Implementation of a guideline versus use of individual prognostic factors to prioritize waiting lists for upper gastrointestinal endoscopy.

Abstract:

BACKGROUND:Studying factors associated with positive gastroscopies in dyspeptic patients can help limit and rationalize waiting lists for endoscopies. Dyspepsia guidelines have a controversial role because their main purpose is to provide specifications on efficient global management of primary care patients. AIM:To assess and weigh the risk of major endoscopic diagnoses against different age groups, gender, Helicobacter pylori infection, compliance with European Society of Primary Care Gastroenterology (ESPCG) guideline statements, and participation of prescribing general practitioners in a quality improvement programme for dyspepsia management, based on these guidelines. METHODS:We consecutively studied the outcomes of 752 gastroscopies with respect to two sets of useful results: the first considered diagnoses of carcinoma, gastric and duodenal ulcer; the second excluded duodenal ulcer. RESULTS:A diagnosis of cancer or gastric/duodenal ulcer was associated with male sex (odds ratio (OR)=1.81, P=0.016), age above 41 years (OR=3.24, P=0.009) and particularly with positivity to H. pylori (OR=4.49, P<0.001), while the risk increased by two and a half times in gastroscopies conforming with ESPCG guidelines (OR=2.47, P=0.003). In the second set of analysis, we noted a statistically significant correlation between cancer or gastric ulcer and compliance with ESPCG guidelines (OR=4.69, P=0.013), but not with H. pylori positivity (OR=1.83, P=0.11); a linear relationship was observed across age groups, with a 60% increase in the risk of disease with every 5-year increase in age (OR=1.59, P=0.002). CONCLUSION:Participation of general practitioners in the Dyspepsia Management Programme (DMP) was not significantly associated with a positive gastroscopy.

authors

Cardin F,Zorzi M,Terranova O

doi

10.1097/01.meg.0000216942.42306.d5

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

549-53

issue

7

eissn

0954-691X

issn

1473-5687

pii

00042737-200707000-00006

journal_volume

19

pub_type

杂志文章
  • Sandostatin causing reversible thrombocytopenia.

    abstract::Esophageal variceal bleeding can be serious or life threatening. Drug-induced thrombocytopenia can further complicate such bleeding episodes. Thrombocytopenia because of sandostatin has been reported in the literature only once previously. We describe a case of sandostatin-induced reversible thrombocytopenia with a po...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328312180a

    authors: Chisholm S,Gummadi B,Vega KJ,House J

    更新日期:2009-04-01 00:00:00

  • Resolution of a complex mediastinal pseudocyst in a patient with alcohol-related chronic pancreatitis following abstinence from alcohol.

    abstract::We describe a 55-year-old patient with alcoholic chronic pancreatitis, a large mediastinal pseudocyst and a hemorrhagic pleural effusion. A single thoracocentesis and withdrawal of alcohol without other conservative or invasive measures resulted in a complete resolution of the pleural effusion and the mediastinal pseu...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200601000-00020

    authors: Groeneveld JH,Tjong A Lieng JG,de Meijer PH

    更新日期:2006-01-01 00:00:00

  • NUDT15 variant is the most common variant associated with thiopurine-induced early leukopenia and alopecia in Korean pediatric patients with Crohn's disease.

    abstract:PURPOSE:Thiopurine-induced leukopenia is a relatively common adverse event related to thiopurine medication in Korean pediatric Crohn's disease. In addition to the mutations of TPMT gene, the NUDT15 c.415C>T variant was recently identified to have a strong association with thiopurine-induced early leukopenia. We conduc...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000564

    authors: Lee YJ,Hwang EH,Park JH,Shin JH,Kang B,Kim SY

    更新日期:2016-04-01 00:00:00

  • An unusual case of haemobilia.

    abstract::Arterio-biliary fistula is an uncommon cause of haemobilia. We describe a case of right hepatic artery pseudo-aneurysm causing arterio-biliary fistula and presenting as severe melaena and cholangitis. Gastroduodenoscopy failed to establish the exact source of bleeding and hepatic artery angiography and selective embol...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200312000-00015

    authors: Rai R,Rose J,Manas D

    更新日期:2003-12-01 00:00:00

  • Treatment of chronic hepatitis C with pegylated interferon and ribavirin in treatment-naive patients in 'true life': a plea in favor of independent postmarketing evaluations.

    abstract:BACKGROUND:Results of treatments for chronic hepatitis C virus are only estimated and disclosed from pivotal trials. AIM:To report the 'true life' results of pegylated interferon and ribavirin in treatment-naive patients. METHODS:A prospective, multicenter observatory in 22 general hospitals. RESULTS:Five-hundred an...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/meg.0b013e32833bb4b0

    authors: Pariente A,Lahmek P,Duprat C,Denis J,Faroux R,Renou C,Nalet B,Morin T,Cadranel JF,Investigator Group belonging to Association Nationale des Gastroentérologues des Hôpitaux Généraux (ANGH).

