Heritable arrhythmias associated with abnormal function of cardiac potassium channels.

Abstract:

:Cardiomyocytes express a surprisingly large number of potassium channel types. The primary physiological functions of the currents conducted by these channels are to maintain the resting membrane potential and mediate action potential repolarization under basal conditions and in response to changes in the concentrations of intracellular sodium, calcium, and ATP/ADP. Here, we review the diversity and functional roles of cardiac potassium channels under normal conditions and how heritable mutations in the genes encoding these channels can lead to distinct arrhythmias. We briefly review atrial fibrillation and J-wave syndromes. For long and short QT syndromes, we describe their genetic basis, clinical manifestation, risk stratification, traditional and novel therapeutic approaches, as well as insights into disease mechanisms provided by animal and cellular models.

journal_name

Cardiovasc Res

journal_title

Cardiovascular research

authors

Crotti L,Odening KE,Sanguinetti MC

doi

10.1093/cvr/cvaa068

subject

Has Abstract

pub_date

2020-07-15 00:00:00

pages

1542-1556

issue

9

eissn

0008-6363

issn

1755-3245

pii

5813728

journal_volume

116

pub_type

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