当前位置： SCI文献检索 > CARDIOVASCULAR RESEARCH期刊下所有文献 > Mediators of perivascular inflammation in the left ventricle of renovascular hypertensive rats.

Mediators of perivascular inflammation in the left ventricle of renovascular hypertensive rats.

Abstract：

OBJECTIVE:Inflammatory cells invade the fibrotic myocardium of spontaneously hypertensive rats at the same sites as where fibroblasts are produced. The role of these inflammatory cells in myocardial fibrogenesis was studied in the present work. METHODS:The production and distribution of proteins that may be implicated in inflammation was examined by immunohistochemistry of sections of left ventricles from 1-month and 4-month renovascular hypertensive and age-matched control rats using antibodies against ICAM-1, LFA-1, TGF beta 1, PDGF-A, T and H kininogens, IgG, IgM, C3, and C5b-9. Infiltrating inflammatory cells were phenotyped by immunohistochemistry. The TGF beta 1 and PDGF-A mRNA levels were checked by RT-PCR. RESULTS:Infiltrating cells were mainly T helper lymphocytes and macrophages, and there were more inflammatory cells in hypertensive rats than in control rats, localized especially around coronary arteries and in microscars. There were more ICAM-1 and LFA-1 in the ventricles of hypertensive than in control rats at 1 month, but the ICAM-1 expressions in hypertensive and control rats were similar at 4 months. TGF beta 1 and PDGF-A mRNA steady states increased in 4-month hypertensive rats, but there was no labeling for TGF beta or PDGF by immunohistochemistry. There was only faint labeling for T and H kininogens, and it was not increased in hypertensive rats. There were deposits of IgM and C5b-9 only in hypertensive rats. CONCLUSION:Thus, inflammatory cells infiltrate the cardiac tissue of renovascular hypertensive rats as in the case of spontaneously hypertensive rats and these cells may use the ICAM-1/LFA-1 system to infiltrate, but neither TGF beta 1 and PDGF-A, nor the kininogen system seem to be associated with cardiac fibrogenesis. Otherwise, the complement system could act as arteriosclerotic and/or leukocyte mobilizing factors.

journal_name

Cardiovasc Res

journal_title

Cardiovascular research

authors

Nicoletti A,Mandet C,Challah M,Bariéty J,Michel JB

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

585-95

issue

4

eissn

0008-6363

issn

1755-3245

pii

0008636395002391

journal_volume

31

pub_type

杂志文章

相关文献

CARDIOVASCULAR RESEARCH文献大全
  • Atheroprotective role of high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P).

    abstract：:Numerous epidemiological studies documented an inverse relationship between plasma high-density lipoprotein (HDL) cholesterol levels and the extent of atherosclerotic disease. However, clinical interventions targeting HDL cholesterol failed to show clinical benefits with respect to cardiovascular risk reduction, sugge...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1093/cvr/cvu136

    authors： Potì F,Simoni M,Nofer JR

    更新日期：2014-08-01 00:00:00

  • The atherogen 3-methylcholanthrene induces multiple DNA adducts in mouse aortic smooth muscle cells: role of cytochrome P4501B1.

    abstract：OBJECTIVE:3-Methylcholanthrene (MC), a polycylic aromatic hydrocarbon, induces atherogenesis in mice fed an atherogenic diet. In this study, we tested the hypothesis that MC would induce DNA adducts in mouse aortic smooth muscle cells (SMCs) and that cytochrome P4501B1 (CYP1B1) plays an important role in the activation...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(01)00536-3

    authors： Moorthy B,Miller KP,Jiang W,Ramos KS

    更新日期：2002-03-01 00:00:00

  • Altered gene expression of prostacyclin synthase and prostacyclin receptor in the thoracic aorta of spontaneously hypertensive rats.

