当前位置： SCI文献检索 > CARDIOVASCULAR RESEARCH期刊下所有文献 > A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation.

A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation.

Abstract：

AIMS:Atrial fibrillation (AF) is the most common cardiac arrhythmia, and early-onset lone AF has been linked to mutations in genes encoding ion channels. Mutations in the pore forming subunit KV4.3 leading to an increase in the transient outward potassium current (Ito) have previously been associated with the Brugada Syndrome. Here we aim to determine if mutations in KV4.3 or in the auxiliary subunit K(+) Channel-Interacting Protein (KChIP) 2 are associated with early-onset lone AF. METHODS AND RESULTS:Two hundred and nine unrelated early-onset lone AF patients (<40 years) were recruited. The entire coding sequence of KCND3 and KCNIP2 was bidirectionally sequenced. One novel non-synonymous mutation A545P was found in KCND3 and was neither present in the control group (n = 432 alleles) nor in any publicly available database. The proband had onset of persistent AF at the age of 22, and no mutations in genes previously associated with AF were found. Electrophysiological analysis of KV4.3-A545P expressed in CHO-K1 cells, revealed that peak-current density was increased and the onset of inactivation was slower compared with WT, resulting in a significant gain-of-function both in the absence and the presence of KChIP2. CONCLUSION:Gain-of-function mutations in KV4.3 have previously been described in Brugada Syndrome, however, this is the first report of a KV4.3 gain-of-function mutation in early-onset lone AF. This association of KV4.3 gain-of-function and early-onset lone AF further supports the hypothesis that increased potassium current enhances AF susceptibility.

journal_name

Cardiovasc Res

journal_title

Cardiovascular research

authors

Olesen MS,Refsgaard L,Holst AG,Larsen AP,Grubb S,Haunsø S,Svendsen JH,Olesen SP,Schmitt N,Calloe K

doi

10.1093/cvr/cvt028

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

488-95

issue

3

eissn

0008-6363

issn

1755-3245

pii

cvt028

journal_volume

98

pub_type

杂志文章,多中心研究

相关文献

CARDIOVASCULAR RESEARCH文献大全
  • Strategies for directing the differentiation of stem cells into the cardiomyogenic lineage in vitro.

    abstract：:Most studies on stem cell transplantation therapy on myocardially infarcted animal models and phase-I human clinical trials have focused on the use of undifferentiated stem cells. There is a strong possibility that some degree of cardiomyogenic differentiation of stem cells in vitro prior to transplantation would resu...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1016/j.cardiores.2003.12.022

    authors： Heng BC,Haider HKh,Sim EK,Cao T,Ng SC

    更新日期：2004-04-01 00:00:00

  • Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart failure via activation of glucagon-like peptide-1 receptor signalling.

    abstract：AIMS:Exercise capacity is reduced in heart failure (HF) patients, due mostly to skeletal muscle abnormalities including impaired energy metabolism, mitochondrial dysfunction, fibre type transition, and atrophy. Glucagon-like peptide-1 (GLP-1) has been shown to improve exercise capacity in HF patients. We investigated t...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvw182

    authors： Takada S,Masaki Y,Kinugawa S,Matsumoto J,Furihata T,Mizushima W,Kadoguchi T,Fukushima A,Homma T,Takahashi M,Harashima S,Matsushima S,Yokota T,Tanaka S,Okita K,Tsutsui H

    更新日期：2016-09-01 00:00:00

  • Oxidized LDL induces ventricular myocyte damage and abnormal electrical activity--role of lipid hydroperoxides.

    abstract：OBJECTIVE:It was our aim to investigate effects of human LDL, copper-, or AAPH-oxidized over different periods of time to different degrees (ox-LDL), on viability and electrophysiological parameters of isolated ventricular myocytes of guinea pigs. METHODS:Guinea pig ventricular myocytes were incubated with ox-LDL or n...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/j.cardiores.2004.12.009

    authors： Zorn-Pauly K,Schaffer P,Pelzmann B,Bernhart E,Wei G,Lang P,Ledinski G,Greilberger J,Koidl B,Jürgens G

