Abstract：
:The effect of circulation time on plasma high density lipoprotein cholesterol concentrations was investigated in 20 male Wistar rats injected with alcohol, stressed with lighting, or fed a high fat diet. Circulation time was measured during anaesthesia with a computerised dichromatic earpiece densitometer. Indocyanine green, 0.5% concentration and 0.05 ml volume, was injected directly into the intracardiac cavity. The densitometer was held against the right foot of the rat, where the concentration of indocyanine green was measured by a light absorption method. Circulation time was defined as the time during which indocyanine green passed from the heart to the foot. At the same time blood was collected for determining high density lipoprotein cholesterol concentration. The rats were randomly divided into three groups, and control circulation time and high density lipoprotein cholesterol concentrations were obtained. In six rats injected with 100% ethyl alcohol, 0.03 ml.100 g-1 body weight in volume, into the abdominal cavity and five rats placed under 400 Lux lighting for 48 h the increase in circulation time was inversely proportional to the increase in high density lipoprotein cholesterol concentration (r = -0.644, p less than 0.05). Of nine rats given a high fat diet containing 7.0% fat for 48 h, all showed increased high density lipoprotein cholesterol concentration, but no correlation was noted between the increases in circulation time and high density lipoprotein cholesterol (r = -0.303).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Ishizuka Tdoi
10.1093/cvr/22.5.368subject
Has Abstractpub_date
1988-05-01 00:00:00pages
368-71issue
5eissn
0008-6363issn
1755-3245journal_volume
22pub_type
杂志文章abstract：AIM:The aim of the study was to determine the potential for K(V)1 potassium channel blockers as inhibitors of human neoinitimal hyperplasia. METHODS AND RESULTS:Blood vessels were obtained from patients or mice and studied in culture. Reverse transcriptase-polymerase chain reaction and immunocytochemistry were used to...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvq305
更新日期：2011-02-01 00:00:00
abstract：AIMS:As cardiovascular disease is characterized by reduced nitric oxide bioavailability, our aim was to determine the impact of this change on the mechanism underlying vascular tone of pressurized arteries in vitro and in vivo. METHODS AND RESULTS:We used pressurized cerebral and mesenteric arteries in vitro and skele...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvt043
更新日期：2013-06-01 00:00:00
abstract：AIMS:TRPM2 is a Ca(2+)-permeable cationic channel of the transient receptor potential (TRP) superfamily that is linked to apoptotic signalling. Its involvement in cardiac pathophysiology is unknown. The aim of this study was to determine whether the pro-apoptotic cytokine tumour necrosis factor-α (TNF-α) induces a TRPM...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvu112
更新日期：2014-07-01 00:00:00
abstract：:The effect of catheterisation on the rabbit aortic wall is investigated employing a technique identical to that used for continuous monitoring of blood pressure in humans. The catheters were introduced into the aorta through the right femoral artery of the rabbit using the Seldinger technique, except that the catheter...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/13.9.541
更新日期：1979-09-01 00:00:00
abstract：OBJECTIVE:Ischemic postconditioning protects the reperfused heart from infarction, and this protection is dependent on the occupancy of adenosine receptors. We further explored the role of adenosine receptors in this salvage. METHODS:In situ rabbit hearts underwent 30 min of regional ischemia and 3 h of reperfusion, a...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/j.cardiores.2006.02.014
更新日期：2006-05-01 00:00:00
abstract：:Having an apparently healthy, thriving infant fail to reach his/her first birthday is profoundly tragic. This tragedy is compounded when the infant's death is unexpected and unexplained, signed out as sudden infant death syndrome (SIDS). Despite impressive success and welcome reductions in these tragic deaths due in l...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1016/j.cardiores.2005.02.013
更新日期：2005-08-15 00:00:00
abstract：:There is evidence that catecholamines may promote the development of cardiac hypertrophy in hypertension. To test the hypothesis that adrenaline directly determines left ventricular mass, normotensive Wistar rats were made adrenaline-deficient by adrenalectomy and hypertensive by administration of glucocorticoid. Bloo...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/19.12.734
更新日期：1985-12-01 00:00:00
