Cathepsin-L contributes to cardiac repair and remodelling post-infarction.

abstract：:We studied the effects of intracoronary vasopressin on the relationship between pressure and flow in the coronary circulation of anaesthetised swine. In addition to measurements at control levels, diastolic pressure-flow relationships were constructed from steady-state points below a coronary pressure of 50 mmHg, wher...

journal_title：Cardiovascular research

authors： Pantely GA,Ladley HD,Anselone CG,Bristow JD

更新日期：1985-07-01 00:00:00

abstract：AIMS:Autonomic dysfunction can promote atrial fibrillation (AF) and results from AF-related remodelling. N-type Ca2+-channels (NTCCs) at sympathetic nerve terminals mediate Ca2+-entry that triggers neurotransmitter release. AF-associated remodelling plays an important role in AF pathophysiology but the effects of NTCC ...

journal_title：Cardiovascular research

authors： Tajiri K,Guichard JB,Qi X,Xiong F,Naud P,Tardif JC,Costa AD,Aonuma K,Nattel S

更新日期：2019-12-01 00:00:00

abstract：:The cardiac SR Ca(2+)-ATPase (SERCA2a) regulates intracellular Ca(2+)-handling and thus, plays a crucial role in initiating cardiac contraction and relaxation. SERCA2a may be modulated through its accessory phosphoprotein phospholamban or by direct phosphorylation through Ca(2+)/calmodulin dependent protein kinase II ...

journal_title：Cardiovascular research

authors： Frank KF,Bölck B,Erdmann E,Schwinger RH

更新日期：2003-01-01 00:00:00

abstract：:Myocardial ischaemia/reperfusion (I/R)-induced remodelling generally includes cell death (necrosis and apoptosis), myocyte hypertrophy, angiogenesis, cardiac fibrosis, and myocardial dysfunction. It is becoming increasingly clear that microRNAs (miRNAs or miRs), a group of highly conserved small (∼18-24 nucleotide) no...

journal_title：Cardiovascular research

authors： Zhu H,Fan GC

更新日期：2012-05-01 00:00:00

abstract：AIMS:Free fatty acids induce apoptosis in cardiomyocytes, which is implicated in lipotoxic cardiomyopathy. However, the underlying mechanisms remain not fully understood. MicroRNAs (miRNAs) are non-coding small RNAs that control gene expression at the post-transcriptional level. Dysregulated miRNAs have been shown to b...

journal_title：Cardiovascular research

authors： Zhu H,Yang Y,Wang Y,Li J,Schiller PW,Peng T

更新日期：2011-10-01 00:00:00

abstract：:Labetolol, which blocks both alpha and beta-adrenoceptors, was found to have direct actions on cardiac muscle which could themselves be antiarrhythmic. It depressed the maximum rate of depolarisation, and reduced conduction velocity, in atrial and ventricular muscle and in Purkinje cells, implying restriction of fast ...

journal_title：Cardiovascular research

authors： Vaughn Williams EM,Millar JS,Campbell TJ

更新日期：1982-05-01 00:00:00

abstract：OBJECTIVE:Cholinergic vasodilation has been thought to play little if any role in the regulation of blood pressure in humans. Autonomic denervation potentiates the vasoconstriction evoked by nitric oxide synthase inhibition in humans, but the mechanism is unclear. We hypothesized that this may be related to loss of neu...

journal_title：Cardiovascular research

authors： Lepori M,Sartori C,Duplain H,Nicod P,Scherrer U

更新日期：2001-09-01 00:00:00

abstract：:Sprouting angiogenesis is an invasive process that involves proteolytic activities required for the degradation of the endothelial basement membrane, cell migration with removal of obstructing matrix proteins, and generation of space in the matrix to allow endothelial cells to form a proper lumen. In the last decade i...

journal_title：Cardiovascular research

authors： van Hinsbergh VW,Koolwijk P

更新日期：2008-05-01 00:00:00

abstract：:The second messenger cyclic guanosine 3'5' monophosphate (cGMP) and its downstream effector protein kinase G (PKG) have been discovered more than 40 years ago. In vessels, PKG1 induces smooth muscle relaxation in response to nitric oxide signalling and thus lowers systemic and pulmonary blood pressure. In platelets, P...

journal_title：Cardiovascular research

authors： Rainer PP,Kass DA

更新日期：2016-07-15 00:00:00

abstract：OBJECTIVE:Evidence suggests important relationships among chronic inflammatory processes, endothelial dysfunction, hypertension and target organ damage. The present study examined the effects of chronic treatment with an anti-inflammatory p38 mitogen-activated protein kinase (MAPK) inhibitor (SB-239063AN) in the N(omeg...