    更新日期：2005-04-01 00:00:00

  • Targeted expression of cyclin D2 ameliorates late stage anthracycline cardiotoxicity.

    abstract：AIMS:Doxorubicin (DOX) is a widely used and effective anti-cancer therapeutic. DOX treatment is associated with both acute and late onset cardiotoxicity, limiting its overall efficacy. Here, the impact of cardiomyocyte cell cycle activation was examined in a juvenile model featuring aspects of acute and late onset DOX ...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvy273

    authors： Zhu W,Reuter S,Field LJ

    更新日期：2019-04-15 00:00:00

  • Impaired P2X signalling pathways in renal microvascular myocytes in genetic hypertension.

    abstract：AIMS:P2X receptors (P2XRs) mediate sympathetic control and autoregulation of renal circulation triggering preglomerular vasoconstriction, which protects glomeruli from elevated pressures. Although previous studies established a casual link between glomerular susceptibility to hypertensive injury and decreased preglomer...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvu249

    authors： Gordienko D,Povstyan O,Sukhanova K,Raphaël M,Harhun M,Dyskina Y,Lehen'kyi V,Jama A,Lu ZL,Skryma R,Prevarskaya N

    更新日期：2015-02-01 00:00:00

  • Is angiotensin II a proliferative factor of cardiac fibroblasts?

    abstract：:Angiotensin II has been implicated as an important factor in cardiac remodeling, particularly in the development of pathological left ventricular hypertrophy. It is generally assumed that angiotensin II is able to alter the phenotype of cardiac myocytes and fibroblasts, and several experiments have suggested that this...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1016/s0008-6363(01)00448-5

    authors： Bouzegrhane F,Thibault G

    更新日期：2002-02-01 00:00:00

  • Effect of beta-aminopropionitrile on the static elastic properties and blood pressure of spontaneously hypertensive rats.

    abstract：:The static elastic properties of the aorta ad systolic blood pressure in the caudal artery have been measured in 55 spontaneously hypertensive rats of the AS strain. Animals were divided into five groups and treated from the age of 4 to 12 weeks as follows: (1) 0.25 mm silver clip positioned around the right renal art...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/15.7.373

    authors： Berry CL,Greenwald SE,Menahem N

    更新日期：1981-07-01 00:00:00

  • Netrin-1 as a novel therapeutic target in cardiovascular disease: to activate or inhibit?

    abstract：:Netrins are a family of laminin-like proteins, which were initially identified for their role in embryonic axonal guidance. Over recent years, it has become apparent that netrin-1 may additionally be involved in the underlying pathology of several multisystem diseases, making it an attractive potential therapeutic tar...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1093/cvr/cvv201

    authors： Layne K,Ferro A,Passacquale G

    更新日期：2015-09-01 00:00:00

  • Comparison of left atrial and left ventricular performance in conscious dogs.

    abstract：:The velocity of contraction has been reported to be more rapid in left atrium (LA) than left ventricle (LV), but the mechanics of contraction in these two chambers have not been compared under physiological conditions. Accordingly, sonomicrometer crystals and solid state pressure transducers were used to measure LV an...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/18.10.604

    authors： Goldman S,Olajos M,Morkin E

    更新日期：1984-10-01 00:00:00

  • Shear stress induces angiotensin converting enzyme expression in cultured smooth muscle cells: possible involvement of bFGF.

    abstract：OBJECTIVE:Hemodynamic stresses are considered to be important regulators of gene expression in vascular cells. In this study, we have investigated the role of shear stress on ACE expression in cultured rat vascular cells, and focused on the regulation of ACE expression in smooth muscle cells. METHODS:Rat aortic endoth...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(99)00269-2

    authors： Gosgnach W,Challah M,Coulet F,Michel JB,Battle T

    更新日期：2000-01-14 00:00:00

  • Oxidized phospholipids inhibit cyclooxygenase-2 in human macrophages via nuclear factor-kappaB/IkappaB- and ERK2-dependent mechanisms.

