Abstract：
:Recently, strains of Streptococcus pneumoniae with greatly increased resistance to penicillin (minimal inhibitory concentrations or MICs, 1--8 microgram/ml) were recovered in cultures of blood from patients in South Africa and from one in Minnesota who had serious pneumococcal infections. The authors undertook a study to determine whether these resistant strains have become prevalent in their locale. Between January and July 1978, the laboratories of hospitals serving the greater Madison, Wisconsin, area (population 200,000) contributed 243 pneumococcal isolates for susceptibility testing by an agar dilution technic. Strains with greatly increased resistance (MICs greater than or equal to 1.0 microgram/ml) were not found; only six strains (2.4%) had relative resistance to penicillin (MICs .125--.50 microgram/ml), a range of susceptibility that has been associated with inconsistent clinical responses to treatment with penicillin. Overall, the susceptibility patterns of these 243 isolates are similar to those reported from other centers in North America over the past 30 years. Routine susceptibility testing of pneumococci by hospital laboratories in our area does not appear to be necessary now, but laboratories are advised to screen blood and spinal fluid isolates by a disk-diffusion method. Studies of these 243 isolates and seven South African multiply-resistant strains using a modified Kirby-Bauer technic, showed that a zone of inhibition less than 35 mm around a 10-unit penicillin disk, or better, less than 17 mm around a 1-microgram oxacillin disk, correlates strongly (P less than .001) with resistance to penicillin (MIC greater than or equal to .1 microgram/ml).
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Maki DG,Helstad AG,Kimball JLdoi
10.1093/ajcp/73.2.177subject
Has Abstractpub_date
1980-02-01 00:00:00pages
177-82issue
2eissn
0002-9173issn
1943-7722journal_volume
73pub_type
杂志文章abstract：:Although acute myeloid leukemias (AMLs) cytochemically negative for myeloperoxidase are now well recognized, myeloid surface antigen-negative AMLs are rare. The morphologic, cytochemical, immunologic, and cytogenetic or molecular features of such cases are described in four adults aged 19 to 60 years. All had AML with...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/107.1.68
更新日期：1997-01-01 00:00:00
abstract：:Five hundred eighty-seven daily urine specimens were examined from 179 consecutive renal allograft recipients with the use of quantitative cytodiagnostic urinalysis. Specimens were divided between those patients receiving cyclosporine (CyA) and steroid immunotherapy (73 patients) and those receiving standard azathiopr...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/89.1.113
更新日期：1988-01-01 00:00:00
abstract：:Loss of intercellular adhesion facilitates tumor invasion. To clarify the relation between altered expression of cell adhesion molecules and progression of T1 superficial bladder tumors, 101 cases (71 T1 tumors, 30 T2/T3 tumors) were examined immunohistochemically for E-cadherin and alpha-, beta-, and gamma-catenins. ...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Quantitative morphometry was used to evaluate the homogeneity of lymphoid cell populations in fine-needle aspiration cytology smears of lymph nodes from eight non-Hodgkin's lymphomas and four benign lymphoid proliferations. Using the standard deviation of log-transformed nuclear areas as the measure of lymphoid cell h...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/92.4.458
更新日期：1989-10-01 00:00:00
abstract：:Twenty cases of inflammatory myofibroblastic tumor (IMT) were studied; 19 involved the lung and 1 the esophagus only. The patients' ages ranged from 3 to 72 years. There were 9 males and 11 females. Involvement of a bronchus was seen in one case and of mediastinal structures in four. Chest pain and dyspnea were common...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/94.5.538
更新日期：1990-11-01 00:00:00
abstract：OBJECTIVES:To describe our experience, both in meeting challenges and in reporting outcomes, of the consolidation of anatomic pathology services in the North Shore-LIJ Health System in February 2011. METHODS:We addressed issues of governance, personnel, physical plant, quality programming, connectivity, and education....
