Abstract：
INTRODUCTION:Dry powder inhalers (DPIs) require a certain threshold of inspiratory effort to generate respirable particles. We undertook a literature review to determine whether this may, in particular clinical settings (young children, elderly subjects, acute or chronic respiratory obstructive syndromes - asthma and COPD), constitute a limitation on their use. STATE OF THE ART:Currently marketed DPIs exhibit different technical characteristics. Many factors may influence their efficacy, so that the predictive utility of in vitro tests is limited. Published clinical studies indicate that aerosol therapies inhaled with DPIs show clinical efficacy even at low inspiratory air flows in adults and children with acute asthma, in acute bronchoconstriction experimentally provoked by methacholine or histamine, in acute asthma attacks in adults and children, and in COPD-related airway obstruction. The efficacy of DPIs appears comparable to that of p-MDIs or nebulisation. However, the studies often have some limitations (including limited statistical power and patient selection) that may affect their value. PERSPECTIVES:The published studies analysed suggest that DPIs may be used in the great majority of clinical situations, subject to careful patient education. Nevertheless, p-MDIs with spacers remain recommended by international guidelines for children under the age of 6. CONCLUSIONS:Additional well-designed clinical studies remain desirable to establish firmly the efficacy of DPIs in these situations.
journal_name
Rev Mal Respirjournal_title
Revue des maladies respiratoiresauthors
Roche N,Dessanges JF,Dubus JCdoi
10.1016/s0761-8425(05)85613-xsubject
Has Abstractpub_date
2005-09-01 00:00:00pages
605-13issue
4eissn
0761-8425issn
1776-2588pii
MDOI-RMR-09-2005-22-4-0761-8425-101019-200530058journal_volume
22pub_type
杂志文章,评审abstract：INTRODUCTION:The Collège des Pneumologues des Hôpitaux Généraux has performed a prospective multicentre epidemiological study which aims to describe the baseline characteristics of all new cases of primary lung cancer histologically or cytologically diagnosed in 2010 and followed-up in the respiratory department of gen...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2015.09.008
更新日期：2016-09-01 00:00:00
abstract：INTRODUCTION:Knowledge of prognostic factors is important for therapeutic decision making but above all, at a population level, for the interpretation of data in the literature and as a guide to clinical research. To be useful in practice they must be both independent and reproducible. Despite an impressive number of p...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：2005-12-01 00:00:00
abstract：INTRODUCTION:Mandibular advancement (MA) has emerged over the last decade as an alternative solution to nasal continuous airway pressure (nCPAP) for the treatment of obstructive sleep apnea syndrome (OSAS). OBSERVATION:We report the case of a patient with history of chronic atrial fibrillation and moderate supine-depe...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/s0761-8425(06)71821-6
更新日期：2006-11-01 00:00:00
abstract：:Inhaled therapy is routinely employed during mechanical ventilation. Several factors affect aerosol delivery: the aerosol device, particle size, ventilator parameters, ventilator circuit and hygrometry. Non invasive ventilation is commonly used for treatment of exacerbations of chronic obstructive pulmonary disease. H...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/s0761-8425(08)73802-6
更新日期：2008-06-01 00:00:00
abstract：:Invasive pulmonary aspergillosis is an opportunistic pneumonia which is particularly common in immuno-depressed subjects. The most frequent risk factors are the intensity and duration of leucopaenia, cytotoxic drugs and steroid therapy. In the respiratory tract, the proliferation of Aspergillus fumigatus becomes possi...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1988-01-01 00:00:00
abstract：:Acquired hemophilia A (AHA) is a rare disease, defined by the production of anti-factor VIII antibodies causing disordered hemostasis. It is idiopathic in 50% of cases, but sometimes associated with solid tumors. We report a case where AHA led to the diagnosis of lung cancer. CASE REPORT:An 82-year-old man with spont...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2017.08.005
更新日期：2018-09-01 00:00:00