    更新日期:2010-11-01 00:00:00

  • Effects of endoscopic papillary balloon dilation and endoscopic sphincterotomy on bacterial contamination of the biliary tract.

    abstract:BACKGROUND AND STUDY AIMS:Although endoscopic papillary balloon dilation (EPBD) has appeared with the expectation of better preserving sphincter of Oddi function than endoscopic sphincterotomy (EST), whether it can more effectively prevent bacterial contamination of the biliary tract than EST is controversial. To addre...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328348c0bf

    authors: Natsui M,Honma T,Genda T,Nakadaira H

    更新日期:2011-09-01 00:00:00

  • Clinical significance of a scoring formula of liver injury for the preoperative evaluation of patients with liver cirrhosis.

    abstract:OBJECTIVE:The aim of this study was to establish a clinical scoring formula of liver injury (SFLI) using the matter element analysis method, in order to provide the necessary information for the preoperative assessment and treatment of liver cirrhosis in clinical practice. MATERIALS AND METHODS:We collected preoperati...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283632189

    authors: Liu W,Zheng J,Xing R

    更新日期:2014-01-01 00:00:00

  • Short article: The effect of implementation of a treatment algorithm for infliximab on remission rates and drug costs in inflammatory bowel disease patients.

    abstract:INTRODUCTION:The effective, but expensive, drug infliximab is used in patients with inflammatory bowel disease (IBD). Monitoring infliximab trough levels and anti-infliximab antibody (ATI) formation can lead to a more cost-effective use of infliximab therapy. The aim of our study was to investigate the effect of implem...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章

    doi:10.1097/MEG.0000000000000763

    authors: Taks M,Pijls PA,Derijks LJ,Ten Broeke R,Grouls RJ,Curvers J,Gilissen LP

    更新日期:2017-02-01 00:00:00

  • The influence of sulindac on patients with primary biliary cirrhosis that responds incompletely to ursodeoxycholic acid: a pilot study.

    abstract:OBJECTIVES:In 30% of patients with primary biliary cirrhosis (PBC) ursodeoxycholic acid (UDCA) causes full biochemical normalization, while 70% are incomplete responders. The only differences between the two groups are the significantly higher cholestasis indices in the incomplete responders. In these patients we inves...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200212000-00014

    authors: Leuschner M,Holtmeier J,Ackermann H,Leuschner U

    更新日期:2002-12-01 00:00:00

  • Liver failure in adult Still's disease during corticosteroid treatment.

    abstract::Adult Still's disease is a well-characterized rheumatic disorder of unknown origin, which may affect multiple organs and may have a fatal course. However, liver failure has rarely been described in adult Still's disease. We present the case of a 25-year-old woman who was admitted with acute liver failure 2 years after...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200301000-00015

    authors: Ott SJ,Baron A,Berghaus T,Lamerz R,Beuers U

    更新日期:2003-01-01 00:00:00

  • Incontinence and anorectal dysfunction in patients with diabetes mellitus.

    abstract::The elucidation of the pathogenesis of faecal incontinence in patients with advanced diabetes mellitus has progressed during the last 15 years. In contrast to earlier concepts which promoted the concept that high stool volumes overwhelm normal continence mechanisms, recent studies indicate that the vast majority of di...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:

    authors: Wald A

    更新日期:1995-08-01 00:00:00

  • The Inflammatory Bowel Disease-Disability Index: validation of the Portuguese version according to the COSMIN checklist.

    abstract:BACKGROUND AND AIM:Recently, the Inflammatory Bowel Disease-Disability Index (IBD-DI) was developed to assess disability in inflammatory bowel disease (IBD). Our aim was to validate the Portuguese version of IBD-DI according to the COnsensus-based Standards for the selection of the health Measurement INstruments (COSMI...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000701

    authors: Soares JB,Pereira R,Costa JM,Arroja B,Gonçalves R

    更新日期:2016-10-01 00:00:00

  • Variceal bleeding in primary biliary cirrhosis patients: a subgroup with improved prognosis and a model to predict survival after first bleeding.

    abstract:BACKGROUND:Varices are a late complication in primary biliary cirrhosis (PBC). However, patients without clinical jaundice do bleed from varices; whether their prognosis differs is unknown. AIM:Evaluate PBC patients, particularly those with bilirubin

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328320005f

    authors: Vlachogiannakos J,Carpenter J,Goulis J,Triantos C,Patch D,Burroughs AK

    更新日期:2009-06-01 00:00:00

  • Transforming growth factor betas and their receptors in human liver cirrhosis.

