Vascular effects of loop diuretics.

abstract：OBJECTIVES:Action potential prolongation related to the alteration of several membrane currents is constantly reported in heart failure (HF) but reports about its role in arrhythmogenesis are sparse. Our aim was to determine, by analogy with long QT syndromes, whether prolonged repolarization is associated with increas...

journal_title：Cardiovascular research

authors： Lacroix D,Gluais P,Marquié C,D'Hoinne C,Adamantidis M,Bastide M

更新日期：2002-04-01 00:00:00

abstract：AIMS:Altered Ca(2+) handling in atrial fibrillation (AF) has been associated with dysregulated protein phosphatase 1 (PP1) and subcellular heterogeneities in protein phosphorylation, but the underlying mechanisms remain unclear. This is due to a lack of investigation into the local, rather than global, regulation of PP...

journal_title：Cardiovascular research

authors： Chiang DY,Li N,Wang Q,Alsina KM,Quick AP,Reynolds JO,Wang G,Skapura D,Voigt N,Dobrev D,Wehrens XH

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVES:Saphenous vein graft failures, resulting from thrombosis and the abnormal proliferation, migration and apoptosis of vascular smooth muscle cells (VSMC) are major limitations of coronary artery bypass surgery. We investigated whether surgical trauma of human saphenous vein induces the early response gene c-fo...

journal_title：Cardiovascular research

authors： Galea J,Armstrong J,Francis SE,Cooper G,Crossman DC,Holt CM

更新日期：1999-11-01 00:00:00

abstract：:Integrative genomics studies have greatly advanced our understanding of cardiovascular pathophysiology over the last decade. Here, we highlight the strengths and challenges of this cutting-edge approach and provide examples where novel insights have arisen through the integration of multi-level genomic information and...

journal_title：Cardiovascular research

authors： Ware JS,Petretto E,Cook SA

更新日期：2013-03-15 00:00:00

abstract：OBJECTIVE:While atrial natriuretic peptide (ANP) has been shown to be released mainly from cardiac muscle cells in response to atrial distension, the regulatory mechanisms of ANP secretion are still not fully understood. We sought to determine whether the ATP-sensitive K+ (K(ATP)) channel modulates the secretion of ANP...

journal_title：Cardiovascular research

authors： Saegusa N,Sato T,Saito T,Tamagawa M,Komuro I,Nakaya H

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:The aim was to compare differences in peak twitch force occurring despite similar degrees of right ventricular hypertrophy in ferrets with pulmonary artery banding at either weanling or juvenile age. METHODS:After inducing pressure overload hypertrophy by banding the pulmonary artery of weanling and juvenile...

journal_title：Cardiovascular research

authors： Gwathmey JK,Liao R,Ingwall JS

更新日期：1995-04-01 00:00:00

abstract：:One of the striking differences that distinguish the adult from the embryonic heart in mammals and set it apart from the heart in urodeles and teleosts is the incapacity of cardiomyocytes to respond to damage by proliferation. While the molecular reasons underlying these characteristics still await elucidation, mounti...

journal_title：Cardiovascular research

authors： Zacchigna S,Giacca M

更新日期：2014-05-01 00:00:00

abstract：:Genetic and environmental factors influence the development of coronary artery disease (CAD). Genetic analyses of families and the population continue to yield important fundamental insights for CAD. For the past four decades, CAD human genetic research focused largely on the study of germline genetic variation in CAD...

journal_title：Cardiovascular research

authors： Patel AP,Natarajan P

更新日期：2019-04-15 00:00:00

abstract：STUDY OBJECTIVE:The aim was to record diastolic transmitral pressure gradients at high sensitivity to quantitate the effect on transmitral pressure gradients of changing the heart rate. DESIGN:Diastolic left atrial and left ventricular pressures were recorded at high sensitivity (40 mm Hg = 10 mm recorded deflection) ...

journal_title：Cardiovascular research

authors： Carmeliet P,Aubert A,Van de Werf F,De Geest H

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVE:Resveratrol, a natural phytoalexin compound, is present in grapes and wine, and it can produce vasorelaxation. However, little is known of its mechanisms of action on ionic currents in endothelial cells. METHODS:The effect of resveratrol on Ca(2+)-activated K+ currents in an endothelial cell line (HUV-EC-C) ...

journal_title：Cardiovascular research

authors： Li HF,Chen SA,Wu SN

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:Transient atrial fibrillation is sometimes observed following adenosine administration and adenosine is known to shorten atrial action potential duration and refractory period. This study was designed to characterise the dose-response relationship of adenosine on these variables relative to arrhythmia inducti...

