Kinetics of onset of rate-dependent effects of Class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification.

abstract：:The G protein-coupled receptor kinases (GRKs) participate with arrestins in the regulation and signal propagation of multiple G protein-coupled receptors (GPCR) of key physiological and pharmacological relevance in the cardiovascular system. The complex mechanisms of regulation of GRK expression, degradation and funct...

journal_title：Cardiovascular research

authors： Penela P,Murga C,Ribas C,Tutor AS,Peregrín S,Mayor F Jr

更新日期：2006-01-01 00:00:00

abstract：AIMS:Although the use of drug-eluting stents (DESs) has been shown to limit neointima hyperplasia, currently available DESs may adversely affect re-endothelialization. To evaluate whether a novel gene silencer pyrrole-imidazole (PI) polyamide targeting transforming growth factor (TGF)-beta1 is a candidate agent for the...

journal_title：Cardiovascular research

authors： Yao EH,Fukuda N,Ueno T,Matsuda H,Nagase H,Matsumoto Y,Sugiyama H,Matsumoto K

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:The aim was to test the hypothesis that A1 receptor mediated cardioprotection by endogenous adenosine is exerted during ischaemia rather than reperfusion. METHODS:Anaesthetised open chest rabbits were subjected to 30 min regional ischaemia and 120 min reperfusion, and randomised to one of six groups: group I...

journal_title：Cardiovascular research

authors： Zhao ZQ,Nakanishi K,McGee DS,Tan P,Vinten-Johansen J

更新日期：1994-02-01 00:00:00

abstract：:Isolated, buffer perfused guinea pig hearts were used to study the effects of sotalol on arrhythmias and electrophysiology during 30 min of myocardial ischaemia, induced by reducing coronary flow to 10% of control, and subsequent reperfusion. Action potentials were recorded using the floating microelectrode technique ...

journal_title：Cardiovascular research

authors： Culling W,Penny WJ,Sheridan DJ

更新日期：1984-07-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of the ATP-sensitive potassium (KATP) channel inhibitor sodium 5-hydroxydecanoate (5-HD) on the reduction in myocardial infarct size afforded by ischaemic preconditioning in the sodium pentobarbitone rabbit. METHODS:New Zealand white rabbits were anaesthetised with sodium pentobarbi...

journal_title：Cardiovascular research

authors： Hide EJ,Thiemermann C

更新日期：1996-06-01 00:00:00

abstract：AIMS:Adequate microcirculatory perfusion, and not just opening of occluded arteries, is critical to salvage heart tissue following myocardial infarction. However, the degree of microvascular perfusion taking place is not known, limited primarily by an inability to directly image coronary microcirculation in a beating h...

journal_title：Cardiovascular research

authors： Kavanagh DPJ,Lokman AB,Neag G,Colley A,Kalia N

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:We recently demonstrated in our swine model of coronary artery spasm that enhanced myosin light chain (MLC) phosphorylations (both MLC mono- and diphosphorylations) play a central role in the pathogenesis of the spasm. However, the molecular mechanism for and the phosphorylation sites for the enhanced MLC pho...

journal_title：Cardiovascular research

authors： Shimokawa H,Seto M,Katsumata N,Amano M,Kozai T,Yamawaki T,Kuwata K,Kandabashi T,Egashira K,Ikegaki I,Asano T,Kaibuchi K,Takeshita A

更新日期：1999-09-01 00:00:00

abstract：AIMS:n-3 Polyunsaturated fatty acids (PUFAs) are known to protect the cardiovascular system and improve blood pressure control. These important dietary constituents are converted into bioactive metabolites, but their role in regulation of the cardiovascular system is unclear. In particular, the functions of the cytochr...

journal_title：Cardiovascular research

authors： Wang RX,Chai Q,Lu T,Lee HC

更新日期：2011-05-01 00:00:00

abstract：Aims:Circulating proteins larger than 3 nm can be transported across continuous endothelial barrier of blood vessels via transcytosis. However, excessive accumulation of serum proteins within the vessel walls is uncommon even for those abundant in the circulation. The aim of this study was to investigate how transcytos...

journal_title：Cardiovascular research

authors： Li HY,Liu XL,Liu YT,Jia ZK,Filep JG,Potempa LA,Ji SR,Wu Y

更新日期：2019-02-01 00:00:00

abstract：AIMS:AMP-activated protein kinase (AMPK) is thought to be a central player in regulating myocardial metabolism and its activation has been shown to inhibit cardiac hypertrophy. Recently, mice with muscle-specific deletion of AMPK β1/β2 subunits (AMPKβ1β2-deficient mice, β1β2M-KO) have been generated and possess <10% of...

