Abstract：
BACKGROUND AND AIMS:The PGAA index was one of the first composite liver fibrosis markers. This study aims, prospectively, to confirm the diagnostic value of PGAA and Fibrotest in patients with alcoholic liver disease and to compare their diagnostic performances. PATIENTS AND METHODS:We prospectively included 200 consecutive patients (159 men and 41 women; mean age: 51±0.7 years).The PGAA index was calculated by combining the results of four laboratory tests (prothrombin time, γ-glutamyl transpeptidase, apolipoprotein A1, and α-2-macroglobulin) scored on a 0-4 scale. The Fibrotest score was computed using the Biopredictive website. The overall diagnostic performances of scores were evaluated in terms of the area under the receiver operating characteristic (AUROC) curve. The Obuchowski measure was assessed taking into account the distribution of fibrosis stages observed in the cohort. RESULTS:For predicting F≥2 fibrosis stage, the AUROC curves of PGAA and Fibrotest were 0.83±0.03 and 0.80±0.03, respectively. For predicting F4 fibrosis stage, the AUROC curves of PGAA and Fibrotest were 0.87±0.03 and 0.86±0.03. There was no difference between the AUROC curves of PGAA and Fibrotest. The Obuchowski measure was 0.92±0.01 for PGAA and Fibrotest. For a value of 10, PGAA had 98% specificity and 97% positive predictive value for the detection of F≥2 fibrosis stage and 80% sensitivity and 92% negative predictive value for F4 stage fibrosis. CONCLUSION:We confirm the comparable diagnostic values of Fibrotest and PGAA. When Fibrotest use is constrained by an increase in unconjugated bilirubin or is not financially viable, PGAA may be an alternative.
journal_name
Eur J Gastroenterol Hepatoljournal_title
European journal of gastroenterology & hepatologyauthors
Naveau S,Essoh BM,Ghinoiu M,Marthey L,Njiké-Nakseu M,Balian A,Lachgar M,Prévot S,Perlemuter Gdoi
10.1097/MEG.0000000000000041subject
Has Abstractpub_date
2014-04-01 00:00:00pages
404-11issue
4eissn
0954-691Xissn
1473-5687journal_volume
26pub_type
杂志文章abstract：OBJECTIVES:The aims of this study were to investigate the expression of cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) in chronic hepatitis C (CHC) by immunohistochemistry, based on the hypothesis that COXs expression could vary according to genotype, viral load, liver steatosis, BMI and response to therapy an...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e3282f01e91
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVES:Sacral nerve stimulation (SNS) may provide long-term symptom relief to patients suffering from chronic constipation. Patients are currently selected for SNS using a 2-week peripheral nerve evaluation (PNE) comprising stimulation by temporary leads. However, only 40% of test responders receive long-term benef...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,随机对照试验
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更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:Minimal hepatic encephalopathy (MHE) impairs daily functioning and health-related quality of life (HRQoL). The modalities of treatment of MHE have not been adequately studied. AIMS:To compare lactulose, probiotics, and L-ornithine L-aspartate (LOLA) in treatment of MHE and effect on HRQoL by Sickness Impact...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,随机对照试验
doi：10.1097/MEG.0b013e32834696f5
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND AND AIMS:The role of thyroid function in the portal hypertension development and prognosis remains unclear. This study aimed to investigate the correlation between serum-free triiodothyronine (fT3) levels and the outcomes of cirrhotic portal hypertension. METHODS:A total of 385 cirrhotic patients with confi...
journal_title：European journal of gastroenterology & hepatology
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abstract：BACKGROUND:As life expectancy rises worldwide and the prevalence of gallstones increases with age, the number of very elderly patients requiring treatment for gallstone diseases is increasing. The aim of this study was to compare the results of cholecystectomy in patients 80 years or older according to different clinic...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e32835b7124
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abstract：AIM:Screening by means of faecal occult blood testing (FOBT) has proved to be effective in reducing colorectal cancer incidence and mortality. We performed a pilot screening for colorectal cancer by latex immunological FOBT in two municipalities of the region Valle d'Aosta, Italy, focusing on problems and obtaining ind...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-200401000-00006
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abstract：:Intestinal lymphangiectasia is a rare condition, which is characterized by the dilation of small bowel lymphatics and presents with signs and symptoms of protein-losing enteropathy. Some patients have complained of occlusive symptoms attributable to the mechanical obstruction caused by the considerable mucosal edema a...
journal_title：European journal of gastroenterology & hepatology
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doi：10.1097/MEG.0b013e3282f5dda4
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abstract：OBJECTIVE:Pregnant women often suffer from gastroesophageal reflux disease (GERD). GERD symptoms are known to influence the quality of life; however, there is a lack of data in pregnant women. The aim of this study was to establish the impact of GERD symptoms on health-related quality of life (HRQOL) during pregnancy. ...