journal_title：Cardiovascular research

authors： Kabell G,Buchanan LV,Gibson JK,Belardinelli L

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:To determine if angiogenesis is altered in adult Endoglin heterozygous (Eng(+/-)) mice, the animal model for the vascular disorder hereditary hemorrhagic telangiectasia type 1 (HHT1). METHODS:Primary cultures of endothelial cells were generated from Eng(+/-) and Eng(+/+) mice and analyzed for proliferation, ...

journal_title：Cardiovascular research

authors： Jerkic M,Rodríguez-Barbero A,Prieto M,Toporsian M,Pericacho M,Rivas-Elena JV,Obreo J,Wang A,Pérez-Barriocanal F,Arévalo M,Bernabéu C,Letarte M,López-Novoa JM

更新日期：2006-03-01 00:00:00

abstract：AIMS:Vascular remodelling and aortic aneurysm formation are induced mainly by inflammatory responses in the adventitia and media. However, relatively little is known about the mechanistic significance of endothelium in the pathogenesis of these vascular disorders. The transcription factor nuclear factor-kappa B (NF-κB)...

journal_title：Cardiovascular research

authors： Saito T,Hasegawa Y,Ishigaki Y,Yamada T,Gao J,Imai J,Uno K,Kaneko K,Ogihara T,Shimosawa T,Asano T,Fujita T,Oka Y,Katagiri H

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to assess whether the plasma levels of soluble adhesion molecules including E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are elevated in patients with variant angina and whether they are released in the coronary circulation...

journal_title：Cardiovascular research

authors： Miwa K,Igawa A,Inoue H

更新日期：1997-10-01 00:00:00

abstract：:Cardiac hypertrophy was induced in rabbits at atmospheric pressure by exposing them to hypoxia equivalent to an altitude of 6000 m for 280 to 350 h. Intracellular action potentials were recorded from Purkinje cells, and from atrial and papillary muscles, contractions of which were also measured. Hearts from normoxic l...

journal_title：Cardiovascular research

authors： Dukes ID,Vaughan Williams EM

更新日期：1984-10-01 00:00:00

abstract：Aims:Circulating proteins larger than 3 nm can be transported across continuous endothelial barrier of blood vessels via transcytosis. However, excessive accumulation of serum proteins within the vessel walls is uncommon even for those abundant in the circulation. The aim of this study was to investigate how transcytos...

journal_title：Cardiovascular research

authors： Li HY,Liu XL,Liu YT,Jia ZK,Filep JG,Potempa LA,Ji SR,Wu Y

更新日期：2019-02-01 00:00:00

abstract：STUDY OBJECTIVE:Afterload reduction is known to reduce regurgitant flow in patients with aortic regurgitation. Both arterial compliance and total peripheral resistance are determinants of afterload. The aim of this study was to evaluate the influence of arterial compliance and total peripheral resistance on the regurgi...

journal_title：Cardiovascular research

authors： Slørdahl SA,Piene H

更新日期：1991-10-01 00:00:00

abstract：:Tension and action potentials have been measured simultaneously from isolated cat papillary muscles. Two groups of experiments are described. In the first group, the external conditions under which the muscle contracted were changed. Specifically, stimulation rate, extra-cellular [Ca++], extracellular [Na++] were alte...

journal_title：Cardiovascular research

authors： Allen DG

更新日期：1977-05-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) is the most common cardiac arrhythmia, and early-onset lone AF has been linked to mutations in genes encoding ion channels. Mutations in the pore forming subunit KV4.3 leading to an increase in the transient outward potassium current (Ito) have previously been associated with the Brugada S...

journal_title：Cardiovascular research

authors： Olesen MS,Refsgaard L,Holst AG,Larsen AP,Grubb S,Haunsø S,Svendsen JH,Olesen SP,Schmitt N,Calloe K

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:Some neuropeptides have direct cardiac effects and also modulate the cardiac effects of catecholamines. Vasopressin is an abundantly available neuropeptide having well known interactions with catecholamines in vascular smooth muscle. The aim of this study was to determine the direct and modulatory effects of ...

journal_title：Cardiovascular research

authors： Sun LS,Sawyer WH,Steinberg SF,Rosen MR

更新日期：1993-09-01 00:00:00

abstract：:Exaggerated cardiovascular responsiveness is common in young men and may cause non-specific symptoms and poor performance. Conventional autonomic function tests are not clinically useful. We have therefore designed a thermal entrainment method to evaluate sympathetic and parasympathetic cardiovascular function in subj...

journal_title：Cardiovascular research

authors： Lindqvist A,Parviainen P,Kolari P,Tuominen J,Välimäki I,Antila K,Laitinen LA

