Organotypic slice culture from human adult ventricular myocardium.

abstract：OBJECTIVES:To assess the functional effects of multipotent adult progenitor cells (MAPCs) transplanted in a rat model of chronic myocardial infarction. METHODS:Forty-four rats underwent coronary ligation and, 14 days later, were randomly allocated to receive in-scar injections (5 x 10(6) cells/150 microL) of green flu...

journal_title：Cardiovascular research

authors： Agbulut O,Mazo M,Bressolle C,Gutierrez M,Azarnoush K,Sabbah L,Niederlander N,Abizanda G,Andreu EJ,Pelacho B,Gavira JJ,Perez-Ilzarbe M,Peyrard S,Bruneval P,Samuel JL,Soriano-Navarro M,García-Verdugo JM,Hagège AA,Próspe

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:Insulin protects cardiomyocytes from apoptosis. Insulin resistance usually refers to a defect in the ability of insulin to stimulate glucose uptake. It is unknown, however, whether or not insulin resistance compromises the cell-protective effect of the hormone. Caspases are a family of cysteine proteases that...

journal_title：Cardiovascular research

authors： Morisco C,Marrone C,Trimarco V,Crispo S,Monti MG,Sadoshima J,Trimarco B

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:The primary aim of this study was to investigate whether activation of Na influx via voltage-gated Na channels can elevate sub-sarcolemmal ('fuzzy-space') [Na] and transiently activate Na/K pump current (I(p)). METHODS AND RESULTS:Initially, Na/K pump activity was characterised in whole-cell voltage-clamped ...

journal_title：Cardiovascular research

authors： Silverman Bd,Warley A,Miller JI,James AF,Shattock MJ

更新日期：2003-03-15 00:00:00

abstract：OBJECTIVE:Anisotropic conduction characteristics, which may be expressed as the ratio of conduction velocities in the longitudinal (Vlong) and transverse (Vtrans) fibre directions, have been shown to stabilise reentry and favour the induction of sustained, uniform ventricular tachycardia. The aim of this study was to i...

journal_title：Cardiovascular research

authors： Hélie F,Cossette J,Vermeulen M,Cardinal R

更新日期：1995-03-01 00:00:00

abstract：:In this study we report about the modulation of connexin45 (Cx45) gap junction channel properties by phosphorylation of the connexin molecules through different protein kinases. Phosphorylation of Cx45 was studied in HeLa cells transfected with mouse Cx45 (mCx45). Using Western blotting (WB) and immunocytochemistry, t...

journal_title：Cardiovascular research

authors： van Veen TA,van Rijen HV,Jongsma HJ

更新日期：2000-06-01 00:00:00

abstract：:Since the establishment of the inflammatory basis of atherosclerosis, several pro- or anti-inflammatory agents have been examined as potential mediators of the biochemical pathways of lesion formation. Interleukin (IL)-8 was first characterized in 1987. Since then, knowledge regarding its role in leucocyte trafficking...

journal_title：Cardiovascular research

authors： Apostolakis S,Vogiatzi K,Amanatidou V,Spandidos DA

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:Activin-like kinase receptor 1 (ALK1) is a transforming growth factor (TGF)-beta type I receptor expressed in vascular mesenchyme, yet its function in vascular mesenchymal cells (VMC) is unclear. We examined ALK1 expression in human coronary atherosclerotic lesions and bovine and human VMC undergoing cellular...

journal_title：Cardiovascular research

authors： Yao Y,Zebboudj AF,Torres A,Shao E,Boström K

更新日期：2007-05-01 00:00:00

abstract：:The cellular and molecular physiology and pathology of insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM) are mostly studied and understood through the use of animal models. Fundamental differences between the IDDM and NIDDM animal models may help to explain the etiology beh...

journal_title：Cardiovascular research

authors： Militante JD,Lombardini JB,Schaffer SW

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVES:Responses to EDHF are usually characterised in the presence of nitric oxide synthase (NOS) and cyclooxygenase (COX) inhibitors. The contribution of NO to endothelium-dependent relaxation in the presence of NOS inhibitors was assessed using NO scavengers with the objective of testing (i) whether any residual ...

journal_title：Cardiovascular research

authors： Chauhan S,Rahman A,Nilsson H,Clapp L,MacAllister R,Ahluwalia A

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:Increased pulse pressure has been observed in aging subjects, but the impact on the structure and reactivity of small arteries has been scarcely evaluated. METHODS:This study presents the modifications of vascular structure and function observed in female rats of 5, 18 and 32 months of age, and their relatio...

