Systolic pressure--diameter relations in the normal conscious dog.

abstract：AIMS:Although increased Na(+)/Ca(2+) exchanger 1 (NCX1) expression is observed during heart failure (HF), the pathological role of NCX1 during the progression of HF remains unclear. We examined alterations of NCX1 expression and activity in hearts after transverse aortic constriction (TAC) surgery and explored whether ...

journal_title：Cardiovascular research

authors： Ujihara Y,Iwasaki K,Takatsu S,Hashimoto K,Naruse K,Mohri S,Katanosaka Y

更新日期：2016-09-01 00:00:00

abstract：AIMS:In obesity, chronic low-grade inflammation and overproduction of reactive oxygen species (ROS) in fat contribute to the development of metabolic syndrome. Suppression of inflammation and ROS production in fat may attenuate the metabolic syndrome. Activation of mineralocorticoid receptor (MR) promotes inflammation ...

journal_title：Cardiovascular research

authors： Hirata A,Maeda N,Hiuge A,Hibuse T,Fujita K,Okada T,Kihara S,Funahashi T,Shimomura I

更新日期：2009-10-01 00:00:00

abstract：:Although it is generally believed that the beneficial effect of loop diuretics is the result of a rapid increase in diuresis, substantial evidence, from a large number of in vitro and in vivo experiments, has accumulated showing that administration of furosemide causes direct vascular effects, which probably contribut...

journal_title：Cardiovascular research

authors： Dormans TP,Pickkers P,Russel FG,Smits P

更新日期：1996-12-01 00:00:00

abstract：:An oscillatory current (Ios) can be recorded after depolarising clamps of a given amplitude and duration. To determine whether Ios depends on other currents activated during the clamp, the Ios was investigated in the absence and in the presence of 4-aminopyridine (4-AP) and cesium (Cs). The following results were obta...

journal_title：Cardiovascular research

authors： Mugelli A

更新日期：1982-11-01 00:00:00

abstract：AIMS:The metabolic syndrome (MS) leads to myocardial fibrosis (MF) and diastolic dysfunction. Statins have proven beneficial effects in MS, but their impact on cardiac remodelling is uncertain. We examined the effects and mechanisms of chronic statin treatment on cardiac remodelling, e.g. fibrosis and diastolic propert...

journal_title：Cardiovascular research

authors： Hermida N,Markl A,Hamelet J,Van Assche T,Vanderper A,Herijgers P,van Bilsen M,Hilfiker-Kleiner D,Noppe G,Beauloye C,Horman S,Balligand JL

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:Insulin seems to have vasodilator properties, but it is unclear if insulin in postprandial concentrations is a specific vasodilator of skeletal muscle resistance arterioles only or that various types of vessels are affected. The aim of the present study was to determine the direct effects and the time course ...

journal_title：Cardiovascular research

authors： de Haan CH,van Dielen FM,Houben AJ,de Leeuw PW,Huvers FC,De Mey JG,Wolffenbuttel BH,Schaper NC

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVES:Saphenous vein graft failures, resulting from thrombosis and the abnormal proliferation, migration and apoptosis of vascular smooth muscle cells (VSMC) are major limitations of coronary artery bypass surgery. We investigated whether surgical trauma of human saphenous vein induces the early response gene c-fo...

journal_title：Cardiovascular research

authors： Galea J,Armstrong J,Francis SE,Cooper G,Crossman DC,Holt CM

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVES:Elevated systemic arterial blood pressure is associated with left ventricular hypertrophy and fibrosis. It has been suggested that both circulating and local myocardial renin-angiotensin systems play a role in mediating these responses. Here we describe the natural history of ventricular hypertrophy and fibr...

journal_title：Cardiovascular research

authors： Bishop JE,Kiernan LA,Montgomery HE,Gohlke P,McEwan JR

更新日期：2000-07-01 00:00:00

abstract：:Currently, a high carbohydrate/low fat diet is recommended for patients with hypertension; however, the potentially important role that the composition of dietary fat and carbohydrate plays in hypertension and the development of pathological left ventricular hypertrophy (LVH) has not been well characterized. Recent st...

journal_title：Cardiovascular research

authors： Sharma N,Okere IC,Duda MK,Chess DJ,O'Shea KM,Stanley WC

更新日期：2007-01-15 00:00:00

abstract：OBJECTIVE:A previous study from this laboratory showed that elevation of endogenous angiotensin II (Ang II) and upregulation of the angiotensin II type 1 (AT(1)) receptor in the carotid body (CB) are involved in the enhanced peripheral chemoreceptor sensitivity in rabbits with chronic heart failure (CHF). NADPH oxidase...

