Effect of Helicobacter pylori eradication on the healing and recurrence of peptic ulcer: combination therapy with low-dose omeprazole and clarithromycin.

Abstract:

AIM:To investigate the effect of eradication of Helicobacter pylori using combination therapy with low-dose omeprazole and clarithromycin on the healing and recurrence of peptide ulcers. PATIENTS AND METHODS:We studied 60 patients with active duodenal ulcers and 60 with gastric ulcers who were H. pylori-positive by the rapid urease test and a histological examination of antral biopsy specimens. The eradication method used was a combination of omeprazole (20 mg a day) and clarithromycin (400 mg twice a day). The patients were followed up for 24 months after the end of the treatment. H. pylori infection and the ulcer stage were investigated by endoscopy every 6 months. We assessed the relationship between H. pylori infection, ulcer healing to a white scar and ulcer recurrence after combination therapy. RESULTS:H. pylori was eradicated in 23 out of 120 patients (22%), with suppression in 101 out of 120 patients (84%). The rate of ulcer healing to a white scar 6 months after treatment was significantly higher and the ulcer recurrence rate within 2 years after treatment was significantly lower in patients with H. pylori suppression or eradication than in those continuously positive for the organism. CONCLUSIONS:These results suggest that not only the eradication but also the suppression of H. pylori may improve ulcer healing and reduce the rate of relapse.

authors

Uemura N,Okamoto S,Mukai T,Yamaguchi S,Kaji M,Hrruma K,Sumii K,Kajiyama G

subject

Has Abstract

pub_date

1995-08-01 00:00:00

pages

S67-9

eissn

0954-691X

issn

1473-5687

journal_volume

7 Suppl 1

pub_type

临床试验,杂志文章
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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    更新日期:1999-08-01 00:00:00

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    更新日期:2002-09-01 00:00:00

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    pub_type: 杂志文章

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    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001044

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    更新日期:2018-04-01 00:00:00

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    pub_type: 杂志文章,多中心研究

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