当前位置： SCI文献检索 > CARDIOVASCULAR RESEARCH期刊下所有文献 > Induced NCX1 overexpression attenuates pressure overload-induced pathological cardiac remodelling.

Induced NCX1 overexpression attenuates pressure overload-induced pathological cardiac remodelling.

Abstract：

AIMS:Although increased Na(+)/Ca(2+) exchanger 1 (NCX1) expression is observed during heart failure (HF), the pathological role of NCX1 during the progression of HF remains unclear. We examined alterations of NCX1 expression and activity in hearts after transverse aortic constriction (TAC) surgery and explored whether NCX1 influences pressure overload-induced pathological cardiac remodelling. METHODS AND RESULTS:We generated novel transgenic mice in which NCX1 expression is controlled by a cardiac-specific, doxycycline (DOX)-dependent promoter. In the absence of DOX, TAC surgery caused substantial chamber dilation with a gradual decrease in contractility by 16 weeks. Cardiomyocytes showed a decline in contractility with abnormal Ca(2+) handling during excitation-contraction (E-C) coupling. Reduced NCX1 activity was observed 8 weeks after TAC and was still apparent at 17 weeks. Induced NCX1 overexpression by DOX treatment starting 8 weeks after TAC returned NCX1 activity to pre-TAC levels and prevented chamber dilation with cardiac dysfunction. DOX treatment not only upregulated NCX1 expression in TAC-operated hearts but also returned L-type Ca(2+) channel and sarcoplasmic reticulum (SR) Ca(2+) ATPase expression levels to those in sham-operated hearts. In DOX-treated myocytes, contractility, T-tubule integrity, synchrony of Ca(2+) release from the SR, and Ca(2+) handling during E-C coupling was preserved 16 weeks after TAC surgery. In addition, DOX treatment attenuated the down-regulation of survival signalling and up-regulation of apoptosis signalling 16 weeks after TAC surgery. CONCLUSION:Induced overexpression of NCX1 attenuated pressure overload-induced pathological cardiac remodelling. Thus, maintaining NCX1 activity may be a potential therapeutic strategy for preventing the progression of HF.

journal_name

Cardiovasc Res

journal_title

Cardiovascular research

authors

Ujihara Y,Iwasaki K,Takatsu S,Hashimoto K,Naruse K,Mohri S,Katanosaka Y

doi

10.1093/cvr/cvw113

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

348-61

issue

4

eissn

0008-6363

issn

1755-3245

pii

cvw113

journal_volume

111

pub_type

杂志文章

相关文献

CARDIOVASCULAR RESEARCH文献大全
  • Contribution of CXCR4(+)/PDGFRbeta(+) progenitor cells in hypoxic alveolar arterioles muscularization: role of myocardin.

    abstract：AIMS:Bone marrow (BM) progenitor cells may contribute to vascular remodelling. The present study aimed to investigate the contribution of BM-derived CXCR4(+) (a CXC chemokine receptor) and PDGFRbeta(+) (platelet-derived growth factor receptor beta) progenitor cells in hypoxia-induced muscularization of alveolar arterio...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvq147

    authors： Jie W,Wang X,Huang L,Guo J,Kuang D,Zhu P,Li M,Zhao X,Duan Y,Wang G,Ao Q

    更新日期：2010-09-01 00:00:00

  • Monocyte-endothelial cell interaction induces expression of adhesion molecules on human umbilical cord endothelial cells.

    abstract：OBJECTIVE:The adhesive interaction of monocytes and endothelial cells has been implicated as a regulatory signal in the cell activation that is involved in the pathogenesis of atherosclerosis. We investigated the effect of monocyte-endothelial cell interaction on the expression of adhesion molecules, intercellular adhe...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/0008-6363(96)00085-5

    authors： Takahashi M,Ikeda U,Masuyama J,Kitagawa S,Kasahara T,Shimpo M,Kano S,Shimada K

    更新日期：1996-08-01 00:00:00

  • HIV infection, highly active antiretroviral therapy and the cardiovascular system.