journal_title：Cardiovascular research

authors： Li YL,Gao L,Zucker IH,Schultz HD

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVES:Diastolic dysfunction that determines symptoms and prognosis in patients with systolic dysfunction causes heart failure even in the absence of systolic dysfunction. Our recent studies have suggested that myocardial stiffening is likely to play a crucial role in triggering deleterious cardiac disorder. This s...

journal_title：Cardiovascular research

authors： Yamamoto K,Masuyama T,Sakata Y,Nishikawa N,Mano T,Yoshida J,Miwa T,Sugawara M,Yamaguchi Y,Ookawara T,Suzuki K,Hori M

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVES:Recombinant retroviral vectors have been shown to be useful tools for marking cells so as to follow their fates during development. The aim of this study was to determine the utility and advantages of an adenoviral vector as a tool to study the heart as it develops from a simple tube into a complex four-cham...

journal_title：Cardiovascular research

authors： Fisher SA,Watanabe M

更新日期：1996-02-01 00:00:00

abstract：:The effect on the microcirculation of long term administration of the alpha 1 blocker prazosin, which increases peripheral blood flow, was studied in skeletal muscles with differing metabolic profiles. Prazosin (50 mg.litre-1), given ad libitum for 5 weeks in the drinking water, resulted in an increase in capillarity ...

journal_title：Cardiovascular research

authors： Dawson JM,Hudlická O

更新日期：1989-11-01 00:00:00

abstract：Aims:Fibroblast growth factor 1 (FGF1), a heparin/heparan sulfate-binding growth factor, is a potent cardioprotective agent against myocardial infarction (MI). The impact of heparin, the standard of care for MI patients entering the emergency room, on cardioprotective effects of FGF1 is unknown, however. Methods and r...

journal_title：Cardiovascular research

authors： Huang C,Liu Y,Beenken A,Jiang L,Gao X,Huang Z,Hsu A,Gross GJ,Wang YG,Mohammadi M,Schultz JEJ

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:The aim was to examine the ventricular expression of brain natriuretic peptide (BNP) in the transplanted human heart. METHODS:Serial right ventricular biopsies (n = 68) and plasma samples (n = 68) were obtained for measurement of BNP and atrial natriuretic peptide (ANP) from 14 orthotopic cardiac transplant ...

journal_title：Cardiovascular research

authors： Ationu A,Burch M,Singer D,Littleton P,Carter N

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVES:While it is probable that the cerebrovascular spasm which occurs after subarachnoid haemorrhage results from the action of haemoglobin, the mechanism of that process remains unclear. These studies were thus designed to test the hypothesis that the action of oxyhaemoglobin results from the iron-catalyzed form...

journal_title：Cardiovascular research

authors： Vollrath B,Chan P,Findlay M,Cook D

更新日期：1995-10-01 00:00:00

abstract：:Myocardial ischaemia increases cellular and extracellular osmolarity, alters membrane permeability to ions and causes moderate cell swelling and interstitial oedema. Ischaemia also reduces the mechanical resistance of the sarcolemma of myocytes, probably as a result of proteolytic digestion of the connections between ...

journal_title：Cardiovascular research

authors： Garcia-Dorado D,Oliveras J

更新日期：1993-09-01 00:00:00

abstract：AIMS:Cardiovascular research requires complex and functionally intact experimental models. Due to major differences in the cellular and subcellular composition of the myocardium between species, the use of human heart tissue is highly desirable. To enhance the experimental use of the human myocardium, we established me...

journal_title：Cardiovascular research

authors： Brandenburger M,Wenzel J,Bogdan R,Richardt D,Nguemo F,Reppel M,Hescheler J,Terlau H,Dendorfer A

更新日期：2012-01-01 00:00:00

abstract：:Gender has an important influence on blood pressure, with premenopausal women having a lower arterial blood pressure than age-matched men. Compared with premenopausal women, postmenopausal women have higher blood pressures, suggesting that ovarian hormones may modulate blood pressure. However, whether sex hormones are...

journal_title：Cardiovascular research

authors： Dubey RK,Oparil S,Imthurn B,Jackson EK

更新日期：2002-02-15 00:00:00

abstract：Aims:MicroRNAs (miRNAs) have been implicated in the pathogenesis of pulmonary hypertension (PH), a multifactorial and progressive condition associated with an increased afterload of the right ventricle leading to heart failure and death. The main aim of this study was to correlate the levels of miR-424(322) with the se...

