Cardiac angiotensin converting enzyme overproduction indicates interstitial activation in renovascular hypertension.

abstract：Aims:To investigate the role of chromobox protein homolog 3 (Cbx3) in vascular smooth muscle cell (VSMC) proliferation, migration, and neointima formation following vascular injury. Methods and results:Overexpression of Cbx3 led to a significant increase in VSMC contractile gene expression and VSMC apoptosis as well a...

journal_title：Cardiovascular research

authors： Zhang C,Chen D,Maguire EM,He S,Chen J,An W,Yang M,Afzal TA,Luong LA,Zhang L,Lei H,Wu Q,Xiao Q

更新日期：2018-03-01 00:00:00

abstract：AIMS:Hypercholesterolaemia and myeloperoxidase (MPO) overexpression are two well-recognized risk factors for ischaemic heart disease. Peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists have recently been shown to reduce ischaemic heart injury in hypercholesterolaemic animals. However, whether PPARgam...

journal_title：Cardiovascular research

authors： Liu HR,Tao L,Gao E,Qu Y,Lau WB,Lopez BL,Christopher TA,Koch W,Yue TL,Ma XL

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVES:Nitric oxide (NO) has complex effects on myocardial function particularly following ischaemia-reperfusion. The goal of this study was to examine the result of repetitive myocardial stunning on myocardial NO release and expression of inducible (iNOS) and constitutive (eNOS) NO synthases. METHODS AND RESULTS:...

journal_title：Cardiovascular research

authors： Baker CS,Rimoldi O,Camici PG,Barnes E,Chacon MR,Huehns TY,Haskard DO,Polak JM,Hall RJ

更新日期：1999-08-15 00:00:00

abstract：OBJECTIVES:Conduction of vasoconstrictor and vasodilator responses in the microcirculation involves electrical coupling through gap junction channels among cells of the vascular wall. The present study determined whether reported differences in the properties of conduction along the arterioles of the epithelial hamster...

journal_title：Cardiovascular research

authors： Sandow SL,Looft-Wilson R,Doran B,Grayson TH,Segal SS,Hill CE

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:The aims of the study were (1) to elucidate the effects of raised oxygen tension on the response of the ductus arteriosus to a range of vasodilators; and (2) to establish the effect, if any, of cyclo-oxygenase inhibition on the interaction between oxygen and prostaglandin (PG)E2. METHODS:Rings of ductus arte...

journal_title：Cardiovascular research

authors： Smith GC,McGrath JC

更新日期：1993-12-01 00:00:00

abstract：:The influence of experimental diabetes on the endothelium mediated relaxation and contractile responses of canine isolated coronary arteries was studied in arteries removed from alloxan treated diabetic (280 mmol.kg-1) and control mongrel dogs. Strips with and without endothelium were suspended in Krebs bicarbonate so...

journal_title：Cardiovascular research

authors： Gebremedhin D,Koltai MZ,Pogátsa G,Magyar K,Hadházy P

更新日期：1988-08-01 00:00:00

abstract：OBJECTIVE:The aim of this work was to compare the effects of supplementation of rat chow diet with potassium (K+) and whey mineral concentrate (Whey), a diet rich in milk minerals, on blood pressure and arterial responses in vitro in spontaneously hypertensive rats (SHR). METHODS:Thirty young SHR and twenty Wistar-Kyo...

journal_title：Cardiovascular research

authors： Wu X,Tolvanen JP,Hutri-Kähönen N,Kähönen M,Mäkynen H,Korpela R,Ruskoaho H,Karjala K,Pörsti I

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:Pigment epithelial-derived factor (PEDF) is a potent anti-angiogenic factor whose effects are partially mediated through the induction of endothelial cell apoptosis. The pathway mediating endothelial cell apoptosis has not been fully established. Here we investigated the participation of peroxisome proliferat...

journal_title：Cardiovascular research

authors： Ho TC,Chen SL,Yang YC,Liao CL,Cheng HC,Tsao YP

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:Migration and proliferation of arterial smooth muscle cells are critical responses during restenosis after balloon angioplasty. We investigated the changes in the expression of Ca(2+) channels and dystrophin, two determinants of contraction, after balloon injury of rat aortas. METHODS:Proliferation and migra...

journal_title：Cardiovascular research

authors： Quignard JF,Harricane MC,Ménard C,Lory P,Nargeot J,Capron L,Mornet D,Richard S

更新日期：2001-01-01 00:00:00

abstract：AIMS:Class III antiarrhythmic agents exhibit reverse rate-dependent lengthening of the action potential duration (APD). In spite of the several theories developed so far to explain this reverse rate dependency (RRD), its mechanism has not yet been clarified. The aim of the present work was to further elucidate the mech...