    abstract：OBJECTIVE:The aim of this study was to evaluate the possible role of prostacyclin (PGI2) in the pathogenesis of hypertension in spontaneously hypertensive rats (SHR). METHODS:Measurement of mRNA and protein levels of PGH synthase (PGHS)-1, PGI2 synthase and the PGI2 receptor, in the thoracic aorta was performed in SHR...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(98)00239-9

    authors： Numaguchi Y,Harada M,Osanai H,Hayashi K,Toki Y,Okumura K,Ito T,Hayakawa T

    更新日期：1999-03-01 00:00:00

  • A₁ adenosine receptor deficiency or inhibition reduces atherosclerotic lesions in apolipoprotein E deficient mice.

    abstract：AIMS:The goal of this study was to determine whether the A1 adenosine receptor (AR) plays a role in atherosclerosis development and to explore its potential mechanisms. METHODS AND RESULTS:Double knockout (DKO) mice, deficient in the genes encoding A1 AR and apolipoprotein E (apoE), demonstrated reduced atheroscleroti...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvu033

    authors： Teng B,Smith JD,Rosenfeld ME,Robinet P,Davis ME,Morrison RR,Mustafa SJ

    更新日期：2014-04-01 00:00:00

  • Acute pericardial distension in pigs: effect of fluid conductance on body surface electrocardiogram QRS size.

    abstract：OBJECTIVES:Pericardial effusion has long been associated with low voltage of the surface electrocardiogram and its clinical utility is well known. The cause of this reduced QRS voltage has usually been attributed to short circuiting of the impulses by the pericardial fluid, but its precise mechanism has not been clearl...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/27.6.1033

    authors： Karatay CM,Fruehan CT,Lighty GW Jr,Spear RM,Smulyan H

    更新日期：1993-06-01 00:00:00

  • Interactions between the sympathetic nervous system and the kidneys in arterial hypertension.

    abstract：:Elevated sympathetic activity changes renal function and accelerates the development of hypertension. Principles of sympatho-renal interactions in chronic hypertension are reviewed. Alterations in the ontogeny of the sympathetic nervous system and the kidney, inherited abnormalities in sensory receptor function and ex...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1016/j.cardiores.2003.11.024

    authors： Grisk O,Rettig R

    更新日期：2004-02-01 00:00:00

  • Genome-wide association studies of cardiac electrical phenotypes.

    abstract：:The genetic basis of cardiac electrical phenotypes has in the last 25 years been the subject of intense investigation. While in the first years, such efforts were dominated by the study of familial arrhythmia syndromes, in recent years, large consortia of investigators have successfully pursued genome-wide association...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvaa144

    authors： Glinge C,Lahrouchi N,Jabbari R,Tfelt-Hansen J,Bezzina CR

    更新日期：2020-07-15 00:00:00

  • Liposomal Hsp90 cDNA induces neovascularization via nitric oxide in chronic ischemia.

    abstract：OBJECTIVE:Induction of angiogenesis has been reported subsequent to eNOS overexpression or activation, the latter involving Hsp90 as a chaperone protein. Here, we investigated the potential of regional Hsp90 overexpression to induce therapeutic neovascularization in vivo in a chronic rabbit hindlimb ischemia model. ME...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/j.cardiores.2004.10.019

    authors： Pfosser A,Thalgott M,Büttner K,Brouet A,Feron O,Boekstegers P,Kupatt C

    更新日期：2005-02-15 00:00:00

  • Extra- and intracellular factors regulating cardiomyocyte proliferation in postnatal life.

    abstract：:One of the striking differences that distinguish the adult from the embryonic heart in mammals and set it apart from the heart in urodeles and teleosts is the incapacity of cardiomyocytes to respond to damage by proliferation. While the molecular reasons underlying these characteristics still await elucidation, mounti...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1093/cvr/cvu057

    authors： Zacchigna S,Giacca M

    更新日期：2014-05-01 00:00:00

  • Distribution of fibrinogen and albumin in normal, ischaemic, and necrotic myocardium during the evolution of myocardial infarction: an immunohistochemical study.