    abstract：OBJECTIVE:Oxidized low-density lipoproteins (ox-LDL) or their components suppress macrophage inflammatory response by down-regulating cytokine synthesis, nitric oxide synthase and inducible cyclooxygenase (Cox-2). This event is crucial for the pathophysiological process leading to the formation of atherosclerotic plaqu...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(02)00437-6

    authors： Eligini S,Brambilla M,Banfi C,Camera M,Sironi L,Barbieri SS,Auwerx J,Tremoli E,Colli S

    更新日期：2002-08-01 00:00:00

  • Pretreatment with the adenosine A1 selective agonist, 2-chloro-N6-cyclopentyladenosine (CCPA), causes a sustained limitation of infarct size in rabbits.

    abstract：OBJECTIVE:The highly selective adenosine A1 receptor agonist, 2-chloro-N6-cyclopentyl-adenosine (CCPA), has been shown to be as cardioprotective as ischaemic preconditioning when evaluated with an early staining method using tetrazolium. However, tetrazolium-positive tissue measured 3 h after reperfusion may still over...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/27.4.652

    authors： Tsuchida A,Liu GS,Wilborn WH,Downey JM

    更新日期：1993-04-01 00:00:00

  • Adventitial fibroblast reactive oxygen species as autacrine and paracrine mediators of remodeling: bellwether for vascular disease?

    abstract：:The importance of the vascular adventitia is increasingly being recognized not only in vascular disease but also in normal maintenance and homeostasis of vessels. Activation of the adventitia and its resident fibrocytic cells in response to injury, stretch, cytokines, and hormones has been shown to stimulate different...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1016/j.cardiores.2007.06.016

    authors： Haurani MJ,Pagano PJ

    更新日期：2007-09-01 00:00:00

  • The effect of therapeutic doses of lidocaine hydrochloride on the effective refractory period of the right ventricle in man.

    abstract：:The effect of lidocaine on the effective refractory period of the right ventricle (EVRP) was measured in 10 patients using the extra stimulus technique of progressive introduction of premature stimuli until a response could not be elicited. In four patients lidocaine produced a significant decrease in the EVRP, in a f...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/9.5.621

    authors： Olsson SB,Harper R,Rydén L,Hilmy WA

    更新日期：1975-09-01 00:00:00

  • Exchange protein activated by cyclic-adenosine monophosphate (Epac) regulates atrial fibroblast function and controls cardiac remodelling.

    abstract：Aims:Heart failure (HF) produces left atrial (LA)-selective fibrosis and promotes atrial fibrillation. HF also causes adrenergic activation, which contributes to remodelling via a variety of signalling molecules, including the exchange protein activated by cAMP (Epac). Here, we evaluate the effects of Epac1-signalling ...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvy173

    authors： Surinkaew S,Aflaki M,Takawale A,Chen Y,Qi XY,Gillis MA,Shi YF,Tardif JC,Chattipakorn N,Nattel S

    更新日期：2019-01-01 00:00:00

  • Remodelling and functional alterations of the rabbit coronary artery in volume overloaded heart.

    abstract：OBJECTIVE:The aim was to study the contractility of the conduit coronary artery to vasoactive agents in developing and established volume overload cardiac hypertrophy and to compare it with structural alterations in the artery. METHODS:Aortic valve insufficiency in rabbits was used to produce a volume overloaded heart...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/27.11.2005

    authors： Gerová M,Holécyová A,Kristek F,Fízel' A,Fízel'ová A

    更新日期：1993-11-01 00:00:00

  • Functional role of collateral flow in the ischaemic dog heart.

    abstract：:Studies were carried out in four different canine preparations to determine the effect of collateral flow on early changes induced by acute segmental ischaemia. The results of these experiments indicated that collateral flow provided a limited and variable amount of protection. When collateral flow was eliminated, myo...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/12.5.309

    authors： Koke JR,Bittar N

    更新日期：1978-05-01 00:00:00

  • The role of V2 vasopressin antagonists in hyponatremia.