更新日期：1989-03-01 00:00:00

abstract：AIMS:Diabetes impinges upon mechanisms of cardiovascular repair. However, the biochemical adaptation of cardiac stem cells to sustained hyperglycaemia remains largely unknown. Here, we investigate the molecular targets of high glucose-induced damage in cardiac progenitor cells (CPCs) from murine and human hearts and at...

journal_title：Cardiovascular research

authors： Katare R,Oikawa A,Cesselli D,Beltrami AP,Avolio E,Muthukrishnan D,Munasinghe PE,Angelini G,Emanueli C,Madeddu P

更新日期：2013-01-01 00:00:00

abstract：:The mechanisms whereby glucose reduces fatty acid-induced release of enzyme from the coronary-ligated isolated perfused working rat heart are investigated. Alterations in the tissue contents of ATP, phosphocreatine, or glycogen could be excluded as possible mechanisms for the beneficial effect of glucose in this syst...

journal_title：Cardiovascular research

authors： Opie LH,Bricknell OL

更新日期：1979-12-01 00:00:00

abstract：AIMS:P2X receptors (P2XRs) mediate sympathetic control and autoregulation of renal circulation triggering preglomerular vasoconstriction, which protects glomeruli from elevated pressures. Although previous studies established a casual link between glomerular susceptibility to hypertensive injury and decreased preglomer...

journal_title：Cardiovascular research

authors： Gordienko D,Povstyan O,Sukhanova K,Raphaël M,Harhun M,Dyskina Y,Lehen'kyi V,Jama A,Lu ZL,Skryma R,Prevarskaya N

更新日期：2015-02-01 00:00:00

abstract：:To investigate the effects of sodium-potassium activated adenosine triphosphatase inhibition on central cardiovascular regulation a microinjection of ouabain was given into the hypothalamus of urethane anaesthetised rats. Doses of 0.01-1.0 micrograms per rat injected into the posterior hypothalamus produced a rise in ...

journal_title：Cardiovascular research

authors： Iyoda I,Takahashi H,Lee LC,Okajima H,Inoue A,Sasaki S,Takeda K,Yoshimura M,Ijichi H

更新日期：1986-04-01 00:00:00

abstract：OBJECTIVE:To determine the role of calcineurin and Src tyrosine kinase in the regulation of inducible nitric oxide synthase (iNOS) expression and protection in cardiomyocytes. METHODS:iNOS expression was studied in isolated neonatal rat ventricular myocyte cultures in response to bacterial lipopolysaccharide (LPS) or ...

journal_title：Cardiovascular research

authors： Obasanjo-Blackshire K,Mesquita R,Jabr RI,Molkentin JD,Hart SL,Marber MS,Xia Y,Heads RJ

更新日期：2006-09-01 00:00:00

abstract：AIMS:The role of endothelial nitric oxide synthase (eNOS)/NO signalling is well documented in late ischaemic preconditioning (IPC); however, the role of eNOS and its activation in early IPC remains controversial. This study investigates the role of eNOS in early IPC and the signalling pathways and molecular interaction...

journal_title：Cardiovascular research

authors： Yang C,Talukder MA,Varadharaj S,Velayutham M,Zweier JL

更新日期：2013-01-01 00:00:00

abstract：AIMS:A blood pressure-independent metabolic shift toward a catabolic state upon high sodium (Na+) diet, ultimately favouring body fluid preservation, has recently been described in pre-clinical controlled settings. We sought to investigate the real-life impact of high Na+ intake on measures of renal Na+/water handling ...

journal_title：Cardiovascular research

authors： Rossitto G,Maiolino G,Lerco S,Ceolotto G,Blackburn G,Mary S,Antonelli G,Berton C,Bisogni V,Cesari M,Seccia TM,Lenzini L,Pinato A,Montezano A,Touyz RM,Petrie MC,Daly R,Welsh P,Plebani M,Rossi GP,Delles C

更新日期：2020-07-16 00:00:00

abstract：STUDY OBJECTIVE:The aim was to investigate the effects of long-term treatment with an alpha 1 blocker, bunazosin hydrochloride, on blood pressure, heart weight, myocardial contractility, and ventricular myosin isoenzyme pattern in spontaneously hypertensive rats (SHR). DESIGN:Bunazosin hydrochloride was given orally i...

journal_title：Cardiovascular research

authors： Takeda N,Nakamura I,Ohkubo T,Iwai T,Tanamura A,Nagano M

更新日期：1991-07-01 00:00:00

abstract：:The kinetics of onset of rate-dependent depression of maximum rate of depolarisation (Vmax) of guinea-pig ventricular action potentials were studied for nine Class I anti-arrhythmic drugs using standard microelectrode techniques. The drugs were found to fall into three well-demarcated subgroups with "fast" (lignocaine...

journal_title：Cardiovascular research

authors： Campbell TJ

更新日期：1983-06-01 00:00:00