Cardiovascular effects of morphine in patients with coronary arterial disease.

Abstract:

:Large doses of morphine sulfate have been reported to cause myocardial lactate production and reduction in coronary blood flow in animals. Similar effects with clinical doses in man would significantly alter the management of cardiac patients. Eleven adult patients with significant coronary arterial disease and normal left ventricular ejection fraction were studied before and 30 minutes after infusion of morphine (0.25 mg/kg IV). Evaluation of myocardial metabolism showed an increase in coronary sinus oxygen content (p less than 0.001) and a reduction in myocardial oxygen consumption. Myocardial lactate extraction was not altered. No change in coronary sinus blood flow was seen. It is concluded that infusion of morphine sulfate, 0.25 mg/kg IV, does not produce global myocardial ischemia in patients with coronary artery disease and normal ventricular function.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Sethna DH,Moffitt EA,Gray RJ,Bussell J,Raymond M,Conklin C,Shell WE,Matloff JM

subject

Has Abstract

pub_date

1982-02-01 00:00:00

pages

109-14

issue

2

eissn

0003-2999

issn

1526-7598

journal_volume

61

pub_type

杂志文章
  • Trauma, systemic inflammatory response syndrome, dietary supplements, illicit steroid use and a questionable malignant hyperthermia reaction.

    abstract:BACKGROUND:Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle calcium regulation associated primarily, but not exclusively, with mutations in the skeletal muscle ryanodine receptor. Associated environmental factors, however, may also be important for expression of the syndrome. METHODS AND RE...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e31819240a5

    authors: Capacchione JF,Radimer MC,Sagel JS,Kraus GP,Sambuughin N,Muldoon SM

    更新日期:2009-03-01 00:00:00

  • Somatosensory evoked potential quantification of ulnar nerve blockade.

    abstract::We investigated the appropriateness of the somatosensory evoked potentials (SSEPs) as an objective monitor of sensory blockade of the ulnar nerve by comparing the effects of saline and lidocaine infiltration of the ulnar nerve at the elbow, with and without epinephrine. The four treatments were administered in random ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Benzon HT,Toleikis JR,Shanks C,Ramseur A,Sloan T

    更新日期:1986-08-01 00:00:00

  • Local GABA(A) receptor blockade reverses isoflurane's suppressive effects on thalamic neurons in vivo.

    abstract::Many in vitro effects of volatile anesthetics are known, but the mechanisms of action are still under debate. Because suppression of sensory perception is one of the major goals of general anesthesia, we studied the effects of isoflurane on the processing of somatosensory information in anesthetized rats. Local iontop...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200106000-00046

    authors: Vahle-Hinz C,Detsch O,Siemers M,Kochs E,Bromm B

    更新日期:2001-06-01 00:00:00

  • Review articles: postoperative delirium: acute change with long-term implications.

    abstract::Delirium is an acute change in cognition and attention, which may include alterations in consciousness and disorganized thinking. Although delirium may affect any age group, it is most common in older patients, especially those with preexisting cognitive impairment. Patients with delirium after surgery recover more sl...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0b013e3182147f6d

    authors: Rudolph JL,Marcantonio ER

    更新日期:2011-05-01 00:00:00

  • Performance of computer-assisted continuous infusion at low concentrations of intravenous sedatives.

    abstract::We studied the performance of a target-controlled drug infusion device, computer-assisted continuous infusion (CACI). Forty-one volunteers received one of midazolam (n = 11), propofol (n = 10), thiopental (n = 10), or fentanyl (n = 10) in sedative concentrations. Concentrations were kept constant for 45-70 min at five...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199705000-00018

    authors: Veselis RA,Glass P,Dnistrian A,Reinsel R

    更新日期:1997-05-01 00:00:00

  • Hyperglycemia impairs isoflurane-induced adenosine triphosphate-sensitive potassium channel activation in vascular smooth muscle cells.

    abstract:BACKGROUND:Isoflurane activates vascular adenosine triphosphate sensitive potassium (K(ATP)) channels, and may induce vasodilation. In the present study, we investigated whether hyperglycemia modifies isoflurane activation of vascular K(ATP) channel. METHODS:We used a cell-attached patch-clamp configuration to test th...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e318163fd5b

    authors: Kawano T,Tanaka K,Mawatari K,Oshita S,Takahashi A,Nakaya Y

    更新日期:2008-03-01 00:00:00

  • Prevention of atelectasis formation during induction of general anesthesia.

