt (TIPSS) is increasingly used to treat complications of portal hypertension, but proven tools for risk assessment of early mortality are lacking. DESIGN:The prospective evaluation of a new 60-day mortality score. PATIENTS AND METHODS:In a tertiary medical c...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200207000-00003

    authors: Brensing KA,Raab P,Textor J,Görich J,Schiedermaier P,Strunk H,Paar D,Schepke M,Sudhop T,Spengler U,Schild H,Sauerbruch T

    更新日期:2002-07-01 00:00:00

  • The association between physical activity and the risk of symptomatic Barrett's oesophagus: a UK prospective cohort study.

    abstract:BACKGROUND:Physical activity affects the functioning of the gastrointestinal system through both local and systemic effects and may play an important role in the aetiology of gastroesophageal reflux disease, Barrett's oesophagus and oesophageal adenocarcinoma. We investigated, for the first time in a large prospective ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000998

    authors: Lam S,Alexandre L,Luben R,Hart AR

    更新日期:2018-01-01 00:00:00

  • Effects of intraluminal local anesthetic on upper gastrointestinal motor, sensory, and peptide hormone responses to intraduodenal glucose.

    abstract:OBJECTIVE:Enterally administered glucose modifies gut sensation, diminishes hunger, and slows gastric emptying by suppressing antral motility and stimulating pyloric pressures. We aimed to clarify the mechanism of small intestinal glucose sensing. METHODS:We studied eight healthy males twice, in random order. An antro...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283200073

    authors: Chaikomin R,Jones KL,Feinle-Bisset C,Meyer JH,Horowitz M,Rayner CK

    更新日期:2009-03-01 00:00:00

  • NUDT15 variant is the most common variant associated with thiopurine-induced early leukopenia and alopecia in Korean pediatric patients with Crohn's disease.

    abstract:PURPOSE:Thiopurine-induced leukopenia is a relatively common adverse event related to thiopurine medication in Korean pediatric Crohn's disease. In addition to the mutations of TPMT gene, the NUDT15 c.415C>T variant was recently identified to have a strong association with thiopurine-induced early leukopenia. We conduc...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000564

    authors: Lee YJ,Hwang EH,Park JH,Shin JH,Kang B,Kim SY

    更新日期:2016-04-01 00:00:00

  • The microbiology of necrotizing pancreatitis and its impact on in-hospital and 1-year all-cause mortality.

    abstract:BACKGROUND/OBJECTIVES:The data regarding the microbial spectrum in necrotizing pancreatitis and its impact on mortality is limited. Therefore, in this study, we aimed to investigate the agents identified in cultures and their impact on in-hospital and 1-year all-cause mortality. METHODS:Patients with necrotizing pancr...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001687

    authors: Biberci Keskin E,Okay G,Muhiddin D,Sharif R,Taşlidere B,Şentürk H

    更新日期:2020-06-01 00:00:00

  • Prognostic factors in hepatocellular carcinoma patients undergoing transarterial chemoembolization and radioembolization: a retrospective study.

    abstract:OBJECTIVE:Most patients with hepatocellular carcinoma are diagnosed at intermediate or advanced stages (BCLC B or C) and undergo palliative local treatments such as transarterial chemoembolization or selective internal radiation therapy, also called radioembolization. In terms of liver function and tumor extent, stages...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001625

    authors: Jeliazkova P,Umgelter A,Braren R,Kaissis G,Mustafa M,Einwächter H

    更新日期:2020-08-01 00:00:00

  • Diagnostic and prognostic values of critical flicker frequency determination as new diagnostic tool for objective HE evaluation in patients undergoing TIPS implantation.

    abstract:OBJECTIVES:The diagnostic and prognostic value of critical flicker frequency (CFF) analysis for assessment of severity and dynamics of hepatic encephalopathy (HE) was studied before and after implantation of a transjugular intrahepatic portosystemic shunt (TIPS). BASIC METHODS:Sixty-three cirrhotic patients were retro...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328310e0c3

    authors: Kircheis G,Bode JG,Hilger N,Kramer T,Schnitzler A,Häussinger D

    更新日期:2009-12-01 00:00:00

  • Five minute endoscopic urea breath test with 25 mg of (13)C-urea in the management of Helicobacter pylori infection.

    abstract:OBJECTIVE:The endoscopic (13)C-urea breath test ((13)C-EUBT), which combines the urea breath test (UBT) with endoscopy, provides high accuracy for the detection of Helicobacter pylori. This study was conducted to determine whether the (13)C-EUBT using low doses of urea and short sampling times could preserve accuracy i...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00042737-200210000-00010

    authors: Isomoto H,Inoue K,Shikuwa S,Furusu H,Nishiyama T,Omagari K,Mizuta Y,Murase K,Murata I,Enjoji A,Kanematsu T,Kohno S

    更新日期:2002-10-01 00:00:00

  • Transforming growth factor betas and their receptors in human liver cirrhosis.

    abstract:BACKGROUND:Transforming growth factor betas (TGF-betas) are a group of homologous polypeptides that exert pleiotropic effects on various cell types and stimulate the formation of extracellular matrix and fibrosis. To evaluate whether TGF-beta isoforms (TGF-beta1, TGF-beta2 and TGF-beta3) and their receptors (types I-II...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199812000-00009

    authors: Baer HU,Friess H,Abou-Shady M,Berberat P,Zimmermann A,Gold LI,Korc M,Büchler MW

    更新日期:1998-12-01 00:00:00