Abstract：
:We compared the systemic toxicity of bupivacaine, levobupivacaine, and ropivacaine in anesthetized rats. We also compared the ability to resuscitate rats after lethal doses of these local anesthetics. Bupivacaine, levobupivacaine, or ropivacaine was infused at a rate of 2 mg. kg(-1). min(-1) while electrocardiogram, electroencephalogram, and arterial pressure were continuously monitored. When asystole was recorded, drug infusion was stopped and a resuscitation sequence was begun. Epinephrine 0.01 mg/kg was administered at 1-min intervals while external cardiac compressions were applied. Resuscitation was considered successful when a systolic arterial pressure > or =100 mm Hg was achieved within 5 min. The cumulative doses of levobupivacaine and ropivacaine that produced seizures were similar and were larger than those of bupivacaine. The cumulative doses of levobupivacaine that produced dysrhythmias and asystole were smaller than the corresponding doses of ropivacaine, but they were larger than those of bupivacaine. The number of successful resuscitations did not differ among groups. However, a smaller dose of epinephrine was required in the Ropivacaine group than in the other groups. We conclude that the systemic toxicity of levobupivacaine is intermediate between that of ropivacaine and bupivacaine when administered at the same rate and that ropivacaine-induced cardiac arrest appears to be more susceptible to treatment than that induced by bupivacaine or levobupivacaine.
journal_name
Anesth Analgjournal_title
Anesthesia and analgesiaauthors
Ohmura S,Kawada M,Ohta T,Yamamoto K,Kobayashi Tdoi
10.1097/00000539-200109000-00039subject
Has Abstractpub_date
2001-09-01 00:00:00pages
743-8issue
3eissn
0003-2999issn
1526-7598journal_volume
93pub_type
杂志文章abstract：:Successful procedural sedation represents a spectrum of patient- and clinician-related goals. The absence of a gold-standard measure of the efficacy of procedural sedation has led to a variety of outcomes being used in clinical trials, with the consequent lack of consistency among measures, making comparisons among tr...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章,评审
doi：10.1213/ANE.0000000000000934
更新日期：2016-01-01 00:00:00
abstract：:Tracheal temperature--the temperature of the tracheal wall--is believed to reflect the core temperature. The trachea reacts quickly to temperature changes because it is surrounded by various large arteries and veins. Using the blood temperature from the cardiopulmonary bypass (CPB) and the jugular vein temperature as ...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章
doi：10.1213/00000539-199304000-00020
更新日期：1993-04-01 00:00:00
abstract：BACKGROUND:In this prospective study, we compared the relationship between propofol concentrations and bispectral index (BIS) in children versus young adults anesthetized with target-controlled infusion (TCI) of propofol. METHODS:Forty-five prepubertal subjects (children) and 45 postpubertal subjects (adults) were stu...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ane.0b013e318164f388
更新日期：2008-04-01 00:00:00
abstract：:The effects of commercial and crystalline solutions of chloroprocaine (CP) (1.6 X 10(-3)-0.4 X 10(-3)M) and sodium bisulfite (SB) (0.8 X 10(-3)-0.08 X 10(-3)M) were studied on the multiplication of human neuroblastoma cells. These cells were chosen because of putative neurotoxicity associated with CP; cell multiplicat...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1987-10-01 00:00:00
abstract：:The "antimuscarinic effect" of fentanyl and its dependence on subtypes of receptors were characterized in isolated porcine coronary arteries. Left anterior descending coronary arteries were dissected from the hearts of 60 adult pigs obtained at a slaughterhouse and prepared for isometric tension studies. The effects o...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
abstract：:A 7-year-old girl manifested the rare anomaly of a ventricular septal defect (VSD) with left aortic arch, right descending aorta, and right ligamentum arteriosum. After open-heart surgery to correct the VSD, symptoms of tracheal obstruction on spontaneous breathing developed, due to tracheal compression by the right l...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1976-07-01 00:00:00
abstract：:Animal studies suggest that increased circulating estrogen and progesterone, and activation of the endorphin system cause prenancy-induced antinociceptive effects. Human studies have provided inconsistent results and have often lacked a nonpregnant control group. In this study, we compared sensitivity to experimental ...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/01.ane.0000239224.48719.28
更新日期：2006-11-01 00:00:00