    abstract:UNLABELLED:General anesthesia promotes atelectasis formation, which is augmented by administration of large oxygen concentrations. We studied the efficacy of positive end-expiratory pressure (PEEP) application during the induction of general anesthesia (fraction of inspired oxygen [FIO(2)] 1.0) to prevent atelectasis. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000087042.02266.f6

    authors: Rusca M,Proietti S,Schnyder P,Frascarolo P,Hedenstierna G,Spahn DR,Magnusson L

    更新日期:2003-12-01 00:00:00

  • Time- and Dose-Dependent Effects of Desflurane in Sensitized Airways.

    abstract:BACKGROUND:Although the bronchodilatory actions of volatile anesthetics, such as halothane, isoflurane, and sevoflurane, have been well documented in previous studies, the properties of desflurane remain controversial. The aim of this study was to investigate the effects of desflurane at different concentrations and du...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000001754

    authors: Zhou J,Iwasaki S,Yamakage M

    更新日期:2017-02-01 00:00:00

  • Closed-loop coadministration of propofol and remifentanil guided by bispectral index: a randomized multicenter study.

    abstract:BACKGROUND:We have developed a proportional-integral-derivative controller allowing the closed-loop coadministration of propofol and remifentanil, guided by a Bispectral Index (BIS) monitor, during induction and maintenance of general anesthesia. The controller was compared with manual target-controlled infusion. METH...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1213/ANE.0b013e318205680b

    authors: Liu N,Chazot T,Hamada S,Landais A,Boichut N,Dussaussoy C,Trillat B,Beydon L,Samain E,Sessler DI,Fischler M

    更新日期:2011-03-01 00:00:00

  • Statistical grand rounds: Importance of appropriately modeling procedure and duration in logistic regression studies of perioperative morbidity and mortality.

    abstract::Multiple logistic regression studies frequently are performed with duration (e.g., operative time) included as an independent variable. We use narrative review of the statistical literature to highlight that when the association between duration and outcome is presumptively significant, the procedure itself (e.g., vid...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0b013e318229d450

    authors: Dexter F,Dexter EU,Ledolter J

    更新日期:2011-11-01 00:00:00

  • Antithrombin III during cardiac surgery: effect on response of activated clotting time to heparin and relationship to markers of hemostatic activation.

    abstract:UNLABELLED:This study was designed to determine if, and to what extent, antithrombin III (AT) levels affect the response of the activated clotting time (ACT) to heparin in concentrations used during cardiac surgery, and to characterize the relationship between AT levels and markers of activation of coagulation during c...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199709000-00005

    authors: Despotis GJ,Levine V,Joist JH,Joiner-Maier D,Spitznagel E

    更新日期:1997-09-01 00:00:00

  • The effect of spinal ibuprofen on opioid withdrawal in the rat.

    abstract:UNLABELLED:This study examines the effect of spinal ibuprofen on the behavioral manifestations associated with the opioid abstinence syndrome. Rats (n = 8 per group) were infused for 5 days with morphine and then pretreated with a spinal bolus dose of ibuprofen before systemic naloxone antagonism (300 microg). Groups i...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200008000-00035

    authors: Dunbar SA,Karamov IG,Buerkle H

    更新日期:2000-08-01 00:00:00

  • Ilioinguinal iliohypogastric nerve blocks--before or after cesarean delivery under spinal anesthesia?

    abstract::Preoperative local anesthetic blockade of somatosensory pathways involved with skin incision and other noxious perioperative stimuli may "preempt" or attenuate the postoperative pain response. Since the Pfannenstiel incision lies within the L1 dermatome, bilateral ilioinguinal, iliohypogastric nerve blocks (IINBs) sho...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199601000-00003

    authors: Huffnagle HJ,Norris MC,Leighton BL,Arkoosh VA

    更新日期:1996-01-01 00:00:00

  • Perioperative management of the multiorgan donor.

    abstract::Organ transplantation is a multidisciplinary specialty that has seen remarkable advances in the past two decades, in the tireless pursuit of providing life-saving therapy for patients suffering from end-stage organ failure. As the scientific basis and clinical practice of organ transplantation continues to evolve, it ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/00000539-199005000-00014

    authors: Robertson KM,Cook DR

    更新日期:1990-05-01 00:00:00

  • Buffered Solutions Versus Isotonic Saline for Resuscitation in Nonsurgical Critically Ill: Protocol for Cochrane Review.

    abstract::Fluid resuscitation is one of the most prevalent treatment in critical care. There is not definitive evidence about the best fluid for resuscitation. The aim of this review will be to asses the efficacy and safety of buffered solution versus saline. We will perform an electronic search in Medline, Embase, and Central....