journal_title：Cardiovascular research

authors： Sung MM,Zordoky BN,Bujak AL,Lally JS,Fung D,Young ME,Horman S,Miller EJ,Light PE,Kemp BE,Steinberg GR,Dyck JR

更新日期：2015-07-15 00:00:00

abstract：OBJECTIVE:The development of collateral microvessels following therapeutic angiogenesis with vascular endothelial growth factor (VEGF) was investigated using a new system of microangiography that employs monochromatic synchrotron radiation (SR) and a high definition video system to visualize arteries with a spatial res...

journal_title：Cardiovascular research

authors： Takeshita S,Isshiki T,Mori H,Tanaka E,Tanaka A,Umetani K,Eto K,Miyazawa Y,Ochiai M,Sato T

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:Progressive loss of cardiomyocytes is one of the most important pathogenic characteristics of heart failure. Apoptosis may be an important mode of cell death in heart failure but it must be demonstrated by multiple criteria and not just TUNEL staining alone. Previously, we and others have demonstrated that be...

journal_title：Cardiovascular research

authors： Knaapen MW,Davies MJ,De Bie M,Haven AJ,Martinet W,Kockx MM

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVES:To elucidate the effect of selective endothelin ET(A)- and mixed ET(A/B)-receptor antagonists on endothelial vasomotor dysfunction in rats with heart failure after myocardial infarction (MI). METHODS:Vasoreactivity and superoxide anion formation were determined in aortic rings from Wistar rats 12 weeks afte...

journal_title：Cardiovascular research

authors： Bauersachs J,Fraccarollo D,Galuppo P,Widder J,Ertl G

更新日期：2000-07-01 00:00:00

abstract：:Felodipine (4(2,3-dichlorophenyl)-1,4-dihydro-2, 6-dimethyl-3-ethoxycarbonyl-5-methoxycarbonyl pyridine)), a selective vasodilating anti-hypertensive drug, was used in the treatment of spontaneously hypertensive rats (SHRs) and age-matched Wistar-Kyoto rats (WKYs) from age 6 to 14 weeks, ie during the time of high blo...

journal_title：Cardiovascular research

authors： Nyborg NC,Mulvany MJ

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVE:The aim was to characterise the influence of a decrease in transsarcolemmal calcium influx on the calcium content of the sarcoplasmic reticulum and on the force of postrest contraction, which is largely activated by calcium released from the sarcoplasmic reticulum. METHODS:Isometric force of postrest contrac...

journal_title：Cardiovascular research

authors： Komai H,Rusy BF

更新日期：1993-05-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to compare the temporal sequence and structural relationship between perivascular and interstitial fibrosis and microscopic scarring seen in the left ventricle in response to either a transient or sustained stimulus to fibrosis. DESIGN:In 72 male Wistar rats (250-350 g) the transient stimul...

journal_title：Cardiovascular research

authors： Silver MA,Pick R,Brilla CG,Jalil JE,Janicki JS,Weber KT

更新日期：1990-09-01 00:00:00

abstract：:The failing heart is characterized by alterations in energy metabolism, including mitochondrial dysfunction and a reduction in fatty acid (FA) oxidation rate, which is partially compensated by an increase in glucose utilization. Together, these changes lead to an impaired capacity to convert chemical energy into mecha...

journal_title：Cardiovascular research

authors： van Bilsen M,van Nieuwenhoven FA,van der Vusse GJ

更新日期：2009-02-15 00:00:00

abstract：OBJECTIVE:Pericytes, located in close proximity to the underlying endothelium, form an integral component of the microvasculature. These cells are intimately involved in angiogenesis, which is of fundamental importance in many physiological and pathological processes. We evaluated the influence of pericyte-conditioned ...

journal_title：Cardiovascular research

authors： McIlroy M,O'Rourke M,McKeown SR,Hirst DG,Robson T

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Lipoprotein lipase (LPL) mediated hydrolysis of circulating triglyceride (TG)-rich lipoproteins provides the heart with fatty acids. The present study was designed to investigate the influence of circulating TG and their lipolysis in facilitating translocation of LPL from the underlying cardiomyocyte cell sur...

journal_title：Cardiovascular research

authors： Pulinilkunnil T,Qi D,Ghosh S,Cheung C,Yip P,Varghese J,Abrahani A,Brownsey R,Rodrigues B

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:Myocardial adaptation has been reported to result from mild but chronic ischaemia in the hearts of patients with coronary artery disease. The aim of this study was to test the hypothesis that the responses of the chronically hypoxic myocardium to an episode of severe ischaemia, or the effects of acute ischaem...

