Melatonin synthesis in the human pineal gland: advantages, implications, and difficulties.

Abstract:

:Rhythms in the mammalian pineal organ depend on afferent information that is derived from the endogenous clock residing in the hypothalamic suprachiasmatic nucleus (SCN). The best characterized function of the pineal gland is the nocturnally elevated synthesis of the hormone melatonin, which provides the body with the signal of the duration of the night period. The rate-limiting enzyme for melatonin synthesis is arylalkylamine N-acetyltransferase (AANAT). In contrast to the transcriptional regulation of the Aanat gene in rodents, a post-translational shaping of the melatonin pattern is indicated in the human pineal gland. Despite the fact that melatonin levels can be determined easily in various body fluids, the molecular elements involved in shaping the rhythmic hormone synthesis cannot be analyzed experimentally in the living organism. However, the use of post-mortem pineal material seems to constitute a valid approach to decipher the regulation of human melatonin synthesis.

journal_name

Chronobiol Int

authors

Ackermann K,Stehle JH

doi

10.1080/07420520500464379

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

369-79

issue

1-2

eissn

0742-0528

issn

1525-6073

pii

R6G8121N1U142741

journal_volume

23

pub_type

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