    abstract：:Cardiovascular complications in the course of human immunodeficiency virus (HIV) infection are multifactorial and may be caused by the virus itself or by the related opportunistic infections and neoplasms. Highly active antiretroviral therapy (HAART) has prolonged many patients' lives, but many cardiac sequelae of HIV...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1016/s0008-6363(02)00828-3

    authors： Barbaro G

    更新日期：2003-10-15 00:00:00

  • Peripheral blood flow and noradrenaline responsiveness: the effect of physiological hyperinsulinemia.

    abstract：OBJECTIVE:Insulin seems to have vasodilator properties, but it is unclear if insulin in postprandial concentrations is a specific vasodilator of skeletal muscle resistance arterioles only or that various types of vessels are affected. The aim of the present study was to determine the direct effects and the time course ...

    journal_title：Cardiovascular research

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0008-6363(97)00035-7

    authors： de Haan CH,van Dielen FM,Houben AJ,de Leeuw PW,Huvers FC,De Mey JG,Wolffenbuttel BH,Schaper NC

    更新日期：1997-04-01 00:00:00

  • Combined therapy with PPARalpha agonist and L-carnitine rescues lipotoxic cardiomyopathy due to systemic carnitine deficiency.

    abstract：OBJECTIVE:Peroxisome proliferator-activated receptors (PPAR) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily and are key regulators of fatty acid oxidation (FAO) in the heart. Systemic carnitine deficiency (SCD) causes disorders of FAO and induces hypertrophic cardiomy...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/j.cardiores.2006.02.005

    authors： Asai T,Okumura K,Takahashi R,Matsui H,Numaguchi Y,Murakami H,Murakami R,Murohara T

    更新日期：2006-06-01 00:00:00

  • The importance of thrombus organization and stellate cell phenotype in collagen I gene expression in human, coronary atherosclerotic and restenotic lesions.

    abstract：OBJECTIVES:Collagen synthesis is one of the major mechanisms of primary atherosclerotic plaque growth and is likely to be similarly important in restenosis. The patterns of collagen gene expression in human restenosis and associations with thrombosis/hemorrhage have not been described. METHODS:Using human coronary art...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：

    authors： Rekhter MD,O'Brien E,Shah N,Schwartz SM,Simpson JB,Gordon D

    更新日期：1996-09-01 00:00:00

  • Differential role of platelet granular mediators in angiogenesis.

    abstract：OBJECTIVES:Platelets contain numerous substances regulating angiogenic response. However, the regulatory role of platelets in blood vessel development remains to be elucidated. We investigated the comprehensive effect of platelets as a cellular system on angiogenesis. METHODS:The following approaches were applied: (a)...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/j.cardiores.2004.04.012

    authors： Brill A,Elinav H,Varon D

    更新日期：2004-08-01 00:00:00

  • Age-dependent cardiomyopathy and heart failure phenotype in mice overexpressing beta(2)-adrenergic receptors in the heart.

    abstract：OBJECTIVE:To explore long-term cardiac phenotype in transgenic (TG) mice with 300-fold overexpression of beta(2)-adrenergic receptors (AR). METHODS:Echocardiography was performed serially on a cohort of wild-type and TG mice (n=26 each) between 4 and 15 months of age. Survival was monitored and autopsy and histologica...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(00)00187-5

    authors： Du XJ,Gao XM,Wang B,Jennings GL,Woodcock EA,Dart AM

    更新日期：2000-12-01 00:00:00

  • Nitric oxide synthase plays a role in Chlamydia pneumoniae-induced atherosclerosis.

    abstract：OBJECTIVE:Chlamydia pneumoniae infection has been associated with atherosclerosis, although the mechanisms by which C. pneumoniae contribute to atherogenesis remain unclear. Altered production of nitric oxide, a known bactericidal and anti-inflammatory agent, represents one possible mechanistic link. To examine this is...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(03)00389-4

    authors： Chesebro BB,Blessing E,Kuo CC,Rosenfeld ME,Puolakkainen M,Campbell LA

    更新日期：2003-10-15 00:00:00

  • Differential effects of red and white wines on inhibition of the platelet-derived growth factor receptor: impact of the mash fermentation.

