PPARdelta and PGC1alpha act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress.

abstract：:Excessive feeding is associated with an increase in the incidence of chronic metabolic diseases, such as obesity, insulin resistance, and type 2 diabetes. Metabolic disturbance induces chronic low-grade inflammation in metabolically-important organs, such as the liver and adipose tissue. Many of the inflammatory signa...

journal_title：Cardiovascular research

authors： Nishida K,Otsu K

更新日期：2017-03-15 00:00:00

abstract：OBJECTIVE:Recently, we have found that rat CMV (RCMV) infected smooth muscle cells (SMCs) in rat carotid arteries when administered 14 days after balloon injury. In the present study we investigated (1) the long term effects of CMV infection on neointimal cross-sectional area, and (2) whether the phenotype of the intim...

journal_title：Cardiovascular research

authors： Persoons MC,Daemen MJ,van Kleef EM,Grauls GE,Wijers E,Bruggeman CA

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:The Na+ activated K+ channel (IK(Na)) may be activated during ischaemia when the intracellular Na+ concentration is raised. As ischaemia is also associated with intracellular acidification, the influence of intracellular pH on this K+ channel was investigated. METHODS:The effects of intracellular Na+ and H+ ...

journal_title：Cardiovascular research

authors： Veldkamp MW,Vereecke J,Carmeliet E

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVES:We studied the effects of chronic left coronary artery ligation on cardiac structure and function in the mouse. METHODS:Morphometric studies of the left ventricle were performed in coronary artery-ligated and sham-operated animals at one, two, three and five weeks after surgery. The fraction of DNA-synthesi...

journal_title：Cardiovascular research

authors： Lutgens E,Daemen MJ,de Muinck ED,Debets J,Leenders P,Smits JF

更新日期：1999-03-01 00:00:00

abstract：:Labetolol, which blocks both alpha and beta-adrenoceptors, was found to have direct actions on cardiac muscle which could themselves be antiarrhythmic. It depressed the maximum rate of depolarisation, and reduced conduction velocity, in atrial and ventricular muscle and in Purkinje cells, implying restriction of fast ...

journal_title：Cardiovascular research

authors： Vaughn Williams EM,Millar JS,Campbell TJ

更新日期：1982-05-01 00:00:00

abstract：AIMS:Animal studies show that transforming growth factor-β1 (TGF-β1) is an important mediator of atrial fibrosis and atrial fibrillation (AF). This study investigated the role of TGF-β1 in human AF and the mechanism of atrial-selective fibrosis. METHODS AND RESULTS:Atrial specimens from 17 open heart surgery patients ...

journal_title：Cardiovascular research

authors： Rahmutula D,Marcus GM,Wilson EE,Ding CH,Xiao Y,Paquet AC,Barbeau R,Barczak AJ,Erle DJ,Olgin JE

更新日期：2013-09-01 00:00:00

abstract：:This review attempts to define the early events that lead to lesions of human atherosclerosis based on careful morphological studies in human autopsy specimens. In contrast to most small laboratory animals, diffuse intimal thickening (DIT) is present in human arteries before atherosclerosis develops, particularly in t...

journal_title：Cardiovascular research

authors： Nakashima Y,Wight TN,Sueishi K

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:Resistin belongs to a family of cysteine-rich secreted polypeptides that are mainly produced by monocytes/macrophages in humans. Recently, high concentrations of resistin were shown to induce vascular endothelial dysfunction and vascular smooth muscle cell proliferation. We examined if resistin was secreted f...

journal_title：Cardiovascular research

authors： Jung HS,Park KH,Cho YM,Chung SS,Cho HJ,Cho SY,Kim SJ,Kim SY,Lee HK,Park KS

更新日期：2006-01-01 00:00:00

abstract：AIMS:Crosstalk between cardiomyocytes and fibroblasts in physiological conditions and during disease remains poorly defined. Previous studies have shown that fibroblasts and myocytes interact via paracrine communication, but several experimental confounding factors, including the use of immature myocytes and the induct...

journal_title：Cardiovascular research

authors： Cartledge JE,Kane C,Dias P,Tesfom M,Clarke L,Mckee B,Al Ayoubi S,Chester A,Yacoub MH,Camelliti P,Terracciano CM

更新日期：2015-03-01 00:00:00

abstract：:The effect of circulation time on plasma high density lipoprotein cholesterol concentrations was investigated in 20 male Wistar rats injected with alcohol, stressed with lighting, or fed a high fat diet. Circulation time was measured during anaesthesia with a computerised dichromatic earpiece densitometer. Indocyanine...

journal_title：Cardiovascular research

authors： Ishizuka T

更新日期：1988-05-01 00:00:00

abstract：OBJECTIVE:The aim was to further characterise an experimental model of preconditioning of isolated rabbit cardiomyocytes and to determine the role of adenosine receptor subtypes in initiation of the protective response. METHODS:Isolated myocytes were subjected to 5 min preincubation in the presence or absence of gluco...