    abstract：:Hyponatremia is a frequent electrolyte disorder. It is often found in congestive cardiac failure, liver cirrhosis, plasma volume contraction and in SiADH. In these disorders hyponatremia is caused by nonosmotic vasopressin and sustained fluid intake. This provides a rationale for V2 vasopressin receptor antagonists in...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1016/s0008-6363(01)00288-7

    authors： Palm C,Reimann D,Gross P

    更新日期：2001-08-15 00:00:00

  • Bacterial DNA induces myocardial inflammation and reduces cardiomyocyte contractility: role of toll-like receptor 9.

    abstract：AIMS:Myocardial function is severely compromised during sepsis. Several underlying mechanisms have been proposed. The innate immune system, i.e. toll-like receptor (TLR) 2 and 4, significantly contributes to cardiac dysfunction. Little is known regarding TLR9 and its pathogenic ligand bacterial DNA in the myocardium. W...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvn011

    authors： Knuefermann P,Schwederski M,Velten M,Krings P,Ehrentraut H,Rüdiger M,Boehm O,Fink K,Dreiner U,Grohé C,Hoeft A,Baumgarten G,Koch A,Zacharowski K,Meyer R

    更新日期：2008-04-01 00:00:00

  • Nitrated fatty acids suppress angiotensin II-mediated fibrotic remodelling and atrial fibrillation.

    abstract：AIM:Atrial fibrosis, one of the most striking features in the pathology of atrial fibrillation (AF), is promoted by local and systemic inflammation. Electrophilic fatty acid nitroalkenes, endogenously generated by both metabolic and inflammatory reactions, are anti-inflammatory mediators that in synthetic form may be u...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvv254

    authors： Rudolph TK,Ravekes T,Klinke A,Friedrichs K,Mollenhauer M,Pekarova M,Ambrozova G,Martiskova H,Kaur JJ,Matthes B,Schwoerer A,Woodcock SR,Kubala L,Freeman BA,Baldus S,Rudolph V

    更新日期：2016-01-01 00:00:00

  • The L-arginine/nitric oxide pathway contributes to the acute release of tissue plasminogen activator in vivo in man.

    abstract：OBJECTIVE:Effective endogenous fibrinolysis requires rapid release of endothelial tissue plasminogen activator (t-PA). Using the nitric oxide synthase inhibitor, L-NG-monomethylarginine (L-NMMA), we examined the contribution of endogenous nitric oxide to substance P-induced t-PA release in vivo in man. METHODS:Blood f...

    journal_title：Cardiovascular research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0008-6363(98)00017-0

    authors： Newby DE,Wright RA,Dawson P,Ludlam CA,Boon NA,Fox KA,Webb DJ

    更新日期：1998-05-01 00:00:00

  • GSK-3β at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways.

    abstract：AIMS:Ischaemic preconditioning (IPC) protects the heart against prolonged lethal ischaemia through a signalling cascade involving Akt, glycogen synthase kinase-3β (GSK-3β), and mitochondrial ATP-sensitive potassium channels (mitoK(ATP)). We previously demonstrated the involvement of the Wnt pathway in IPC in vivo via G...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvr002

    authors： Vigneron F,Dos Santos P,Lemoine S,Bonnet M,Tariosse L,Couffinhal T,Duplaà C,Jaspard-Vinassa B

    更新日期：2011-04-01 00:00:00

  • Bidirectional cross-regulation between ErbB2 and β-adrenergic signalling pathways.

    abstract：AIMS:Despite the observation that ErbB2 regulates sensitivity of the heart to doxorubicin or ErbB2-targeted cancer therapies, mechanisms that regulate ErbB2 expression and activity have not been studied. Since isoproterenol up-regulates ErbB2 in kidney and salivary glands and β2AR and ErbB2 complex in brain and heart, ...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvv274

    authors： Sysa-Shah P,Tocchetti CG,Gupta M,Rainer PP,Shen X,Kang BH,Belmonte F,Li J,Xu Y,Guo X,Bedja D,Gao WD,Paolocci N,Rath R,Sawyer DB,Naga Prasad SV,Gabrielson K

    更新日期：2016-03-01 00:00:00

  • Lack of effect of anti-hypertensive treatment with felodipine on cardiovascular structure of young spontaneously hypertensive rats.