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/AJCPZHEYK8XF4FCK
更新日期：2013-07-01 00:00:00
abstract：:Two monoclonal antibodies, UCD/AB 6.11 and UCD/PR 10.11, were evaluated for their patterns of immunohistochemical reactivity in a survey of paraffin-embedded human tissues by the avidin-biotin-immunoperoxidase technique. By two-dimensional immunoblotting, UCD/AB 6.11 reacts with keratin number 18 and UCD/PR 10.11 iden...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/89.4.472
更新日期：1988-04-01 00:00:00
abstract：Objectives:Fibromatosis of the breast is an uncommon neoplasm with potential for local recurrence. Treatment has traditionally been surgical excision with current trends toward conservative management. Given the option of observation after diagnosis by core needle biopsy (CNB), we sought to evaluate the accuracy of CNB...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/aqx065
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVES:To assess physicians' and nurses' satisfaction with the service provided by the laboratory at Gondar University Hospital. METHODS:We conducted a cross-sectional study involving 196 nurses and physicians. RESULTS:Overall level of satisfaction was 51.1% for nurses and 51.5% for physicians. Lack of consistenc...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/AJCPU1PLVOIN5JQI
更新日期：2013-09-01 00:00:00
abstract：:Point-of-care testing (POCT) is a means of providing patient services more rapidly. Most evaluations of bedside laboratory testing devices have emphasized analytical performance in tertiary care settings. In contrast, the authors compare the operating cost of POCT for glucose and an electrolyte/glucose/blood urea nitr...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/103.2.240
更新日期：1995-02-01 00:00:00
abstract：:Three cases of microcystic adenomas of the pancreas with special reference to multicentric origin are described. The gross features and light microscopic findings were consistent with those described as being microcystic adenomas, but in two cases the gross examination and gelatin-embedded giant slices revealed multip...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/94.2.150
更新日期：1990-08-01 00:00:00
abstract：:Thirty-five consecutive renal biopsy specimens were evaluated by light histology using paraffin and glycol methacrylate embedding. The clarity of the renal structures was found to be much better, and the renal lesions better defined, using glycol methyacrylate embedding. ...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/64.5.655
更新日期：1975-11-01 00:00:00
abstract：:The occurrence and characteristics of intracellular immunoglobulin inclusions in non-Hodgkin's lymphomas are described. Lymphoma cells from three patients with immunoblastic sarcoma contained classic cytoplasmic, periodic acid-Schiff (PAS)-positive Russell bodies. Immunoperoxidase staining revealed monoclonal IgG (k) ...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/69.1.306
更新日期：1978-03-01 00:00:00
abstract：OBJECTIVES:To examine high expression of tumor necrosis factor ligand superfamily member 13 (TNFSF13), which is correlated with several malignancies. METHODS:TNFSF13 messenger RNA expression in tumor cells and fibroblasts in a cohort of patients with non-small cell lung cancer (NSCLC) was analyzed by quantitative real...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/AJCP4JP8BZOMHEAW
更新日期：2014-02-01 00:00:00
abstract：:Characteristically, mantle cell lymphoma (MCL) expresses surface immunoglobulin (sIg), CD19, CD20, and CD5 and lacks CD10 and CD23. Rare CD5-MCL variants have been described. This report describes a case of leukemic MCL with morphologically and immunophenotypically distinct classic MCL and blastoid-variant MCL (BV-MCL...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/UD2C-6JVP-WHXQ-Q217
更新日期：2004-07-01 00:00:00
abstract：Objectives:To determine the impact of systemwide charge display on laboratory utilization. Methods:This was a randomized controlled trial with a baseline period and an intervention period. Tests were randomized to a control arm or an active arm. The maximum allowable Medicare reimbursement rate was displayed for tests...