journal_title：Cardiovascular research

authors： Armstrong S,Ganote CE

更新日期：1994-07-01 00:00:00

abstract：AIMS:Intracellular Ca(2+) ([Ca(2+)](i)) regulation in endothelial cells depends on transient receptor potential channels (TRPs), and the role of canonical TRPs (TRPCs) during hypoxia-reoxygenation (H-R) is unclear. We hypothesized that TRPC3 contributes to endothelial nitric oxide (NO) release and that H-R may reduce T...

journal_title：Cardiovascular research

authors： Huang JH,He GW,Xue HM,Yao XQ,Liu XC,Underwood MJ,Yang Q

更新日期：2011-08-01 00:00:00

abstract：AIMS:The P2Y12 antagonist ticagrelor reduces mortality in patients with acute coronary syndrome (ACS), compared with clopidogrel, and the mechanisms underlying this effect are not clearly understood. Arterial thrombosis is the key event in ACS; however, direct vascular effects of either ticagrelor or clopidogrel with f...

journal_title：Cardiovascular research

authors： Reiner MF,Akhmedov A,Stivala S,Keller S,Gaul DS,Bonetti NR,Savarese G,Glanzmann M,Zhu C,Ruf W,Yang Z,Matter CM,Lüscher TF,Camici GG,Beer JH

更新日期：2017-01-01 00:00:00

abstract：AIMS:Expression of extracellular matrix protein CCN1 is induced in end-stage ischaemic cardiomyopathy in humans, and after cardiac ischaemia and reperfusion in experimental animal models. Despite its well-documented angiogenic activities, CCN1 increases the cytotoxicities of the tumour necrosis factor family cytokines,...

journal_title：Cardiovascular research

authors： Hsu PL,Su BC,Kuok QY,Mo FE

更新日期：2013-04-01 00:00:00

abstract：:Estimation of infarct size from enzyme activities in plasma or serum presupposes known values of circulatory parameters such as the extravascular distribution volume Ve and the permeability constant P for the transport of enzyme between intravascular volume Vi and Ve. In man, parameter values are used that are extrapo...

journal_title：Cardiovascular research

authors： Willems GM,Muijtjens AM,Lambi FH,Hermens WT

更新日期：1979-10-01 00:00:00

abstract：AIMS:Sulfur dioxide (SO₂) is an air pollutant that impedes neonatal development and induces adverse cardiorespiratory health effects, including tachycardia. Here, an animal model was developed that enabled characterization of (i) in vivo alterations in heart rate and (ii) altered activity in brainstem neurons that cont...

journal_title：Cardiovascular research

authors： Woerman AL,Mendelowitz D

更新日期：2013-07-01 00:00:00

abstract：:The influence of experimental diabetes on the endothelium mediated relaxation and contractile responses of canine isolated coronary arteries was studied in arteries removed from alloxan treated diabetic (280 mmol.kg-1) and control mongrel dogs. Strips with and without endothelium were suspended in Krebs bicarbonate so...

journal_title：Cardiovascular research

authors： Gebremedhin D,Koltai MZ,Pogátsa G,Magyar K,Hadházy P

更新日期：1988-08-01 00:00:00

abstract：AIM:Age and injury cause structural and functional changes in coronary artery smooth muscle cells (caSMCs) that influence the pathogenesis of coronary artery disease. Although paracrine signalling is widely believed to drive phenotypic changes in caSMCs, here we show that developmental origin within the fetal epicardiu...

journal_title：Cardiovascular research

authors： Wei K,Díaz-Trelles R,Liu Q,Diez-Cuñado M,Scimia MC,Cai W,Sawada J,Komatsu M,Boyle JJ,Zhou B,Ruiz-Lozano P,Mercola M

更新日期：2015-07-15 00:00:00

abstract：OBJECTIVE:Ischaemic preconditioning may be mediated by oxygen free radicals generated during preconditioning. Conflicting results have been reported regarding the effect of superoxide dismutase (SOD) in attenuating the cardioprotective effect of preconditioning. The aim of the study was to reconcile this conflict by ex...

journal_title：Cardiovascular research

authors： Tanaka M,Fujiwara H,Yamasaki K,Sasayama S

更新日期：1994-07-01 00:00:00

abstract：:Cardiomyocyte death secondary to transient ischaemia occurs mainly during the first minutes of reperfusion in the form of contraction band necrosis. Research on the mechanisms leading to sarcolemmal rupture and necrosis during initial reperfusion identified several promising pharmacological targets directed either to ...