    abstract：:Felodipine (4(2,3-dichlorophenyl)-1,4-dihydro-2, 6-dimethyl-3-ethoxycarbonyl-5-methoxycarbonyl pyridine)), a selective vasodilating anti-hypertensive drug, was used in the treatment of spontaneously hypertensive rats (SHRs) and age-matched Wistar-Kyoto rats (WKYs) from age 6 to 14 weeks, ie during the time of high blo...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/19.9.528

    authors： Nyborg NC,Mulvany MJ

    更新日期：1985-09-01 00:00:00

  • Cardiac depression after experimental air embolism in pigs: role of addition of a surface-active agent.

    abstract：OBJECTIVE:Air bubbles entering the coronary artery may have harmful effects on cardiac function. From the physical point of view it is the relatively high surface tension of the blood-air interface which causes bubbles to trap in small vessels. The aim of the present study was to reduce depression of myocardial functio...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(97)00063-1

    authors： van Blankenstein JH,Slager CJ,Soei LK,Boersma H,Stijnen T,Schuurbiers JC,Krams R,Lachmann B,Verdouw PD

    更新日期：1997-06-01 00:00:00

  • Signal transduction in spontaneous myogenic tone in isolated arterioles from rat skeletal muscle.

    abstract：OBJECTIVE:The mechanism of spontaneous myogenic tone was investigated in isolated arteriolar segments. METHODS:Arterioles were isolated from rat cremaster muscle. Segments were endothelium-denuded and mounted in a pressure myograph at 75 mmHg. Under this condition, segments spontaneously constricted from a passive dia...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(98)00161-8

    authors： Bakker EN,Kerkhof CJ,Sipkema P

    更新日期：1999-01-01 00:00:00

  • Dyslipidemia and endothelium-dependent relaxation in internal mammary arteries used for coronary bypass surgery.

    abstract：OBJECTIVE:Impairment of endothelium-dependent relaxation is related to dyslipidemia and may be an early marker for atherosclerosis in angiographically smooth arteries. The aim of the present study was to relate preoperative serum lipids to endothelium-dependent relaxation in internal mammary arteries of patients underg...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(97)00081-3

    authors： Voors AA,Oosterga M,Buikema H,May JF,Grandjean JG,van Buiten A,van Gilst WH

    更新日期：1997-06-01 00:00:00

  • Female-related skeletal muscle phenotype in patients with moderate chronic heart failure before and after dynamic exercise training.

    abstract：UNLABELLED:This study hypothesized that female patients with chronic heart failure (CHF), similarly as previously reported for male patients, have a decreased proportion of type I (slow twitch) muscle fibers combined with fiber atrophy, and respond to exercise training with an increased muscular fiber area and performa...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(98)00313-7

    authors： Tyni-Lenné R,Jansson E,Sylvén C

    更新日期：1999-04-01 00:00:00

  • Tumor necrosis factor alpha as an endogenous stimulator for circulating coupling factor 6.

    abstract：OBJECTIVE:We recently showed that mitochondrial coupling factor 6 (CF6) is present as a pressor substance and a prostacyclin inhibitor in systemic circulation. However, the regulation mechanism for circulating CF6 is unknown. We investigated the role of tumor necrosis factor-alpha (TNF-alpha) in the generation and rele...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/j.cardiores.2004.01.031

    authors： Sasaki S,Osanai T,Tomita H,Matsunaga T,Magota K,Okumura K

    更新日期：2004-06-01 00:00:00

  • Effects on labile metabolites of temporal delay in freezing biopsy samples of dog myocardium in liquid nitrogen.

    abstract：:Sudden hypothermia utilising liquid nitrogen has been used for immediate inhibition of metabolic reactions and preservation of labile compounds in heart muscle. It has been suggested that this rapid transfer of tissue into liquid nitrogen, within 1 to 2 s, is essential for accurate assessment of internal milieu condit...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/12.3.162

    authors： Allison TB,Ramey CA,Holsinger JW Jr

    更新日期：1978-03-01 00:00:00