    abstract：:The role of mediators of inflammation in the pathogenesis and evolution of myocardial infarction has attracted increased interest as interventions which inhibit the inflammatory response after coronary artery occlusion have been shown to decrease infarct size. The distribution of fibrinogen and albumin in ischaemia my...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/20.1.36

    authors： Fishbein MC,Kulber D,Stancl M,Edwalds G

    更新日期：1986-01-01 00:00:00

  • Spontaneous diastolic contractions and phosphorylation of the cardiac ryanodine receptor at serine-2808 in congestive heart failure in rat.

    abstract：OBJECTIVE:The role of phosphorylation of the ryanodine receptor at serine-2808 (RyRS2808) in congestive heart failure (CHF) is controversial, and effects of RyRS2808 phosphorylation on contraction are unclear. It has been reported that diastolic sarcomere length (SL) fluctuations accompany propagating contractile waves...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/j.cardiores.2005.07.010

    authors： Obayashi M,Xiao B,Stuyvers BD,Davidoff AW,Mei J,Chen SR,ter Keurs HE

    更新日期：2006-01-01 00:00:00

  • Facilitation of noradrenaline release by activation of adenosine A(2A) receptors triggers both phospholipase C and adenylate cyclase pathways in rat tail artery.

    abstract：OBJECTIVE:The present work is aimed at elucidating the signalling pathway(s) triggered by activation of A(2A) receptors involved in the facilitation of noradrenaline release in rat tail artery as an attempt to clarify their role in the cardiovascular system. METHODS:Electrically evoked (5 Hz, 100 pulses, 1 ms) tritium...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/j.cardiores.2004.05.015

    authors： Fresco P,Diniz C,Gonçalves J

    更新日期：2004-09-01 00:00:00

  • Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations.

    abstract：AIMS:Recent immunohistochemical studies observed the loss of plakoglobin (PG) from the intercalated disc (ID) as a hallmark of arrhythmogenic right ventricular cardiomyopathy (ARVC), suggesting a final common pathway for this disease. However, the underlying molecular processes are poorly understood. METHODS AND RESUL...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvq353

    authors： Gehmlich K,Syrris P,Peskett E,Evans A,Ehler E,Asimaki A,Anastasakis A,Tsatsopoulou A,Vouliotis AI,Stefanadis C,Saffitz JE,Protonotarios N,McKenna WJ

    更新日期：2011-04-01 00:00:00

  • Evaluation of reperfusion strategy for the globally ischaemic rat heart. Recovery of function and energy metabolism.

    abstract：OBJECTIVE:The sequelae of myocardial ischaemia can in principle be alleviated by repeated reperfusion, but the accumulation of adenosine monophosphate (AMP) and the loss of interstitial adenosine may lead to adenylate depletion. Repeated oxidative stress could predispose the heart to reperfusion injury. The aim of this...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/26.5.502

    authors： Høst N,Peuhkurinen K,Haunsø S,Hassinen I

    更新日期：1992-05-01 00:00:00

  • Peptidyl-prolyl isomerases: a full cast of critical actors in cardiovascular diseases.

    abstract：:Peptidyl-prolyl cis-trans-isomerases are a highly conserved family of immunophilins. The three peptidyl-prolyl cis-trans-isomerase subfamilies are cyclophilins, FK-506-binding proteins, and parvulins. Peptidyl-prolyl cis-trans-isomerases are expressed in multiple human tissues and regulate different cellular functions...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1093/cvr/cvv096

    authors： Perrucci GL,Gowran A,Zanobini M,Capogrossi MC,Pompilio G,Nigro P

    更新日期：2015-06-01 00:00:00

  • Downstream resistance effects of intracoronary thrombosis in the stenosed canine coronary artery.

    abstract：OBJECTIVE:The presence is well established in unstable angina of intracoronary thrombosis in a stenosed epicardial coronary artery. The effects of the thrombus formation on the distal microcirculation are however still unclear. METHODS:We adapted the Folts canine model of left circumflex coronary arterial stenosis and...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(98)00270-3

    authors： Mansaray M,Belcher PR,Vergroesen I,Wright ZM,Hynd JW,Drake-Holland AJ,Noble MI