journal_title：Cardiovascular research

authors： Moreau P,d'Uscio LV,Lüscher TF

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:Cardiac parasympathetic nerve activity is reduced in most cardiovascular disease states, and this may contribute to enhanced cardiac sympathetic responsiveness. Disruption of inhibitory G-proteins (Gi) ablates the cholinergic pathway and increases cardiac endothelial nitric oxide (NO) synthase (eNOS) expressi...

journal_title：Cardiovascular research

authors： Danson EJ,Zhang YH,Sears CE,Edwards AR,Casadei B,Paterson DJ

更新日期：2005-09-01 00:00:00

abstract：:Cardiomyocytes express a surprisingly large number of potassium channel types. The primary physiological functions of the currents conducted by these channels are to maintain the resting membrane potential and mediate action potential repolarization under basal conditions and in response to changes in the concentratio...

journal_title：Cardiovascular research

authors： Crotti L,Odening KE,Sanguinetti MC

更新日期：2020-07-15 00:00:00

abstract：AIMS:SR-B1 is a cholesterol transporter that exerts anti-atherogenic properties in liver and peripheral tissues in mice. Bone marrow (BM) transfer studies suggested an atheroprotective role in cells of haematopoietic origin. Here, we addressed the specific contribution of SR-B1 in the monocyte/macrophage. METHODS AND ...

journal_title：Cardiovascular research

authors： Galle-Treger L,Moreau M,Ballaire R,Poupel L,Huby T,Sasso E,Troise F,Poti F,Lesnik P,Le Goff W,Gautier EL,Huby T

更新日期：2020-03-01 00:00:00

abstract：AIMS:Increased proinflammatory cytokines after myocardial infarction augment the progression of heart failure (HF) and are of prognostic significance. Recently, we demonstrated that increased proinflammatory cytokines in the brains of HF rats increased paraventricular nucleus (PVN) superoxide and down-regulated neurona...

journal_title：Cardiovascular research

authors： Kang YM,He RL,Yang LM,Qin DN,Guggilam A,Elks C,Yan N,Guo Z,Francis J

更新日期：2009-09-01 00:00:00

abstract：:The effects of hypoxia and subsequent reoxygenation were examined in isolated left ventricular papillary muscles from the rat at 28 degrees C and 33 degrees C. Studies of relaxation were carried out in isometric and physiologically sequenced contractions. In studies of isometric contractions, the following variables w...

journal_title：Cardiovascular research

authors： Nakamura Y,Wiegner AW,Bing OH

更新日期：1986-09-01 00:00:00

abstract：:The failing heart is characterized by alterations in energy metabolism, including mitochondrial dysfunction and a reduction in fatty acid (FA) oxidation rate, which is partially compensated by an increase in glucose utilization. Together, these changes lead to an impaired capacity to convert chemical energy into mecha...

journal_title：Cardiovascular research

authors： van Bilsen M,van Nieuwenhoven FA,van der Vusse GJ

更新日期：2009-02-15 00:00:00

abstract：:The effect of axial rotation on flow through and pressure gradient across saphenous vein segments was studied using 15 cadaver long saphenous veins. A significant reduction in flow occurred at a mean rotation of 25 degrees/cm and a significant increase in head loss across the segments occurred at a mean rotation of 23...

journal_title：Cardiovascular research

authors： Gordon A,Williams J,Buxton B

更新日期：1975-07-01 00:00:00

abstract：AIMS:It is well established that leukotrienes (LTs), products of the 5-lipoxygenase (5-LO) pathway, participate in inflammatory tissue reactions and immune responses. In the present study, the impact of the 5-LO pathway on vasculogenesis of mouse embryonic stem (ES) cells was investigated. METHODS AND RESULTS:Immunohi...

journal_title：Cardiovascular research

authors： Finkensieper A,Kieser S,Bekhite MM,Richter M,Mueller JP,Graebner R,Figulla HR,Sauer H,Wartenberg M

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:Exposure to anoxia has been reported to activate ATP-sensitive potassium (K+(ATP)) channels in isolated ventricular myocytes. We aimed to investigate the mechanisms underlying the anoxia-induced activation of K+(ATP) channels. METHODS:Guinea pig ventricular myocytes were isolated using collagenase digestion....

journal_title：Cardiovascular research

authors： Shigematsu S,Arita M

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:Intercellular adhesion molecule (ICAM)-1 is an immunoglobulin-like cell adhesion molecule expressed by several cell types, including proliferating vascular smooth muscle cells (VSMC). Cross-linking ICAM-1 on the surface of different cell types has previously been shown to cause an increase in cellular activat...