journal_title：Cardiovascular research

authors： Bányász T,Horváth B,Virág L,Bárándi L,Szentandrássy N,Harmati G,Magyar J,Marangoni S,Zaza A,Varró A,Nánási PP

更新日期：2009-11-01 00:00:00

abstract：:Cholesterol is an essential component of both the peripheral nervous system and central nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes and oligodendrocytes and is almost completely isolated from other pools of cholesterol in the body, but a small fraction can be taken up from t...

journal_title：Cardiovascular research

authors： Vitali C,Wellington CL,Calabresi L

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:Dexamethasone-eluting stents are currently under evaluation to prevent post-angioplasty restenosis. The efficacy and safety of dexamethasone as an anti-restenotic agent is still unclear. We assess the effect of perivascular delivery of dexamethasone on vascular pathology in a mouse model of restenosis. METHO...

journal_title：Cardiovascular research

authors： Pires NM,Schepers A,van der Hoeven BL,de Vries MR,Boesten LS,Jukema JW,Quax PH

更新日期：2005-12-01 00:00:00

abstract：:Since data on velocity fields in the ascending aorta downstream of normal aortic valves in pigs have not yet been obtained velocity profiles were visualised using a hot film anemometer needle probe before and after total cardiopulmonary bypass and cold cardioplegic arrest. Furthermore, measurements were made during in...

journal_title：Cardiovascular research

authors： Hasenkam JM,Ostergaard JH,Pedersen EM,Paulsen PK,Nygaard H,Schurizek BA,Johannsen G

更新日期：1988-07-01 00:00:00

abstract：:The mechanisms whereby glucose reduces fatty acid-induced release of enzyme from the coronary-ligated isolated perfused working rat heart are investigated. Alterations in the tissue contents of ATP, phosphocreatine, or glycogen could be excluded as possible mechanisms for the beneficial effect of glucose in this syst...

journal_title：Cardiovascular research

authors： Opie LH,Bricknell OL

更新日期：1979-12-01 00:00:00

abstract：:In this review, we summarize current knowledge on the genetics of coronary artery disease, based on 10 years of genome-wide association studies. The discoveries began with individual studies using 200K single nucleotide polymorphism arrays and progressed to large-scale collaborative efforts, involving more than a 100 ...

journal_title：Cardiovascular research

authors： Erdmann J,Kessler T,Munoz Venegas L,Schunkert H

更新日期：2018-07-15 00:00:00

abstract：:Attempts were made to demonstrate release of vasoactive substances from the heart during coronary occlusion (for 60 min) and reperfusion (for 60 min), and to clarify the pathophysiological significance of them. Vasoactive substances were detected by superfusion of rabbit aortic and dog coronary arterial strips with gr...

journal_title：Cardiovascular research

authors： Tanabe M,Terashita ZI,Fujiwara S,Shimamoto N,Goto N,Nishikawa K,Hirata M

更新日期：1982-02-01 00:00:00

abstract：AIMS:Although increased Na(+)/Ca(2+) exchanger 1 (NCX1) expression is observed during heart failure (HF), the pathological role of NCX1 during the progression of HF remains unclear. We examined alterations of NCX1 expression and activity in hearts after transverse aortic constriction (TAC) surgery and explored whether ...

journal_title：Cardiovascular research

authors： Ujihara Y,Iwasaki K,Takatsu S,Hashimoto K,Naruse K,Mohri S,Katanosaka Y

更新日期：2016-09-01 00:00:00

abstract：AIMS:The hypoxia-inducible factor-1 (HIF-1) is the master modulator of hypoxic gene expression. The effects of chronically stabilized cardiac HIF-1α and its role in the diseased heart are not precisely known. The aims of this study were as follows: (i) to elucidate consequences of HIF-1α stabilization in the heart; (ii...

journal_title：Cardiovascular research

authors： Hölscher M,Schäfer K,Krull S,Farhat K,Hesse A,Silter M,Lin Y,Pichler BJ,Thistlethwaite P,El-Armouche A,Maier LS,Katschinski DM,Zieseniss A

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:Progressive loss of cardiomyocytes is one of the most important pathogenic characteristics of heart failure. Apoptosis may be an important mode of cell death in heart failure but it must be demonstrated by multiple criteria and not just TUNEL staining alone. Previously, we and others have demonstrated that be...

journal_title：Cardiovascular research

authors： Knaapen MW,Davies MJ,De Bie M,Haven AJ,Martinet W,Kockx MM

更新日期：2001-08-01 00:00:00

abstract：AIMS:Vascular calcification often occurs with advancing age, atherosclerosis, and metabolic disorders such as diabetes mellitus and end-stage renal disease. Vascular calcification is associated with cardiovascular events and increased mortality. Nitric oxide (NO) is crucial for maintaining vascular function, but little...