    更新日期：1999-04-01 00:00:00

  • Comparative DNA methylation and gene expression analysis identifies novel genes for structural congenital heart diseases.

    abstract：AIMS:For the majority of congenital heart diseases (CHDs), the full complexity of the causative molecular network, which is driven by genetic, epigenetic, and environmental factors, is yet to be elucidated. Epigenetic alterations are suggested to play a pivotal role in modulating the phenotypic expression of CHDs and t...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvw195

    authors： Grunert M,Dorn C,Cui H,Dunkel I,Schulz K,Schoenhals S,Sun W,Berger F,Chen W,Sperling SR

    更新日期：2016-10-01 00:00:00

  • Redox signalling in vascular responses to shear and stretch.

    abstract：:Blood vessels are permanently exposed to stretch and shear stress due to blood pressure and blood flow. Significant variations in the mechanical environment, of physiological or pathophysiological nature, occur in vivo. These trigger acute changes in vessel diameter that tend to restore basal levels of tensile and she...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1016/j.cardiores.2006.05.008

    authors： Lehoux S

    更新日期：2006-07-15 00:00:00

  • Effect of acetylcholine on aconitine induced delayed afterdepolarisation in the frog atrium and ventricle.

    abstract：:The effect of acetylcholine on the aconitine induced delayed afterdepolarisation and triggered electrical activities under nominally calcium free conditions were studied in frog atrium and ventricle. The changes in intracellular potassium activity were also examined. The aconitine induced delayed afterdepolarisation a...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/21.11.804

    authors： Sawanobori T,Hirano Y,Hiraoka M

    更新日期：1987-11-01 00:00:00

  • Analogue computation of indices of contraction from regional measurements in intact hearts.

    abstract：:Computation of indices of regional myocardial contractility such as the shortening, or the work done by or on a segment of myocardium in a single cardial cycle is tedious to perform manually, and complex interfacing and software is needed for digital computation. We describe the principles of an on-line, analogue devi...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/17.12.767

    authors： Lab MJ,Gartside I,Wassermann S

    更新日期：1983-12-01 00:00:00

  • CaMKII-mediated increased lusitropic responses to beta-adrenoreceptor stimulation in ANP-receptor deficient mice.

    abstract：OBJECTIVE:Mice with genetic disruption of the guanylyl cyclase-A (GC-A) receptor for atrial natriuretic peptide (ANP), have chronic arterial hypertension and marked cardiac hypertrophy. Intriguingly, despite pronounced remodeling, cardiac contractile functions and cardiomyocyte Ca(2+)-handling are preserved and even en...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/j.cardiores.2006.10.003

    authors： Yurukova S,Kilić A,Völker K,Leineweber K,Dybkova N,Maier LS,Brodde OE,Kuhn M

    更新日期：2007-03-01 00:00:00

  • Controversies regarding hormone therapy: Insights from inflammation and hemostasis.

    abstract：:Many observational studies and experimental and animal studies have demonstrated that estrogen therapy (ET) or hormone therapy (HT) significantly reduces the risk of coronary heart disease. Nonetheless, recent randomized controlled trials and the Nurses' Health Study in secondary prevention demonstrate trends toward a...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1016/j.cardiores.2005.12.004

    authors： Koh KK,Yoon BK

    更新日期：2006-04-01 00:00:00

  • Doppler blood velocity in the pulmonary artery of infants, children, and adults.

    abstract：:A pulsed, range gated, directional, ultrasonic, Doppler blood velocity meter was used to record signals from the pulmonary artery in 52 normal subjects ranging in age from less than 1 week to over 30 years. Signals were obtained from an unfocused transducer in the second or third left intercostal space using a 2.25 MH...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/20.11.816

    authors： Targett RC,Heldt GP,McIlroy MB

    更新日期：1986-11-01 00:00:00

  • Gene expression of proteins influencing the calcium homeostasis in patients with persistent and paroxysmal atrial fibrillation.