abstract：:A new single injection procedure, the fascia iliaca compartment block, is described for blocking the femoral, lateral cutaneous, and obturator nerves. The technique consists of injecting a local anesthetic immediately behind the fascia iliaca at the union of the lateral with the two medial thirds of the inguinal ligam...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：UNLABELLED:We evaluated the effect of 1, 20, and 40 mL of epidural saline flush on recovery from lidocaine epidural anesthesia. Eight volunteers were studied for three study periods, each separated by 72 h. The volume of saline was randomized, and a new catheter was inserted for each study period. A standardized dose o...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00000539-199910000-00034
更新日期：1999-10-01 00:00:00
abstract：:Target-controlled infusion of IV anesthetic drugs is approved worldwide with the exception of the United States. The purpose of this special article is to review regulatory pathways that could lead to target-controlled infusion (TCI) clearance or approval in the United States. ...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章,评审
doi：10.1213/ANE.0000000000001018
更新日期：2016-01-01 00:00:00
abstract：:We studied three groups of patients without previous renal impairment, undergoing elective coronary artery bypass surgery. Group H (n = 7) underwent open heart surgery using moderate hypothermia (28 degrees C); Groups N and M (n = 8, each) were managed at normothermia. The extracorporeal circuit was primed with Hartma...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1213/00000539-199405000-00004
更新日期：1994-05-01 00:00:00
abstract：:The nasal route is preferred for fiberoptic intubation. Placing a lubricated endotracheal tube through the nostril can guide the fiberoptic scope towards the larynx. It would be helpful for optimal visualization of the vocal cord when the scope is passed through the endotracheal tube if the length of nares-vocal cord ...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/01.ANE.0000149900.68354.33
更新日期：2005-05-01 00:00:00
abstract：UNLABELLED:There has been growing interest in determining the possible immune consequences of opioid administration for the management of postoperative pain. We studied the effects of morphine and tramadol on pain and immune function during the postoperative period in 30 patients undergoing abdominal surgery for uterin...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章
doi：10.1097/00000539-200006000-00028
更新日期：2000-06-01 00:00:00
abstract：:Two hundred adults undergoing laparoscopic cholecystectomy were enrolled in a prospectively randomized, double-blind investigation comparing ondansetron, 4 mg (Group O) with the combination of droperidol, 0.625 mg, and metoclopramide, 10 mg (Group DM). Antiemetic drugs were administered intravenously (IV) after induct...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00000539-199611000-00032
更新日期：1996-11-01 00:00:00
abstract：:The effects of nitrous oxide-oxygen plus small doses of fentanyl with (N = 7) and without (N = 15) naloxone and the effects of nitrous oxide-oxygen plus halothane (N = 13) on plasma concentration of arginine vasopressin (AVP) and cortisol were studied in normal patients before and during gynecologic laparotomies. Pati...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:A number of cardiac arrests and severe hypotensive episodes have been witnessed associated with the intravenous infusion of fresh frozen plasma (FFP). To clarify the possible role of hypocalcemia, 28 thermally injured anesthetized pediatric patients with massive blood loss were studied to examine the cardiovascular re...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：UNLABELLED:The Meyer-Overton hypothesis predicts that the potency of conventional inhaled anesthetics correlates inversely with lipophilicity: minimum alveolar anesthetic concentration (MAC) x the olive oil/gas partition coefficient equals a constant of approximately 1.82 +/- 0.56 atm (mean +/- SD), whereas MAC x the o...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1097/00000539-199904000-00035
更新日期：1999-04-01 00:00:00
abstract：:The effects of sevoflurane on the beta-adrenoceptor (beta AR) system, consisting of the receptor, stimulatory guanosine triphosphate (GTP) binding protein (Gs), and adenylate cyclase (AC), were studied in rat myocardial membrane. Cyclic adenosine monophosphate (cAMP) production rate was measured as cAMP generation sti...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/00000539-199409000-00011
更新日期：1994-09-01 00:00:00
abstract：:Transesophageal echocardiography (TEE) is increasingly used intraoperatively as a monitor of ventricular function and volume. Despite its increasing use, whether data from TEE monitoring can be interpreted accurately on-line in real-time is unknown. We studied the performance of five community-based, full-time cardiac...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章