journal_title：Cardiovascular research

authors： Olzinski AR,McCafferty TA,Zhao SQ,Behm DJ,Eybye ME,Maniscalco K,Bentley R,Frazier KS,Milliner CM,Mirabile RC,Coatney RW,Willette RN

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:The mechanosensitive nonselective cation channel (NSC(MS)) and endothelin-1 (ET-1) play critical roles in the regulation of vascular tone. This study was undertaken to investigate the effect of ET-1 on NSC(MS) and on the myogenic response of arteries. METHODS:Cell-attached patch-clamp techniques were applied...

journal_title：Cardiovascular research

authors： Lee HA,Baek EB,Park KS,Jung HJ,Kim JI,Kim SJ,Earm YE

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:The aim was to test the hypothesis that in normal humans angiotensin II would stimulate local release of noradrenaline under basal conditions or during a sympathetic stimulus provided by lower body negative pressure (LBNP). METHODS:Nine healthy volunteers received intra-arterial infusions of angiotensin II, ...

journal_title：Cardiovascular research

authors： Goldsmith SR,Rector TS,Bank AJ,Garr M,Kubo SH

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:Increased pulse pressure has been observed in aging subjects, but the impact on the structure and reactivity of small arteries has been scarcely evaluated. METHODS:This study presents the modifications of vascular structure and function observed in female rats of 5, 18 and 32 months of age, and their relatio...

journal_title：Cardiovascular research

authors： Moreau P,d'Uscio LV,Lüscher TF

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:The aim was to further characterise an experimental model of preconditioning of isolated rabbit cardiomyocytes and to determine the role of adenosine receptor subtypes in initiation of the protective response. METHODS:Isolated myocytes were subjected to 5 min preincubation in the presence or absence of gluco...

journal_title：Cardiovascular research

authors： Armstrong S,Ganote CE

更新日期：1994-07-01 00:00:00

abstract：AIMS:Human C-peptide has a beneficial effect on the prevention of diabetic neuropathy, nephropathy, and vascular complications; however, its role in protection against increased vascular permeability in diabetes remains unclear. Our purpose was to explore the potential protective role of C-peptide against microvascular...

journal_title：Cardiovascular research

authors： Lim YC,Bhatt MP,Kwon MH,Park D,Lee S,Choe J,Hwang J,Kim YM,Ha KS

更新日期：2014-01-01 00:00:00

abstract：AIMS:The effects of serelaxin, a recombinant form of human relaxin-2 peptide, on vascular function in the coronary microvascular and systemic macrovascular circulation remain largely unknown. This mechanistic, clinical study assessed the effects of serelaxin on myocardial perfusion, aortic stiffness, and safety in pati...

journal_title：Cardiovascular research

authors： Corcoran D,Radjenovic A,Mordi IR,Nazir SA,Wilson SJ,Hinder M,Yates DP,Machineni S,Alcantara J,Prescott MF,Gugliotta B,Pang Y,Tzemos N,Semple SI,Newby DE,McCann GP,Squire I,Berry C

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:Plasma endothelin (ET) concentrations are increased in heart failure. The aims of the present study were to investigate to what extent cardiac ET mRNA expression is induced in ischemic heart failure and whether there may be compensatory downregulation of myocardial mRNA levels for the ETA and ETB receptor su...

journal_title：Cardiovascular research

authors： Tønnessen T,Christensen G,Oie E,Holt E,Kjekshus H,Smiseth OA,Sejersted OM,Attramadal H

更新日期：1997-03-01 00:00:00

abstract：Aims:Endothelial hyperpermeability exacerbates multiple organ damage during inflammation or infection. The endothelial glycocalyx, a protective matrix covering the luminal surface of endothelial cells (ECs), undergoes enzymatic shedding during inflammation, contributing to barrier hyperpermeability. A disintegrin and m...

journal_title：Cardiovascular research

authors： Yang X,Meegan JE,Jannaway M,Coleman DC,Yuan SY

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:M cells have been described in many mammalian species. They are thought to be relevant for the genesis of long QT intervals, afterdepolarizations and for dispersion in action potential duration and in repolarization time. Their role in the human heart is subject to debate. METHODS:We simulated action potent...

journal_title：Cardiovascular research

authors： Conrath CE,Wilders R,Coronel R,de Bakker JM,Taggart P,de Groot JR,Opthof T

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:Preexposure of macrophages to oxidized low-density lipoprotein (oxLDL) attenuates formation of reactive oxygen species (ROS) upon stimulation with phorbol 12-myristate 13-acetate (PMA) or acute exposure to oxLDL. We examined whether attenuation of the oxidative burst is attributed to down-regulation of protei...