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1213/ANE.0000000000001616

    authors: Barea-Mendoza JA,Antequera AM,Plana MN,Chico-Fernández M,Muriel A,Sáez I,Estrada-Lorenzo JM,Montejo-González JC

    更新日期:2016-12-01 00:00:00

  • Intrathecal morphine reduces infarct size in a rat model of ischemia-reperfusion injury.

    abstract:UNLABELLED:Systemically-administered morphine reduces infarct size in rat models of myocardial ischemia-reperfusion. We sought to determine whether much smaller doses of spinally-administered morphine offer a similar cardioprotective benefit. Barbiturate-anesthetized, open-chested, Wistar rats with chronic indwelling t...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000105878.96434.05

    authors: Groban L,Vernon JC,Butterworth J

    更新日期:2004-04-01 00:00:00

  • Pharmacologic basis of responses to midazolam in the isolated, cross-perfused, canine right atrium.

    abstract::The effects of midazolam on atrial rate and contractile force in the isolated canine atrium perfused with donor blood were investigated. When midazolam in a dose range of 100-1000 micrograms was injected directly into the sinus node artery of the isolated atrium, biphasic (negative followed by positive) chronotropic a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Saegusa K,Furukawa Y,Ogiwara Y,Takeda M,Chiba S

    更新日期:1987-08-01 00:00:00

  • Postoperative ventilatory failure in an obese, myopathic woman with periodic somnolence: A case report.

    abstract::An obese woman with periodic sommolence developed postoperative ventilatory problems following an uncomplicated cholecystectomy. A severe myopathic process involving the respiratory muscles was found at necropsy. A brother, who died a week later, had myotonic dystrophy. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197507000-00026

    authors: Tsueda K,Shibutani K,Lefkowitz M

    更新日期:1975-07-01 00:00:00

  • The efficacy of a novel approach to transversus abdominis plane block for postoperative analgesia after colorectal surgery.

    abstract:BACKGROUND:The analgesic efficacy of transversus abdominis plane (TAP) block has been established for patients undergoing abdominal surgery. We evaluated the efficacy of a novel approach to TAP block for postoperative analgesia after colorectal surgery. METHODS:Forty adult ASA physical status I to III patients undergo...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0b013e3182159bf8

    authors: Bharti N,Kumar P,Bala I,Gupta V

    更新日期:2011-06-01 00:00:00

  • Anesthetic concerns for robot-assisted laparoscopy in an infant.

    abstract::A 2-mo-old infant with biliary atresia was scheduled for laparoscopic Kasai with robot assistance. Before surgery, a practice trial maneuvering the cumbersome robotic equipment was performed to ensure rapid access to the patient in case of emergency. IV access, tracheal intubation, and arterial line placement followed...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000137394.99683.66

    authors: Mariano ER,Furukawa L,Woo RK,Albanese CT,Brock-Utne JG

    更新日期:2004-12-01 00:00:00

  • Intraoperative management of patients with carcinoid heart disease having valvular surgery: a review of one hundred consecutive cases.

    abstract:BACKGROUND:Cardiac surgery for carcinoid heart disease is complicated by hemodynamic instability secondary to carcinoid crises, cardiovascular dysfunction, and blood loss. The safety of vasopressors and the benefit of aprotinin during concomitant octreotide administration are uncertain. METHODS:We reviewed the effects...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000284704.57806.0b

    authors: Weingarten TN,Abel MD,Connolly HM,Schroeder DR,Schaff HV

    更新日期:2007-11-01 00:00:00

  • Conjugated estrogen reduces transfusion and coagulation factor requirements in orthotopic liver transplantation.

    abstract:UNLABELLED:We conducted a prospective, randomized study to determine the efficacy of conjugated estrogen in reducing blood product transfusion during orthotopic liver transplantation (OLT). Patients undergoing OLT were included in the study. Only those having a reaction time of more than 30 mm or 15 min (19 -28 mm) on ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199806000-00008

    authors: Frenette L,Cox J,McArdle P,Eckhoff D,Bynon S

    更新日期:1998-06-01 00:00:00

  • Left ventricular systolic and diastolic function is unaltered during propofol infusion in newborn swine.

