Abstract:
:Time- and space-resolved diffuse reflectance measurements were used to identify the optical parameters, the reduced scattering and absorption coefficients, of bulk living tissue in the region from 1.15 to 1.52 microm. Although in this region the detector was limited in its temporal resolution, we applied a peak-time shift analysis successfully to determine these coefficients in a human forearm, and then determined the absorption spectrum by space-resolved diffuse reflectance measurements. The absorption spectrum of a water content of 52% determined by magnetic resonance imaging experiments is in good agreement with the absorption coefficient obtained by optical measurements. Moreover, magnetic resonance imaging measurements suggest that the deviation of the absorption coefficients from the water spectrum in the strong water absorption band is caused by the heterogeneity of water distribution in tissue: the low content of water in the skin. These findings indicate that this optical method is potentially applicable to the non-invasive measurement of water in tissue, especially in a region lower than about 1.3-1.35 microm, which may be useful in monitoring oedema and tissue swelling.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Nishimura G,Kida I,Tamura Mdoi
10.1088/0031-9155/51/11/021subject
Has Abstractpub_date
2006-06-07 00:00:00pages
2997-3011issue
11eissn
0031-9155issn
1361-6560pii
S0031-9155(06)15489-5journal_volume
51pub_type
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