    abstract:BACKGROUND:Transforming growth factor betas (TGF-betas) are a group of homologous polypeptides that exert pleiotropic effects on various cell types and stimulate the formation of extracellular matrix and fibrosis. To evaluate whether TGF-beta isoforms (TGF-beta1, TGF-beta2 and TGF-beta3) and their receptors (types I-II...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199812000-00009

    authors: Baer HU,Friess H,Abou-Shady M,Berberat P,Zimmermann A,Gold LI,Korc M,Büchler MW

    更新日期:1998-12-01 00:00:00

  • The role of cAMP-MAPK signalling in the regulation of human hepatocellular carcinoma growth in vitro.

    abstract:OBJECTIVE:We have previously identified that primary human hepatocellular carcinoma (HCC) is associated with altered guanine nucleotide regulatory protein (G-protein) expression concomitant with decreased adenylyl cyclase (AC) and increased mitogen activated protein kinase (MAPK) activity in vivo. This study aims to ad...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199912000-00009

    authors: Schmidt CM,McKillop IH,Cahill PA,Sitzmann JV

    更新日期:1999-12-01 00:00:00

  • Intraductal papillary mucinous neoplasms of the pancreas: diagnosis and management.

    abstract::Intraductal papillary mucinous neoplasms (IPMNs), characterized by intraductal papillary growth and thick mucin secretion, have increasingly been recognized. Despite modern preoperative evaluation, major difficulties still remain in distinguishing malignant invasive types from benign IPMNs. Following a PubMed database...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/MEG.0b013e32833b00f9

    authors: Dongbin L,Fei L,Werner Josefin B,Roland A

    更新日期:2010-09-01 00:00:00

  • Hepcidin and inflammatory bowel disease: dual role in host defence and iron homoeostasis.

    abstract:OBJECTIVE:Hepcidin is an endogenous antimicrobial peptide with a key role in iron homoeostasis. Hepcidin is similar to defensin, the deficiency of which is associated with Crohn's disease. To date there has been no validated method to reliably assay serum hepcidin. We studied iron indices in inflammatory bowel disease ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32830e2885

    authors: Arnold J,Sangwaiya A,Bhatkal B,Geoghegan F,Busbridge M

    更新日期:2009-04-01 00:00:00

  • Effects of low-power argon plasma coagulation thermoablation of Barrett's epithelium on oesophageal motility.

    abstract:INTRODUCTION:Oesophageal dysmotility contributes to the pathogenesis of Barrett's epithelium (BE) allowing prolonged mucosal contact with injurious refluxate. Argon plasma coagulation (APC) is effective for BE ablation, but it is unknown whether the procedure affects oesophageal motility. AIM:To assess the effect of l...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/01.meg.0000216928.91618.9a

    authors: Basu KK,Talwar V,de Caestecker JS

    更新日期:2006-07-01 00:00:00

  • A test-and-treat policy does not save endoscopy workload in a non-referral hospital.

    abstract:AIM:To assess the impact that a test-and-treat policy with open-access urea breath testing (UBT) has had on the referral rates for endoscopy in a district hospital. Additionally, we examined for any change in the proportion of serious pathology detected endoscopically after adopting the policy. METHODS:Analysis of dat...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200203000-00009

    authors: Mahadeva S,Connelly J,Sahay P

    更新日期:2002-03-01 00:00:00

  • A new organotypic model to study cell interactions in the intestinal mucosa.

    abstract:BACKGROUND:Recently, we demonstrated that freshly elutriated monocytes differentiate into macrophages with a phenotype similar to that of intestinal macrophages in a three-dimensional model of intestinal epithelial cells. Here we describe a more organotypic model to study cell interactions in the intestinal mucosa. ME...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200608000-00017

    authors: Spottl T,Hausmann M,Gunckel M,Herfarth H,Herlyn M,Schoelmerich J,Rogler G

    更新日期:2006-08-01 00:00:00

  • Cardiac dysfunction in patients with cirrhosis: is the systolic component its main feature?

    abstract:OBJECTIVE:To investigate the subclinical cardiac morphological and functional modifications in cirrhotic patients according to the stage of liver disease. PATIENTS AND METHODS:One hundred and thirteen cirrhotic patients underwent standard Doppler echocardiography and were compared with healthy individuals. Left ventri...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000340

    authors: Cesari M,Fasolato S,Rosi S,Angeli P

    更新日期:2015-06-01 00:00:00

  • Relationship between genotypes of hepatitis C virus and histopathological manifestations in chronic hepatitis C patients.

    abstract:OBJECTIVE:The aim of this study was to assess the relationship between HCV genotype and histological liver injury. DESIGN:Prospective study on a cohort of patients with biopsy proven chronic hepatitis C. SETTING:University medical centre. PARTICIPANTS:Enrolled were 324 consecutive patients (male 197, median age 52 y...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200012030-00007

    authors: Adinolfi LE,Utili R,Andreana A,Tripodi MF,Rosario P,Mormone G,Ragone E,Pasquale G,Ruggiero G