journal_title：American journal of clinical pathology
pub_type： 杂志文章,随机对照试验
doi：10.1093/ajcp/aqx110
更新日期：2017-11-20 00:00:00
abstract：:This study evaluates the sensitivity and detection time of a new radiometric broth (BACTEC 13A medium, Johnston Laboratories, Towson, MD) designed for direct blood culturing for Mycobacteria. A total of 1,848 blood specimens were cultured in parallel by a new method in which blood was directly inoculated into 13A medi...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/91.3.316
更新日期：1989-03-01 00:00:00
abstract：:Forty-five renal biopsies with amyloidosis were studied by light microscopy with Congo red staining and action of potassium permanganate and by immunofluorescence with antihuman tissue A component antiserum antilight and heavy chains of immunoglobulins antisera. The patients were classified on the basis of concordance...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/87.6.756
更新日期：1987-06-01 00:00:00
abstract：:The demonstration of tartrate-resistant acid phosphatase (TRAP) activity has long been a cornerstone in the diagnosis of hairy cell leukemia (HCL). Recently a monoclonal antibody to this enzyme has been developed that can be used in an immunoperoxidase method on paraffin-embedded tissues. By using a peroxidase-labeled...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/108.3.308
更新日期：1997-09-01 00:00:00
abstract：:Ewing family tumors (EFTs) and prostate carcinomas are characterized by rearrangement of ETS genes, most commonly FLI1 (EFTs) and ERG (prostate carcinomas). Previously, we characterized an antibody against ERG (EPR3864) for detecting ERG-rearranged prostate carcinoma. Because EPR3864 also cross-reacts with FLI1, we ev...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/AJCPN4L1BMRQPEIT
更新日期：2013-06-01 00:00:00
abstract：:Platelet satellitism (PS), the phenomenon of platelet rosetting around polymorphonuclear neutrophils (PMN), which is observed in ethylenediamineetetraacetic acid (EDTA)-anticoagulated blood at room temperature, is caused by the presence of IgG autoantibodies in the serum. Fourteen patients with PS were studied, and th...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/103.6.740
更新日期：1995-06-01 00:00:00
abstract：:Epithelial hyperplasia, a component of proliferative breast disease (PBD), is a known risk factor for the development of breast carcinoma. To determine if criteria established for tissue biopsy could be used to more precisely define cytologic criteria for diagnosis of PBD, 37 breast fine-needle aspirates with biopsy d...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/103.4.438
更新日期：1995-04-01 00:00:00
abstract：:A comparative evaluation of two commercial kits that detect antinuclear antibodies via indirect immunofluorescence was undertaken using an adult ambulatory population. The sensitivity and specificity of the kits were compared to determine which of the two was more efficient as a screening test for systemic lupus eryth...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/81.3.308
更新日期：1984-03-01 00:00:00
abstract：:Two hundred forty-three patients who had pathologically verified primary osteosarcomas of bone, treated at The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute over a 24-year period, form the basis of this study. These cases provide a basis for comparison of those patients currentl...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/67.5.427
更新日期：1977-05-01 00:00:00
abstract：:The demonstration of carcinoembryonic antigen (CEA) in serum and in tissue sections may be of value in diagnosis and follow-up of several malignant tumors. Anti-CEA sera, however, cross-react with normal antigens, also present in tumors. The staining patterns of three commercially produced anti-CEA sera were investiga...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/79.1.25
更新日期：1983-01-01 00:00:00
abstract：:Cryostat sections from fully developed papular lesions of lymphomatoid papulosis (histologic subtype A or B) have been examined by immunoenzymatic staining with 24 monoclonal antibodies against lymphoid cells and their subsets. The lesions demonstrated essentially identical cellular compositions and consisted of T-lym...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/84.5.587
更新日期：1985-11-01 00:00:00
abstract：:Primary thymic epithelial neoplasms have been the subject of much controversy in recent years owing to the difficulties posed by these tumors for precise histopathologic typing and prognostication. A number of classification schemes using different terminology have been proposed, none of which has satisfactorily manag...
journal_title：American journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1093/ajcp/111.6.826
更新日期：1999-06-01 00:00:00
abstract：:With the new screening and treatment guidelines and the prospect of human papillomavirus vaccination for adolescents, the current total volume of Papanicolaou (Pap) tests will be significantly reduced. We used available data to assess the current supply and demand in the cytotechnology labor market and how an expected...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/40DW4TG5TKNUEM71
更新日期：2007-10-01 00:00:00
abstract：:Hyperparathyroidism may occasionally present as a neck mass resulting from cystic change in a parathyroid adenoma. We report an unusual instance of hyperparathyroidism presenting as a palpable, but asymptomatic hyperplastic parathyroid gland cyst. We conclude that hyperplastic parathyroid glands may undergo cystic deg...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/77.1.104
更新日期：1982-01-01 00:00:00
abstract：:In the thymus, the relationship between lymphofollicular hyperplasia and mucosa-associated lymphoid tissue (MALT)-type lymphoma is uncertain. We analyzed 14 cases with a diagnosis of thymic follicular hyperplasia in patients with connective tissue disease (n = 2), myasthenia gravis (n = 11), or both (n = 1). In 11 cas...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/G3AC-P7K8-2JNK-8C3U
更新日期：2002-01-01 00:00:00