abstract：:The G protein-coupled receptor kinases (GRKs) participate with arrestins in the regulation and signal propagation of multiple G protein-coupled receptors (GPCR) of key physiological and pharmacological relevance in the cardiovascular system. The complex mechanisms of regulation of GRK expression, degradation and funct...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1016/j.cardiores.2005.09.011
更新日期：2006-01-01 00:00:00
abstract：:The significance of pre-existing coronary collaterals for preservation of the myocardium during coronary occlusion and reperfusion was studied in anaesthetised open-chest dogs. The extent of myocardial ischaemic damage was assessed by the accumulation of calcium in the central zone of the ischaemic area and the size o...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/14.5.288
更新日期：1980-05-01 00:00:00
abstract：AIMS:The hypoxia-inducible factor-1 (HIF-1) is the master modulator of hypoxic gene expression. The effects of chronically stabilized cardiac HIF-1α and its role in the diseased heart are not precisely known. The aims of this study were as follows: (i) to elucidate consequences of HIF-1α stabilization in the heart; (ii...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvs014
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:R 75,231, a potent and specific nucleoside transport inhibitor, largely prevents cardiac damage and death in catecholamine challenged rabbits. The major biochemical effect of nucleoside transport inhibition in ischaemic and reperfused myocardium is a prolonged accumulation of adenosine. The cardioprotection b...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/27.1.111
更新日期：1993-01-01 00:00:00
abstract：OBJECTIVE:Mice with genetic disruption of the guanylyl cyclase-A (GC-A) receptor for atrial natriuretic peptide (ANP), have chronic arterial hypertension and marked cardiac hypertrophy. Intriguingly, despite pronounced remodeling, cardiac contractile functions and cardiomyocyte Ca(2+)-handling are preserved and even en...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/j.cardiores.2006.10.003
更新日期：2007-03-01 00:00:00
abstract：OBJECTIVE:The aim was to investigate the effects of slowing the recovery of ischaemia induced intracellular acidosis with hypercapnic acidosis or dimethyl amiloride (DMA) on the extent of reperfusion induced cell death. METHODS:Isolated arterially perfused rabbit papillary muscles and septa were suspended in a control...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
abstract：:The function of the right ventricle (RV) determines the prognosis of patients with pulmonary hypertension. While much progress has been made in the treatment of pulmonary hypertension, therapies for the RV are less well established. In this review of treatment strategies for the RV, first we focus on ways to reduce wa...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1093/cvr/cvx148
更新日期：2017-10-01 00:00:00
abstract：AIMS:Intracellular Ca(2+) ([Ca(2+)](i)) regulation in endothelial cells depends on transient receptor potential channels (TRPs), and the role of canonical TRPs (TRPCs) during hypoxia-reoxygenation (H-R) is unclear. We hypothesized that TRPC3 contributes to endothelial nitric oxide (NO) release and that H-R may reduce T...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvr102
更新日期：2011-08-01 00:00:00
abstract：:Regional myocardial anoxia was produced in dogs by perfusion of the left circumflex artery (LCA) with deoxygenated blood. Isolated sarcoplasmic reticulum fragments (cardiac relaxing system) showed decreased Ca2+ binding and uptake. The ability of isolated mitochondria to utilise long-chain fatty acids was markedly red...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/11.6.568
更新日期：1977-11-01 00:00:00
abstract：OBJECTIVE:The aim of the presented method was the characterization of different complex heart rate dynamics in conscious rabbits as well as during general anaesthesia and vagal blockade. This was done by non-linear prediction of original measured and special surrogate data in the phase space. METHOD:The development of...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：:Hyponatremia is a frequent electrolyte disorder. It is often found in congestive cardiac failure, liver cirrhosis, plasma volume contraction and in SiADH. In these disorders hyponatremia is caused by nonosmotic vasopressin and sustained fluid intake. This provides a rationale for V2 vasopressin receptor antagonists in...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1016/s0008-6363(01)00288-7
更新日期：2001-08-15 00:00:00
abstract：:Myocardial ischaemia increases cellular and extracellular osmolarity, alters membrane permeability to ions and causes moderate cell swelling and interstitial oedema. Ischaemia also reduces the mechanical resistance of the sarcolemma of myocytes, probably as a result of proteolytic digestion of the connections between ...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1093/cvr/27.9.1555
