Abstract：
:The failing heart is characterized by alterations in energy metabolism, including mitochondrial dysfunction and a reduction in fatty acid (FA) oxidation rate, which is partially compensated by an increase in glucose utilization. Together, these changes lead to an impaired capacity to convert chemical energy into mechanical work. This has led to the concept that supporting cardiac energy conversion through metabolic interventions provides an important adjuvant therapy for heart failure. The potential success of such a therapy depends on whether the shift from FA towards glucose utilization should be considered beneficial or detrimental, a question still incompletely resolved. In this review, the current status of the literature is evaluated and possible causes of observed discrepancies are discussed. It is cautiously concluded that for the failing heart, from a therapeutic point of view, it is preferable to further stimulate glucose oxidation rather than to normalize substrate metabolism by stimulating FA utilization. Whether this also applies to the pre-stages of cardiac failure remains to be established.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
van Bilsen M,van Nieuwenhoven FA,van der Vusse GJdoi
10.1093/cvr/cvn282subject
Has Abstractpub_date
2009-02-15 00:00:00pages
420-8issue
3eissn
0008-6363issn
1755-3245pii
cvn282journal_volume
81pub_type
杂志文章,评审abstract：:Exogenous angiotensin II causes noradrenaline supersensitivity in rat mesenteric vasculature preparations. The noradrenaline supersensitivity of tissues from renal/salt hypertensive rats, with low plasma renin activity, is not caused by endogenous angiotensin II since it was unaffected by Sar1 Ileu8 angiotensin II. Di...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/10.2.232
更新日期：1976-03-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(01)00207-3
更新日期：2001-06-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvw231
更新日期：2017-01-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvu250
更新日期：2015-02-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/25.8.700
更新日期：1991-08-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/25.4.314
更新日期：1991-04-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/24.6.456
更新日期：1990-06-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvp280
更新日期：2010-01-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/10.1.13
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/13.7.392
更新日期：1979-07-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(01)00536-3
更新日期：2002-03-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 历史文章,杂志文章,评审
doi：10.1093/cvr/cvy084
更新日期：2018-07-15 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(96)00185-x
更新日期：1997-01-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/j.cardiores.2006.02.014
更新日期：2006-05-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1016/s0008-6363(97)00059-x
更新日期：1997-04-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(97)00314-3
更新日期：1998-04-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/18.8.514
更新日期：1984-08-01 00:00:00
abstract：OBJECTIVE:The aim was to determine if either heparin or N-acetylheparin could reduce the extent of myocardial injury resulting from 90 min of coronary artery occlusion and 6 h of reperfusion in the anaesthetised dog. METHODS:Heparin or N-acetylheparin was given in three repeated intravenous doses of 2 mg.kg-1. Drug or...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvaa241
更新日期：2020-08-10 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/0008-6363(95)00235-9
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journal_title：Cardiovascular research
pub_type： 杂志文章,评审
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更新日期：2011-07-15 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/j.cardiores.2005.05.025
更新日期：2005-11-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1016/j.cardiores.2003.11.024
更新日期：2004-02-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvu264
更新日期：2015-03-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvv152
更新日期：2015-07-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvaa161
更新日期：2020-06-12 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/j.cardiores.2005.11.021
更新日期：2006-03-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(96)00268-4
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvn228
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/21.4.241
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