abstract：:Recurrence of pulmonary embolism can occur in presence of coagulation disorders or cancer. It can also develop without any of these factors. Coagulation tests should search for abnormalities such as inherited deficiencies of antithrombin, protein C, protein S, factor V mutation, variation of the prothrombin gene, hype...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：:Bradykinin and related kinins formed in tissues and fluids during inflammation, exert many physiological effects mediated by two receptor subtypes: B1 and B2. The involvement of kinins in bronchial asthma has been speculated in numerous clinicals reports. The effects of bradykinin on airways have been studied in vivo ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1991-01-01 00:00:00
abstract：:We report a study of 8 patients with acute Mycoplasma pneumoniae infection of the respiratory tract admitted to the Army Hospital Desgenettes over a 10 months period. Our clinical observations are compared with a review of the literature. We observed a seasonal outbreak in spring and autumn. This infection was encount...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
abstract：:Mediastinoscopy is a technique which enables palpation, inspection and biopsy of superior mediastinal glands. When this examination is done routinely in patients suffering from lung cancer which is presumed to be operable, 25-30% are found to have a positive gland and the greater part of these individuals become inope...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Meningeal metastases from malignant mesotheliomas are rarely observed. We report the case of a 54-year-old man with an asymptomatic pleural effusion and simultaneous sensitive and motor disorders of the right hemibody. A meningeal localization of a pleural malignant mesothelioma was discovered and confirmed by a compa...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:The diagnosis of pulmonary hydatid cysts in children is generally easy and does not require endoscopic exploration, because the radiological aspects of an intact or a complicated cyst are most often suggestive. There are, nevertheless, some cases of pulmonary hydatids where the cyst is partially evacuated and then inf...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：INTRODUCTION:To investigate the safety, feasibility and effectiveness of an inpatient pulmonary rehabilitation program (i-PR) after lung resection (LR) for cancer. METHODS:Between January 2007 and December 2009, we conducted a prospective observational study on patients admitted in our institution. An i-PR was offered...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2012.12.002
更新日期：2013-01-01 00:00:00
abstract：INTRODUCTION:There are very few surveys devoted to the prevalence of asthma and COPD in the general population. The Motorola Health System has been developed to make such surveys easier. OBJECTIVES:The main objective was to assess the acceptability and efficacy of the Motorola Health system in collecting health data a...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2015.02.089
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:In order to achieve a better definition of the indications for surgical excision of pulmonary metastases in colorectal cancer (CCR), a retrospective study of the eight year survival of patients who had been operated on was carried out with reference to the principal prognostic factors. METHODS AND RESULTS:Be...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：INTRODUCTION:The aim of the study was to assess, compliance with maintenance treatment in patients with persistent asthma in clinical practice. METHODS:This observational, cross-sectional, prospective, multicenter study was conducted in metropolitan France on patients with persistent asthma under the care of a represe...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,多中心研究
doi：10.1016/j.rmr.2018.02.003
更新日期：2018-03-01 00:00:00
abstract：AIM:The main objective of the survey was to determine the frequency of the mono and polysensitizations in patients consulting for respiratory allergy, rhinitis or/and asthma. The secondary objectives were to evaluate the severity, the number and the type of the sensitizations, the frequency of the asthma or rhinitis as...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,多中心研究
doi：10.1016/s0761-8425(09)74670-4
更新日期：2009-05-01 00:00:00
abstract：:Mediastinal liposarcomas (LPS) are rare tumours. We report a case of primary myxoid LPS in a 22-year-old woman suffering from cough, dyspnoea on exercise and asthenia for 3 weeks. Thoracic MRI showed a large tumour on the right side. After neoadjuvant chemotherapy, a complete resection was performed, followed by adjuv...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2010.05.019
更新日期：2011-01-01 00:00:00
abstract：INTRODUCTION:Interstitial lung diseases (ILD) in systemic sclerosis (SSc) are mainly encountered in patients with diffuse disease although they may occur less frequently in patients with limited cutaneous disease. BACKGROUND:In SSc early detection of ILD should be achieved by high resolution computed tomography and pu...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/s0761-8425(07)92767-9