更新日期：1993-09-01 00:00:00
abstract：:Ischemic preconditioning is a well-established phenomenon first described in experimental preparations in which brief episodes of ischemia/reperfusion applied prior to a longer coronary artery occlusion reduce myocardial infarct size. There are ample correlates of ischemic preconditioning in the clinical realm. Precon...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1016/j.cardiores.2006.01.012
更新日期：2006-05-01 00:00:00
abstract：AIMS:Therapeutic use of sulfhydrylated inhibitor S-zofenopril has raised different hypotheses regarding the role played by its thiol group in the beneficial clinical effects exerted compared with other angiotensin-converting enzyme (ACE) inhibitors. Here, we investigated hydrogen sulfide (H2S) pathway as accountable fo...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvu026
更新日期：2014-04-01 00:00:00
abstract：AIMS:A robust inflammatory response to tissue injury is a necessary part of the repair process but the deposition of scar tissue is a direct downstream consequence of this response in many tissues including the heart. Adult zebrafish not only possess the capacity to regenerate lost cardiomyocytes but also to remodel an...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvz221
更新日期：2020-06-01 00:00:00
abstract：AIMS:Cathepsin-L (CTSL) is a member of the lysozomal cysteine protease family, which participates in remodelling of various tissues. Herein, we sought to examine the potential regulation of CTSL in cardiac remodelling post-infarction. METHODS AND RESULTS:Experimental myocardial infarction (MI) was created in CTSL-defi...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvq328
更新日期：2011-02-01 00:00:00
abstract：:Blood flow autoregulation results from the ability of resistance arteries to reduce or increase their diameters in response to changes in intravascular pressure. The mechanism by which arteries maintain a constant blood flow to organs over a range of pressures relies on this myogenic response, which defines the intrin...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1093/cvr/cvs152
更新日期：2012-07-15 00:00:00
abstract：:There is mounting interest in the use of the monophasic action potential for electrophysiological investigation of regional myocardial ischaemia. There is, however, no systematic study of the relation between the changes in monophasic action potential and regional myocardial blood flow. In this study monophasic action...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/20.10.740
更新日期：1986-10-01 00:00:00
abstract：:Changes in left ventricular internal diameter resulting from increasing intrapericardial pressure induced by increasing the pericardial fluid volume were studied in closed chest, anaesthetized dogs. Left ventricular internal diameters were measured by placing an ultrasonic dimension catheter in the left ventricle at t...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/9.6.707
更新日期：1975-11-01 00:00:00
abstract：OBJECTIVES:Collagen synthesis is one of the major mechanisms of primary atherosclerotic plaque growth and is likely to be similarly important in restenosis. The patterns of collagen gene expression in human restenosis and associations with thrombosis/hemorrhage have not been described. METHODS:Using human coronary art...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：OBJECTIVE:Dexamethasone-eluting stents are currently under evaluation to prevent post-angioplasty restenosis. The efficacy and safety of dexamethasone as an anti-restenotic agent is still unclear. We assess the effect of perivascular delivery of dexamethasone on vascular pathology in a mouse model of restenosis. METHO...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/j.cardiores.2005.06.015
更新日期：2005-12-01 00:00:00
abstract：OBJECTIVES:Age-related medial calcification (elastocalcinosis) of large arteries is accelerated in diabetes and appears mainly in distal arteries. The aim was to devise a rat model of elastocalcinosis in association with diabetes to examine the hypothesis that diabetes accelerates vascular calcification experimentally....
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/j.cardiores.2006.11.001
更新日期：2007-02-01 00:00:00
abstract：:The heart contains not only cardiomyocytes but also other cell types such as endothelial cells and fibroblasts. Functional crosstalk among these cell types is important for normal cardiac function and is also involved in disease pathophysiology. Recent data indicate that redox signalling within and between endothelial...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1093/cvr/cvu050
更新日期：2014-05-01 00:00:00