journal_title：Cardiovascular research

authors： Lawson C,Ainsworth ME,McCormack AM,Yacoub M,Rose ML

更新日期：2001-06-01 00:00:00

abstract：:Cholesterol is an essential component of both the peripheral nervous system and central nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes and oligodendrocytes and is almost completely isolated from other pools of cholesterol in the body, but a small fraction can be taken up from t...

journal_title：Cardiovascular research

authors： Vitali C,Wellington CL,Calabresi L

更新日期：2014-08-01 00:00:00

abstract：STUDY OBJECTIVE:The objectives were (a) to describe the effects of vasoactive drugs in normal rats upon cardiovascular function assessed by computing aortic haemodynamic power and input impedance, each separated into their component parts, and (b) to study the relationship between left ventricular pulsatile power outpu...

journal_title：Cardiovascular research

authors： Wright G

更新日期：1991-11-01 00:00:00

abstract：:Estimation of infarct size from enzyme activities in plasma or serum presupposes known values of circulatory parameters such as the extravascular distribution volume Ve and the permeability constant P for the transport of enzyme between intravascular volume Vi and Ve. In man, parameter values are used that are extrapo...

journal_title：Cardiovascular research

authors： Willems GM,Muijtjens AM,Lambi FH,Hermens WT

更新日期：1979-10-01 00:00:00

abstract：Aims:Endothelial hyperpermeability exacerbates multiple organ damage during inflammation or infection. The endothelial glycocalyx, a protective matrix covering the luminal surface of endothelial cells (ECs), undergoes enzymatic shedding during inflammation, contributing to barrier hyperpermeability. A disintegrin and m...

journal_title：Cardiovascular research

authors： Yang X,Meegan JE,Jannaway M,Coleman DC,Yuan SY

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:We have previously demonstrated that nuclear factor kappa B (NFkappaB) activation is needed for the development of cardiac hypertrophy in vivo. NFkappaB is a downstream transcription factor in the Toll-like receptor (TLR)-mediated signaling pathway; therefore, we investigated a role of TLR4 in cardiac hypertr...

journal_title：Cardiovascular research

authors： Ha T,Li Y,Hua F,Ma J,Gao X,Kelley J,Zhao A,Haddad GE,Williams DL,William Browder I,Kao RL,Li C

更新日期：2005-11-01 00:00:00

abstract：AIMS:Antihypertensive drugs are included in the medical therapy of vascular Ehlers-Danlos syndrome (vEDS). The β-blocker celiprolol has been suggested to prevent arterial damage in vEDS, but the underlying mechanism remains unclear. It is also unknown whether the widely used angiotensin II receptor type 1 antagonist lo...

journal_title：Cardiovascular research

authors： Dubacher N,Münger J,Gorosabel MC,Crabb J,Ksiazek AA,Caspar SM,Bakker ENTP,van Bavel E,Ziegler U,Carrel T,Steinmann B,Zeisberger S,Meienberg J,Matyas G

更新日期：2020-02-01 00:00:00

abstract：:Atrial fibrillation is the most common cardiac arrhythmia with an overall prevalence of almost 1%. Increasing prevalence and associated risks such as stroke and mortality have increased the need for better and more reliable therapeutic treatment. This has stimulated research to elucidate the pathophysiological mechani...

journal_title：Cardiovascular research

authors： Thijssen VL,Ausma J,Borgers M

更新日期：2001-10-01 00:00:00

abstract：AIMS:Hypercholesterolaemia and myeloperoxidase (MPO) overexpression are two well-recognized risk factors for ischaemic heart disease. Peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists have recently been shown to reduce ischaemic heart injury in hypercholesterolaemic animals. However, whether PPARgam...

journal_title：Cardiovascular research

authors： Liu HR,Tao L,Gao E,Qu Y,Lau WB,Lopez BL,Christopher TA,Koch W,Yue TL,Ma XL

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:The aim was to assess the significance of polymorphonuclear leucocytes on the myocardial capillary permeability to a small hydrophilic indicator, on the vascular tone of the resistance vessels, and on contractile function following ischaemia and reperfusion. METHODS:Open chest, anaesthetised dogs were random...

journal_title：Cardiovascular research

authors： Svendsen JH,Hansen PR,Ali S,Baandrup U,Haunsø S

更新日期：1993-07-01 00:00:00

abstract：:The significance of pre-existing coronary collaterals for preservation of the myocardium during coronary occlusion and reperfusion was studied in anaesthetised open-chest dogs. The extent of myocardial ischaemic damage was assessed by the accumulation of calcium in the central zone of the ischaemic area and the size o...

journal_title：Cardiovascular research

authors： Tanabe M,Fujiwara S,Ohta N,Shimamoto N,Hirata M

更新日期：1980-05-01 00:00:00