    abstract：AIMS:Moderate wine consumption is associated with a significant reduction of cardiovascular mortality. The molecular basis of this phenomenon remains unknown. Platelet-derived growth factor (PDGF) is an important contributor to atherogenesis. We investigated the effects of selected red and white wines on PDGF receptor ...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvn340

    authors： Sparwel J,Vantler M,Caglayan E,Kappert K,Fries JW,Dietrich H,Böhm M,Erdmann E,Rosenkranz S

    更新日期：2009-03-01 00:00:00

  • Ventricular expression of brain natriuretic peptide gene following orthotopic cardiac transplantation in children--a three year follow up.

    abstract：OBJECTIVE:The aim was to examine ventricular brain natriuretic peptide (B-type natriuretic peptide, BNP) gene expression and to determine its relationship with ventricular BNP and circulating BNP levels in paediatric cardiac transplant recipients, over a three year period after transplantation. METHODS:Total RNA extra...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/27.12.2135

    authors： Ationu A,Sorensen K,Whitehead B,Singer D,Burch M,Carter ND

    更新日期：1993-12-01 00:00:00

  • MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1.

    abstract：AIMS:Free fatty acids induce apoptosis in cardiomyocytes, which is implicated in lipotoxic cardiomyopathy. However, the underlying mechanisms remain not fully understood. MicroRNAs (miRNAs) are non-coding small RNAs that control gene expression at the post-transcriptional level. Dysregulated miRNAs have been shown to b...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvr145

    authors： Zhu H,Yang Y,Wang Y,Li J,Schiller PW,Peng T

    更新日期：2011-10-01 00:00:00

  • Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failure.

    abstract：OBJECTIVE:Experimental evidence suggests that modulation of myocardial substrate metabolism can markedly affect the progression of chronic heart failure (HF). We tested whether the inhibition of carnitine palmitoyl transferase-I (CPT-I), the enzyme regulating mitochondrial fatty acid oxidation, slows left ventricular r...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/j.cardiores.2005.02.004

    authors： Lionetti V,Linke A,Chandler MP,Young ME,Penn MS,Gupte S,d'Agostino C,Hintze TH,Stanley WC,Recchia FA

    更新日期：2005-06-01 00:00:00

  • Evidence for P(2)-purinoceptors contribution in H(2)O(2)-induced contraction of rat aorta in the absence of endothelium.

    abstract：OBJECTIVE:H(2)O(2) can contract many arteries, however the underlying mechanisms are not fully understood. This study aims to test whether H(2)O(2)-induced vasoconstriction could be functionally attributed to the activation of P(2)-purinoceptors in rat aorta and to explore its possible signaling mechanisms. METHODS:Is...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(00)00123-1

    authors： Shen JZ,Zheng XF,Kwan CY

    更新日期：2000-08-18 00:00:00

  • GSK-3β at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways.

    abstract：AIMS:Ischaemic preconditioning (IPC) protects the heart against prolonged lethal ischaemia through a signalling cascade involving Akt, glycogen synthase kinase-3β (GSK-3β), and mitochondrial ATP-sensitive potassium channels (mitoK(ATP)). We previously demonstrated the involvement of the Wnt pathway in IPC in vivo via G...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvr002

    authors： Vigneron F,Dos Santos P,Lemoine S,Bonnet M,Tariosse L,Couffinhal T,Duplaà C,Jaspard-Vinassa B

    更新日期：2011-04-01 00:00:00

  • Does altered glucocorticoid homeostasis increase cardiovascular risk?

    abstract：:The hypothalamic-pituitary-adrenal (HPA) axis, like the sympathetic nervous system and the renin-angiotensin-aldosterone (RAA) system, sustains life in stressful situations by increasing vascular tone and ensuring fuel availability. It also modulates inflammation and tissue repair processes. Untoward cardiovascular ef...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1016/j.cardiores.2004.07.006

    authors： Girod JP,Brotman DJ

    更新日期：2004-11-01 00:00:00

  • Soluble Notch ligand and receptor peptides act antagonistically during angiogenesis.