    abstract:UNLABELLED:Propofol is a cardiac depressant with minimal diastolic effects in the adult myocardium. Cardiac effects of propofol in the newborn are unknown. We examined hemodynamic variables and systolic and diastolic left ventricular function in 12 newborn pigs exposed to propofol at three different infusion rates (7.5...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199804000-00008

    authors: Graham MR,Thiessen DB,Mutch WA

    更新日期:1998-04-01 00:00:00

  • Systemic toxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivacaine-infused rats.

    abstract::We compared the systemic toxicity of bupivacaine, levobupivacaine, and ropivacaine in anesthetized rats. We also compared the ability to resuscitate rats after lethal doses of these local anesthetics. Bupivacaine, levobupivacaine, or ropivacaine was infused at a rate of 2 mg. kg(-1). min(-1) while electrocardiogram, e...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200109000-00039

    authors: Ohmura S,Kawada M,Ohta T,Yamamoto K,Kobayashi T

    更新日期:2001-09-01 00:00:00

  • Electroencephalographic burst suppression in elderly and young patients anesthetized with isoflurane.

    abstract::The electroencephalograms of seven elderly (70-85 years) and seven younger patients (23-31 years) anesthetized with a concentration of isoflurane sufficient to produce burst suppression were studied. Anesthesia in these unpremedicated subjects was induced by inhalation of nitrous oxide, isoflurane, and oxygen. Trachea...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Schwartz AE,Tuttle RH,Poppers PJ

    更新日期:1989-01-01 00:00:00

  • Reactive oxygen species as mediators of cardiac injury and protection: the relevance to anesthesia practice.

    abstract::Reactive oxygen species (ROS) are central to cardiac ischemic and reperfusion injury. They contribute to myocardial stunning, infarction and apoptosis, and possibly to the genesis of arrhythmias. Multiple laboratory studies and clinical trials have evaluated the use of scavengers of ROS to protect the heart from the e...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/01.ANE.0000180999.81013.D0

    authors: Kevin LG,Novalija E,Stowe DF

    更新日期:2005-11-01 00:00:00

  • Catheter-associated masses in patients receiving intrathecal analgesic therapy.

    abstract:UNLABELLED:A cohort of seven patients receiving intrathecal analgesic drug therapy for chronic intractable pain underwent radiocontrast myelography and computed tomography (CT) scanning to screen for catheter-associated intrathecal masses. Three of seven patients examined had intraspinal masses associated with the tip ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200301000-00039

    authors: McMillan MR,Doud T,Nugent W

    更新日期:2003-01-01 00:00:00

  • Orthostatic hypotension occurs frequently in the first hour after anesthesia.

    abstract:UNLABELLED:Symptoms of orthostatic intolerance are common after general anesthesia and are associated with an increased risk of postoperative morbidity. The contribution of orthostatic hypotension (OH) has not been well defined. We conducted a head-up tilt test on patients after general anesthesia for minor surgery to ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000093388.17298.90

    authors: Cowie DA,Shoemaker JK,Gelb AW

    更新日期:2004-01-01 00:00:00

  • The efficiency of an autotransfusion system for tumor cell removal from blood salvaged during cancer surgery.

    abstract::The efficiency of a gravity-dependent autotransfusion system (ATS) for filtering tumor cells from blood was examined under laboratory and clinical conditions. In laboratory studies, reconstituted whole blood was seeded with known numbers of cultured A431 human vulva carcinoma cells then filtered through the ATS. Cance...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199406000-00017

    authors: Karczewski DM,Lema MJ,Glaves D

    更新日期:1994-06-01 00:00:00

  • Modulation of noninactivating K+ channels in rat cerebellar granule neurons by halothane, isoflurane, and sevoflurane.

    abstract:UNLABELLED:Neuronal baseline K(+) channels were activated by several volatile anesthetics. Whole-cell recordings from cultured cerebellar granule neurons of 7-day-old male Sprague-Dawley rats showed outward-rectifying K(+) currents with a conductance of approximately 1.1 +/- 0.3 nS (n = 20) at positive potentials. The ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000055365.31940.0a

    authors: Shin WJ,Winegar BD

    更新日期:2003-05-01 00:00:00