更新日期：2007-10-01 00:00:00
abstract：INTRODUCTION:Primary sarcomas of the mediastinum are rare and account for 2 to 8% of malignant mediastinal tumours. The aim of this study is to describe their clinical and pathological characteristics. PATIENTS AND METHODS:Fifteen cases of primary mediastinal sarcoma, diagnosed between 1993 and 2009, were reviewed ret...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2010.05.015
更新日期：2011-01-01 00:00:00
abstract：:Excessive widening of the alveolar-arterial gradient for oxygen, with respect to the subject's age and oxygen uptake, is the most sensitive signal of a disturbance in pulmonary gas exchange, whether it is due to ventilation, circulation or diffusion. During incremental exercise, simultaneous measurements of metabolic ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2012.05.018
更新日期：2012-12-01 00:00:00
abstract：INTRODUCTION:Advertising information on cigarette package participate to the reduction of health risks from smoking. Impact on smokers has been poorly studied. This study intended to determine the smoker perception of nicotine and tar yields of cigarettes. METHODS:Consulting in an outpatient smoking cessation clinic, ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/s0761-8425(04)71237-1
更新日期：2004-02-01 00:00:00
abstract：:Recent progress in the physiology of the upper airways has led to significant advances in evaluating the dynamics of upper airway occlusion during sleep. Measuring the collapsibility of the upper airways and localizing the site of obstruction should theoretically lead to efficacious non-mechanical treatment and enable...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：2000-06-01 00:00:00
abstract：INTRODUCTION:The nerve growth factor (NGF) is known as a factor involved in neuronal growth and survival. From recent studies it may also be considered as a mediator of inflammation, in particular in the airways. STATE OF ART:Several animal studies have shown that NGF may increase the sensory innervation, and particip...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/s0761-8425(04)71290-5
更新日期：2004-04-01 00:00:00
abstract：:In order to achieve mediastinal lymph node staging in bronchial cancer, axial mediastinoscopy (combined with left anterior mediastinoscopy for cancers of the left upper lobe) is by far the most efficient and the most reliable technique. Since mediastinoscopy has been part of the investigations that can be made before ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
abstract：:The authors report an "analytic epidemiological" study, showing the risk of relapse in tuberculous patients in the Bas-Rhin in 1967 to 1977. This was possible thanks to statutory notification of tuberculous cases, with an index updated by annual returns. The study relates to French subjects notified as new cases of al...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：INTRODUCTION:This questionnaire-based epidemiological study was aimed at identifying possible sleep disturbance in a sample of active French males. METHODS:Eight hundred and fifty male subjects, aged 22 to 66 years, completed a structured sleep questionnaire supplemented by information about their life habits and medi...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2010.07.003
更新日期：2010-09-01 00:00:00
abstract：OBJECTIVE:The management of COPD aims to improve integrated indices such as health-related quality of life (HRQoL). Experts recommend repeated and methodical assessment of HRQoL, particularly by the use of questionnaires. Though these tools give pertinent information for groups of patients, they have limitations in des...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2010.03.020
更新日期：2010-05-01 00:00:00
abstract：:The natural history and pathophysiology of chronic airflow obstruction (BPCO) remain poorly understood. Therapy cannot cure the disease but should be aimed at palliating its effects: to reduce dyspnoea, to improve the exercise performance, to minimise the complications, to stabilise the disease and improve the quality...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Thrombocytopenia induced by rifampicin in the absence of prior sensitization is exceptional, especially when it occurs in a patient without risk factors. We report the case of a patient aged 25 years with no past history of medical, surgical or knowledge of having taken rifampicin previously, who was hospitalized for ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2013.03.009
更新日期：2013-11-01 00:00:00
