Abstract:
:Of all protein PTMs, glycosylation is by far the most common, and is a target for proteomic research. Glycosylation plays key roles in controlling various cellular processes and the modifications of the glycan structures in diseases highlight the clinical importance of this PTM. Glycosylation analysis remains a difficult task. MS, in combination with modern separation methodologies, is one of the most powerful and versatile techniques for the structural analysis of glycoconjugates. This review describes methodologies based on MS for detailed characterization of glycoconjugates in complex biological samples at the sensitivity required for proteomic work.
journal_name
Proteomicsjournal_title
Proteomicsauthors
Morelle W,Canis K,Chirat F,Faid V,Michalski JCdoi
10.1002/pmic.200600129subject
Has Abstractpub_date
2006-07-01 00:00:00pages
3993-4015issue
14eissn
1615-9853issn
1615-9861journal_volume
6pub_type
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