journal_title：Cardiovascular research

authors： Kanno Y,Into T,Lowenstein CJ,Matsushita K

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:Insulin protects cardiomyocytes from apoptosis. Insulin resistance usually refers to a defect in the ability of insulin to stimulate glucose uptake. It is unknown, however, whether or not insulin resistance compromises the cell-protective effect of the hormone. Caspases are a family of cysteine proteases that...

journal_title：Cardiovascular research

authors： Morisco C,Marrone C,Trimarco V,Crispo S,Monti MG,Sadoshima J,Trimarco B

更新日期：2007-12-01 00:00:00

abstract：AIMS:The expression of PUMA (p53-up-regulated modulator of apoptosis), an apoptosis-regulating gene, increases during endoplasmic reticulum stress. The mechanisms by which cyclic stretch influences the regulation of PUMA in vascular smooth muscle cells (VSMCs) during apoptosis remain unclear. We hypothesized that cycli...

journal_title：Cardiovascular research

authors： Cheng WP,Wang BW,Chen SC,Chang H,Shyu KG

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:This study was conducted to evaluate to what extent the ischemia-reperfusion injury resulting from the cardiopulmonary bypass (CPB) and aortic cross-clamping procedures during coronary artery bypass grafting (CABG) contributes to the systemic inflammatory response generally found in these patients. METHODS:S...

journal_title：Cardiovascular research

authors： Fransen EJ,Maessen JG,Hermens WT,Glatz JF,Buurman WA

更新日期：2000-03-01 00:00:00

abstract：:Arterial blood pressures were measured simultaneously in the thoracic and abdominal aortas in the same conscious rats. Intravenous administration of sodium nitroprusside caused a greater fall in systolic blood pressure in the abdominal aorta than in the thoracic aorta, whereas intravenous administration of methoxamine...

journal_title：Cardiovascular research

authors： Gardiner SM,Bennett T

更新日期：1986-05-01 00:00:00

abstract：OBJECTIVE:The regulation of pulmonary prostacyclin synthesis is not completely understood. We tested the hypothesis that prostacyclin production is predominantly stimulated by hemodynamic factors, such as increased shear-stress, and is thus increased in rats with chronic hypoxic pulmonary hypertension. METHODS:To this...

journal_title：Cardiovascular research

authors： Blumberg FC,Lorenz C,Wolf K,Sandner P,Riegger GA,Pfeifer M

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:Polymorphonuclear leukocytes (PMN), retained in the microvascular bed, can contribute to postischemic myocardial reperfusion injury. Since a beneficial effect of ACE-inhibition on reperfusion injury has been reported, we investigated the impact of cilazaprilat on PMN dependent reperfusion injury in isolated g...

journal_title：Cardiovascular research

authors： Kupatt C,Habazettl H,Zahler S,Weber C,Becker BF,Messmer K,Gerlach E

更新日期：1997-12-01 00:00:00

abstract：:Zero drift may be a cause of imprecision when micromanometer tipped catheters are used for intravascular pressure measurement over long periods of time. Drift of only a few mm Hg may represent a significant error when accurate recording of low vascular pressures is required. To overcome this problem a micromanometer t...

journal_title：Cardiovascular research

authors： Gibbs JS,Cunningham D,Sparrow J,Poole-Wilson PA,Fox KM

更新日期：1989-02-01 00:00:00

abstract：:Because of ventricular interdependence, part of the measured left ventricular diastolic pressure can be attributed to the right ventricle. Therefore, we examined the hypothesis that left ventricular diastolic properties are modified by alterations in right ventricular compliance and pressure even without a change in r...

journal_title：Cardiovascular research

authors： Santamore WP,Constantinescu M,Vinten-Johansen J,Johnston WE,Little WC

更新日期：1988-11-01 00:00:00

abstract：AIM:Atrial fibrosis, one of the most striking features in the pathology of atrial fibrillation (AF), is promoted by local and systemic inflammation. Electrophilic fatty acid nitroalkenes, endogenously generated by both metabolic and inflammatory reactions, are anti-inflammatory mediators that in synthetic form may be u...

journal_title：Cardiovascular research

authors： Rudolph TK,Ravekes T,Klinke A,Friedrichs K,Mollenhauer M,Pekarova M,Ambrozova G,Martiskova H,Kaur JJ,Matthes B,Schwoerer A,Woodcock SR,Kubala L,Freeman BA,Baldus S,Rudolph V

更新日期：2016-01-01 00:00:00

abstract：:Diabetic cardiomyopathy is a term used to describe cardiac muscle damage-induced heart failure. Multiple structural and biochemical reasons have been suggested to induce this disorder. The most prominent feature of the diabetic myocardium is attenuated insulin signalling that reduces survival kinases (Akt), potentiall...

journal_title：Cardiovascular research

authors： Puthanveetil P,Wan A,Rodrigues B

更新日期：2013-03-01 00:00:00