当前位置： SCI文献检索 > CARDIOVASCULAR RESEARCH期刊下所有文献 > Female-related skeletal muscle phenotype in patients with moderate chronic heart failure before and after dynamic exercise training.

Female-related skeletal muscle phenotype in patients with moderate chronic heart failure before and after dynamic exercise training.

Abstract：

UNLABELLED:This study hypothesized that female patients with chronic heart failure (CHF), similarly as previously reported for male patients, have a decreased proportion of type I (slow twitch) muscle fibers combined with fiber atrophy, and respond to exercise training with an increased muscular fiber area and performance, and with an unaltered fiber type distribution. METHODS:Sixteen women [age 62 +/- 10 years (mean +/- SD)] with stable, moderate CHF (left ventricular ejection fraction 28 +/- 8%) underwent percutaneous needle biopsies of the lateral vastus muscle, and assessments of isokinetic muscle strength and exercise tests with respiratory gas and blood lactate analyses, before and after 8 weeks of intensive knee extensor endurance training. RESULTS:When compared to healthy age-matched women, the women with CHF unexpectedly had a normal proportion of type I fibers (51 +/- 15%), but a decreased cross-sectional area in both type I and II fibers. Exercise training increased the cross-sectional area of muscle fibers up to the reference range (21%, p < 0.04), while the relative number of type I fibers decreased (12%, p < 0.03). Training also increased muscle strength (16%, p < 0.0001) and peak oxygen uptake (20%, p < 0.0001). The increase in peak oxygen uptake was directly related to the training-induced increase in fiber areas (r = 0.63; p < 0.03), and decrease in lactate accumulation was inversely related to the training-induced decrease in the relative number of type I fibers (r = -0.62; p < 0.02). CONCLUSIONS:As for men with CHF, a skeletal muscle atrophy was found in women, but contrary to the hypothesis, the proportion of type I muscle fibers was normal. Exercise training counteracted the atrophy suggesting skeletal muscle trainability in female CHF patients.

journal_name

Cardiovasc Res

journal_title

Cardiovascular research

authors

Tyni-Lenné R,Jansson E,Sylvén C

doi

10.1016/s0008-6363(98)00313-7

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

99-103

issue

eissn

0008-6363

issn

1755-3245

pii

S0008-6363(98)00313-7

journal_volume

pub_type

杂志文章

在线工具

Female-related skeletal muscle phenotype in patients with moderate chronic heart failure before and after dynamic exercise training.