journal_title：Cardiovascular research

authors： Köhl R,Preiss S,von Knethen A,Brüne B

更新日期：2006-08-01 00:00:00

abstract：:Cardiomyocytes express a surprisingly large number of potassium channel types. The primary physiological functions of the currents conducted by these channels are to maintain the resting membrane potential and mediate action potential repolarization under basal conditions and in response to changes in the concentratio...

journal_title：Cardiovascular research

authors： Crotti L,Odening KE,Sanguinetti MC

更新日期：2020-07-15 00:00:00

abstract：:An investigation of changes in the Mg2+ -dependent, Na+ -K+ -stimulated sarcolemmal ATPase and of intracellular electrolytes in the left failing heart due to pressure overload (aortic banding) was carried out in dogs. There was no change in the sarcolemmal Mg2+ -ATPase of the left or right ventricle for the whole dura...

journal_title：Cardiovascular research

authors： Prasad K,Khatter JC,Bharadwaj B

更新日期：1979-02-01 00:00:00

abstract：OBJECTIVE:Anisotropic conduction characteristics, which may be expressed as the ratio of conduction velocities in the longitudinal (Vlong) and transverse (Vtrans) fibre directions, have been shown to stabilise reentry and favour the induction of sustained, uniform ventricular tachycardia. The aim of this study was to i...

journal_title：Cardiovascular research

authors： Hélie F,Cossette J,Vermeulen M,Cardinal R

更新日期：1995-03-01 00:00:00

abstract：:One of the obstacles to a better understanding of the pathogenesis of human cardiomyopathies has been poor availability of heart-tissue samples at early stages of disease development. This has possibly changed by the advent of patient-derived induced pluripotent stem cell (hiPSC) from which cardiomyocytes can be deriv...

journal_title：Cardiovascular research

authors： Eschenhagen T,Mummery C,Knollmann BC

更新日期：2015-04-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to quantify the changes in placental blood flow and combined ventricular output with gestational age in normal human fetuses to determine the percentage of total cardiac output that placental blood flow represented, and whether this changed with age. DESIGN:Two dimensional echocardiographic...

journal_title：Cardiovascular research

authors： Sutton MG,Plappert T,Doubilet P

更新日期：1991-07-01 00:00:00

abstract：:Although it is generally believed that the beneficial effect of loop diuretics is the result of a rapid increase in diuresis, substantial evidence, from a large number of in vitro and in vivo experiments, has accumulated showing that administration of furosemide causes direct vascular effects, which probably contribut...

journal_title：Cardiovascular research

authors： Dormans TP,Pickkers P,Russel FG,Smits P

更新日期：1996-12-01 00:00:00

abstract：AIMS:The metabolic syndrome (MS) leads to myocardial fibrosis (MF) and diastolic dysfunction. Statins have proven beneficial effects in MS, but their impact on cardiac remodelling is uncertain. We examined the effects and mechanisms of chronic statin treatment on cardiac remodelling, e.g. fibrosis and diastolic propert...

journal_title：Cardiovascular research

authors： Hermida N,Markl A,Hamelet J,Van Assche T,Vanderper A,Herijgers P,van Bilsen M,Hilfiker-Kleiner D,Noppe G,Beauloye C,Horman S,Balligand JL

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:Heart failure is associated with reduced function of sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a) but increased function of sarcolemmal Na+/Ca2+ exchanger (NCX), leading to decreased SR Ca2+ content and loss of frequency-potentiation of contractile force. We reported that SERCA2a-overexpression in transg...

journal_title：Cardiovascular research

authors： Maier LS,Wahl-Schott C,Horn W,Weichert S,Pagel C,Wagner S,Dybkova N,Müller OJ,Näbauer M,Franz WM,Pieske B

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:Smooth muscle cell proliferation and migration are the predominant responses to intimal and medial injury after percutaneous transluminal coronary angioplasty. The in vivo inhibitory effect of heparin on these responses is well documented. To test the hypothesis that the antiproliferative effect of heparin in...

journal_title：Cardiovascular research

authors： Hamon M,Bauters C,Wernert N,Courtin P,Delcayre C,Adamantidis M,Lablanche JM,Bertrand ME,Dupuis B,Swynghedauw B

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:A circadian rhythm of blood pressure has been demonstrated both in subjects who are physically active during the day and in those confined to bed. The study of the circadian rhythm of arterial flow and peripheral resistance, on the other hand, is limited to pioneer experiments. This paper is aimed at demonstr...

journal_title：Cardiovascular research

authors： Casiglia E,Pizziol A,Piacentini F,Biasin R,Onesto C,Tikhonoff V,Prati R,Palatini P,Pessina AC

更新日期：1999-01-01 00:00:00