journal_title：Cardiovascular research

authors： Tajima M,Katayose D,Bessho M,Isoyama S

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:Hemodynamic stresses are considered to be important regulators of gene expression in vascular cells. In this study, we have investigated the role of shear stress on ACE expression in cultured rat vascular cells, and focused on the regulation of ACE expression in smooth muscle cells. METHODS:Rat aortic endoth...

journal_title：Cardiovascular research

authors： Gosgnach W,Challah M,Coulet F,Michel JB,Battle T

更新日期：2000-01-14 00:00:00

abstract：OBJECTIVE:Insulin seems to have vasodilator properties, but it is unclear if insulin in postprandial concentrations is a specific vasodilator of skeletal muscle resistance arterioles only or that various types of vessels are affected. The aim of the present study was to determine the direct effects and the time course ...

journal_title：Cardiovascular research

authors： de Haan CH,van Dielen FM,Houben AJ,de Leeuw PW,Huvers FC,De Mey JG,Wolffenbuttel BH,Schaper NC

更新日期：1997-04-01 00:00:00

abstract：UNLABELLED:Recent investigations have established the feasibility of using exogenously delivered angiogenic growth factors to increase collateral artery development in animal models of myocardial and hindlimb ischemia. OBJECTIVE:Our aim was to evaluate the ability of a stabilized form of acidic fibroblast growth facto...

journal_title：Cardiovascular research

authors： Hershey JC,Corcoran HA,Baskin EP,Gilberto DB,Mao X,Thomas KA,Cook JJ

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:The present study investigated whether activation of phosphatidylinositol 3-kinase (PI3-kinase) is involved in the stimulation of hypertrophic growth of adult ventricular cardiomyocytes under alpha- or beta-adrenoceptor stimulation. METHODS:Adult ventricular rat cardiomyocytes were used either directly after...

journal_title：Cardiovascular research

authors： Schlüter KD,Goldberg Y,Taimor G,Schäfer M,Piper HM

更新日期：1998-10-01 00:00:00

abstract：AIMS:Vascular remodelling and aortic aneurysm formation are induced mainly by inflammatory responses in the adventitia and media. However, relatively little is known about the mechanistic significance of endothelium in the pathogenesis of these vascular disorders. The transcription factor nuclear factor-kappa B (NF-κB)...

journal_title：Cardiovascular research

authors： Saito T,Hasegawa Y,Ishigaki Y,Yamada T,Gao J,Imai J,Uno K,Kaneko K,Ogihara T,Shimosawa T,Asano T,Fujita T,Oka Y,Katagiri H

更新日期：2013-01-01 00:00:00

abstract：:Mechanical stress signals transmitted through the heart walls during hemodynamic loading are sensed by the myocytes, which respond with changes in contractile performance and gene expression. External forces play an important role in physiological heart development and hypertrophy, but disruption of the well-balanced ...

journal_title：Cardiovascular research

authors： Linke WA

更新日期：2008-03-01 00:00:00

abstract：:This review attempts to define the early events that lead to lesions of human atherosclerosis based on careful morphological studies in human autopsy specimens. In contrast to most small laboratory animals, diffuse intimal thickening (DIT) is present in human arteries before atherosclerosis develops, particularly in t...

journal_title：Cardiovascular research

authors： Nakashima Y,Wight TN,Sueishi K

更新日期：2008-07-01 00:00:00

abstract：AIMS:The TRPV1, transient receptor potential vanilloid type 1, agonist capsaicin is considered to be beneficial for cardiovascular health because it dilates coronary arteries through an endothelial-dependent mechanism and may slow atheroma progression. However, recent reports indicate that high doses of capsaicin may c...

journal_title：Cardiovascular research

authors： Hiett SC,Owen MK,Li W,Chen X,Riley A,Noblet J,Flores S,Sturek M,Tune JD,Obukhov AG

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Washed platelets have been shown to protect isolated buffer perfused rat hearts from injury and dysfunction following ischaemia-reperfusion. This study was designed to investigate whether platelet glutathione redox cycle contributes to the protective effect of platelets. METHODS:Isolated rat hearts were perf...

journal_title：Cardiovascular research

authors： Yang BC,Mehta A,Mehta JL

更新日期：1994-10-01 00:00:00

abstract：:In the heart, Ca(2+) influx via Ca(V)1.2 L-type calcium channels (LTCCs) is a multi-functional signal that triggers muscle contraction, controls action potential duration, and regulates gene expression. The use of LTCC Ca(2+) as a multi-dimensional signalling molecule in the heart is complicated by several aspects of ...

journal_title：Cardiovascular research

authors： Shaw RM,Colecraft HM

更新日期：2013-05-01 00:00:00