    abstract：OBJECTIVE:Persistent atrial fibrillation (AF) results in an impairment of atrial function. In order to elucidate the mechanism behind this phenomenon, we investigated the gene expression of proteins influencing calcium handling. METHODS:Right atrial appendages were obtained from eight patients with paroxysmal AF, ten ...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(99)00045-0

    authors： Brundel BJ,van Gelder IC,Henning RH,Tuinenburg AE,Deelman LE,Tieleman RG,Grandjean JG,van Gilst WH,Crijns HJ

    更新日期：1999-05-01 00:00:00

  • Early ischaemic preconditioning requires Akt- and PKA-mediated activation of eNOS via serine1176 phosphorylation.

    abstract：AIMS:The role of endothelial nitric oxide synthase (eNOS)/NO signalling is well documented in late ischaemic preconditioning (IPC); however, the role of eNOS and its activation in early IPC remains controversial. This study investigates the role of eNOS in early IPC and the signalling pathways and molecular interaction...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvs287

    authors： Yang C,Talukder MA,Varadharaj S,Velayutham M,Zweier JL

    更新日期：2013-01-01 00:00:00

  • Selective increase in endothelin-1 and endothelin A receptor subtype in the hypertrophied myocardium of the aorto-venacaval fistula rat.

    abstract：OBJECTIVE:At present little is known about the factors that regulate the expression of the endothelins and their receptors in cardiac tissue in vivo. The aim of this study was to investigate changes in expression of the endothelins (ET-1, ET-2, and ET-3) and their receptors (ETAR and ETBR) in the hypertrophied heart of...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：

    authors： Brown LA,Nunez DJ,Brookes CI,Wilkins MR

    更新日期：1995-06-01 00:00:00

  • Do statins have an antiarrhythmic activity?

    abstract：:Sudden cardiac death, which is mainly associated with the presence of life-threatening ventricular arrhythmias, is a common 'killer' among patients with coronary artery disease. Moreover, atrial fibrillation is the most common arrhythmia encountered in the clinical practice. The beneficial effect of statins on cardiov...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1016/j.cardiores.2007.02.029

    authors： Kostapanos MS,Liberopoulos EN,Goudevenos JA,Mikhailidis DP,Elisaf MS

    更新日期：2007-07-01 00:00:00

  • Frontiers in positron emission tomography imaging of the vulnerable atherosclerotic plaque.

    abstract：:Rupture of vulnerable atherosclerotic plaques leading to an atherothrombotic event is the primary driver of myocardial infarction and stroke. The ability to detect non-invasively the presence and evolution of vulnerable plaques could have a huge impact on the future identification and management of atherosclerotic car...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1093/cvr/cvz162

    authors： MacAskill MG,Newby DE,Tavares AAS

    更新日期：2019-12-01 00:00:00

  • Intra-uterine growth retardation results in increased cardiac arrhythmias and raised diastolic blood pressure in adult rats.

    abstract：OBJECTIVES:Epidemiological evidence in humans suggests that intrauterine growth retardation is associated with an increased risk of hypertension and coronary heart disease in later life. To begin to understand the mechanisms involved, we developed and exploited a rat model of intrauterine growth retardation to assess p...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(00)00167-x

    authors： Hu XW,Levy A,Hart EJ,Nolan LA,Dalton GR,Levi AJ

    更新日期：2000-11-01 00:00:00

  • Cardiomyopathies in disorders of oxidative metabolism.

    abstract：:Primary cardiomyopathy is an important cause of mortality in children and adults. Apart from inherited disorders of myocardial contractile and structural proteins, several defects of energy metabolism may cause cardiomyopathy. Most of the energy required for myocardial contraction is derived from aerobic metabolism. F...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1016/s0008-6363(97)00141-7

    authors： Antozzi C,Zeviani M

    更新日期：1997-08-01 00:00:00