    abstract：AIMS:Notch signalling is essential for blood vessel formation. During angiogenesis, the Notch ligand DLL4 on the leading tip cell activates Notch receptors on the adjacent stalk cells. DLL4-Notch signalling is impaired by the Notch ligand JAG1 in endothelial cells. The Delta/Serrate/Lag2 (DSL) domain of the Notch ligan...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvv151

    authors： Klose R,Berger C,Moll I,Adam MG,Schwarz F,Mohr K,Augustin HG,Fischer A

    更新日期：2015-07-01 00:00:00

  • Effect of adenosine therapy at reperfusion on myocardial infarct size in dogs.

    abstract：OBJECTIVES:The concept of lethal reperfusion injury in ischemic myocardium has been the subject of controversy. Adenosine administered during reperfusion has been reported to limit lethal reperfusion injury in several studies. On the contrary, it has been reported that cardioprotection may not be achieved with adenosin...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/0008-6363(95)00235-9

    authors： Vander Heide RS,Reimer KA

    更新日期：1996-05-01 00:00:00

  • Aerobic interval training attenuates remodelling and mitochondrial dysfunction in the post-infarction failing rat heart.

    abstract：AIMS:Following a large myocardial infarction (MI), remaining viable muscle often undergoes pathological remodelling and progresses towards chronic heart failure. Mitochondria may also be affected by this process and, due to their functional importance, likely contribute to the progression of the disease. Aerobic interv...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvt080

    authors： Kraljevic J,Marinovic J,Pravdic D,Zubin P,Dujic Z,Wisloff U,Ljubkovic M

    更新日期：2013-07-01 00:00:00

  • NADPH oxidase-4 promotes eccentric cardiac hypertrophy in response to volume overload.

    abstract：AIMS:Chronic pressure or volume overload induce concentric vs. eccentric left ventricular (LV) remodelling, respectively. Previous studies suggest that distinct signalling pathways are involved in these responses. NADPH oxidase-4 (Nox4) is a reactive oxygen species-generating enzyme that can limit detrimental cardiac r...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvz331

    authors： Schnelle M,Sawyer I,Anilkumar N,Mohamed BA,Richards DA,Toischer K,Zhang M,Catibog N,Sawyer G,Mongue-Din H,Schröder K,Hasenfuss G,Shah AM

    更新日期：2021-01-01 00:00:00

  • Effects of sotalol on arrhythmias and electrophysiology during myocardial ischaemia and reperfusion.

    abstract：:Isolated, buffer perfused guinea pig hearts were used to study the effects of sotalol on arrhythmias and electrophysiology during 30 min of myocardial ischaemia, induced by reducing coronary flow to 10% of control, and subsequent reperfusion. Action potentials were recorded using the floating microelectrode technique ...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/18.7.397

    authors： Culling W,Penny WJ,Sheridan DJ

    更新日期：1984-07-01 00:00:00

  • ATPo but not cAMPi activates a chloride conductance in mouse ventricular myocytes.

    abstract：OBJECTIVE:The aim was to test for the presence of cAMPi activated and ATPo activated chloride conductances (ICl(cAMP) and ICl(ATP)) in mouse ventricular myocytes. METHODS:Membrane currents were measured in enzymatically dissociated ventricular myocytes using the whole cell configuration of the patch clamp technique. ...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：

    authors： Levesque PC,Hume JR

    更新日期：1995-03-01 00:00:00

  • Role of CuZn superoxide dismutase on carotid body function in heart failure rabbits.

    abstract：AIMS:Peripheral chemoreflex sensitivity is potentiated in both clinical and experimental chronic heart failure (CHF). NADPH oxidase-derived superoxide mediates angiotensin II (Ang II)-enhanced carotid body (CB) chemoreceptor sensitivity in CHF rabbits, and tempol, the superoxide dismutase (SOD) mimetic, inhibits this A...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvn350

    authors： Ding Y,Li YL,Zimmerman MC,Davisson RL,Schultz HD

    更新日期：2009-03-01 00:00:00

  • Delayed preconditioning in cardiac myocytes with respect to development of a proinflammatory phenotype: role of SOD and NOS.