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pub_type： 杂志文章,评审
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更新日期：2005-04-01 00:00:00
abstract：OBJECTIVES:Several trials have demonstrated that oral delayed-release mesalamine might be administered once daily. We aimed to conduct a meta-analysis to investigate this. METHODS:A comprehensive and multiple-source literature search was carried out. Only randomized-controlled trials (RCTs) were investigated by compar...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,meta分析
doi：10.1097/MEG.0b013e328350fc81
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:Liver steatosis (LS) and chronic infection with hepatitis B virus (HBV) are two common causes of chronic liver disease in Iran. LS is also a common histopathological feature of chronic hepatitis B (CHB). Association of chronic HBV infection and LS has not been extensively studied. AIM:We investigated the pr...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
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更新日期：2009-05-01 00:00:00
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journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
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更新日期：1996-10-01 00:00:00
abstract：AIM:To assess the safety and efficacy of percutaneous radiofrequency thermal ablation (RFA) in the treatment of nonsurgical hepatocellular carcinoma (HCC) in daily practice.
METHODS:A total of 63 consecutive patients with HCC (solitary nodule journal_title：European journal of gastroenterology & hepatology pub_type： 杂志文章 doi：10.1097/MEG.0b013e3282f1cc4a 更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:Early detection and treatment is important for the management of colorectal cancer (CRC). AIM:To assess patient and doctor delay and their determinants. METHODS:A retrospective observational study in a primary care setting concerning 197 patients with CRC. The time between initial symptoms and the onset of...
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pub_type： 杂志文章
doi：10.1097/MEG.0b013e32834c4839
更新日期：2011-11-01 00:00:00
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journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e32835ddb85
更新日期：2013-06-01 00:00:00
abstract：:Ulcerative colitis (UC) is a lifelong disease. Patients with UC have an approximately 20% risk of developing colorectal cancer. The risk of neoplasia increases with the duration of the disease. Why some patients develop colorectal cancer and others do not is still poorly understood. UC patients who develop cancer have...
journal_title：European journal of gastroenterology & hepatology
pub_type： 评论,杂志文章,评审
doi：10.1097/00042737-200602000-00001
更新日期：2006-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1097/MEG.0b013e32825a6ab4
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journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
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更新日期：2004-09-01 00:00:00
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journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,评审
doi：10.1097/00042737-200505000-00006
更新日期：2005-05-01 00:00:00
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journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-199908002-00006
更新日期：1999-08-01 00:00:00
abstract：OBJECTIVES:Many individuals previously diagnosed with chronic hepatitis C virus (HCV) infection are likely to be lost to medical follow-up and, therefore, remain untreated despite new highly effective drug treatment, direct acting antivirals. We aim to identify and retrieve these chronic HCV-infected individuals to re-...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000001593
更新日期：2020-07-01 00:00:00
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journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
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更新日期：2015-03-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2017-03-01 00:00:00
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journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000001123
更新日期：2018-08-01 00:00:00
abstract：:Prophylactic antibiotics have been recommended in patients with a previous history of spontaneous bacterial peritonitis (SBP). Recently, there has been interest in the use of rifaximin for the prevention of SBP and hepatorenal syndrome (HRS). We conducted a meta-analysis to evaluate this association of rifaximin. We s...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,meta分析,评审
doi：10.1097/MEG.0000000000000940
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Faecal microbiota transplantation (FMT) is currently being established as a second-line treatment for recurrent Clostridium difficile infection. FMT is further being considered for other infectious and inflammatory conditions. Safe and reproducible methods for donor screening, laboratory processing and clini...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000000958
更新日期：2017-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the effects of transcutaneous electrical nerve stimulation (TENS) on intraductal biliary pressure (IDP) in basal conditions and after intravenous morphine and oral meal stimulation. DESIGN AND METHODS:Fifteen patients (5 male, 10 female) aged 31-83 years (mean 61.5 +/- 13.7 years) with prior chol...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-200301000-00005
更新日期：2003-01-01 00:00:00