journal_title：Cardiovascular research

authors： Inserte J,Barrabés JA,Hernando V,Garcia-Dorado D

更新日期：2009-07-15 00:00:00

abstract：BACKGROUND:Clinical trials suggest that sotalol and dofetilide are much more effective in preventing atrial fibrillation (AF) than in terminating it. This study evaluated potential mechanisms of discordant sotalol and dofetilide effects on AF termination vs. prevention. METHODS:We applied 240-electrode epicardial mapp...

journal_title：Cardiovascular research

authors： Derakhchan K,Villemaire C,Talajic M,Nattel S

更新日期：2001-04-01 00:00:00

abstract：AIMS:Despite the observation that ErbB2 regulates sensitivity of the heart to doxorubicin or ErbB2-targeted cancer therapies, mechanisms that regulate ErbB2 expression and activity have not been studied. Since isoproterenol up-regulates ErbB2 in kidney and salivary glands and β2AR and ErbB2 complex in brain and heart, ...

journal_title：Cardiovascular research

authors： Sysa-Shah P,Tocchetti CG,Gupta M,Rainer PP,Shen X,Kang BH,Belmonte F,Li J,Xu Y,Guo X,Bedja D,Gao WD,Paolocci N,Rath R,Sawyer DB,Naga Prasad SV,Gabrielson K

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:The aims of the study were (1) to elucidate the effects of raised oxygen tension on the response of the ductus arteriosus to a range of vasodilators; and (2) to establish the effect, if any, of cyclo-oxygenase inhibition on the interaction between oxygen and prostaglandin (PG)E2. METHODS:Rings of ductus arte...

journal_title：Cardiovascular research

authors： Smith GC,McGrath JC

更新日期：1993-12-01 00:00:00

abstract：:Cardiac accumulation patterns of pyrophosphate labelled with techetium-99m (TcPyP) in rats one hour to 7 days after coronary artery ligation were studied by light microscopy, myocardial scintigraphy, imaging the isolated heart and by direct measurement of tissue activity. Results suggest that myocardial cells taking u...

journal_title：Cardiovascular research

authors： Lessem J,Polimeni PI,Page E,Resnekov L,Harper PV,Stark V

更新日期：1980-06-01 00:00:00

abstract：OBJECTIVE:Diastolic dysfunction is a characteristic finding of the aged mammalian heart. Parvalbumin acts as a Ca2+ sink and enhances relaxation in skeletal muscle, and overexpression of parvalbumin in myocardium increased cardiac relaxation in vitro as well as in vivo. Therefore, the objective of this study is to test...

journal_title：Cardiovascular research

authors： Schmidt U,Zhu X,Lebeche D,Huq F,Guerrero JL,Hajjar RJ

更新日期：2005-05-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to determine whether taurine influences the membrane surface charges in cardiac muscle. DESIGN:Screening of the negative charges at the outside surface of the membrane results in a shift of the steady state inactivation of the sodium system towards less negative potentials. This feature was...

journal_title：Cardiovascular research

authors： Dumaine R,Schanne OF,Ruiz-Petrich E

更新日期：1990-11-01 00:00:00

abstract：OBJECTIVE:It has been suggested that nitric oxide (NO) is involved in the regulation of myocardial function in a variety of diseases such as dilated cardiomyopathy, myocarditis, heart transplant rejection, and septic shock. However, the underlying mechanism of NO mediated reduction of cardiac contractility has not been...

journal_title：Cardiovascular research

authors： Kelm M,Schäfer S,Dahmann R,Dolu B,Perings S,Decking UK,Schrader J,Strauer BE

更新日期：1997-11-01 00:00:00

abstract：AIMS:Levels of circulating CD14(high)CD16(+) monocytes increase in atherosclerotic patients and are predictive of future cardiovascular events. Platelet activation has been identified as a crucial determinant in the acquisition of a CD16(+) phenotype by classical CD14(high)CD16(-) cells. We tested the hypothesis that a...

journal_title：Cardiovascular research

authors： Layne K,Di Giosia P,Ferro A,Passacquale G

更新日期：2016-07-01 00:00:00

abstract：Aims:Hypertensive cardiac hypertrophy is associated with reduced coronary flow reserve, but its impact on coronary flow regulation and vasomotor function remains incompletely understood and requires further investigation. Methods and results:Left ventricular hypertrophy was induced in mice by transverse aortic coarcta...

journal_title：Cardiovascular research

authors： Tsai SH,Lu G,Xu X,Ren Y,Hein TW,Kuo L

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:The contribution of vascular changes to the development of heart failure is largely unknown. In the present study, we evaluated endothelial and vascular contractile function in the rat hindlimb vascular bed after myocardial infarction (MI), including the modulatory role of basal nitric oxide (NO) production ...

journal_title：Cardiovascular research

authors： Ceiler DL,Nelissen-Vrancken M,De Mey JG,Smits JF

更新日期：1999-08-15 00:00:00