Abstract:
BACKGROUND:The immunoreactivity of methionine-enkephalin (Met-enkephalin), one of the endogenous opioid peptides, is expressed in the liver in different types of chronic diseases. This finding suggests that the liver may be a source of endogenous opioids in disease state. In-vitro studies have shown that morphine, which exerts its effect by binding to opioid receptors, enhances hepatitis C virus replication and that it interferes with the antiviral effects of interferon. Thus, it was hypothesized that liver-derived endogenous opioids, which also bind to opioid receptors, may interfere with the response to antiviral therapy with interferon. AIM:To correlate the expression of Met-enkephalin immunoreactivity (MEIR) in the liver of patients with chronic hepatitis C with their response to treatment with pegylated interferon and ribavirin. METHODS:We sought to investigate the expression of the immunoreactivities of Met-enkephalin and of the δ-opioid receptor 1 (DOR1), to which Met-enkephalin binds, preferentially, in liver samples from 23 patients with chronic hepatitis C who had undergone antiviral therapy. Twelve patients obtained a sustained virological response, and 11 patients were relapsers after or nonresponders to treatment. Among the 12 patients with sustained virological response, one patient (8.3%) expressed MEIR and another one expressed DOR1 immunoreactivity (8.3%), whereas none of the patients expressed both immunoreactivities. Among the group of nonresponders/relapsers, one patient expressed MEIR (9%), two patients expressed DOR1 immunoreactivity (18.2%), and seven patients expressed both (63.6%). The difference between responders and nonresponders in the expression of both immunoreactivities was significantly different (P<0.001). CONCLUSION:Our data are in favor of the hypothesis that enhanced expression of MEIR and DOR1 immunoreactivity correlates with poor response to antiviral therapy that includes interferon. Thus, this study provides a rationale to study the effect of opiate antagonists in combination with antiviral therapy with interferon and ribavirin in patients who express MEIR in the liver and who have not responded to or who have relapsed after treatment with those antiviral medications.
journal_name
Eur J Gastroenterol Hepatoljournal_title
European journal of gastroenterology & hepatologyauthors
Floreani A,Antoniazzi S,Mescoli C,Bergasa NVdoi
10.1097/MEG.0b013e3283509197subject
Has Abstractpub_date
2012-04-01 00:00:00pages
427-30issue
4eissn
0954-691Xissn
1473-5687journal_volume
24pub_type
杂志文章abstract:BACKGROUND:Survival of Helicobacter pylori is dependent upon urease in the cytoplasm and at the bacterial surface. We have sought to clarify how alkaline ammonium salts, released from urea by this enzyme, might alter mucus pH and so affect growth and motility of the bacterium in the gastric mucus environment. METHODS:...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200304000-00010
更新日期:2003-04-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e328332d2dd
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abstract:BACKGROUND:Hepatorenal syndrome (HRS) is a severe complication of liver cirrhosis, with poor survival. Rifaximin is a gut-selective broad-spectrum antibiotic. AIM:The aim of this study was to evaluate the role of rifaximin as a primary prevention of HRS. PATIENTS AND METHODS:Eighty patients with liver cirrhosis and a...
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pub_type: 杂志文章,随机对照试验
doi:10.1097/MEG.0000000000000967
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:To investigate the prevalence of Helicobacter pylori in patients with erosive oesophagitis in comparison with asymptomatic subjects. DESIGN:Hospital based case-control study. METHODS:Two hundred and nineteen consecutive patients with erosive oesophagitis diagnosed over 2 years were studied. Patients with s...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199806000-00005
更新日期:1998-06-01 00:00:00
abstract::We describe two cases of oesophageal intramural pseudo-diverticulosis associated with a cervical oesophageal web presenting as intermittent dysphagia. In both cases, disruption of the web endoscopically resulted in lasting relief from symptoms. This observation, together with a review of the literature written during ...
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doi:10.1097/00042737-199911000-00026
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,多中心研究
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更新日期:2012-07-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2008-11-01 00:00:00
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更新日期:2005-05-01 00:00:00
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更新日期:2010-09-01 00:00:00
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更新日期:2003-12-01 00:00:00
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更新日期:2017-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1097/MEG.0000000000000492
更新日期:2016-01-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e3283464111
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:Patients with liver cirrhosis have a high prevalence of gastrointestinal symptoms. The use of antiacid therapy (AAT) in these patients is unexplored. We aimed to assess the use of AAT in cirrhotic patients. METHODS:A total of 128 consecutive cirrhotic patients were evaluated for the use of and indications f...
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pub_type: 杂志文章
doi:10.1097/MEG.0b013e3282f4aa01
更新日期:2008-06-01 00:00:00
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doi:
更新日期:1995-03-01 00:00:00
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更新日期:2017-09-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,评审
doi:10.1097/00042737-199909000-00002
更新日期:1999-09-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
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doi:10.1097/00042737-200404000-00003
更新日期:2004-04-01 00:00:00
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更新日期:2004-10-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,meta分析,评审
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更新日期:2007-12-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1097/00042737-199906000-00004
更新日期:1999-06-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199803000-00011
更新日期:1998-03-01 00:00:00
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更新日期:2010-03-01 00:00:00
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更新日期:2020-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00