journal_title：Cardiovascular research

authors： Baptista R,Marques C,Catarino S,Enguita FJ,Costa MC,Matafome P,Zuzarte M,Castro G,Reis A,Monteiro P,Pêgo M,Pereira P,Girão H

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Transient atrial fibrillation is sometimes observed following adenosine administration and adenosine is known to shorten atrial action potential duration and refractory period. This study was designed to characterise the dose-response relationship of adenosine on these variables relative to arrhythmia inducti...

journal_title：Cardiovascular research

authors： Kabell G,Buchanan LV,Gibson JK,Belardinelli L

更新日期：1994-09-01 00:00:00

abstract：:A recently developed highly sensitive radioimmunoassay method for detecting plasma kinin was used to re-evaluate the results of previous studies, in which plasma kinin had been measured with a bioassay method. To clarify the mechanism of plasma kinin release in global myocardial ischaemia the left main coronary artery...

journal_title：Cardiovascular research

authors： Matsuki T,Shoji T,Yoshida S,Kudoh Y,Motoe M,Inoue M,Nakata T,Hosoda S,Shimamoto K,Yellon D

更新日期：1987-06-01 00:00:00

abstract：Aims:Atherosclerosis is an inflammatory disease wherein cholesterol-loaded macrophages play a major role. MicroRNAs and microparticles propagate inflammatory pathways and are involved in cardiovascular disease. We aimed to screen and validate circulating microRNAs correlated with atherosclerosis development in humans, ...

journal_title：Cardiovascular research

authors： Ceolotto G,Giannella A,Albiero M,Kuppusamy M,Radu C,Simioni P,Garlaschelli K,Baragetti A,Catapano AL,Iori E,Fadini GP,Avogaro A,Vigili de Kreutzenberg S

更新日期：2017-11-01 00:00:00

abstract：:Mechanical stress signals transmitted through the heart walls during hemodynamic loading are sensed by the myocytes, which respond with changes in contractile performance and gene expression. External forces play an important role in physiological heart development and hypertrophy, but disruption of the well-balanced ...

journal_title：Cardiovascular research

authors： Linke WA

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:Inflammatory cells invade the fibrotic myocardium of spontaneously hypertensive rats at the same sites as where fibroblasts are produced. The role of these inflammatory cells in myocardial fibrogenesis was studied in the present work. METHODS:The production and distribution of proteins that may be implicated...

journal_title：Cardiovascular research

authors： Nicoletti A,Mandet C,Challah M,Bariéty J,Michel JB

更新日期：1996-04-01 00:00:00

abstract：:The function of the right ventricle (RV) determines the prognosis of patients with pulmonary hypertension. While much progress has been made in the treatment of pulmonary hypertension, therapies for the RV are less well established. In this review of treatment strategies for the RV, first we focus on ways to reduce wa...

journal_title：Cardiovascular research

authors： Westerhof BE,Saouti N,van der Laarse WJ,Westerhof N,Vonk Noordegraaf A

更新日期：2017-10-01 00:00:00

abstract：:In this review, we summarize current knowledge on the genetics of coronary artery disease, based on 10 years of genome-wide association studies. The discoveries began with individual studies using 200K single nucleotide polymorphism arrays and progressed to large-scale collaborative efforts, involving more than a 100 ...

journal_title：Cardiovascular research

authors： Erdmann J,Kessler T,Munoz Venegas L,Schunkert H

更新日期：2018-07-15 00:00:00

abstract：OBJECTIVE:The restitution mechanism has been the focus of attention as the possible mechanism behind ventricular fibrillation (VF). However, its contribution in chronic ischemic heart has not been established. METHODS:We investigated chronic ischemic dogs with occlusion of left anterior descending artery. Sixty unipol...

journal_title：Cardiovascular research

authors： Yuuki K,Hosoya Y,Kubota I,Yamaki M

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:The vasoconstrictor effect of endothelins (ET) is mediated by endothelin A (ETA) and endothelin B (ETB) receptors. Furthermore, ETB receptor stimulation results in release of vasodilators. Hence, ETA receptor antagonists should attenuate ET-mediated vasoconstriction. The aim of the present study was to evalua...

journal_title：Cardiovascular research

authors： Zhang Y,Oliver JR,Horowitz JD

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE AND METHODS:In this study, we investigated whether Ca(2+) transients are altered in Purkinje cell aggregates dispersed from the subendocardium overlying the infarcted zone of the left ventricle (IZPCs) 48 h after coronary artery occlusion. To do so, we combined epifluorescent imaging with microelectrode recor...

journal_title：Cardiovascular research

authors： Boyden PA,Barbhaiya C,Lee T,ter Keurs HE

更新日期：2003-03-01 00:00:00