doi：10.1097/00000539-199606000-00006
更新日期：1996-06-01 00:00:00
abstract：:The effects of midazolam on atrial rate and contractile force in the isolated canine atrium perfused with donor blood were investigated. When midazolam in a dose range of 100-1000 micrograms was injected directly into the sinus node artery of the isolated atrium, biphasic (negative followed by positive) chronotropic a...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1987-08-01 00:00:00
abstract：UNLABELLED:The electrophysiologic effects of sevoflurane are not well characterized in humans. Among patients with refractory epilepsy, this study compared 1) electroencephalographic (EEG) interictal spike activity during wakefulness and sevoflurane anesthesia, and 2) electrocorticographically (ECoG) recorded intericta...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：:Selective segmental nerve blocks with local anesthetics are applied for diagnostic purposes in patients with chronic back pain to determine the segmental level of the pain. We performed this study to establish myotomal motor effects after L4 spinal nerve blocks by lidocaine and ropivacaine and to evaluate the relation...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1213/01.ANE.0000122268.70154.A9
更新日期：2004-08-01 00:00:00
abstract：UNLABELLED:Encouraged by the popularity of the pulse oximeter pulse-tone, we developed and tested an auditory display of six physiologic variables. The display consisted of a cardiovascular sound triggered by every heartbeat (conveying heart rate) and a respiratory sound triggered by every breath (conveying respiratory...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1097/00000539-200202000-00025
更新日期：2002-02-01 00:00:00
abstract：:We have recently reported a chronic allodynialike symptom in rats after ischemic spinal cord injury. This pain-related behavior is resistant to a number of pharmacologic treatments, including morphine, clonidine, carbamazepine, baclofen, and muscimol. In the present report, we present evidence indicating that systemic...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/00000539-199205000-00005
更新日期：1992-05-01 00:00:00
abstract：:Myocardial injury after noncardiac surgery (MINS) differs from myocardial infarction in being defined by troponin elevation apparently from cardiac ischemia with or without signs and symptoms. Such myocardial injury is common, silent, and strongly associated with mortality. MINS is usually asymptomatic and only detect...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章,评审
doi：10.1213/ANE.0000000000004567
更新日期：2020-07-01 00:00:00
abstract：UNLABELLED:In this study, we tested the validity of the bispectral index (BIS) monitor during conscious and deep sedation of children by comparing it with the University of Michigan Sedation Scale (UMSS), a validated observational pediatric sedation scale. Eighty-six children <12 yr of age were enrolled in this observa...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章
doi：10.1213/01.ane.0000067402.02136.a2
更新日期：2003-07-01 00:00:00
abstract：:In the perioperative period, artificial colloids are most often infused in doses of 500-1000 mL intravenously. This randomized study compared the effects on intravascular volume and coagulation of approximately 2000 mL of two isooncotic artificial colloids: 6% hydroxyethyl starch (HES; MW 200,000; substitution ratio 0...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00000539-199512000-00020
更新日期：1995-12-01 00:00:00
abstract：BACKGROUND:Pulse oximetry-derived oxygen saturation is typically >97% in normoxia and hyperoxia, limiting its clinical use. The new Oxygen Reserve Index (ORi), a relative indicator of the partial pressure of oxygen dissolved in arterial blood (PaO2) in the range of 100-200 mm Hg, may allow additional monitoring of oxyg...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章
doi：10.1213/ANE.0000000000003706
更新日期：2019-08-01 00:00:00
abstract：:Twenty-four male patients scheduled for elective pulmonary resection were studied to determine whether continuous insufflation of oxygen to the nonventilated lung would reduce intrapulmonary shunting (Qs/Qt) and arterial oxygen desaturation. Measurements of physiologic variables were made using pulmonary arterial and ...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1982-06-01 00:00:00
abstract：:The protective effect of a nonionic surface-active polyol agent (Pluronic F-68) against bolus injection and constant-rate IV infusion of air was studied in 21 dogs anesthetized with pentobarbital. Aortic, pulmonary artery and right ventricular pressures, cardiac output, end-tidal CO2 concentration, wasted ventilation,...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/00000539-197511000-00030
更新日期：1975-11-01 00:00:00