    更新日期:2000-03-01 00:00:00

  • Short article: Outcome of medical and surgical management for perforated jejunal diverticulitis.

    abstract:OBJECTIVES:Perforated jejunal diverticulitis (PJD) is rare, but it has high mortality rates. The role of nonsurgical management is debated. The aim of this study is to assess the outcomes of medical and surgical management of PJD. PATIENTS AND METHODS:A single-centre study on a series of emergency patients diagnosed w...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001265

    authors: Garcia-Granero A,Argüelles BG,Gallardo CM,Carreño O,Giner F,Pellino G,Frasson M

    更新日期:2019-01-01 00:00:00

  • When is a herb a drug?

    abstract::With the growing popularity and use of herbal remedies in the industrial countries there has been an increasing recognition and reporting of adverse reactions. Drug development represents discovery and characterization of naturally occurring plant metabolites or their synthetic analogues. Therefore, a herbal remedy sh...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200504000-00001

    authors: Aithal GP

    更新日期:2005-04-01 00:00:00

  • Association of gastric disease with polymorphisms in the inflammatory-related genes IL-1B, IL-1RN, IL-10, TNF and TLR4.

    abstract:OBJECTIVES:This study aimed to investigate if single nucleotide polymorphisms (SNPs) in a series of inflammatory genes were associated with the development of the most common pathologies thought to precede gastric cancer development namely; Helicobacter pylori (H. pylori)-associated gastritis and intestinal metaplasia....

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283140eea

    authors: Murphy G,Thornton J,McManus R,Swan N,Ryan B,Hughes DJ,O'Morain CA,O'Sullivan M

    更新日期:2009-06-01 00:00:00

  • Helicobacter pylori and non-steroidal anti-inflammatory drugs: lone agents or partners in crime?

    abstract::A variety of mechanisms are responsible for the gastric and duodenal mucosal injury known to result from the consumption of non-steroidal anti-inflammatory drugs (NSAIDs). Many of these mechanisms may be influenced by coexistent infection with Helicobacter pylori. However, evidence of increased risk from NSAIDs in pat...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 评论,杂志文章

    doi:10.1097/00042737-199710000-00003

    authors: Roseveare CD,Colin-Jones DG

    更新日期:1997-10-01 00:00:00

  • Qualitative and quantitative clinical evaluation of the laser-assisted ratio analyser for detection of Helicobacter pylori infection by (13)C-urea breath tests.

    abstract:OBJECTIVES:Currently, the (13)C-urea breath test is the reference method for non-invasive diagnosis of Helicobacter pylori infection and therapy control. Therefore, new technologies have been developed to measure the ratio of (13)CO(2)/(12)CO(2) in breath. The laser-assisted ratio analyser (LARA) device is based on opt...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200107000-00008

    authors: Braden B,Gelbmann C,Dietrich CF,Caspary WF,Schölmerich J,Lock G

    更新日期:2001-07-01 00:00:00

  • Immunoproliferative small intestinal disease in Greece: presentation of 13 cases including two from Albania.

    abstract:OBJECTIVES:Immunoproliferative small intestinal disease (IPSID) represents a spectrum of clinicopathological entities including alpha-chain disease and other types of lymphoplasmacytic proliferations of the lamina propria of the small intestine, presenting with severe malabsorption. IPSID has been described mainly in t...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/01.meg.0000228976.64774.04

    authors: Economidou I,Manousos ON,Triantafillidis JK,Vaslamatzis MM,Zafiropoulou R,Papadakis T

    更新日期:2006-09-01 00:00:00

  • Noninvasive assessment of pediatric inflammatory bowel disease with ¹⁸F-fluorodeoxyglucose-positron emission tomography and computed tomography.

    abstract:OBJECTIVES:¹⁸F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) is a less invasive diagnostic tool and promising in detecting gastrointestinal lesions of pediatric inflammatory bowel disease (IBD) patients. Co-registration of low-dose computed tomography (CT) could lead to improvements in the assessment of d...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283410222

    authors: Däbritz J,Jasper N,Loeffler M,Weckesser M,Foell D

    更新日期:2011-01-01 00:00:00

  • Clinical and surgical recurrence of Crohn's disease after ileocolonic resection in a specialist unit.

    abstract:BACKGROUND:Postoperative clinical and endoscopic recurrence is common in Crohn's disease. AIM:We aimed to assess postoperative recurrence and management in a cross-sectional patient cohort in one specialist unit, before the introduction of a uniform postoperative preventive strategy. METHODS:Review of patients who ha...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328326a01e

    authors: Ng SC,Lied GA,Arebi N,Phillips RK,Kamm MA

    更新日期:2009-05-01 00:00:00