Abstract:
:Elevated sympathetic activity changes renal function and accelerates the development of hypertension. Principles of sympatho-renal interactions in chronic hypertension are reviewed. Alterations in the ontogeny of the sympathetic nervous system and the kidney, inherited abnormalities in sensory receptor function and exaggerated responsiveness to mental stress contribute to inappropriately high sympathetic activity in primary or essential hypertension. Careful characterization of clinical study populations shows that elevated sympathetic activity and "essential" hypertension are not unequivocally associated. Prospective clinical studies which investigate a broader array of physiological functions and experiments in recombinant inbred rodents with less traumatic nerve recording techniques than currently available will help to define under which conditions elevated sympathetic activity is indeed a cause of primary hypertension. Signals arising from the kidney which activate the renin-angiotensin system and afferent renal nerves increase sympathetic activity. These mechanisms importantly contribute to the pathogenesis of hypertension secondary to renal artery stenosis and end-stage renal disease.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Grisk O,Rettig Rdoi
10.1016/j.cardiores.2003.11.024subject
Has Abstractpub_date
2004-02-01 00:00:00pages
238-46issue
2eissn
0008-6363issn
1755-3245pii
S0008636303007338journal_volume
61pub_type
杂志文章,评审abstract:OBJECTIVE:To determine the effect of acute left ventricular dilatation on refractoriness in normal hearts. METHODS:During sustained ventricular fibrillation (VF) in isolated perfused hearts, recording of local activation time yields VF intervals which provide an index of local refractoriness. Simultaneous measurement ...
journal_title:Cardiovascular research
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journal_title:Cardiovascular research
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更新日期:1977-03-01 00:00:00
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更新日期:1985-02-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章,评审
doi:10.1016/s0008-6363(97)00141-7
更新日期:1997-08-01 00:00:00
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更新日期:2011-04-01 00:00:00
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更新日期:1987-04-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/28.8.1258
更新日期:1994-08-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
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更新日期:2000-08-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
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更新日期:2004-07-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
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更新日期:2008-06-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/cvq296
更新日期:2011-02-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/j.cardiores.2004.07.004
更新日期:2004-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/j.cardiores.2004.02.016
更新日期:2004-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/cvr/27.10.1826
更新日期:1993-10-01 00:00:00
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更新日期:2002-02-01 00:00:00
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更新日期:2000-02-01 00:00:00
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更新日期:2012-01-01 00:00:00
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更新日期:1985-10-01 00:00:00
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更新日期:2021-01-23 00:00:00
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更新日期:2003-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章,评审
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更新日期:2004-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/cvz306
更新日期:2020-10-01 00:00:00