    abstract：OBJECTIVE:Both superoxide dismutase (SOD) and nitric oxide synthase (NOS) have been implicated in delayed preconditioning (DP) to ischemia/reperfusion (I/R) in the heart. We used isolated cardiac myocytes to test the hypothesis that SOD and NOS may interact in the development of DP. METHODS:Mouse neonatal cardiac myoc...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(03)00502-9

    authors： Rui T,Cepinskas G,Feng Q,Kvietys PR

    更新日期：2003-10-01 00:00:00

  • Prevention of ischemic rigor contracture during coronary occlusion by inhibition of Na(+)-H+ exchange.

    abstract：OBJECTIVE:To determine the effect of Na(+)-H+ exchange blockade on ischemic rigor contracture and reperfusion-induced hypercontracture. METHODS:Thirty-six pigs were submitted to 55 min of coronary occlusion and 5 h reperfusion. Myocardial segment length analysis with ultrasonic microcrystals was used to detect ischemi...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(97)00106-5

    authors： Garcia-Dorado D,González MA,Barrabés JA,Ruiz-Meana M,Solares J,Lidon RM,Blanco J,Puigfel Y,Piper HM,Soler-Soler J

    更新日期：1997-07-01 00:00:00

  • Influence of training on myocardial responses of rats subjected to conditions of ischaemia and hypoxia.

    abstract：:Physical training has been advocated to minimize the problems associated with coronary heart disease; however, the responsible mechanisms are obscure. Rats trained to run on a treadmill were subjected to acute conditions of hypoxia and myocardial ischaemia. Trained rats were better able to maintain a higher level of c...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/10.3.359

    authors： Carey RA,Tipton CM,Lund DR

    更新日期：1976-05-01 00:00:00

  • Myocardial temperature reduction attenuates necrosis after prolonged ischemia in rabbits.

    abstract：OBJECTIVE:Previously we observed that a large reduction in infarct size was attained by cooling the risk region of the heart, either before or early after the onset of a 30-min coronary artery occlusion. While this is a standard duration of ischemia used in the rabbit model of infarction, it may not reflect the situati...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(98)00191-6

    authors： Hale SL,Kloner RA

    更新日期：1998-12-01 00:00:00

  • Sympathomimetic amines and cardiac arrhythmias.

    abstract：STUDY OBJECTIVE:The aim was to investigate the arrhythmogenic properties of several sympathomimetic amines and their antagonism by adrenergic blocking drugs. DESIGN:Arrhythmia was induced by the investigated drugs, injected intravenously: adrenaline (ADR); noradrenaline (NA); phenylephrine (PE); isoprenaline (IP); ter...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/24.9.754

    authors： Oppenheimer E,Akavia E,Shavit S,Korczyn AD

    更新日期：1990-09-01 00:00:00

  • Modulation of conductive elements by Pitx2 and their impact on atrial arrhythmogenesis.

    abstract：:The development of the heart is a complex process during which different cell types progressively contribute to shape a four-chambered pumping organ. Over the last decades, our understanding of the specification and transcriptional regulation of cardiac development has been greatly augmented as has our understanding o...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1093/cvr/cvr078

    authors： Franco D,Chinchilla A,Daimi H,Dominguez JN,Aránega A

    更新日期：2011-07-15 00:00:00

  • Early exercise training after myocardial infarction prevents contractile but not electrical remodelling or hypertrophy.

    abstract：AIMS:Exercise started early after myocardial infarction (MI) improves in vivo cardiac function and myofilament responsiveness to Ca(2+). We investigated whether this represents partial or complete reversal of cellular remodelling. METHODS AND RESULTS:Mice with MI following left coronary ligation were given free access...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvp381

    authors： Bito V,de Waard MC,Biesmans L,Lenaerts I,Ozdemir S,van Deel E,Abdel-Mottaleb Y,Driesen R,Holemans P,Duncker DJ,Sipido KR

    更新日期：2010-04-01 00:00:00